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Long-term outcome of PDT for local failure after CRT or RT for oesophageal cancer
Long-term outcome of PDT for local failure after CRT or RT for oesophageal cancer
The long-term local control and effect of photodynamic therapy (PDT) using talaporfin sodium and a diode laser (talaporfin...
Diagnostic accuracy of anti-integrin αvβ6 in ulcerative colitis: a diagnostic meta-analysis
Diagnostic accuracy of anti-integrin αvβ6 in ulcerative colitis: a diagnostic meta-analysis
Ulcerative colitis (UC) presents with diagnostic challenges due to symptom overlap with other gastrointestinal (GI) disord...
Efficacy and recovery of remimazolam versus midazolam in sedated upper gastrointestinal endoscopy: a multicenter randomized controlled trial in Japan (RECOVER Study)
Efficacy and recovery of remimazolam versus midazolam in sedated upper gastrointestinal endoscopy: a multicenter randomized controlled trial in Japan (RECOVER Study)
Sedation is increasingly essential for gastrointestinal endoscopy. Remimazolam, an ultra-short-acting benzodiazepine, has ...
mutation predicts resistance to immune checkpoint inhibitor-based therapy in intrahepatic cholangiocarcinoma
mutation predicts resistance to immune checkpoint inhibitor-based therapy in intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with limited treatment options and a poor prognosis. Alt...
-related pancreatitis: natural history and the impact of the pancreas-specific deletion on pancreatitis in mice
-related pancreatitis: natural history and the impact of the pancreas-specific deletion on pancreatitis in mice
The transient receptor potential cation channel subfamily V member 6 (TRPV6) gene, encoding a calcium-selective ion channe...
Clinicopathological features and prognosis of metastatic tumors in the small bowel: a large multicenter analysis of the JSCCR database in Japan
Clinicopathological features and prognosis of metastatic tumors in the small bowel: a large multicenter analysis of the JSCCR database in Japan
Owing to the rarity of metastatic tumors in the small bowel, their clinicopathological features, and prognostic factors re...
Mortality and cancer risk in patients with chronic pancreatitis in japan: insights into the importance of surveillance for pancreatic cancer
Mortality and cancer risk in patients with chronic pancreatitis in japan: insights into the importance of surveillance for pancreatic cancer
Since the 2010s, Japan’s national health insurance system has covered key management for chronic pancreatitis (CP), ...
Predictors of lymph node metastases, recurrence, and survival in patients with pedunculated-type T1 colorectal cancer
Predictors of lymph node metastases, recurrence, and survival in patients with pedunculated-type T1 colorectal cancer
The oncologic outcomes of pedunculated-type T1 colorectal cancer (CRC) remain unknown. We determined the risk factors for ...
Clinical significance of comprehensive genomic profiling in unresectable or recurrent gastrointestinal stromal tumors: a multicenter retrospective cohort study
Clinical significance of comprehensive genomic profiling in unresectable or recurrent gastrointestinal stromal tumors: a multicenter retrospective cohort study
Tyrosine kinase inhibitors (TKIs) targeting KIT and PDGFRA mutations are the mainstay of treatment for gastrointestinal st...
Deep learning-based mismatch repair prediction using colorectal cancer macroscopic images: a diagnostic study
Deep learning-based mismatch repair prediction using colorectal cancer macroscopic images: a diagnostic study
Mismatch repair (MMR) testing is recommended for all colorectal cancer (CRC) patients, but this assay necessitates the inv...
An endoscopic real-time in situ assessment of intestinal permeability in type 2 diabetes: links to microbiota and hyperglycemia
An endoscopic real-time in situ assessment of intestinal permeability in type 2 diabetes: links to microbiota and hyperglycemia
Although impaired intestinal barrier function is implicated in type 2 diabetes (T2D), its direct in vivo assessment in hum...
STAMBPL1 promotes the progression of gastric cancer via deubiquitinating IQGAP1 to activate the JAK2/STAT3 pathway
STAMBPL1 promotes the progression of gastric cancer via deubiquitinating IQGAP1 to activate the JAK2/STAT3 pathway
Gastric cancer (GC) is a highly aggressive malignancy with limited therapeutic options and poor clinical outcomes. Aberran...
Evaluation of endoscopic submucosal dissection as a treatment option for duodenal tumors ≥ 20 mm: a systematic review and meta-analysis by lesion size
Evaluation of endoscopic submucosal dissection as a treatment option for duodenal tumors ≥ 20 mm: a systematic review and meta-analysis by lesion size
The role of endoscopic submucosal dissection (ESD) in treating superficial non-ampullary duodenal epithelial tumors (SNADE...
Growth differentiation factor 15: from stress response to clinical utility in chronic liver diseases
Growth differentiation factor 15: from stress response to clinical utility in chronic liver diseases
The clinical landscape of chronic liver disease has changed with effective antiviral therapies, enabling the eradication o...
Paired liver–spleen high-frequency ultrasound deep learning network for full-stage liver fibrosis classification and clinical benefit compared with 2D-SWE in chronic hepatitis B cohort: a prospective multicenter study
Paired liver–spleen high-frequency ultrasound deep learning network for full-stage liver fibrosis classification and clinical benefit compared with 2D-SWE in chronic hepatitis B cohort: a prospective multicenter study
Elastography techniques such as two-dimensional shear wave elastography (2D-SWE) often result in missed or misdiagnoses wh...
Multi-modal molecular and spatial profiling reveals NNT as a prognostic biomarker in obesity-associated colorectal cancer
Multi-modal molecular and spatial profiling reveals NNT as a prognostic biomarker in obesity-associated colorectal cancer
Obesity is a known risk factor for colorectal cancer (CRC), but its impact on prognosis and tumor biology remains unclear....
Group 1 innate lymphoid cells and inflammatory macrophages exacerbate fibrosis in creeping fat through IFN-γ secretion
Group 1 innate lymphoid cells and inflammatory macrophages exacerbate fibrosis in creeping fat through IFN-γ secretion
Creeping fat is a characteristic of Crohn's disease and impacts the disease course. We evaluated creeping fat formatio...
Circulating miR-485-3p as a biomarker for VEGF-associated therapeutic response to atezolizumab plus bevacizumab in hepatocellular carcinoma
Circulating miR-485-3p as a biomarker for VEGF-associated therapeutic response to atezolizumab plus bevacizumab in hepatocellular carcinoma
In atezolizumab/bevacizumab (atezo/bev) therapy for unresectable hepatocellular carcinoma (HCC), the tumor immune environm...
Prevalence and risk factors for lymph node metastasis in duodenal neuroendocrine tumors: a systematic review and meta-analysis
Prevalence and risk factors for lymph node metastasis in duodenal neuroendocrine tumors: a systematic review and meta-analysis
Although the status of lymph node metastasis (LNM) is crucial in determining treatment strategy for duodenal neuroendocrin...
Clinical application of targeted α-emitter therapy in gastroenteropancreatic neuroendocrine neoplasms
Clinical application of targeted α-emitter therapy in gastroenteropancreatic neuroendocrine neoplasms
Effective therapeutic strategies for advanced gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) remain challengin...
Educational interventions to enhance support for balancing work and treatment in inflammatory bowel disease patients
Educational interventions to enhance support for balancing work and treatment in inflammatory bowel disease patients
Inflammatory bowel disease (IBD) significantly impacts employment and work productivity, necessitating support for balanci...
Post-marketing surveillance of tofacitinib in patients with ulcerative colitis in Japan: a final report of safety and effectiveness data
Post-marketing surveillance of tofacitinib in patients with ulcerative colitis in Japan: a final report of safety and effectiveness data
We present the final analysis of a tofacitinib post-marketing surveillance (PMS) study in Japanese patients with ulcerativ...
Endoscopic liquid biopsy of bile: superior diagnostic and prognostic performance of bile-derived exosomal miR-21-5p for biliary tract cancers
Endoscopic liquid biopsy of bile: superior diagnostic and prognostic performance of bile-derived exosomal miR-21-5p for biliary tract cancers
Compared to peripheral blood, bile as a microenvironment within the biliary tract is expected to contain a higher concentr...
Identification of novel plasma proteins as promising noninvasive biomarker for early diagnosis and surveillance of pancreatic ductal adenocarcinoma
Identification of novel plasma proteins as promising noninvasive biomarker for early diagnosis and surveillance of pancreatic ductal adenocarcinoma
Although cancer antigen 19–9 (CA 19–9) is the only FDA-approved biomarker for pancreatic ductal adenocarcinoma...
Impact of early aggressive treatment on long-term biochemical marker patterns in inflammatory bowel disease
Impact of early aggressive treatment on long-term biochemical marker patterns in inflammatory bowel disease
The disease course of inflammatory bowel disease (IBD) is highly variable; early and precise identification of patients wi...
Current status and trends in ERCP and post-ERCP pancreatitis in Japan: a nationwide observational study
Current status and trends in ERCP and post-ERCP pancreatitis in Japan: a nationwide observational study
Endoscopic retrograde cholangiopancreatography (ERCP) is indispensable for the management of biliary and pancreatic diseas...
Factors associated with actionable gene aberrations in pancreatic cancer based on the C-CAT database
Factors associated with actionable gene aberrations in pancreatic cancer based on the C-CAT database
Comprehensive genomic profiling (CGP) tests are increasingly used to explore the genomically matched therapies for solid t...
Serum FGF19 combined with GGT and other biomarkers predicted native liver survival following Kasai portoenterostomy in early biliary atresia
Serum FGF19 combined with GGT and other biomarkers predicted native liver survival following Kasai portoenterostomy in early biliary atresia
Accurately predicting the prognosis of biliary atresia (BA) prior to Kasai portoenterostomy (KPE) remains a challenge. The...
Abnormalities of intracellular organelles in metabolic dysfunction-associated steatotic disease
Abnormalities of intracellular organelles in metabolic dysfunction-associated steatotic disease
The concept of metabolic dysfunction-associated steatotic disease (MASLD) is increasingly being recognized. The mechanisms...
An axon guidance-related microRNA panel identifies perivascular plexus local recurrence following curative surgery in patients with pancreatic cancer
An axon guidance-related microRNA panel identifies perivascular plexus local recurrence following curative surgery in patients with pancreatic cancer
Complete oncological local control is essential for a potential cure in patients with pancreatic ductal adenocarcinoma (PD...
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