Circulating miR-485-3p as a biomarker for VEGF-associated therapeutic response to atezolizumab plus bevacizumab in hepatocellular carcinoma

Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229–63. https://doi.org/10.3322/caac.21834.

Article  PubMed  Google Scholar 

Llovet JM, Kelley RK, Villanueva A, et al. Hepatocellular carcinoma. Nat Rev Dis Primers. 2021;7:6. https://doi.org/10.1038/s41572-020-00240-3.

Article  PubMed  Google Scholar 

European Association for the Study of the Liver. Electronic address eee, European Association for the Study of the L. EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma. J Hepatol. 2018;69:182–236. https://doi.org/10.1016/j.jhep.2018.03.019.

Article  Google Scholar 

Bolondi L, Burroughs A, Dufour JF, et al. Heterogeneity of patients with intermediate (BCLC B) hepatocellular carcinoma: proposal for a subclassification to facilitate treatment decisions. Semin Liver Dis. 2012;32:348–59. https://doi.org/10.1055/s-0032-1329906.

Article  CAS  PubMed  Google Scholar 

Finn RS, Qin S, Ikeda M, et al. Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma. N Engl J Med. 2020;382:1894–905. https://doi.org/10.1056/NEJMoa1915745.

Article  CAS  PubMed  Google Scholar 

Bartel DP. Metazoan MicroRNAs. Cell. 2018;173:20–51. https://doi.org/10.1016/j.cell.2018.03.006.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oura K, Morishita A, Masaki T. Molecular and functional roles of microRNAs in the progression of hepatocellular carcinoma-a review. Int J Mol Sci. 2020. https://doi.org/10.3390/ijms21218362.

Article  PubMed  PubMed Central  Google Scholar 

Arroyo JD, Chevillet JR, Kroh EM, et al. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci U S A. 2011;108:5003–8. https://doi.org/10.1073/pnas.1019055108.

Article  PubMed  PubMed Central  Google Scholar 

Olejarz W, Kubiak-Tomaszewska G, Chrzanowska A, et al. Exosomes in angiogenesis and anti-angiogenic therapy in cancers. Int J Mol Sci. 2020. https://doi.org/10.3390/ijms21165840.

Article  PubMed  PubMed Central  Google Scholar 

Hato T, Zhu AX, Duda DG. Rationally combining anti-VEGF therapy with checkpoint inhibitors in hepatocellular carcinoma. Immunotherapy. 2016;8:299–313. https://doi.org/10.2217/imt.15.126.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oura K, Morishita A, Tadokoro T, et al. Immune microenvironment and the effect of vascular endothelial growth factor inhibition in hepatocellular carcinoma. Int J Mol Sci. 2024. https://doi.org/10.3390/ijms252413590.

Article  PubMed  PubMed Central  Google Scholar 

Hiraoka A, Michitaka K, Kumada T, et al. Validation and potential of albumin-bilirubin grade and prognostication in a nationwide survey of 46,681 hepatocellular carcinoma patients in Japan: the need for a more detailed evaluation of hepatic function. Liver Cancer. 2017;6:325–36. https://doi.org/10.1159/000479984.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25:402–8. https://doi.org/10.1006/meth.2001.1262.

Article  CAS  PubMed  Google Scholar 

Zhang J, Zhang Y, Ma Y, et al. Therapeutic potential of exosomal circRNA derived from synovial mesenchymal cells via targeting circEDIL3/miR-485-3p/PIAS3/STAT3/VEGF functional module in rheumatoid arthritis. Int J Nanomedicine. 2021;16:7977–94. https://doi.org/10.2147/IJN.S333465.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang H, Kang B, Ha Y, et al. High serum IL-6 correlates with reduced clinical benefit of atezolizumab and bevacizumab in unresectable hepatocellular carcinoma. JHEP Rep. 2023;5: 100672. https://doi.org/10.1016/j.jhepr.2023.100672.

Article  PubMed  PubMed Central  Google Scholar 

Jost-Brinkmann F, Demir M, Wree A, et al. Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma: results from a German real-world cohort. Aliment Pharmacol Ther. 2023;57:1313–25. https://doi.org/10.1111/apt.17441.

Article  CAS  PubMed  Google Scholar 

Matoya S, Suzuki T, Matsuura K, et al. The neutrophil-to-lymphocyte ratio at the start of the second course during atezolizumab plus bevacizumab therapy predicts therapeutic efficacy in patients with advanced hepatocellular carcinoma: a multicenter analysis. Hepatol Res. 2023;53:511–21. https://doi.org/10.1111/hepr.13886.

Article  CAS  PubMed  Google Scholar 

Giovannini C, Suzzi F, Tovoli F, et al. Low-baseline PD1+ granulocytes predict responses to atezolizumab-bevacizumab in hepatocellular carcinoma. Cancers (Basel). 2023. https://doi.org/10.3390/cancers15061661.

Article  PubMed  PubMed Central  Google Scholar 

Yang Z, Suda G, Maehara O, et al. Changes in serum growth factors during resistance to atezolizumab plus bevacizumab treatment in patients with unresectable hepatocellular carcinoma. Cancers (Basel). 2023. https://doi.org/10.3390/cancers15030593.

Article  PubMed  PubMed Central  Google Scholar 

Oyama T, Ran S, Ishida T, et al. Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells. J Immunol. 1998;160:1224–32.

Article  CAS  PubMed  Google Scholar 

Boucher Y, Kumar AS, Posada JM, et al. Bevacizumab improves tumor infiltration of mature dendritic cells and effector T-cells in triple-negative breast cancer patients. NPJ Precis Oncol. 2021;5:62. https://doi.org/10.1038/s41698-021-00197-w.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Terme M, Pernot S, Marcheteau E, et al. VEGFA-VEGFR pathway blockade inhibits tumor-induced regulatory T-cell proliferation in colorectal cancer. Cancer Res. 2013;73:539–49. https://doi.org/10.1158/0008-5472.CAN-12-2325.

Article  CAS  PubMed  Google Scholar 

Niho S, Kunitoh H, Nokihara H, et al. Randomized phase II study of first-line carboplatin-paclitaxel with or without bevacizumab in Japanese patients with advanced non-squamous non-small-cell lung cancer. Lung Cancer. 2012;76:362–7. https://doi.org/10.1016/j.lungcan.2011.12.005.

Article  PubMed  Google Scholar 

Comments (0)

No login
gif