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Cirrhotic cardiomyopathy in children with biliary atresia and genetic intrahepatic cholestasis: clinical course and outcomes
Cirrhotic cardiomyopathy in children with biliary atresia and genetic intrahepatic cholestasis: clinical course and outcomes
Cirrhotic cardiomyopathy (CCM) is an under recognized entity in children. The present study aimed to explore the prevalenc...
Diabetes mellitus is linked to higher mortality in alcohol-related acute-on-chronic liver failure
Diabetes mellitus is linked to higher mortality in alcohol-related acute-on-chronic liver failure
Acute-on-chronic liver failure (ACLF) is a rapidly progressive syndrome marked by high short-term mortality. While diabete...
SOX9 promotes hepatocyte proliferation via upregulating TGF-α expression during liver regeneration
SOX9 promotes hepatocyte proliferation via upregulating TGF-α expression during liver regeneration
The liver possesses a remarkable capacity for regeneration. Previous studies have shown that SOX9/HNF4α double-positi...
Expanding treatment indications in chronic hepatitis B: Should we treat all patients?
Expanding treatment indications in chronic hepatitis B: Should we treat all patients?
Nucleos(t)ide analogues (NUCs) are first-line agents for chronic hepatitis B (CHB). Current guidelines provide recommendat...
Cancer-associated fibroblasts in hepatocellular carcinoma: heterogeneity, mechanisms and therapeutic targets
Cancer-associated fibroblasts in hepatocellular carcinoma: heterogeneity, mechanisms and therapeutic targets
Hepatocellular carcinoma (HCC) is one of the common malignant cancers worldwide. Although immunotherapy has improved the t...
Predictive value of neutrophil-to-lymphocyte ratio in recurrent HCC after repeat hepatectomy or salvage liver transplantation
Predictive value of neutrophil-to-lymphocyte ratio in recurrent HCC after repeat hepatectomy or salvage liver transplantation
Hepatocellular carcinoma (HCC) is the most prevalent type of primary liver cancer, characterized by a high rate of recurre...
The Asian Pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic dysfunction-associated fatty liver disease
The Asian Pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic dysfunction-associated fatty liver disease
Metabolic dysfunction-associated fatty liver disease (MAFLD) affects over one-fourth of the global adult population and is...
Acute kidney injury stage 1a increases mortality of patients with cirrhosis: a prospective multicenter cohort study
Acute kidney injury stage 1a increases mortality of patients with cirrhosis: a prospective multicenter cohort study
Acute kidney injury is a severe complication of cirrhosis. However, the impact of mild decreases in renal function is cont...
Analysis of risk factors for immune checkpoint inhibitor-associated liver injury: a retrospective analysis based on clinical study and real-world data
Analysis of risk factors for immune checkpoint inhibitor-associated liver injury: a retrospective analysis based on clinical study and real-world data
Immune-mediated hepatotoxicity (IMH) induced by immune checkpoint inhibitors (ICIs) can lead to fatal outcomes. Exploring ...
Safety of tenofovir alafenamide in the context of hyperlipidemia and cardiovascular diseases: a nationwide analysis
Safety of tenofovir alafenamide in the context of hyperlipidemia and cardiovascular diseases: a nationwide analysis
Despite numerous small-scale studies, the correlation between tenofovir alafenamide fumarate (TAF) and hyperlipidemia rema...
Patterns and outcomes of early and late recurrence after hepatectomy for hepatocellular carcinoma with microvascular invasion: a multicenter study in China
Patterns and outcomes of early and late recurrence after hepatectomy for hepatocellular carcinoma with microvascular invasion: a multicenter study in China
A few studies focus on the long-term outcomes and surveillance strategies for patients with hepatocellular carcinoma (HCC)...
Global prevalence, metabolic characteristics, and outcomes of lean-MAFLD: a systematic review and meta-analysis
Global prevalence, metabolic characteristics, and outcomes of lean-MAFLD: a systematic review and meta-analysis
Metabolic Dysfunction-Associated Fatty Liver disease (MAFLD) among lean individuals is increasingly recognized. We aimed t...
Efficacy of measuring natural killer-activating receptor ligands to predict the pathogenesis of metabolic dysfunction-associated steatotic liver disease
Efficacy of measuring natural killer-activating receptor ligands to predict the pathogenesis of metabolic dysfunction-associated steatotic liver disease
The proportion of non-B/non-C hepatocellular carcinoma cases is increasing, and the principal cause is metabolic dysfuncti...
Explainable attention-enhanced heuristic paradigm for multi-view prognostic risk score development in hepatocellular carcinoma
Explainable attention-enhanced heuristic paradigm for multi-view prognostic risk score development in hepatocellular carcinoma
Existing prognostic staging systems depend on expensive manual extraction by pathologists, potentially overlooking latent ...
Incidence and predictors of hepatocellular carcinoma in NAFLD without diagnosed cirrhosis: a nationwide real-world U.S. study
Incidence and predictors of hepatocellular carcinoma in NAFLD without diagnosed cirrhosis: a nationwide real-world U.S. study
A substantial proportion of patients with nonalcoholic fatty liver disease (NAFLD)-related hepatocellular carcinoma (HCC) ...
Recompensation in treatment-naïve HBV-related decompensated cirrhosis: a 5-year multi-center observational study comparing patients with ascites and bleeding
Recompensation in treatment-naïve HBV-related decompensated cirrhosis: a 5-year multi-center observational study comparing patients with ascites and bleeding
Recompensation between patients with ascites and bleeding was unknown in treatment-naïve HBV-related decompensated ci...
How non-alcoholic fatty liver disease and cirrhosis affect the heart
How non-alcoholic fatty liver disease and cirrhosis affect the heart
Liver diseases affect the heart and the vascular system. Cardiovascular complications appear to be a leading cause of deat...
Ending stigmatizing language in alcohol and liver disease: a liver societies’ statement
Ending stigmatizing language in alcohol and liver disease: a liver societies’ statement
Authors and AffiliationsConsortiaEuropean Association for the Study of the LiverAmerican Association for the Study of Live...
Serial circulating tumor DNA profiling predicts tumor recurrence after liver transplantation for liver cancer
Serial circulating tumor DNA profiling predicts tumor recurrence after liver transplantation for liver cancer
Minimal residual disease (MRD) is proposed to be responsible for tumor recurrence. The role of circulating tumor DNA (ctDN...
Why is the functional cure rate of young children with chronic hepatitis B receiving antiviral therapy considerably high?
Why is the functional cure rate of young children with chronic hepatitis B receiving antiviral therapy considerably high?
Terrault NA, Lok AS, McMahon BJ, Chang KM, Hwang JP, Jonas MM, et al. Update on prevention, diagnosis, and treatment of ch...
A multicenter propensity score analysis of significance of hepatic resection type for early-stage hepatocellular carcinoma
A multicenter propensity score analysis of significance of hepatic resection type for early-stage hepatocellular carcinoma
The impact of hepatic resection type on long-term oncological prognosis of patients with early-stage hepatocellular carcin...
Is lenvatinib in combination with transarterial chemoembolization benefit for unresectable hepatocellular carcinoma (uHCC)? The age interference needs to be eliminated
Is lenvatinib in combination with transarterial chemoembolization benefit for unresectable hepatocellular carcinoma (uHCC)? The age interference needs to be eliminated
Fu Z, Li X, Zhong J, Chen X, Cao K, Ding N, et al. Lenvatinib in combination with transarterial chemoembolization for trea...
Autophagy and extracellular vesicles in the liver endothelium: friends or foes?
Autophagy and extracellular vesicles in the liver endothelium: friends or foes?
Role of autophagy in liver sinusoidal endothelial cells (LSECs) and their interaction with hepatic stellate cells (HSC). E...
Proteome-wide Mendelian randomization highlights AIF1 and HLA-DQA2 as targets for primary sclerosing cholangitis
Proteome-wide Mendelian randomization highlights AIF1 and HLA-DQA2 as targets for primary sclerosing cholangitis
Primary sclerosing cholangitis (PSC) is a kind of cholestatic liver disease without effective therapies and its pathogenes...
Intrahepatic cholestasis of pregnancy: insights into pathogenesis and advances in omics studies
Intrahepatic cholestasis of pregnancy: insights into pathogenesis and advances in omics studies
Intrahepatic cholestasis of pregnancy (ICP) is the most common pregnancy-specific liver disease. It is characterized by pr...
Targeting ferroptosis in hepatocellular carcinoma
Targeting ferroptosis in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a common malignant tumor with complex survival mechanism and drug resistance, resulting ...
TACE plus tyrosine kinase inhibitors and immune checkpoint inhibitors versus TACE plus tyrosine kinase inhibitors for the treatment of patients with hepatocellular carcinoma: a meta-analysis and trial sequential analysis
TACE plus tyrosine kinase inhibitors and immune checkpoint inhibitors versus TACE plus tyrosine kinase inhibitors for the treatment of patients with hepatocellular carcinoma: a meta-analysis and trial sequential analysis
We conducted a meta-analysis and trial sequential analysis (TSA) to compare the therapeutic efficacy and adverse events (A...
Gender differences in non-alcoholic fatty liver disease in obese children and adolescents: a large cross-sectional study
Gender differences in non-alcoholic fatty liver disease in obese children and adolescents: a large cross-sectional study
Previous studies have reported sex differences in non-alcoholic fatty liver disease (NAFLD) among adults; however, little ...
Fibroblast growth factor inhibition by molecular-targeted agents mitigates immunosuppressive tissue microenvironment in hepatocellular carcinoma
Fibroblast growth factor inhibition by molecular-targeted agents mitigates immunosuppressive tissue microenvironment in hepatocellular carcinoma
Combination immunotherapy refers to the use of immune checkpoint inhibitors (ICI) and molecular-targeted agents (MTA), whi...
Complementary role of peripheral and central autonomic nervous system on insulin-like growth factor-1 activation to prevent fatty liver disease
Complementary role of peripheral and central autonomic nervous system on insulin-like growth factor-1 activation to prevent fatty liver disease
Insulin-like growth factor-1 (IGF-1) is involved in the pathology of non-alcoholic fatty liver disease (NAFLD) and amelior...
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