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What do we mean by gut health?
A new Consensus Statement puts forward a definition of ‘gut health’ in an attempt to bring some clarity and co...
Global position statement supporting a World Health Assembly resolution on steatotic liver disease
Global position statement supporting a World Health Assembly resolution on steatotic liver disease
Steatotic liver disease has a high human and economic burden, yet remains absent from WHO normative guidance, action plans...
Deciphering cytochrome P450 reductase role in MASLD: molecular mechanisms and pathophysiological implications
Deciphering cytochrome P450 reductase role in MASLD: molecular mechanisms and pathophysiological implications
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent and rapidly growing global health concern ...
The critical role of gut–brain signalling in eating behaviour and obesity
The critical role of gut–brain signalling in eating behaviour and obesity
The process of eating can be divided into three distinct phases of behaviour: food seeking, food consumption and non-prand...
γδ T cells in colorectal and liver cancer
γδ T cells in colorectal and liver cancer
Among tissue-resident immune cells, γδ T cells have a unique role in local immune surveillance. Under homeostati...
Liver disease care amid wars and conflicts
This Comment highlights the effects of war- and armed conflict-related healthcare disruptions on chronic liver conditions ...
Cirrhosis, portal hypertension and hepatocellular carcinoma: a stage-based approach
Cirrhosis, portal hypertension and hepatocellular carcinoma: a stage-based approach
Cirrhosis and hepatocellular carcinoma (HCC) are interconnected outcomes of chronic liver disease, with portal hypertensio...
Rome Foundation Working Team Report on overlap in disorders of gut–brain interaction
Rome Foundation Working Team Report on overlap in disorders of gut–brain interaction
In patients with disorders of gut–brain interaction (DGBI), overlapping non-gastrointestinal conditions such as fibr...
Preventing the progression of cirrhosis to decompensation and death
Preventing the progression of cirrhosis to decompensation and death
Two main stages are differentiated in patients with advanced chronic liver disease (ACLD), one compensated (cACLD) with an...
Coeliac disease: complications and comorbidities
Coeliac disease: complications and comorbidities
Coeliac disease is an autoimmune disease characterized by small intestinal villus atrophy and inflammation upon exposure t...
Understanding the therapeutic toolkit for inflammatory bowel disease
Understanding the therapeutic toolkit for inflammatory bowel disease
Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn’s disease, is a group of chronic, immune...
Is precision microbiome medicine just around the corner?
Is precision microbiome medicine just around the corner?
A study in Nature Medicine developed a new clinical test based on a gut metagenome-derived multispecies biomarker panel fo...
MASLD as a non-communicable disease
Non-communicable diseases represent the primary cause of mortality and morbidity globally, accounting for 74% of all death...
New potent HBV replication inhibitors for the management of chronic hepatitis B are needed
New potent HBV replication inhibitors for the management of chronic hepatitis B are needed
With several drugs in use that inhibit the hepatitis B virus polymerases (nucleos(t)ide analogues (or NUCs)), some argue t...
RET signalling controls gut motility
RET signalling controls gut motility
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New options for late-line treatment of metastatic colorectal cancer
New options for late-line treatment of metastatic colorectal cancer
Metastatic colorectal cancer is a heterogeneous disease associated with poor patient outcomes. Although the past ...
Gut microbiota in overweight and obesity: crosstalk with adipose tissue
Gut microbiota in overweight and obesity: crosstalk with adipose tissue
Overweight and obesity are characterized by excessive fat mass accumulation produced when energy intake exceeds energy exp...
Microbiota-based biomarkers and therapeutics for cancer management
Microbiota-based biomarkers and therapeutics for cancer management
New light is being shed on the interactions between the gut microbiome, cancer cell signalling and the host immune respons...
Tumour-associated macrophages and pancreatic cancer: an inflammatory loop
Tumour-associated macrophages and pancreatic cancer: an inflammatory loop
In a new study published in Nature, researchers have investigated the role of tumour-associated macrophages (TAMs) in panc...
Upgrading therapeutic ambitions and treatment outcomes
Upgrading therapeutic ambitions and treatment outcomes
Important studies published in 2023 outlined new agents and strategies for the management of inflammatory bowel disease. T...
Role of steatotic liver disease in prediction and prevention of cardiometabolic diseases
Role of steatotic liver disease in prediction and prevention of cardiometabolic diseases
Steatotic liver disease has emerged as an important risk factor for cardiovascular disease, type 2 diabetes mellitus and c...
Elafibranor in primary biliary cholangitis
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Resmetirom safe for nonalcoholic fatty liver disease
A 52-week randomized, double-blind, placebo-controlled phase III trial (MAESTRO-NAFLD-1) evaluated the safety of resmetiro...
See the reality again in the field of liver transplantation
In 2023, we witnessed advances in allocation policies and marginal donors, including living donors. Key improvements inclu...
Amitriptyline as second-line treatment for IBS in primary care settings
Titrated low-dose amitriptyline (a tricyclic antidepressant) was superior to placebo as a second-line treatment for irrita...
Fresh perspectives on how to build, maintain and repair the ENS
Fresh perspectives on how to build, maintain and repair the ENS
Enteric nervous system function is essential for survival. Studies published in 2023 have provided important novel insight...
EASL SLD Summit 2023
In September 2023, Nature Reviews Gastroenterology & Hepatology attended the European Association for the Study of the...