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Rome Foundation Working Team Report on overlap in disorders of gut–brain interaction
Rome Foundation Working Team Report on overlap in disorders of gut–brain interaction
In patients with disorders of gut–brain interaction (DGBI), overlapping non-gastrointestinal conditions such as fibr...
Preventing the progression of cirrhosis to decompensation and death
Preventing the progression of cirrhosis to decompensation and death
Two main stages are differentiated in patients with advanced chronic liver disease (ACLD), one compensated (cACLD) with an...
Coeliac disease: complications and comorbidities
Coeliac disease: complications and comorbidities
Coeliac disease is an autoimmune disease characterized by small intestinal villus atrophy and inflammation upon exposure t...
Understanding the therapeutic toolkit for inflammatory bowel disease
Understanding the therapeutic toolkit for inflammatory bowel disease
Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn’s disease, is a group of chronic, immune...
Is precision microbiome medicine just around the corner?
Is precision microbiome medicine just around the corner?
A study in Nature Medicine developed a new clinical test based on a gut metagenome-derived multispecies biomarker panel fo...
MASLD as a non-communicable disease
Non-communicable diseases represent the primary cause of mortality and morbidity globally, accounting for 74% of all death...
New potent HBV replication inhibitors for the management of chronic hepatitis B are needed
New potent HBV replication inhibitors for the management of chronic hepatitis B are needed
With several drugs in use that inhibit the hepatitis B virus polymerases (nucleos(t)ide analogues (or NUCs)), some argue t...
RET signalling controls gut motility
RET signalling controls gut motility
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New options for late-line treatment of metastatic colorectal cancer
New options for late-line treatment of metastatic colorectal cancer
Metastatic colorectal cancer is a heterogeneous disease associated with poor patient outcomes. Although the past ...
Gut microbiota in overweight and obesity: crosstalk with adipose tissue
Gut microbiota in overweight and obesity: crosstalk with adipose tissue
Overweight and obesity are characterized by excessive fat mass accumulation produced when energy intake exceeds energy exp...
Microbiota-based biomarkers and therapeutics for cancer management
Microbiota-based biomarkers and therapeutics for cancer management
New light is being shed on the interactions between the gut microbiome, cancer cell signalling and the host immune respons...
Tumour-associated macrophages and pancreatic cancer: an inflammatory loop
Tumour-associated macrophages and pancreatic cancer: an inflammatory loop
In a new study published in Nature, researchers have investigated the role of tumour-associated macrophages (TAMs) in panc...
Upgrading therapeutic ambitions and treatment outcomes
Upgrading therapeutic ambitions and treatment outcomes
Important studies published in 2023 outlined new agents and strategies for the management of inflammatory bowel disease. T...
Role of steatotic liver disease in prediction and prevention of cardiometabolic diseases
Role of steatotic liver disease in prediction and prevention of cardiometabolic diseases
Steatotic liver disease has emerged as an important risk factor for cardiovascular disease, type 2 diabetes mellitus and c...
Elafibranor in primary biliary cholangitis
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Resmetirom safe for nonalcoholic fatty liver disease
A 52-week randomized, double-blind, placebo-controlled phase III trial (MAESTRO-NAFLD-1) evaluated the safety of resmetiro...
See the reality again in the field of liver transplantation
In 2023, we witnessed advances in allocation policies and marginal donors, including living donors. Key improvements inclu...
Amitriptyline as second-line treatment for IBS in primary care settings
Titrated low-dose amitriptyline (a tricyclic antidepressant) was superior to placebo as a second-line treatment for irrita...
Fresh perspectives on how to build, maintain and repair the ENS
Fresh perspectives on how to build, maintain and repair the ENS
Enteric nervous system function is essential for survival. Studies published in 2023 have provided important novel insight...
EASL SLD Summit 2023
In September 2023, Nature Reviews Gastroenterology & Hepatology attended the European Association for the Study of the...
No excess cancer risk for non-erosive disease
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SMART cancer risk prediction
A new machine-learning (ML) tool outperforms all existing hepatocellular carcinoma risk prediction methods in patients wit...
Folate receptor-γ in MASH-related fibrosis
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Innovation is needed to increase viral hepatitis testing globally
Innovation is needed to increase viral hepatitis testing globally
Innovative approaches to increase testing are needed to achieve the 2030 hepatitis B and hepatitis C elimination targets. ...
Implications of the evolving knowledge of the genetic architecture of MASLD
Implications of the evolving knowledge of the genetic architecture of MASLD
Metabolic dysfunction-associated steatotic liver disease (MASLD) has a strong heritable component, and genome-wide associa...
Deciphering the different phases of preclinical inflammatory bowel disease
Deciphering the different phases of preclinical inflammatory bowel disease
Inflammatory bowel disease (IBD) is an immune-mediated inflammatory disease (IMID) of the gastrointestinal tract and inclu...
Understanding remodelling of bile ducts to promote polycystic liver disease
Understanding remodelling of bile ducts to promote polycystic liver disease
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