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A case of complete remission by cabozantinib as an end-line treatment for advanced hepatocellular carcinoma
A case of complete remission by cabozantinib as an end-line treatment for advanced hepatocellular carcinoma
Cabozantinib is a multi-kinase inhibitor targeting multiple tyrosine kinases. It improves overall survival and progression...
Successful radical surgery for lymph node metastasis in a patient with hepatocellular carcinoma following atezolizumab plus bevacizumab combination therapy: a case report and literature review
Successful radical surgery for lymph node metastasis in a patient with hepatocellular carcinoma following atezolizumab plus bevacizumab combination therapy: a case report and literature review
A woman in her early 80 s was followed up in our hospital for chronic hepatitis C after viral eradication. We detected rap...
Successful novel use of dupilumab for gastrointestinal involvement of idiopathic hypereosinophilic syndrome: case report and review of the literature
Successful novel use of dupilumab for gastrointestinal involvement of idiopathic hypereosinophilic syndrome: case report and review of the literature
Hypereosinophilic syndrome (HES) is characterized by blood and tissue hypereosinophilia leading to organ damage. Gastroint...
A small bowel adenocarcinoma harboring a DDR2 mutation in a celiac patient
A small bowel adenocarcinoma harboring a DDR2 mutation in a celiac patient
We present the case of a 62-year-old man with a history of celiac disease and IgA deficiency, following a strict gluten-fr...
A case of colon cancer implanted on endoscopic resection ulcer certified by cancer genomic testing
A case of colon cancer implanted on endoscopic resection ulcer certified by cancer genomic testing
A 90 year-old man underwent endoscopic mucosal resection for lesions in the descending and sigmoid colons as well...
Portal vein stenting blocked the inflow tract and completely resolved bile duct varices, formed by cavernous transformation of the portal vein
Portal vein stenting blocked the inflow tract and completely resolved bile duct varices, formed by cavernous transformation of the portal vein
There is no established treatment for bleeding bile duct varices (BDVs). We report the first case of portal vein (PV) sten...
Tubular adenoma at the hepatico-jejunal anastomosis in familial adenomatous polyposis (FAP) following pancreaticoduodenectomy: challenges in adenoma surveillance and management
Tubular adenoma at the hepatico-jejunal anastomosis in familial adenomatous polyposis (FAP) following pancreaticoduodenectomy: challenges in adenoma surveillance and management
Upper gastrointestinal tumors, including ampullary adenomas, occur frequently in patients with familial adenomatous polypo...
Endoscopic ultrasound-guided fine-needle biopsy diagnosing pancreatic metastasis seven years after renal leiomyosarcoma resection: a case report
Endoscopic ultrasound-guided fine-needle biopsy diagnosing pancreatic metastasis seven years after renal leiomyosarcoma resection: a case report
Renal leiomyosarcoma metastasis to the pancreas is exceptionally rare. Here, we present a case of metastatic recurrence in...
A case of immune checkpoint inhibitor-associated hemophagocytosis after initiation of atezolizumab plus bevacizumab therapy for advanced hepatocellular carcinoma
A case of immune checkpoint inhibitor-associated hemophagocytosis after initiation of atezolizumab plus bevacizumab therapy for advanced hepatocellular carcinoma
A woman in the 70s with a decreased appetite and weight loss (4 kg) in the last 3 months was referred to...
Endoscopic ultrasound-guided drainage for mediastinal abscess: first report of bridge to surgery for esophageal cancer
Endoscopic ultrasound-guided drainage for mediastinal abscess: first report of bridge to surgery for esophageal cancer
Perforated esophageal cancer rarely results in the formation of mediastinal abscess. Endoscopic ultrasound (EUS)-guided ab...
Variceal bleeding following treatment with atezolizumab plus bevacizumab in two patients with unresectable hepatocellular carcinoma
Variceal bleeding following treatment with atezolizumab plus bevacizumab in two patients with unresectable hepatocellular carcinoma
Bleeding-related adverse events may occur due to anti-vascular endothelial growth factors. Here, we report two cases of va...
Metastatic melanoma: an unexpected cause of acute liver failure
Metastatic melanoma: an unexpected cause of acute liver failure
Acute liver failure secondary to metastatic melanoma is exceedingly rare with the literature limited to case reports. The ...
Rapid deterioration of steatotic liver disease due to portal vein stenosis after pancreaticoduodenectomy
Rapid deterioration of steatotic liver disease due to portal vein stenosis after pancreaticoduodenectomy
Steatotic liver disease after pancreatoduodenectomy occurs due to various factors, such as exocrine pancreatic insufficien...
Diffuse large B-cell lymphoma of the gallbladder with hepatoduodenal invasion exhibiting a necrotic tendency
Diffuse large B-cell lymphoma of the gallbladder with hepatoduodenal invasion exhibiting a necrotic tendency
We report a case of diffuse large B-cell lymphoma (DLBCL) of the gallbladder with extensive hepatoduodenal invasion, which...
Portal cavernoma cholangiopathy treated with living donor liver transplantation: a case report and review of the literature
Portal cavernoma cholangiopathy treated with living donor liver transplantation: a case report and review of the literature
Portal cavernoma cholangiopathy (PCC) is a complex condition associated with portal hypertension, particularly in patients...
Endoscopic ultrasound navigated application of botulinum toxin in severe esophageal motility disorder
Endoscopic ultrasound navigated application of botulinum toxin in severe esophageal motility disorder
The use of botulinum toxin in the therapy of esophageal motility disorders is reserved for elderly and comorbid patients c...
Comprehensive genome analysis of hepatitis B virus using nanopore sequencing technology in patients with previously resolved infection and spontaneous reactivation without drug exposure
Comprehensive genome analysis of hepatitis B virus using nanopore sequencing technology in patients with previously resolved infection and spontaneous reactivation without drug exposure
A 75-year-old Japanese woman experienced persistent fatigue and progressive jaundice for 6 weeks, and was subsequently dia...
A case of gastric/duodenal diffuse large B cell lymphoma observed during the administration of tacrolimus/azathioprine for dermatomyositis
A case of gastric/duodenal diffuse large B cell lymphoma observed during the administration of tacrolimus/azathioprine for dermatomyositis
The patient was diagnosed with amyopathic dermatomyositis complicated with interstitial pneumonia (IP) at age 35. She had ...
Cognitive and ataxic adverse events following entrectinib treatment in NTRK1 fusion gene-positive intrahepatic cholangiocarcinoma: a case report
Cognitive and ataxic adverse events following entrectinib treatment in NTRK1 fusion gene-positive intrahepatic cholangiocarcinoma: a case report
We report the rare case of severe cognitive disorder and ataxia caused by entrectinib in a patient with NTRK1 fusion gene-...
Pathological complete response of hepatocellular carcinoma confirmed by conversion hepatectomy following atezolizumab plus bevacizumab therapy: a case report and literature review
Pathological complete response of hepatocellular carcinoma confirmed by conversion hepatectomy following atezolizumab plus bevacizumab therapy: a case report and literature review
The combination regimen of atezolizumab plus bevacizumab (Atezo/Bev) is currently used as first-line treatment in patients...
Colitis induced by IL-17A-inhibitors
Colitis induced by IL-17A-inhibitors
Interleukin (IL)-17A is essential for intestinal mucosal integrity, contributing to the prevention of detrimental immunity...
A case of refractory immune checkpoint inhibitor-induced colitis improved by the treatment with vedolizumab and granulocyte–monocyte apheresis combination therapy
A case of refractory immune checkpoint inhibitor-induced colitis improved by the treatment with vedolizumab and granulocyte–monocyte apheresis combination therapy
A 68-year-old man developed immune-related adverse event (irAE) colitis after the initiation of nivolumab and ipilimumab c...
Nintedanib-associated enterocolitis with intractable diarrhea: a case report
Nintedanib-associated enterocolitis with intractable diarrhea: a case report
Revised idiopathic pulmonary fibrosis treatment guidelines were published in 2015, and nintedanib was conditionally recomm...
Metastatic pancreatic cancer with multiple metastases confined to the large intestine: a case report and literature review
Metastatic pancreatic cancer with multiple metastases confined to the large intestine: a case report and literature review
The incidence and mortality rate of pancreatic cancer are increasing worldwide. Regional lymph nodes, liver, lung, and per...
Acinar cystic transformation in the pancreatic tail
Acinar cystic transformation in the pancreatic tail
Pancreatic acinar cystic transformation (ACT) is a rare non-neoplastic cystic lesion that is predominantly located at the ...
A case of synchronous IgG4-associated pleuritis and type 1 autoimmune pancreatitis
A case of synchronous IgG4-associated pleuritis and type 1 autoimmune pancreatitis
A 50-year-old man presented to the emergency department with left chest pain, epigastralgia, and low-grade fever for sever...
Unexpected anti-tumor effect of immune checkpoint inhibitors followed by transcatheter arterial chemoembolization for hepatocellular carcinoma
Unexpected anti-tumor effect of immune checkpoint inhibitors followed by transcatheter arterial chemoembolization for hepatocellular carcinoma
The abscopal effect has recently attracted much attention because this effect is enhanced by immune checkpoint inhibitors ...
Multiple enteric muco-submucosal elongated polyps causing intussusception
Multiple enteric muco-submucosal elongated polyps causing intussusception
A 20-year-old woman presented to our hospital with abdominal pain. Abdominal computed tomography revealed multiple masses ...
A case of pseudomyxoma peritonei arising from a perforated intraductal papillary mucinous neoplasm that underwent cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
A case of pseudomyxoma peritonei arising from a perforated intraductal papillary mucinous neoplasm that underwent cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
Pseudomyxoma peritonei (PMP) of pancreatic origin arising from an intraductal papillary mucinous neoplasm (IPMN) is rare. ...
LAMS use in malignant stricture of duodenal apex with synchronous malignant biliary obstruction: a potentially effective and simpler endoscopic approach
LAMS use in malignant stricture of duodenal apex with synchronous malignant biliary obstruction: a potentially effective and simpler endoscopic approach
We report the first case of lumen apposing metal stent (LAMS) use in malignant stricture of the duodenal apex to treat gas...
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