Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229–63.

PubMed  Google Scholar 

Ajani JA, D'Amico TA, Bentrem DJ, et al. Gastric Cancer, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology. J Natl Compr Canc Netw. 2025;23(5):169–191.

Lim SH, An M, Lee H, et al. Determinants of response to sequential pembrolizumab with trastuzumab plus platinum/5-FU in HER2-positive gastric cancer: a phase II chemoimmunotherapy trial. Clin Cancer Res. 2025;31(8):1476–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang C, Chen L, Ye C, et al. Thirdhand smoke exposure promotes gastric tumor development in mouse and human. Environ Int. 2024;191:108986.

Article  CAS  PubMed  Google Scholar 

Majeed S, Aparnathi MK, Nixon KCJ, et al. Targeting the ubiquitin-proteasome system using the UBA1 inhibitor TAK-243 is a potential therapeutic strategy for small-cell lung cancer. Clin Cancer Res. 2022;28(9):1966–78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu F, Chen J, Li K, et al. Ubiquitination and deubiquitination in cancer: from mechanisms to novel therapeutic approaches. Mol Cancer. 2024;23(1):148.

Article  PubMed  PubMed Central  Google Scholar 

Song SR, Seo SU, Woo SM, et al. Tubeimoside-1 enhances TRAIL-induced apoptotic cell death through STAMBPL1-mediated c-FLIP downregulation. Int J Mol Sci. 2023;24(14):11840.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fang H, Liang H, Yang C, et al. STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer. Elife. 2025;13:RP102433.

Article  PubMed  PubMed Central  Google Scholar 

Zhang H, Wang Z, Zhang J, et al. A MYC-STAMBPL1-TOE1 positive feedback loop mediates EGFR stability in hepatocellular carcinoma. Cell Rep. 2024;43(10):114812.

Article  CAS  PubMed  Google Scholar 

Shahriyar SA, Woo SM, Seo SU, et al. Cepharanthine enhances TRAIL-mediated apoptosis through STAMBPL1-mediated downregulation of survivin expression in renal carcinoma cells. Int J Mol Sci. 2018;19(10):3280.

Article  PubMed  PubMed Central  Google Scholar 

Wang D, Xu C, Yang W, et al. E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression. Mol Cell. 2022;82(4):770-784.e9.

Article  CAS  PubMed  Google Scholar 

Ambroise G, Yu TT, Zhang B, et al. Systematic analysis reveals a functional role for STAMBPL1 in the epithelial-mesenchymal transition process across multiple carcinomas. Br J Cancer. 2020;123(7):1164–77.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Z, Zhang Y, Shen Y, et al. Liquidambaric acid inhibits cholangiocarcinoma progression by disrupting the STAMBPL1/NRF2 positive feedback loop. Phytomedicine. 2025;136:156303.

Article  CAS  PubMed  Google Scholar 

Chen X, Shi H, Bi X, et al. Targeting the deubiquitinase STAMBPL1 triggers apoptosis in prostate cancer cells by promoting XIAP degradation. Cancer Lett. 2019;456:49–58.

Article  CAS  PubMed  Google Scholar 

Wang Z, Zhang Y, Shen Y, et al. Unlocking hepatocellular carcinoma aggression: STAMBPL1-mediated TRAF2 deubiquitination activates WNT/PI3K/NF-kb signaling pathway. Biol Direct. 2024;19(1):18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Johnson M, Sharma M, Henderson BR. IQGAP1 regulation and roles in cancer. Cell Signal. 2009;21(10):1471–8.

Article  CAS  PubMed  Google Scholar 

Hu HF, Gao GB, He X, et al. Targeting ARF1-IQGAP1 interaction to suppress colorectal cancer metastasis and vemurafenib resistance. J Adv Res. 2023;51:135–47.

Article  CAS  PubMed  Google Scholar 

Hu W, Wang Z, Zhang S, et al. IQGAP1 promotes pancreatic cancer progression and epithelial-mesenchymal transition (EMT) through Wnt/β-catenin signaling. Sci Rep. 2019;9(1):7539.

Article  PubMed  PubMed Central  Google Scholar 

Liu J, Ni X, Li Y, et al. Downregulation of IQGAP1 inhibits epithelial-mesenchymal transition via the HIF1α/VEGF-A signaling pathway in gastric cancer. J Cell Biochem. 2019;120(9):15790–9.

Article  CAS  PubMed  Google Scholar 

Xie W, Han Z, Zuo Z, et al. ASAP1 activates the IQGAP1/CDC42 pathway to promote tumor progression and chemotherapy resistance in gastric cancer. Cell Death Dis. 2023;14(2):124.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Z, Tang X, Li W, et al. HIST1H2BK predicts neoadjuvant-chemotherapy response and mediates 5-fluorouracil resistance of gastric cancer cells. Transl Oncol. 2024;46:102017.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang X, Huang J, Jiang Y, et al. Intercellular adhesion molecule 2 as a novel prospective tumor suppressor induced by ERG promotes ubiquitination-mediated radixin degradation to inhibit gastric cancer tumorigenicity and metastasis. J Transl Med. 2023;21(1):670.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang S, Qin X, Fu S, et al. STAMBPL1/TRIM21 balances AXL stability impacting mesenchymal phenotype and immune response in KIRC. Adv Sci. 2025;12(1):e2405083.

Article  Google Scholar 

Liu R, Yang G, Bao M, et al. STAMBPL1 promotes breast cancer cell resistance to cisplatin partially by stabilizing MKP-1 expression. Oncogene. 2022;41(16):2265–74.

Article  CAS  PubMed  Google Scholar 

Walch A, Seidl S, Hermannstädter C, et al. Combined analysis of Rac1, IQGAP1, Tiam1 and E-cadherin expression in gastric cancer. Mod Pathol. 2008;21(5):544–52.

Article  CAS  PubMed  Google Scholar 

Xiong Z, Zhuang RL, Yu SL, et al. Cancer-associated fibroblasts regulate mitochondrial metabolism and inhibit chemosensitivity via ANGPTL4-IQGAP1 axis in prostate cancer. J Adv Res. 2024;S2090–1232(24):00559–69.

Google Scholar 

Li X, Zhao X, Su X, et al. Iqgap1 overexpression attenuates chemosensitivity through YAP-mediated ferroptosis inhibition in esophageal squamous cell cancer cells. Arch Biochem Biophys. 2024;758:110064.

Article  CAS  PubMed  Google Scholar 

Li CH, Sun XJ, Niu SS, et al. Overexpression of IQGAP1 promotes the angiogenesis of esophageal squamous cell carcinoma through the AKT and ERK-mediated VEGF-VEGFR2 signaling pathway. Oncol Rep. 2018;40(3):1795–802.

CAS  PubMed  Google Scholar 

Birladeanu AM, Rogalska M, Potiri M, et al. The scaffold protein IQGAP1 links heat-induced stress signals to alternative splicing regulation in gastric cancer cells. Oncogene. 2021;40(36):5518–32.

Article  CAS  PubMed  Google Scholar 

Deng C, Xie C, Li Z, et al. Multi-omics analysis identifies diagnostic circulating biomarkers and potential therapeutic targets, revealing IQGAP1 as an oncogene in gastric cancer. NPJ Precis Oncol. 2025;9(1):105.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu Y, Chen YC, Sang JR, et al. RhoC protein stimulates migration of gastric cancer cells through interaction with scaffold protein IQGAP1. Mol Med Rep. 2011;4(4):697–703.

CAS  PubMed  Google Scholar 

Wu Y, Tao Y, Chen Y, et al. RhoC regulates the proliferation of gastric cancer cells through interaction with IQGAP1. PLoS ONE. 2012;7(11):e48917.

Article  CAS  PubMed