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Cellular and molecular targets in β-Thalassemia: advances in iron Regulation, Erythropoiesis, and Gene-Based therapies
Cellular and molecular targets in β-Thalassemia: advances in iron Regulation, Erythropoiesis, and Gene-Based therapies
β-Thalassemia is a prevalent autosomal recessive genetic disorder caused by mutations in the β-globin gene, lead...
Genome-wide analysis and functional validation of the GH1 gene family in cotton under salt stress
Genome-wide analysis and functional validation of the GH1 gene family in cotton under salt stress
Glycoside hydrolase family 1 (GH1) proteins are widely distributed in plants and function as β-glucosidases involved ...
IGFBP7 and CCT2 are novel lactylation-driven mediators of endothelial-to-mesenchymal transition in idiopathic pulmonary fibrosis
IGFBP7 and CCT2 are novel lactylation-driven mediators of endothelial-to-mesenchymal transition in idiopathic pulmonary fibrosis
Lactylation is a post-translational modification that can influence the onset and progression of various diseases.However,...
MSC-Exosomes alleviate cognitive impairment after mild traumatic brain injury by inhibiting ferroptosis via PI3K/AKT/mTOR-mediated upregulation of GPX4
MSC-Exosomes alleviate cognitive impairment after mild traumatic brain injury by inhibiting ferroptosis via PI3K/AKT/mTOR-mediated upregulation of GPX4
Mild traumatic brain injury (mTBI) is a prevalent condition accounting for over 70% of all traumatic brain injury (TBI) ca...
LETM2 regulates mitochondrial function and autophagy in diabetic foot ulcers: implications for oxidative stress and therapeutic targeting
LETM2 regulates mitochondrial function and autophagy in diabetic foot ulcers: implications for oxidative stress and therapeutic targeting
Background A major complication of diabetes, diabetic foot ulcers (DFU), has been linked to mitochondrial dysfunction and ...
Functional genomics of a food-related thermotolerant strain AAB5: genetic determinants of stress response, CAZyme repertoire, and CRISPR-Cas system
Functional genomics of a food-related thermotolerant strain AAB5: genetic determinants of stress response, CAZyme repertoire, and CRISPR-Cas system
The thermotolerant Acetobacter oryzifermentans strain AAB5, originally isolated from unripe grape vinegar was identified b...
Genetic strategies for avian influenza resilience in poultry: from host-pathogen interaction studies to precision breeding
Genetic strategies for avian influenza resilience in poultry: from host-pathogen interaction studies to precision breeding
Avian influenza virus (AIV) remains a persistent threat to global poultry production and public health, owing to its abili...
The C2H2 Zinc-Finger protein ELR1 negatively regulates cytokinin metabolism and signaling pathway in rice
The C2H2 Zinc-Finger protein ELR1 negatively regulates cytokinin metabolism and signaling pathway in rice
Cytokinins are a class of important plant hormones that are closely associated with processes such as cell division, meris...
Systematic evaluation of CrRNA design parameters for optimized Cas13d-mediated RNA targeting in chicken cells
Systematic evaluation of CrRNA design parameters for optimized Cas13d-mediated RNA targeting in chicken cells
The CRISPR-Cas13 system has emerged as a powerful platform for programmable RNA targeting, offering efficient and sequence...
Investigating the impact of MCTP2 on immune suppression and drug resistance in glioblastoma
Investigating the impact of MCTP2 on immune suppression and drug resistance in glioblastoma
The purpose of this study is to explore the role in MCTP2 glioblastoma (GBM) relapse and associated therapy target, especi...
Non-coding RNAs-regulated SLC7A11 modulates ferroptosis: a new strategy for cancer therapy
Non-coding RNAs-regulated SLC7A11 modulates ferroptosis: a new strategy for cancer therapy
Ferroptosis is an iron-dependent form of regulated cell death that plays a dual role in cancer progression and suppression...
Exploring the potential of miR-9a-5p in circadian rhythm and cognitive recovery following brain injury in neonatal rats
Exploring the potential of miR-9a-5p in circadian rhythm and cognitive recovery following brain injury in neonatal rats
Neonatal hypoxic-ischemic encephalopathy (HIE) affects approximately 0.2%–0.3% of live births in developed countries...
The role of chimeric FAM72B transcripts generated by intergenic mRNA trans-splicing in breast cancer
The role of chimeric FAM72B transcripts generated by intergenic mRNA trans-splicing in breast cancer
Family with sequence similarity 72 (FAM72) is a protein-coding gene family located on chromosome 1 (chr1) in humans, and i...
Crosstalk between miRNAs and oxidative stress: implications for cancer pathogenesis and therapy
Crosstalk between miRNAs and oxidative stress: implications for cancer pathogenesis and therapy
Oxidative stress (OS), caused by an imbalance between reactive oxygen species (ROS) and antioxidant defenses, has a dual r...
β-Lapachone sensitizes glioblastoma to Temozolomide by inhibiting NF-κB signaling
β-Lapachone sensitizes glioblastoma to Temozolomide by inhibiting NF-κB signaling
Temozolomide (TMZ) constitutes the first-line chemotherapeutic regimen for glioblastoma (GBM), yet its clinical efficacy r...
Comparative analysis of chloroplast genomes of and its purplish-red-flowered variety
Comparative analysis of chloroplast genomes of and its purplish-red-flowered variety
Loropetalum chinense var. rubrum is a highly favored ornamental plant in landscaping applications, where its vibrant purpl...
Metabolic engineering of lipids for crop resilience and nutritional improvements towards sustainable agriculture
Metabolic engineering of lipids for crop resilience and nutritional improvements towards sustainable agriculture
Metabolic engineering of lipids in crops presents a promising strategy to enhance resilience against environmental stresso...
In silico analysis of () gene in different cultivars of
In silico analysis of () gene in different cultivars of
Chenopodium quinoa is an emerging halophyte plant that has gained significant attention from researchers in recent years d...
Comprehensive analysis of orthologous genes reveals functional dynamics and energy metabolism in the rhizospheric microbiome of
Comprehensive analysis of orthologous genes reveals functional dynamics and energy metabolism in the rhizospheric microbiome of
Moringa oleifera, known for its nutritional and therapeutic properties, exhibits a complex relationship with its rhizosphe...
Can the molecular and transgenic breeding of crops be an alternative and sustainable technology to meet food demand?
Can the molecular and transgenic breeding of crops be an alternative and sustainable technology to meet food demand?
The gradual increase in the worldwide population represents various challenges, and one of the most alarming being the foo...
Roles of Immunity and Endogenous Retroelements in the Pathogenesis of Rheumatoid Arthritis and Treatment Strategies
Roles of Immunity and Endogenous Retroelements in the Pathogenesis of Rheumatoid Arthritis and Treatment Strategies
Rheumatoid arthritis (RA) is a chronic, inflammatory, autoimmune disease that primarily affects the joints. RA usually res...
Autoimmune mechanisms and inflammation in obesity-associated type 2 diabetes, atherosclerosis, and non-alcoholic fatty liver disease
Autoimmune mechanisms and inflammation in obesity-associated type 2 diabetes, atherosclerosis, and non-alcoholic fatty liver disease
Obesity, characterized by the excessive accumulation of white adipose tissue, is a significant global health burden and a ...
EXO1 as a potential biomarker for prognosis, immune infiltration, and immunotherapy in pan-cancer analysis
EXO1 as a potential biomarker for prognosis, immune infiltration, and immunotherapy in pan-cancer analysis
Human EXO1 is a 5' → 3' exonuclease that plays a critical role in regulating cell cycle checkpoi...
Exploring the molecular pathways of miRNAs in testicular cancer: from diagnosis to therapeutic innovations
Exploring the molecular pathways of miRNAs in testicular cancer: from diagnosis to therapeutic innovations
Cancer diagnostics highlight the critical requirement for sensitive and accurate tools with functional biomarkers for earl...
Identification and mechanistic analysis of shared biomarkers and pathogenesis in acute pancreatitis and sepsis based on differential gene expression and protein interaction networks
Identification and mechanistic analysis of shared biomarkers and pathogenesis in acute pancreatitis and sepsis based on differential gene expression and protein interaction networks
Acute pancreatitis (AP) is a common gastrointestinal inflammatory disease that requires hospitalization, with 40–70%...
Identification of a NEK7-related pyroptosis gene signature against pancreatic cancer and evaluation of its potential in tumor microenvironment remodeling via regulating inflammasome complex
Identification of a NEK7-related pyroptosis gene signature against pancreatic cancer and evaluation of its potential in tumor microenvironment remodeling via regulating inflammasome complex
The treatment options for pancreatic ductal adenocarcinoma (PDAC) remain limited. It is therefore important to explore new...
Multi-omics integration reveals YWHAE as a key mediator of ferroptosis in ARDS
Multi-omics integration reveals YWHAE as a key mediator of ferroptosis in ARDS
Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterized by severe hypoxemia and high mort...
SNP’s use as a potential chemotoxicity stratification tool in breast cancer: from bench to clinic
SNP’s use as a potential chemotoxicity stratification tool in breast cancer: from bench to clinic
Breast cancer (BC) remains one of the most prevalent malignancies affecting women worldwide, necessitating ongoing researc...
RNA-binding protein HuR interacts with UFM1 mRNA to ameliorate chondrocyte inflammation, apoptosis and extracellular matrix degradation
RNA-binding protein HuR interacts with UFM1 mRNA to ameliorate chondrocyte inflammation, apoptosis and extracellular matrix degradation
To investigate the mechanisms by which the RNA-binding protein HuR /ELAVL1 interacts with UFM1 mRNA to ameliorate chondroc...
Mitochondrial genome evolution in the orchid subfamily Cypripedioideae (Orchidaceae)
Mitochondrial genome evolution in the orchid subfamily Cypripedioideae (Orchidaceae)
In this study, the mitogenomes of nine species in the subfamily Cypripedioideae were newly sequenced and assembled using b...
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