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Epistatic effects of and genes on the development of Alzheimer’s disease in African Americans
Epistatic effects of and genes on the development of Alzheimer’s disease in African Americans
Genome-wide association studies (GWAS) of Alzheimer’s disease (AD) have identified a large number of susceptibility ...
A novel mutation in associated with a syndromic immunodeficiency and cardiomyopathy
A novel mutation in associated with a syndromic immunodeficiency and cardiomyopathy
Genetic variants in Folliculin interacting protein 1 (FNIP1) were recently discovered as monogenic causes for immunodefici...
Exploring the therapeutic potential of interleukin-6 receptor blockade in autoimmune diseases using drug target mendelian randomization
Exploring the therapeutic potential of interleukin-6 receptor blockade in autoimmune diseases using drug target mendelian randomization
The blockade of the interleukin 6 receptor (IL-6R) demonstrates significant potential in various autoimmune diseases (ADs)...
Analysis of Complement Factor H gene polymorphisms and their association with clinical manifestations ofleptospirosis
Analysis of Complement Factor H gene polymorphisms and their association with clinical manifestations ofleptospirosis
Leptospirosis is caused by pathogenic leptospires, posing a significant public health problem. Host susceptibility to Lept...
Novel polymorphic and copy number diversity in the antibody IGH locus of South African individuals
Novel polymorphic and copy number diversity in the antibody IGH locus of South African individuals
The heavy chain of an antibody is crucial for mediating antigen binding. IGHV genes, which partially encode the heavy chai...
VaxOptiML: leveraging machine learning for accurate prediction of MHC-I and II epitopes for optimized cancer immunotherapy
VaxOptiML: leveraging machine learning for accurate prediction of MHC-I and II epitopes for optimized cancer immunotherapy
Cancer immunotherapy hinges on accurate epitope prediction for advancing vaccine development. VaxOptiML (available at http...
Syndecan-1: a key player in health and disease
Syndecan-1: a key player in health and disease
Syndecan-1 (SDC-1) is a transmembrane protein localized on the basolateral surface of epithelial cells, encompassing a cor...
Uncovering selection pressures on the IRF gene family in bats’ immune system
Uncovering selection pressures on the IRF gene family in bats’ immune system
Unlike other mammals, bats serve as natural reservoirs for several highly pathogenic viruses without exhibiting symptoms o...
AMPed up immunity: 418 whole genomes reveal intraspecific diversity of koala antimicrobial peptides
AMPed up immunity: 418 whole genomes reveal intraspecific diversity of koala antimicrobial peptides
Characterising functional diversity is a vital element to understanding a species’ immune function, yet many immunog...
functional analysis of the human, chimpanzee, and gorilla MHC-A repertoires
functional analysis of the human, chimpanzee, and gorilla MHC-A repertoires
T cells recognize peptides displayed on the surface of cells on MHC molecules. Genetic variation in MHC genes alters their...
HCV immunodominant peptide mapping reveals unique HLA-A*02-restricted signatures: insights for CD8 T-cell-based vaccines and immunotherapies
HCV immunodominant peptide mapping reveals unique HLA-A*02-restricted signatures: insights for CD8 T-cell-based vaccines and immunotherapies
Several barriers for the development of an HCV vaccine still exist, including the genetic diversity of the virus, and the ...
Primary regulatory T cell activator FOXP3 is present across Amphibia
Primary regulatory T cell activator FOXP3 is present across Amphibia
The overall structure of the immune system is highly conserved across jawed vertebrates, but characterization and descript...
Suppressed activation of the and by V617F gold nanoparticles
Suppressed activation of the and by V617F gold nanoparticles
Philadelphia chromosome-negative myeloproliferative neoplasms (Ph-MPNs) are characterized by the overproduction of myeloid...
Kirsten Falk 1963-2024
Kirsten Falk 1963-2024
Kirsten Falk working at the HPLC system, ca. 1990. Copyright Olaf RötzschkeKirsten F...
Phylogenetic and structural insights into the origin of C-type lectin Mincle in vertebrates
Phylogenetic and structural insights into the origin of C-type lectin Mincle in vertebrates
Our bodies are continuously exposed to injurious insults by infection and tissue damage, which are primarily sensed by inn...
Allele co-segregation and haplotype diversity of MHC IIβ genes in the small-spotted catshark
Allele co-segregation and haplotype diversity of MHC IIβ genes in the small-spotted catshark
The major histocompatibility complex (MHC) constitutes a functionally relevant multigene family playing an essential role ...
Correction to: HCV immunodominant peptide mapping reveals unique HLA‑A* 02‑restricted signatures: insights for CD8 T‑cell‑based vaccines and immunotherapies
Correction to: HCV immunodominant peptide mapping reveals unique HLA‑A* 02‑restricted signatures: insights for CD8 T‑cell‑based vaccines and immunotherapies
Laboratório de Virologia Básica E Aplicada, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenid...
The COVID-19 inflammation and high mortality mechanism trigger
The COVID-19 inflammation and high mortality mechanism trigger
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lasted from March 2020 to May...
A novel missense mutation in the AIRE gene underlying autoimmune polyglandular syndrome type 1
A novel missense mutation in the AIRE gene underlying autoimmune polyglandular syndrome type 1
The immune regulator gene AIRE plays an essential role in the establishment of immune tolerance and the prevention of auto...
Investigating associations between HLA DQA1 ~ DQB1 haplotypes, H. pylori infection, metaplasia, and anti-CagA IgA seropositivity in a Turkish gastritis cohort
Investigating associations between HLA DQA1 ~ DQB1 haplotypes, H. pylori infection, metaplasia, and anti-CagA IgA seropositivity in a Turkish gastritis cohort
Helicobacter pylori was reported as an important cause of gastritis, and gastric ulcers and CagA oncoprotein-producing H. ...
Immunogenetics, sylvatic plague and its vectors: insights from the pathogen reservoir Mastomys natalensis in Tanzania
Immunogenetics, sylvatic plague and its vectors: insights from the pathogen reservoir Mastomys natalensis in Tanzania
Yersinia pestis is a historically important vector-borne pathogen causing plague in humans and other mammals. Contemporary...
The KIR2DL1 intermediate upstream element participates in gene activation
The KIR2DL1 intermediate upstream element participates in gene activation
The human KIR genes encode a family of class I MHC receptors that are expressed on subsets of NK cells. The expression of ...
Macroevolution of avian T cell receptor C segments using genomic data
Macroevolution of avian T cell receptor C segments using genomic data
All jawed vertebrates have four T cell receptor (TCR) chains expressed by thymus-derived lymphocytes that play a significa...
Comparative genomics of the T cell receptor μ locus in marsupials and monotremes
Comparative genomics of the T cell receptor μ locus in marsupials and monotremes
T cells are a primary component of the vertebrate adaptive immune system. There are three mammalian T cell lineages based ...
Genomic view of the origins of cell-mediated immunity
Genomic view of the origins of cell-mediated immunity
NKp30 is an activating natural killer cell receptor (NKR) with a single-exon variable (VJ)–type immunoglobulin super...
Correlation between human leukocyte antigen ligands and killer cell immunoglobulin-like receptors in aplastic anemia patients from Shaanxi Han
Correlation between human leukocyte antigen ligands and killer cell immunoglobulin-like receptors in aplastic anemia patients from Shaanxi Han
Regulating natural killer (NK) cell responses in hematological malignancies largely depend on molecular interactions betwe...
Ancient fish lineages illuminate toll-like receptor diversification in early vertebrate evolution
Ancient fish lineages illuminate toll-like receptor diversification in early vertebrate evolution
Since its initial discovery over 50 years ago, understanding the evolution of the vertebrate RAG- mediated adapti...
Increased circulating Th17 cell populations in patients with pancreatic ductal adenocarcinoma
Increased circulating Th17 cell populations in patients with pancreatic ductal adenocarcinoma
T-helper 17 (Th17) cells are a subset of CD4+ helper T cells that produce interleukin 17 (IL-17) and play a crucial role i...
Prof. Dr. Jan Klein (1936-2023)
Prof. Dr. Jan Klein (1936-2023)
Jan Klein was born in 1936 in Stemplovec, a small town in the Czech Republic. Quite f...
Factors regulating the differences in frequency of infiltration of Th17 and Treg of the blood–brain barrier
Factors regulating the differences in frequency of infiltration of Th17 and Treg of the blood–brain barrier
Controlling CD4+ immune cell infiltration of the brain is a leading aim in designing therapeutic strategies for a range of...
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