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Genome-wide diversity and MHC characterisation in a critically endangered freshwater turtle susceptible to disease
Genome-wide diversity and MHC characterisation in a critically endangered freshwater turtle susceptible to disease
Small, isolated populations are often vulnerable to increased inbreeding and genetic drift, both of which elevate the risk...
HLA diversity and signatures of selection in the Maniq, a nomadic hunter-gatherer population in Southern Thailand
HLA diversity and signatures of selection in the Maniq, a nomadic hunter-gatherer population in Southern Thailand
The Maniq, a small and isolated nomadic hunter-gatherer population from the rainforests of Southern Thailand, offer a uniq...
Molecular evolution of the transcription factor genes and expression profiles in response to stimulations and spinal cord injury repair in lamprey )
Molecular evolution of the transcription factor genes and expression profiles in response to stimulations and spinal cord injury repair in lamprey )
Positive regulatory domain member (PRDM) family proteins play important roles in nervous system development, neural stem c...
Dysregulation of lncRNAs in NK cells from breast cancer patients: implications for NK cell functions
Dysregulation of lncRNAs in NK cells from breast cancer patients: implications for NK cell functions
Natural killer (NK) cells, a key component of the innate immune system, play a crucial role in detecting and eliminating c...
Genetic diversity of in Latin American Creole cattle: an update of the state of the art
Genetic diversity of in Latin American Creole cattle: an update of the state of the art
Genetic diversity of the bovine leukocyte antigen BoLA-DRB3 gene has been reported in cattle breeds due to its central rol...
Association between single-nucleotide polymorphism rs868875 of gene and clinical severity of COVID-19 in a Brazilian population
Association between single-nucleotide polymorphism rs868875 of gene and clinical severity of COVID-19 in a Brazilian population
COVID-19, caused by the SARS-CoV-2 virus, has had a global impact, leading to high incidence and mortality rates worldwide...
Immunoglobulin genetics of a model squamate reptile,
Immunoglobulin genetics of a model squamate reptile,
Squamate reptiles are a diverse group of terrestrial vertebrates that includes over 10,000 species. Despite their broad di...
Genetic insights into the major histocompatibility complex class I BF2 gene of Korean native chickens in relation to the LEI0258 microsatellite marker and the 90-SNP panel
Genetic insights into the major histocompatibility complex class I BF2 gene of Korean native chickens in relation to the LEI0258 microsatellite marker and the 90-SNP panel
The chicken major histocompatibility complex (MHC) represents a “minimal essential MHC” consisting of classica...
Evaluation of lymphoid defects in specific inborn errors of immunity using a single-tube multicolor flow cytometry assay
Evaluation of lymphoid defects in specific inborn errors of immunity using a single-tube multicolor flow cytometry assay
The present study aimed to evaluate lymphoid defects in patients with specific IEIs (n = 28) using a 12-antibo...
Compact genomic architecture of the axolotl MHC region: setting the record straight
Compact genomic architecture of the axolotl MHC region: setting the record straight
The Major Histocompatibility Complex (MHC) is a gene-dense genomic region essential to adaptive immunity, exhibiting both ...
Epistatic effects of and genes on the development of Alzheimer’s disease in African Americans
Epistatic effects of and genes on the development of Alzheimer’s disease in African Americans
Genome-wide association studies (GWAS) of Alzheimer’s disease (AD) have identified a large number of susceptibility ...
A novel mutation in associated with a syndromic immunodeficiency and cardiomyopathy
A novel mutation in associated with a syndromic immunodeficiency and cardiomyopathy
Genetic variants in Folliculin interacting protein 1 (FNIP1) were recently discovered as monogenic causes for immunodefici...
Exploring the therapeutic potential of interleukin-6 receptor blockade in autoimmune diseases using drug target mendelian randomization
Exploring the therapeutic potential of interleukin-6 receptor blockade in autoimmune diseases using drug target mendelian randomization
The blockade of the interleukin 6 receptor (IL-6R) demonstrates significant potential in various autoimmune diseases (ADs)...
Analysis of Complement Factor H gene polymorphisms and their association with clinical manifestations ofleptospirosis
Analysis of Complement Factor H gene polymorphisms and their association with clinical manifestations ofleptospirosis
Leptospirosis is caused by pathogenic leptospires, posing a significant public health problem. Host susceptibility to Lept...
Novel polymorphic and copy number diversity in the antibody IGH locus of South African individuals
Novel polymorphic and copy number diversity in the antibody IGH locus of South African individuals
The heavy chain of an antibody is crucial for mediating antigen binding. IGHV genes, which partially encode the heavy chai...
VaxOptiML: leveraging machine learning for accurate prediction of MHC-I and II epitopes for optimized cancer immunotherapy
VaxOptiML: leveraging machine learning for accurate prediction of MHC-I and II epitopes for optimized cancer immunotherapy
Cancer immunotherapy hinges on accurate epitope prediction for advancing vaccine development. VaxOptiML (available at http...
Syndecan-1: a key player in health and disease
Syndecan-1: a key player in health and disease
Syndecan-1 (SDC-1) is a transmembrane protein localized on the basolateral surface of epithelial cells, encompassing a cor...
Uncovering selection pressures on the IRF gene family in bats’ immune system
Uncovering selection pressures on the IRF gene family in bats’ immune system
Unlike other mammals, bats serve as natural reservoirs for several highly pathogenic viruses without exhibiting symptoms o...
AMPed up immunity: 418 whole genomes reveal intraspecific diversity of koala antimicrobial peptides
AMPed up immunity: 418 whole genomes reveal intraspecific diversity of koala antimicrobial peptides
Characterising functional diversity is a vital element to understanding a species’ immune function, yet many immunog...
functional analysis of the human, chimpanzee, and gorilla MHC-A repertoires
functional analysis of the human, chimpanzee, and gorilla MHC-A repertoires
T cells recognize peptides displayed on the surface of cells on MHC molecules. Genetic variation in MHC genes alters their...
HCV immunodominant peptide mapping reveals unique HLA-A*02-restricted signatures: insights for CD8 T-cell-based vaccines and immunotherapies
HCV immunodominant peptide mapping reveals unique HLA-A*02-restricted signatures: insights for CD8 T-cell-based vaccines and immunotherapies
Several barriers for the development of an HCV vaccine still exist, including the genetic diversity of the virus, and the ...
Primary regulatory T cell activator FOXP3 is present across Amphibia
Primary regulatory T cell activator FOXP3 is present across Amphibia
The overall structure of the immune system is highly conserved across jawed vertebrates, but characterization and descript...
Suppressed activation of the and by V617F gold nanoparticles
Suppressed activation of the and by V617F gold nanoparticles
Philadelphia chromosome-negative myeloproliferative neoplasms (Ph-MPNs) are characterized by the overproduction of myeloid...
Kirsten Falk 1963-2024
Kirsten Falk 1963-2024
Kirsten Falk working at the HPLC system, ca. 1990. Copyright Olaf RötzschkeKirsten F...
Phylogenetic and structural insights into the origin of C-type lectin Mincle in vertebrates
Phylogenetic and structural insights into the origin of C-type lectin Mincle in vertebrates
Our bodies are continuously exposed to injurious insults by infection and tissue damage, which are primarily sensed by inn...
Allele co-segregation and haplotype diversity of MHC IIβ genes in the small-spotted catshark
Allele co-segregation and haplotype diversity of MHC IIβ genes in the small-spotted catshark
The major histocompatibility complex (MHC) constitutes a functionally relevant multigene family playing an essential role ...
Correction to: HCV immunodominant peptide mapping reveals unique HLA‑A* 02‑restricted signatures: insights for CD8 T‑cell‑based vaccines and immunotherapies
Correction to: HCV immunodominant peptide mapping reveals unique HLA‑A* 02‑restricted signatures: insights for CD8 T‑cell‑based vaccines and immunotherapies
Laboratório de Virologia Básica E Aplicada, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenid...
The COVID-19 inflammation and high mortality mechanism trigger
The COVID-19 inflammation and high mortality mechanism trigger
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lasted from March 2020 to May...
A novel missense mutation in the AIRE gene underlying autoimmune polyglandular syndrome type 1
A novel missense mutation in the AIRE gene underlying autoimmune polyglandular syndrome type 1
The immune regulator gene AIRE plays an essential role in the establishment of immune tolerance and the prevention of auto...
Investigating associations between HLA DQA1 ~ DQB1 haplotypes, H. pylori infection, metaplasia, and anti-CagA IgA seropositivity in a Turkish gastritis cohort
Investigating associations between HLA DQA1 ~ DQB1 haplotypes, H. pylori infection, metaplasia, and anti-CagA IgA seropositivity in a Turkish gastritis cohort
Helicobacter pylori was reported as an important cause of gastritis, and gastric ulcers and CagA oncoprotein-producing H. ...
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