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Profiling of extracellular vesicle-associated microRNAs reveals a regulated response to potato virus Y infection in tomato
Plant extracellular vesicles (EVs) serve as critical mediators of intercellular communication during plant-pathogen intera...
Navigating tensions between scientific advancement and ethical practice in biobanking: a qualitative study in Japan
The long-term sustainability of biobanking depends on governance systems that are both ethically robust and operationally ...
SOX9 gene anomalies and campomelic / acampomelic campomelic dysplasia: case report and literature review
Campomelic dysplasia (CD) is a rare skeletal disorder characterized by the hallmark sign of bent femur or tibial bones or ...
An auxiliary diagnosis model for the pathological classification of cervical cancer based on radiomics biomarkers
IntroductionCervical cancer remains a major global health burden, and accurate pathological classification is essential fo...
Editorial: The importance of faculty development in medical education
Effective faculty development is increasingly recognized as a strategic lever for both individual educator growth and inst...
Case Report: Biallelic PADI6 frameshift variants contribute to preimplantation embryonic lethality
ObjectivesPreimplantation embryonic lethality (PREMBL) is a major cause of female infertility, characterized by early embr...
Age at natural menopause, reproductive lifespan and Alzheimer’s disease in females: is APOE ε4 the missing link?
BackgroundThe apolipoprotein E (APOE) gene represents the strongest genetic determinant of sporadic Alzheimer’s disease (A...
Correction: A comprehensive analysis of the prognostic characteristics of microRNAs in breast cancer
There was a mistake in Figure 6 as published. The authors misused the images of NC, antagomiR-551b and agomiR-551b in Figu...
Exercise stress and tissue remodeling: advances in exosome-mediated RNA–RBP networks in musculoskeletal injury repair and functional recovery
Exercise is a double-edged sword. It can either cause adaptive remodeling of musculoskeletal tissues or lead to acute or c...
Aberrant expression of the MID1 protein in neurons of Huntington’s disease brain
Huntington’s disease (HD) is caused by a CAG repeat expansion mutation in the Huntingtin (HTT) gene that transcribes into ...
Promoter hypomethylation of CDH7: a novel epigenetic marker associated with cerebral small vessel disease
IntroductionCerebral small vessel disease (SVD), manifesting as white matter hyperintensities (WMH), lacunar infarctions, ...
When genomics companies act as biobanks: governance challenges in an era of genomic assetization
IntroductionContemporary genomics companies increasingly perform core biobanking functions—collecting, storing, and sharin...
Case Report: Type II tyrosinemia caused by mutations at the c.843_844 inv p.(Trp282Gly) variant locus
ObjectiveTo identify the genetic etiology in a neonate with persistent hypertyrosinemia and characterize the functional im...
Potential effects on the signaling network mediated by overexpression of the vitronectin gene in Hu sheep ruminal epithelial cells using multi-omics analysis
Vitronectin (VTN) is a multifunctional extracellular matrix protein involved in cell adhesion, migration, and signal trans...
Molecular mediators of motion: RNA–RBP networks in exercise-induced osteoarthritis protection
Osteoarthritis (OA) is a relatively common chronic degenerative disease of joints that was originally considered an imbala...
Editorial: Inborn errors of carbohydrate metabolism volume II
Inherited disorders of carbohydrate metabolism comprise a heterogeneous and expanding group of rare disorders that disrupt...
An in silico protocol for predicting genetic biomarkers in rare diseases: a case study in sporadic amyotrophic lateral sclerosis
Studying the genetics of rare diseases is challenging because small sample sizes limit the statistical power of standard m...
Exploring prognostic genes related to lactylation and programmed cell death in pancreatic ductal adenocarcinoma: a comprehensive study combining bulk transcriptomics and experimental verification
BackgroundThere is a strong correlation between lactylation, programmed cell death, and the progression of cancer. This st...
Correction: Association between telomere length and skin cancer and aging: a mendelian randomization analysis
• Please read through all the templates before choosing • Pick the most relevant text template(s) from the following page ...
Fragmenting the future with FLARE: a comprehensive fragmentomics pipeline based on long-read nanopore sequencing
PurposeCell-free DNA (cfDNA) fragmentation patterns carry biological information beyond fragment length, revealing nucleas...
Case report: Multiple approach analysis in a case of clinically assessed myotonia congenita
IntroductionMyotonia congenita (MC) is a non-dystrophic muscular disease characterized by impaired muscle relaxation after...
Gender-specific association of STON2 rs2371597 polymorphism in keratoconus patients of Saudi origin
IntroductionKeratoconus (KC) is a progressive eye condition characterized by the gradual thinning and protrusion of the co...
UDP-glucuronosyltransferases 2A3 as a biomarker for ulcerative colitis and colon cancer
1 IntroductionUlcerative colitis (UC) is an idiopathic chronic inflammatory bowel disease (Conrad et al., 2014). Patients ...
Integration of single-cell and bulk analysis reveals TBXAS1 as a key platelet-related gene causing poor prognosis in osteosarcoma
IntroductionOsteosarcoma is the most common primary bone tumor in children, adults, and elderly people over 60 years old (...
Identification of crucial drought-tolerant genes of barley through comparative transcriptomic analysis and yeast-based stress assay
1 IntroductionWater comprises roughly 80%–95% of fresh plant body biomass, serving as an essential medium for the physiolo...
Validation of selection signatures for coat color in the Podolica Italiana gray cattle breed
IntroductionIn wild animal species, coloration is considered as one of the mechanisms of camouflage, intra- and inter-spec...
AnchorFCI: harnessing genetic anchors for enhanced causal discovery of cardiometabolic disease pathways
1 IntroductionCardiometabolic diseases, including cardiovascular disease and metabolic syndrome, are major global health c...
Four new genome sequences of the Pallas’s cat (Otocolobus manul): an insight into the patterns of within-species variability
1 IntroductionManul, also called Pallas’s cat or Rock Wildcat (Otocolobus manul), is the only representative of the genus ...
Comprehensive evaluation of AlphaMissense predictions by evidence quantification for variants of uncertain significance
BackgroundAdvances in genomic technologies, particularly next-generation sequencing, have revolutionized the detection and...
DMOIT: denoised multi-omics integration approach based on transformer multi-head self-attention mechanism
1 IntroductionWith the advent of high-throughput sequencing technologies, various types of omics data, including genomics,...
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