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LMTK3 regulates breast cancer angiogenesis via a context-dependent mesenchymal-epithelial transition program
LMTK3 regulates breast cancer angiogenesis via a context-dependent mesenchymal-epithelial transition program
Angiogenesis constitutes a critical rate-limiting determinant of tumor progression in breast cancer (BC). Resistance to co...
Effective delivery of genome editor to cervical cancer targeting Mcl1 for cancer therapy
Effective delivery of genome editor to cervical cancer targeting Mcl1 for cancer therapy
CRISPR/Cas9 represents a transformative advancement in precision therapies, offering the promise of more effective and tar...
C1orf35 contributes to high anabolic metabolism by simultaneously promoting aerobic glycolysis and oxidative phosphorylation in multiple myeloma cells
C1orf35 contributes to high anabolic metabolism by simultaneously promoting aerobic glycolysis and oxidative phosphorylation in multiple myeloma cells
Similar to other malignancies, multiple myeloma (MM) has acquired several functional capabilities known as “Hallmark...
Ataxia-telangiectasia mutated kinase inhibition overcomes gemcitabine resistance in intrahepatic cholangiocarcinoma via DNA ligase I-dependent repair vulnerability
Ataxia-telangiectasia mutated kinase inhibition overcomes gemcitabine resistance in intrahepatic cholangiocarcinoma via DNA ligase I-dependent repair vulnerability
Gemcitabine-based chemotherapy remains the standard first-line treatment for cholangiocarcinoma (CCA), but acquired resist...
Therapeutic advances with KRASG12C inhibitors and combination strategies in non-small cell lung cancer brain metastases
Therapeutic advances with KRASG12C inhibitors and combination strategies in non-small cell lung cancer brain metastases
Non-small cell lung cancer (NSCLC) frequently metastasizes to the brain in approximately 20–40% of cases. Mutations ...
Correction: Targeted suppression of tumor growth by CREPT promoter-driven diphtheria toxin fragment A
State Key Laboratory of Membrane Biology, School of Basic Medical Sciences, Tsinghua Medicine, Tsinghua University, Beijin...
Pleiotropic mechanisms of cancer-associated fibroblast-mediated resistance in hepatocellular carcinoma: emerging therapeutic vulnerabilities and targeting strategies
Pleiotropic mechanisms of cancer-associated fibroblast-mediated resistance in hepatocellular carcinoma: emerging therapeutic vulnerabilities and targeting strategies
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death around the world, with therapy resista...
MSCs delivering LIGHT prime immune response against CAFs to harness antigen loss variants
MSCs delivering LIGHT prime immune response against CAFs to harness antigen loss variants
The tumor niche promotes immune tolerance, enabling malignant cells to evade surveillance. Mesenchymal stem cells (MSCs) h...
Blocking the functional domain of cancer cell surface TIP1 upregulates Midkine via the β-catenin/Wnt signaling pathway
Blocking the functional domain of cancer cell surface TIP1 upregulates Midkine via the β-catenin/Wnt signaling pathway
Drug resistance exhibited by cancer cells remains one of the primary reasons for the failure of therapeutic approaches to ...
AAV for ovarian cancer gene therapy
AAV for ovarian cancer gene therapy
Recent advancements in ovarian cancer treatment, particularly with PARP inhibitors, have markedly enhanced the recurrence-...
UBE2N inhibition abrogates cancer chemoresistance and metastasis in lung adenocarcinoma
UBE2N inhibition abrogates cancer chemoresistance and metastasis in lung adenocarcinoma
Chemoresistance and metastasis remain significant challenges in cancer therapy, resulting in treatment failures for cancer...
The dual role of GPX4 in breast cancer: mechanisms of therapeutic resistance and potential for novel targeted therapies
The dual role of GPX4 in breast cancer: mechanisms of therapeutic resistance and potential for novel targeted therapies
Glutathione peroxidase 4 (GPX4) is a key intracellular antioxidant enzyme that maintains oxidative homeostasis by catalyzi...
Barriers and solutions for CAR-T therapy in solid tumors
Barriers and solutions for CAR-T therapy in solid tumors
Chimeric antigen receptor (CAR)-T cell therapy has emerged as a transformative approach for cancer treatment, particularly...
Modified hTERT promoters-driven purine nucleoside phosphorylase-gene therapy in association with chemo- and targeted therapy in the context of ovarian cancer
Modified hTERT promoters-driven purine nucleoside phosphorylase-gene therapy in association with chemo- and targeted therapy in the context of ovarian cancer
Ovarian cancer has the highest mortality-to-incidence ratio among gynecologic cancers worldwide. E.coli Purine Nucleoside ...
Enhancer hijacking drives FAM20C expression to promote papillary thyroid cancer progression
Enhancer hijacking drives FAM20C expression to promote papillary thyroid cancer progression
Papillary thyroid cancer (PTC) is the most common endocrine cancer, with a good prognosis in most cases. However, aggressi...
SLC34A2 inhibits tumorigenesis and progression via upregulating LRRK2/TTF-1/SELENBP1 axis in lung adenocarcinoma
SLC34A2 inhibits tumorigenesis and progression via upregulating LRRK2/TTF-1/SELENBP1 axis in lung adenocarcinoma
Alveolar type II epithelial (AT2) cells have the properties of stem cells, abnormal AT2 cells serve as one of the original...
Modification of the tumor microenvironment enhances immunity with plasmid gene therapy
Modification of the tumor microenvironment enhances immunity with plasmid gene therapy
Local intratumor delivery with electroporation of low levels of plasmids encoding molecules, induces an antitumor effect w...
The golden key to open mystery boxes of SMARCA4-deficient undifferentiated thoracic tumor: focusing immunotherapy, tumor microenvironment and epigenetic regulation
The golden key to open mystery boxes of SMARCA4-deficient undifferentiated thoracic tumor: focusing immunotherapy, tumor microenvironment and epigenetic regulation
SMARCA4-deficient undifferentiated thoracic tumor is extremely invasive. This tumor with poor prognosis is easily confused...
Cancer-associated fibroblast exosomes promote prostate cancer metastasis through miR-500a-3p/FBXW7/HSF1 axis under hypoxic microenvironment
Cancer-associated fibroblast exosomes promote prostate cancer metastasis through miR-500a-3p/FBXW7/HSF1 axis under hypoxic microenvironment
Metastasis is the main cause of deaths in prostate cancer (PCa). However, the exact mechanisms underlying PCa metastasis a...
Emerging role of RNA modification and long noncoding RNA interaction in cancer
Emerging role of RNA modification and long noncoding RNA interaction in cancer
RNA modification, especially N6-methyladenosine, 5-methylcytosine, and N7-methylguanosine methylation, participates in the...
Transactivation of Met signaling by oncogenic Gnaq drives the evolution of melanoma in Hgf-Cdk4 mice
Transactivation of Met signaling by oncogenic Gnaq drives the evolution of melanoma in Hgf-Cdk4 mice
Recent pan-cancer genomic analyses have identified numerous oncogenic driver mutations that occur in a cell-type and tissu...
A guardian turned rogue: TP53 promoter translocations rewire stress responses to oncogenic effectors in osteosarcoma
A guardian turned rogue: TP53 promoter translocations rewire stress responses to oncogenic effectors in osteosarcoma
Osteosarcoma is the most prevalent malignant bone tumour in children, adolescents and young adults. Despite a multitude of...
Recent progress of CDK4/6 inhibitors’ current practice in breast cancer
Recent progress of CDK4/6 inhibitors’ current practice in breast cancer
Dysregulated cellular proliferation represents a hallmark feature across all cancers. Aberrant activation of the cyclin-de...
PLK1 and its substrate MISP facilitate intrahepatic cholangiocarcinoma progression by promoting lymphatic invasion and impairing E-cadherin adherens junctions
PLK1 and its substrate MISP facilitate intrahepatic cholangiocarcinoma progression by promoting lymphatic invasion and impairing E-cadherin adherens junctions
Intrahepatic cholangiocarcinoma (iCCA) is a subtype of CCA and has a high mortality rate and a relatively poor prognosis. ...
SPP1+ TAM subpopulations in tumor microenvironment promote intravasation and metastasis of head and neck squamous cell carcinoma
SPP1+ TAM subpopulations in tumor microenvironment promote intravasation and metastasis of head and neck squamous cell carcinoma
Macrophages are heterogeneous cells that play multifaceted roles in cancer progression and metastasis. However, the phenot...
Cancer-associated fibroblast exosome LINC00355 promotes epithelial-mesenchymal transition and chemoresistance in colorectal cancer through the miR-34b-5p/CRKL axis
Cancer-associated fibroblast exosome LINC00355 promotes epithelial-mesenchymal transition and chemoresistance in colorectal cancer through the miR-34b-5p/CRKL axis
This study was designed to investigate the role and mechanism of cancer-associated fibroblasts (CAFs)-derived exosomes (CA...
Leveraging synthetic lethality to uncover potential therapeutic target in gastric cancer
Leveraging synthetic lethality to uncover potential therapeutic target in gastric cancer
Since trastuzumab was approved in 2012 for the first-line treatment of gastric cancer (GC), no significant advancement in ...
Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance
Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance
MSCs (mesenchymal stem cells), responsible for tissue repair, rarely undergo cell fusion with somatic cells. Here, we show...
TNFRSF19 promotes endoplasmic reticulum stress-induced paraptosis via the activation of the MAPK pathway in triple-negative breast cancer cells
TNFRSF19 promotes endoplasmic reticulum stress-induced paraptosis via the activation of the MAPK pathway in triple-negative breast cancer cells
TNFRSF19 is a member of the tumor necrosis factor receptor superfamily, and its function exhibits variability among differ...
Chimeric TβRII-SE/Fc overexpression by a lentiviral vector exerts strong antitumoral activity on colorectal cancer-derived cell lines in vitro and on xenografts
Chimeric TβRII-SE/Fc overexpression by a lentiviral vector exerts strong antitumoral activity on colorectal cancer-derived cell lines in vitro and on xenografts
The TGF signaling pathway is a key regulator of cancer progression. In this work, we report for the first time the antitum...
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