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The epigenetics of frailty
The epigenetics of frailty
The conceptual change of frailty, from a physical to a biopsychosocial phenotype, expanded the field of frailty, including...
SET protein as an epigenetics target
SET protein as an epigenetics target
The SET gene has four transcripts reported in NCBI, coding two isoforms of SET proteins. The most known function of SET pr...
DNA methylation as a window into female reproductive aging
DNA methylation as a window into female reproductive aging
People with ovaries experience reproductive aging as their reproductive function and system declines. This has significant...
Hypomethylation of Wnt signaling regulator genes in developmental language disorder
Hypomethylation of Wnt signaling regulator genes in developmental language disorder
Background: Developmental language disorder (DLD) is a neurodevelopmental disorder. Considering the pivotal role of epigen...
Twin study: genotype-dependent epigenetic factors affecting free thyroxine levels in the normal range
Twin study: genotype-dependent epigenetic factors affecting free thyroxine levels in the normal range
Aim: To explore the clinical application of DNA methylation affecting thyroid function, we evaluated the association of DN...
Integrated analysis of transcriptome and epigenome reveals ENSR00000272060 as a potential biomarker in gastric cancer
Integrated analysis of transcriptome and epigenome reveals ENSR00000272060 as a potential biomarker in gastric cancer
Background: Enhancer RNAs (eRNAs) are involved in gene expression regulation. Although functional roles of eRNAs in the pa...
microRNAs and their therapeutic strategy in phase I and phase II clinical trials
microRNAs and their therapeutic strategy in phase I and phase II clinical trials
miRNAs play a crucial therapeutic role in diseases such as cancer, diabetes and viral infections, with around 1900 identif...
Mitochondrial D-loop methylation levels inversely correlate with disease duration in amyotrophic lateral sclerosis
Mitochondrial D-loop methylation levels inversely correlate with disease duration in amyotrophic lateral sclerosis
Aim: To correlate mitochondrial D-loop region methylation levels and mtDNA copy number with disease duration in familial a...
Data science using the human epigenome for predicting multifactorial diseases and symptoms
Data science using the human epigenome for predicting multifactorial diseases and symptoms
Tweetable abstract This article reviews machine learning models that leverages epigenomic data for predicting multifactori...
POU2F2-mediated upregulation of lncRNA PTPRG-AS1 inhibits ferroptosis in breast cancer via miR-376c-3p/SLC7A11 axis
POU2F2-mediated upregulation of lncRNA PTPRG-AS1 inhibits ferroptosis in breast cancer via miR-376c-3p/SLC7A11 axis
Background: Triple-negative breast cancer (TNBC) is a subtype of BC with high rates of mortality. The mechanism of PTPRG-A...
Unlocking the epigenetic symphony: histone acetylation's impact on neurobehavioral change in neurodegenerative disorders
Unlocking the epigenetic symphony: histone acetylation's impact on neurobehavioral change in neurodegenerative disorders
Recent genomics and epigenetic advances have empowered the exploration of DNA/RNA methylation and histone modifications cr...
Digital PCR-based GRHL2 methylation testing in acute myeloid leukemia: diagnosis, prognosis and monitoring
Digital PCR-based GRHL2 methylation testing in acute myeloid leukemia: diagnosis, prognosis and monitoring
Background: Acute myeloid leukemia (AML) is a challenging disease with high rates of recurrence. The role of the cancer-re...
Epigenetic disruption of histone deacetylase-2 accelerated apoptotic signaling and retarded malignancy in gastric cells
Epigenetic disruption of histone deacetylase-2 accelerated apoptotic signaling and retarded malignancy in gastric cells
Background: The objective of this research was to determine whether HDAC2 function is associated with gastric cancer progr...
Alteration of DNA methyltransferases by eribulin elicits broad DNA methylation changes with potential therapeutic implications for triple-negative breast cancer
Alteration of DNA methyltransferases by eribulin elicits broad DNA methylation changes with potential therapeutic implications for triple-negative breast cancer
Background: Triple-negative breast cancer (TNBC) is an aggressive disease with limited treatment options. Eribulin, a chem...
Fatty acid metabolism-related lncRNA prognostic signature for serous ovarian carcinoma
Fatty acid metabolism-related lncRNA prognostic signature for serous ovarian carcinoma
Background: To explore the role of fatty acid metabolism (FAM)-related lncRNAs in the prognosis and antitumor immunity of ...
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