Anderson CP, Shen M, Eisenstein RS, Leibold EA (2012) Mammalian iron metabolism and its control by iron regulatory proteins. Biochim Biophys Acta 1823:1468–1483. https://doi.org/10.1016/j.bbamcr.2012.05.010
Article CAS PubMed PubMed Central Google Scholar
Anthony J, Varalakshmi S, Sekar AK, Devarajan N, Janakiraman B, Peramaiyan R (2024) Glutaminase - a potential target for cancer treatment. BioMedicine 14:29–37. https://doi.org/10.37796/2211-8039.1445
Article PubMed PubMed Central Google Scholar
Bedolla N, Liu L, Liu X, Xie Q, Ren Y (2025) Ursolic acid enhances radiosensitivity in esophageal squamous cell carcinoma by modulating p53/SLC7A11/GPX4 pathway-mediated ferroptosis. Toxicon 255:108233. https://doi.org/10.1016/j.toxicon.2025.108233
Article CAS PubMed Google Scholar
Bi G, Liang J, Zhao M, Zhang H, Jin X, Lu T, Zheng Y, Bian Y, Chen Z, Huang Y, Besskaya V, Zhan C, Wang Q, Tan L (2022) MiR-6077 promotes cisplatin/pemetrexed resistance in lung adenocarcinoma via CDKN1A/cell cycle arrest and KEAP1/ferroptosis pathways. Mol Ther 28:366–386. https://doi.org/10.1016/j.omtn.2022.03.020
Bian Z, Sun X, Liu L, Qin Y, Zhang Q, Liu H, Mao L, Sun S (2023) Sodium butyrate induces CRC cell ferroptosis via the CD44/SLC7A11 pathway and exhibits a synergistic therapeutic effect with Erastin. Cancers (Basel). https://doi.org/10.3390/cancers15020423
Budanov AV (2014) The role of tumor suppressor p53 in the antioxidant defense and metabolism. Subcell Biochem 85:337–358. https://doi.org/10.1007/978-94-017-9211-0_18
Article PubMed PubMed Central Google Scholar
Burnett JC, Rossi JJ (2012) RNA-based therapeutics: current progress and future prospects. Chem Biol 19:60–71. https://doi.org/10.1016/j.chembiol.2011.12.008
Article CAS PubMed PubMed Central Google Scholar
Cai L, Hu X, Ye L, Bai P, Jie Y, Shu K (2022) Long non-coding RNA ADAMTS9-AS1 attenuates ferroptosis by targeting microRNA-587/solute carrier family 7 member 11 axis in epithelial ovarian cancer. Bioengineered 13:8226–8239. https://doi.org/10.1080/21655979.2022.2049470
Article CAS PubMed PubMed Central Google Scholar
Chang K, Chen Y, Zhang X, Zhang W, Xu N, Zeng B, Wang Y, Feng T, Dai B, Xu F, Ye D, Wang C (2023) DPP9 stabilizes NRF2 to suppress ferroptosis and induce Sorafenib resistance in clear cell renal cell carcinoma. Cancer Res 83:3940–3955. https://doi.org/10.1158/0008-5472.CAN-22-4001
Article CAS PubMed Google Scholar
Chen F, Wang L (2023) Long noncoding RNA CASC11 suppresses sorafenib-triggered ferroptosis via stabilizing SLC7A11 mRNA in hepatocellular carcinoma cells. Discov Oncol 14:145. https://doi.org/10.1007/s12672-023-00761-9
Article CAS PubMed PubMed Central Google Scholar
Chen D, Tavana O, Chu B, Erber L, Chen Y, Baer R, Gu W (2017) NRF2 is a major target of ARF in p53-Independent tumor suppression. Mol Cell 68:224–232e224. https://doi.org/10.1016/j.molcel.2017.09.009
Article CAS PubMed PubMed Central Google Scholar
Chen X, Yu C, Kang R, Tang D (2020) Iron metabolism in ferroptosis. Front Cell Dev Biol 8:590226. https://doi.org/10.3389/fcell.2020.590226
Article PubMed PubMed Central Google Scholar
Chen L, Li W, Li Z, Song Y, Zhao J, Chen Z, Kazobinka G, Li L, Xing Y, Hou T (2021) CircNUDT21 promotes bladder cancer progression by modulating the miR-16-1-3p/MDM2/p53 axis. Mol Ther 26:625–636. https://doi.org/10.1016/j.omtn.2021.08.032
Chen H, Wang L, Liu J, Wan Z, Zhou L, Liao H, Wan R (2023a) LncRNA ITGB2-AS1 promotes cisplatin resistance of non-small cell lung cancer by inhibiting ferroptosis via activating the FOSL2/NAMPT axis. Cancer Biol Ther 24:2223377. https://doi.org/10.1080/15384047.2023.2223377
Article CAS PubMed PubMed Central Google Scholar
Chen Z, Wang W, Abdul Razak SR, Han T, Ahmad NH, Li X (2023b) Ferroptosis as a potential target for cancer therapy. Cell Death Dis 14:460. https://doi.org/10.1038/s41419-023-05930-w
Article PubMed PubMed Central Google Scholar
Chen J, Li X, Tao J, Luo L (2024) Identification of marine-derived SLC7A11 inhibitors: molecular docking, structure-based virtual screening, cytotoxicity prediction, and molecular dynamics simulation. Mar Drugs. https://doi.org/10.3390/md22080375
Article PubMed PubMed Central Google Scholar
Chen Y, Zhao T, Chen H, Chen J, Han W (2025) RNA binding protein ALYREF regulates ferroptosis to facilitate LUAD growth and metastasis via promoting SLC7A11 mRNA stability. Sci Rep 15:1351. https://doi.org/10.1038/s41598-024-83276-9
Article CAS PubMed PubMed Central Google Scholar
Coppe JP, Desprez PY, Krtolica A, Campisi J (2010) The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol 5:99–118. https://doi.org/10.1146/annurev-pathol-121808-102144
Article CAS PubMed PubMed Central Google Scholar
Costa I, Barbosa DJ, Benfeito S, Silva V, Chavarria D, Borges F, Remiao F, Silva R (2023) Molecular mechanisms of ferroptosis and their involvement in brain diseases. Pharmacol Ther 244:108373. https://doi.org/10.1016/j.pharmthera.2023.108373
Article CAS PubMed Google Scholar
Debela DT, Muzazu SG, Heraro KD, Ndalama MT, Mesele BW, Haile DC, Kitui SK, Manyazewal T (2021) New approaches and procedures for cancer treatment: current perspectives. SAGE Open Med 9:20503121211034366. https://doi.org/10.1177/20503121211034366
Article PubMed PubMed Central Google Scholar
Deng R, Cui X, Dong Y, Tang Y, Tao X, Wang S, Wang J, Chen L (2021) Construction of circRNA-based ceRNA network to reveal the role of circRNAs in the progression and prognosis of hepatocellular carcinoma. Front Genet 12:626764. https://doi.org/10.3389/fgene.2021.626764
Article CAS PubMed PubMed Central Google Scholar
Deng L, He S, Guo N, Tian W, Zhang W, Luo L (2023) Molecular mechanisms of ferroptosis and relevance to inflammation. Inflamm Res 72(2):281–299. https://doi.org/10.1007/s00011-022-01672-1
Article CAS PubMed Google Scholar
Ding F, Yu Y, Zhao J, Wei S, Zhang Y, Han JH, Li Z, Jiang HB, Ryu D, Cho M, Bae SJ, Park W, Ha KT, Gao B (2025) The interplay of cellular senescence and reprogramming shapes the biological landscape of aging and cancer revealing novel therapeutic avenues. Front Cell Dev Biol 13:1593096. https://doi.org/10.3389/fcell.2025.1593096
Article PubMed PubMed Central Google Scholar
Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B 3rd, Stockwell BR (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149:1060–1072. https://doi.org/10.1016/j.cell.2012.03.042
Article CAS PubMed PubMed Central Google Scholar
Donehower LA, Soussi T, Korkut A, Liu Y, Schultz A, Cardenas M, Li X, Babur O, Hsu TK, Lichtarge O, Weinstein JN, Akbani R, Wheeler DA (2019) Integrated analysis of TP53 gene and pathway alterations in the cancer genome atlas. Cell Rep 28:1370–1384e1375. https://doi.org/10.1016/j.celrep.2019.07.001
Article CAS PubMed PubMed Central Google Scholar
Dong X, Hu X, Chen J, Hu D, Chen LF (2018) BRD4 regulates cellular senescence in gastric cancer cells via E2F/miR-106b/p21 axis. Cell Death Dis 9:203. https://doi.org/10.1038/s41419-017-0181-6
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