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Combining Surface Modification and Bioactive Cues to Enhance Medpor® Implant Integration
Combining Surface Modification and Bioactive Cues to Enhance Medpor® Implant Integration
Achieving stable and functional integration of synthetic implants with host tissue remains a key challenge in tissue engin...
Neutral Buoyancy as a Simple Approach to Simulated Microgravity
Neutral Buoyancy as a Simple Approach to Simulated Microgravity
It is well recognized that interesting biological phenomena occur in various organisms in microgravity. However, real micr...
Therapeutic Efficacy of Mesenchymal Stem Cells (MSCs) on Alzheimer’s Disease: Review of Clinical Results
Therapeutic Efficacy of Mesenchymal Stem Cells (MSCs) on Alzheimer’s Disease: Review of Clinical Results
Alzheimer's disease (AD) presents significant unmet medical needs with no effective therapeutic options. Current pharm...
Umbilical Cord Mesenchymal Stem Cells and Wnt Pathway Modulation: A Novel Therapy for Liver Cirrhosis and Steatosis
Umbilical Cord Mesenchymal Stem Cells and Wnt Pathway Modulation: A Novel Therapy for Liver Cirrhosis and Steatosis
The Wnt signalling pathway, one of the key classical stem cell pathways, plays an important role in helping the liver rege...
Polydeoxyribonucleotide (PDRN) in Dentistry: Narrative Review for Mechanisms and Emerging Clinical Applications
Polydeoxyribonucleotide (PDRN) in Dentistry: Narrative Review for Mechanisms and Emerging Clinical Applications
Polydeoxyribonucleotide (PDRN) has emerged as a promising and cost-effective biological agent in regenerative medicine due...
Transcriptomic Profiling Reveals Mechanisms of Anoikis Resistance in Spheroid-Cultured Human Umbilical Cord Mesenchymal Stem Cells
Transcriptomic Profiling Reveals Mechanisms of Anoikis Resistance in Spheroid-Cultured Human Umbilical Cord Mesenchymal Stem Cells
Mesenchymal stem (stromal) cells are a promising cell source for regenerative medicine, but their therapeutic efficacy is ...
Human Amniotic Mesenchymal Stromal Cells Promote Bone Regeneration via Regulating Ameloblastoma-Derived-Bone Marrow Mesenchymal Cells Crosstalk and Autophagy in Ameloblastoma Microenvironment
Human Amniotic Mesenchymal Stromal Cells Promote Bone Regeneration via Regulating Ameloblastoma-Derived-Bone Marrow Mesenchymal Cells Crosstalk and Autophagy in Ameloblastoma Microenvironment
Growing evidence validates the vital function of mesenchymal stem cells (MSCs) in tumor development. Our previous findings...
Dual-Drug Stent with Sirolimus and WKYMVm Promotes Endothelialization and Limits Hyperplasia
Dual-Drug Stent with Sirolimus and WKYMVm Promotes Endothelialization and Limits Hyperplasia
Conventional drug-eluting stents suppress neointimal hyperplasia but delay re-endothelialization, raising long-term safety...
Human Subcutaneous Derived Stromal Vascular Fraction Endothelial Cells Display Venous and Arterial Markers in Culture and 3D Capillaries
Human Subcutaneous Derived Stromal Vascular Fraction Endothelial Cells Display Venous and Arterial Markers in Culture and 3D Capillaries
The Stromal Vascular Fraction (SVF) derived from human subcutaneous fat has attracted pivotal interest in clinical applica...
Therapeutic Effects of N-Acetylcysteine-Primed, Iron Oxide Nanoparticle-Enhanced Mesenchymal Stem Cell Exosomes in Ototoxicity Hearing Loss
Therapeutic Effects of N-Acetylcysteine-Primed, Iron Oxide Nanoparticle-Enhanced Mesenchymal Stem Cell Exosomes in Ototoxicity Hearing Loss
Sensorineural hearing loss caused by ototoxic agents remains irreversible due to the limited regenerative capacity of coch...
Engineering Mesenchymal Stem Cells with Nanomaterials for Tumor Microenvironment Regulation and Precision Therapy
Engineering Mesenchymal Stem Cells with Nanomaterials for Tumor Microenvironment Regulation and Precision Therapy
The tumor microenvironment (TME) is a major obstacle to effective cancer therapy, driving tumor progression, metastasis, a...
Alkaline Phosphatase–Regulated C–C Motif Chemokine Ligand 5 (CCL5) Functions as a Critical Mediator of Hair Follicle Neogenesis
Alkaline Phosphatase–Regulated C–C Motif Chemokine Ligand 5 (CCL5) Functions as a Critical Mediator of Hair Follicle Neogenesis
Alkaline phosphatase (ALP) is a well-established molecular marker of dermal papilla (DP) cells, and its activity closely c...
Development of Lung Mimics Using Homogeneous Pluripotent Stem Cells in Deep-Well Plate with Antioxidant-Enriched Media for Drug Screening and Infectious Disease Research
Development of Lung Mimics Using Homogeneous Pluripotent Stem Cells in Deep-Well Plate with Antioxidant-Enriched Media for Drug Screening and Infectious Disease Research
Organoids are three-dimensional (3D) in vitro cell culture systems that grow and self-organize, with cells differentiating...
Rapid and Efficient Combined Decellularization with Physical, Chemical and Enzymatic Treatment for Production of Bovine-Derived Meniscal Implant to Replace Damaged Meniscus
Rapid and Efficient Combined Decellularization with Physical, Chemical and Enzymatic Treatment for Production of Bovine-Derived Meniscal Implant to Replace Damaged Meniscus
Xenogeneic menisci offer a promising biomaterial with high biocompatibility, closely resembling the native meniscus. Howev...
Biochemical and Mechanical Signal Differentially Contribute to Survival in Surface-Modified Cell Model
Biochemical and Mechanical Signal Differentially Contribute to Survival in Surface-Modified Cell Model
Regenerative cell sources such as bone marrow-multipotent stem cells (BM-MSCs) face poor survival after transplantation du...
Biomimetic Constructs for Achilles Tendon Regeneration and their Translation to Human Medicine
Biomimetic Constructs for Achilles Tendon Regeneration and their Translation to Human Medicine
Achilles tendon injuries are among the most common lower-body tendon injuries, often resulting fromoveruse and repetitive ...
Correction: A 3D Printed Poly(ε-caprolactone)-Collagen Hybrid Mesh (TissueDerm) for Breast Reconstruction after Mastectomy in a Pig Model
Correction: A 3D Printed Poly(ε-caprolactone)-Collagen Hybrid Mesh (TissueDerm) for Breast Reconstruction after Mastectomy in a Pig Model
Characterization of PCL mesh and TissueDerm. A CAD designed PCL mesh B Photograph of 3D printed PCL mesh and TissueDerm C ...
Liraglutide Promoted Osteogenic Differentiation of Dental Pulp Stem Cells via H3K18 Lactylation-Dependent DSPP Activation
Liraglutide Promoted Osteogenic Differentiation of Dental Pulp Stem Cells via H3K18 Lactylation-Dependent DSPP Activation
Dental pulp stem cells (DPSCs) are critical for periodontal tissue regeneration, yet their therapeutic potential is limite...
Recent Progress of Dopamine-Modified Tissue Adhesives for Biomedical Applications in Underwater Environments
Recent Progress of Dopamine-Modified Tissue Adhesives for Biomedical Applications in Underwater Environments
Underwater adhesion of polymeric adhesives is highly desirable in specific applications such as wound dressings, wearable ...
Poly(2-Methacryloxyethyl Phosphorylcholine-Co-Butyl Methacrylate) Coating Enhances Biomimetic Mineralization of Bioglass and Promotes Cellular Proliferation
Poly(2-Methacryloxyethyl Phosphorylcholine-Co-Butyl Methacrylate) Coating Enhances Biomimetic Mineralization of Bioglass and Promotes Cellular Proliferation
Biologically active glasses (BG) are widely studied as potential materials for bone tissue engineering, owing to their cap...
Phenotype-Preserving Co-culture of Osteoblasts and Chondrocytes Enhances Bone-Cartilage Interface Integration in a PRP-Augmented Scaffold
Phenotype-Preserving Co-culture of Osteoblasts and Chondrocytes Enhances Bone-Cartilage Interface Integration in a PRP-Augmented Scaffold
Effective bone-cartilage integration remains a challenge in orthopedic surgery. Conventional methods often fail to reconst...
Corneal Endothelium Regeneration with Decellularized Porcine Corneal Extracellular Matrix Scaffolds
Corneal Endothelium Regeneration with Decellularized Porcine Corneal Extracellular Matrix Scaffolds
To evaluate the structural, biochemical, and functional performance of decellularized porcine corneal extracellular matrix...
Correction: Exosomes of Human Fetal Cartilage Progenitor Cells (hFCPCs) Inhibited Interleukin-1β (IL-1β)-Induced Osteoarthritis Phenotype via miR-125b-5p
Correction: Exosomes of Human Fetal Cartilage Progenitor Cells (hFCPCs) Inhibited Interleukin-1β (IL-1β)-Induced Osteoarthritis Phenotype via miR-125b-5p
Anti-inflammatory effect of hFCPC-Exo and miR-125b-5p on IL-1β signal pathways in chondrocytes. hFCPCs were used to produc...
Stepwise Administration of Bone-Targeted Lipid Nanoparticles Encapsulating Valproic Acid and TUDCA Facilitates Direct Reprogramming for Osteoporosis Treatment
Stepwise Administration of Bone-Targeted Lipid Nanoparticles Encapsulating Valproic Acid and TUDCA Facilitates Direct Reprogramming for Osteoporosis Treatment
The ultimate goal of regenerative medicine is to restore damaged tissues to a healthy state in the body. Direct reprogramm...
Short- and Medium-Term Surgical Outcomes of Tissue-Engineered Pulmonary Valve Replacement in Sheep
Short- and Medium-Term Surgical Outcomes of Tissue-Engineered Pulmonary Valve Replacement in Sheep
Tissue-engineered pulmonary valves (TEPVs) hold considerable potential for improving outcomes in valve replacement surgeri...
SIRT4 Regulated by a Mechanosensor, PIEZO1 Shows a Protective Function to Suppress Ox-LDL Uptake in Endothelial Cells
SIRT4 Regulated by a Mechanosensor, PIEZO1 Shows a Protective Function to Suppress Ox-LDL Uptake in Endothelial Cells
Endothelial cells (ECs) are key regulators of vascular function, adapting to mechanical forces, such as shear stress to ma...
Strontium-Doped Marine Collagen Membranes Promote Osteogenesis by Inducing M2 Macrophage Polarization
Strontium-Doped Marine Collagen Membranes Promote Osteogenesis by Inducing M2 Macrophage Polarization
The design of bone biomaterials has shifted from promoting bone differentiation to “immune osteogenic coupling”...
Enhancing Long-Term Survival and Self-Renewal of Primary Hepatocytes via Rapid Spheroid Formation Using Rocker System through Co-Culturing with HUVEC Over-Expressing RSPO1
Enhancing Long-Term Survival and Self-Renewal of Primary Hepatocytes via Rapid Spheroid Formation Using Rocker System through Co-Culturing with HUVEC Over-Expressing RSPO1
Porcine primary hepatocytes are vital for liver therapy due to their procurement ease and robust functions. However, they ...
circRNA_Atp8a1 Promotes Glycolytic Reprogramming in Damage of Intestinal Mucosal Barrier by Upregulating IGF2 through miR-200b-3p
circRNA_Atp8a1 Promotes Glycolytic Reprogramming in Damage of Intestinal Mucosal Barrier by Upregulating IGF2 through miR-200b-3p
This study investigated a circRNA (Circ_Atp8a1) in regulating intestinal epithelial repair in intestinal mucosal barrier d...
Establishment of Immune-Evasive iPSCs from PBMCs Using B2M Knockout and CD47/HLA-E Overexpression
Establishment of Immune-Evasive iPSCs from PBMCs Using B2M Knockout and CD47/HLA-E Overexpression
Induced pluripotent stem cells (iPSCs) represent a promising source for regenerative therapies, yet allogeneic transplanta...
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