Chen Y, Guo B, Zhang Y, Bao X, Li D, Lin J. Injectable hypoxia-preconditioned human exfoliated deciduous teeth stem cells encapsulated within Gelma-Amp microspheres for bone regeneration in periodontitis. Colloids Surf B Biointerfaces. 2025;247:114452.

Article  CAS  PubMed  Google Scholar 

Yang Y, Alves T, Miao MZ, Wu YC, Li G, Lou J, et al. Single-cell transcriptomic analysis of dental pulp and periodontal ligament stem cells. J Dent Res. 2024;103:71–80.

Article  CAS  PubMed  Google Scholar 

Chen Y, Wang X, Wu Z, Jia S, Wan M. Epigenetic regulation of dental-derived stem cells and their application in pulp and periodontal regeneration. PeerJ. 2023;11:e14550.

Article  PubMed  PubMed Central  Google Scholar 

Inchingolo AM, Inchingolo AD, Nardelli P, Latini G, Trilli I, Ferrante L, et al. Stem cells: present understanding and prospects for regenerative dentistry. J Funct Biomater. 2024;15:308.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shaman AM, Bain SC, Bakris GL, Buse JB, Idorn T, Mahaffey KW, et al. Effect of the glucagon-like peptide-1 receptor agonists semaglutide and liraglutide on kidney outcomes in patients with Type 2 diabetes: pooled analysis of sustain 6 and leader. Circulation. 2022;145:575–85.

Article  CAS  PubMed  Google Scholar 

Hou H, Xue P, Wang Y, Li Y. Liraglutide regulates proliferation, differentiation, and apoptosis of preosteoblasts through a signaling network of Notch/Wnt/Hedgehog signaling pathways. Eur Rev Med Pharmacol Sci. 2020;24:12408–22.

PubMed  Google Scholar 

Xie Z, Hu J, Li M, Hu X, Chen J. Health technology assessment: evaluation of 7 glucagon-like peptide-1 receptor agonists for the treatment of type 2 diabetes mellitus. Risk Manag Healthc Policy. 2024;17:1053–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pandey A, Rath G, Chawala R, Goyal AK. A comprehensive review on liraglutide and novel nanocarrier-based systems for the effective delivery of liraglutide. Naunyn Schmiedebergs Arch Pharmacol. 2025;398:8241–58.

Article  CAS  PubMed  Google Scholar 

Gan Z, Zhao M, Xia Y, Yan Y, Ren W. Carbon metabolism in the regulation of macrophage functions. Trends Endocrinol Metab. 2024;35:62–73.

Article  CAS  PubMed  Google Scholar 

Yu X, Yang J, Xu J, Pan H, Wang W, Yu X, et al. Histone lactylation: from tumor lactate metabolism to epigenetic regulation. Int J Biol Sci. 2024;20:1833–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang N, Wang W, Wang X, Mang G, Chen J, Yan X, et al. Histone lactylation boosts reparative gene activation post-myocardial infarction. Circ Res. 2022;131:893–908.

Article  CAS  PubMed  Google Scholar 

Zhao P, Qiao C, Wang J, Zhou Y, Zhang C. Histone lactylation facilitates hepatocellular carcinoma progression by upregulating endothelial cell‐specific molecule 1 expression. Mol Carcinog. 2024;63:2078–89.

Article  CAS  PubMed  Google Scholar 

Wu J, Hu M, Jiang H, Ma J, Xie C, Zhang Z, et al. Endothelial cell‐derived lactate triggers bone mesenchymal stem cell histone lactylation to attenuate osteoporosis. Adv Sci. 2023;10:e2301300.

Article  Google Scholar 

Hashimoto T, Ushikubo G, Arao N, Hatabi K, Tsubota K, Hosoi Y. Oxamate, an Ldha inhibitor, inhibits stemness, including Emt and high DNA repair ability, induces senescence, and exhibits radiosensitizing effects in glioblastoma cells. Int J Mol Sci. 2025;26:5710.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang N, Zhang Y, Xu J, Wang P, Wu B, Lu S, et al. Alpha-Myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure. Cell Res. 2023;33:679–98.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu Y, Yu N, Rivas CA, Mehrnia N, Kantarci A, Van Dyke TE. Rve1 promotes Axin2+ cell regeneration and reduces bacterial invasion. J Dent Res. 2023;102:1478–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang Z, Li J, Lin H, Zhang S, Liu F, Rao Z, et al. Understanding the multi-functionality and tissue-specificity of decellularized dental pulp matrix hydrogels for endodontic regeneration. Acta Biomater. 2024;181:202–21.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Yuan X, Wu Y, Pei M, Yang M, Wu X, et al. Liraglutide regulates bone destruction and exhibits anti-inflammatory effects in periodontitis in vitro and in vivo. J Dent. 2020;94:103310.

Article  CAS  PubMed  Google Scholar 

Gheonea TC, Surlin P, Nicolae FM, Gheorghe DN, Popescu DM, Rogoveanu I. Dipeptidyl-peptidase-4 and glucagon-like-peptide-1, a link in the connection between periodontitis and diabetes mellitus—What do we know so far? A scoping review. J Clin Med. 2024;13:903.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu S, Hu Y, Wang Z, Tan Q, Zang Y, Zhang Z, et al. The mechanism of liraglutide on promoting osteogenesis via macrophages polarization under the inflammatory and oxidative stress in osteoporosis. Life Sci. 2025;377:123717.

Article  CAS  PubMed  Google Scholar 

Zhai S, Liu C, Vimalraj S, Subramanian R, Abullais SS, Arora S, et al. Glucagon-like peptide-1 receptor promotes osteoblast differentiation of dental pulp stem cells and bone formation in a zebrafish scale regeneration model. Peptides. 2023;163:170974.

Article  CAS  PubMed  Google Scholar 

Zhao C, Liang J, Yang Y, Yu M, Qu X. The impact of glucagon-like peptide-1 on bone metabolism and its possible mechanisms. Front Endocrinol. 2017;8:98.

Article  Google Scholar 

Wang Y, Sun Y, Yang B, Li J, Liang C. The effect and mechanism of liraglutide on the biological functions of Bmscs in diabetic patients. Oral Dis. 2024;30:5160–74.

Article  PubMed  Google Scholar 

Gao L, Li S, Li Y. Liraglutide promotes the osteogenic differentiation in Mc3T3-E1 cells via regulating the expression of Smad2/3 through Pi3K/Akt and Wnt/Beta-Catenin pathways. DNA Cell Biol. 2018;37:1031–43.

Article  CAS  PubMed  Google Scholar 

Bao C, Ma Q, Ying X, Wang F, Hou Y, Wang D, et al. Histone lactylation in macrophage biology and disease: from plasticity regulation to therapeutic implications. EBioMedicine. 2025;111:105502.

Article  CAS  PubMed  Google Scholar 

Xu K, Zhang K, Wang Y, Gu Y. Comprehensive review of histone lactylation: structure, function, and therapeutic targets. Biochem Pharmacol. 2024;225:116331.

Article  CAS  PubMed  Google Scholar 

Zhao S, Cheng J, Zhou G, Tao L, Xing J, Liu L, et al. Histone lactylation-driven Ythdf2 promotes non-small cell lung cancer cell glycolysis and stemness by recognizing M6a modification of Sfrp2. Biochem Pharmacol. 2025;240:117097.

Article  CAS  PubMed  Google Scholar 

Li F, Zhang H, Huang Y, Li D, Zheng Z, Xie K, et al. Single-cell transcriptome analysis reveals the association between histone lactylation and cisplatin resistance in bladder cancer. Drug Resist Updat. 2024;73:101059.

Article  CAS  PubMed  Google Scholar 

Prasad M, Butler WT, Qin C. Dentin sialophosphoprotein in biomineralization. Connect Tissue Res. 2010;51:404–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu S, Guo J, Yang D, Yan X, Zhang Z, Wei P, et al. The Atf4‐regulated Lncrna Malat1 promotes odontoblastic differentiation of human dental pulp stem cells via histone demethylase Jmjd3: an in vitro study. Int Endod J. 2024;57:50–63.

Article  PubMed  Google Scholar