Umbilical Cord Mesenchymal Stem Cells and Wnt Pathway Modulation: A Novel Therapy for Liver Cirrhosis and Steatosis

Adams LA, Lymp JF, St Sauver J, Sanderson SO, Lindor KD, Feldstein A, et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology. 2005;129:113–21.

Article  PubMed  Google Scholar 

White DL, Kanwal F, El-Serag HB. Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review. Clin Gastroenterol Hepatol. 2012;10):1342-159.e2.

Article  PubMed  PubMed Central  Google Scholar 

European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD), & European Association for the Study of Obesity (EASO). EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). J Hepatol. 2024;81:492–542.

Article  CAS  Google Scholar 

Chiabotto G, Ceccotti E, Tapparo M, Camussi G, Bruno S. Human liver stem cell-derived extracellular vesicles target hepatic stellate cells and attenuate their pro-fibrotic phenotype. Front Cell Dev Biol. 2021;9:777462.

Article  PubMed  PubMed Central  Google Scholar 

Mancina RM, Valenti L, Romeo S. Human genetics of steatotic liver disease: insights into insulin resistance and lipid metabolism. Nat Metab. 2025;7:2199–211.

Article  CAS  PubMed  Google Scholar 

Dyson J, Jaques B, Chattopadyhay D, Lochan R, Graham J, Das D, et al. Hepatocellular cancer: the impact of obesity, type 2 diabetes and a multidisciplinary team. J Hepatol. 2014;60:110–7.

Article  PubMed  Google Scholar 

Li X, Zhang T, Lv W, Wang H, Chen H, Xu Q, et al. Intratracheal administration of polystyrene microplastics induces pulmonary fibrosis by activating oxidative stress and Wnt/β-catenin signaling pathway in mice. Ecotoxicol Environ Saf. 2022;232:113238.

Article  CAS  PubMed  Google Scholar 

Ma Q, Yu J, Zhang X, Wu X, Deng G. Wnt/β-catenin signaling pathway-a versatile player in apoptosis and autophagy. Biochimie. 2023;211:57–67.

Article  CAS  PubMed  Google Scholar 

Kudo M. Gd-EOB-DTPA-MRI could predict WNT/β-catenin mutation and resistance to immune checkpoint inhibitor therapy in hepatocellular carcinoma. Liver Cancer. 2020;9(5):479–90.

Article  PubMed  PubMed Central  Google Scholar 

Cuadra B, Silva V, Huang YL, Diaz Y, Rivas C, Molina C, et al. The immunoregulatory and regenerative potential of activated human stem cell secretome mitigates acute-on-chronic liver failure in a rat model. Int J Mol Sci. 2024;25:2073.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ding F, Liu Y, Li J, Wei X, Zhao J, Liu X, et al. TC14012 enhances the anti-fibrosis effects of UC-MSCs on the liver by reducing collagen accumulation and ameliorating inflammation. Stem Cell Res Ther. 2024;15:44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng L, Yu P, Li F, Jiang X, Jiao X, Shen Y, et al. Human umbilical cord-derived mesenchymal stem cell-exosomal miR-627-5p ameliorates non-alcoholic fatty liver disease by repressing FTO expression. Hum Cell. 2021;34:1697–708.

Article  CAS  PubMed  Google Scholar 

Chen P, Yuan M, Yao L, Xiong Z, Liu P, Wang Z, et al. Human umbilical cord-derived mesenchymal stem cells ameliorate liver fibrosis by improving mitochondrial function via Slc25a47-Sirt3 signaling pathway. Biomed Pharm. 2024;171:116133.

Article  CAS  Google Scholar 

Cheng X, Xu X, Chen D, Zhao F, Wang W. Therapeutic potential of targeting the Wnt/β-catenin signaling pathway in colorectal cancer. Biomed Pharmacother. 2019;110:473–81.

Article  CAS  PubMed  Google Scholar 

Liu J, Xiao Q, Xiao J, Niu C, Li Y, Zhang X, et al. Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities. Signal Transduct Target Ther. 2022;7:3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

MacDonald BT, Tamai K, He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell. 2009;17:9–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kawamura Y, Arase Y, Ikeda K, Seko Y, Imai N, Hosaka T, et al. Large-scale long-term follow-up study of Japanese patients with non-alcoholic fatty liver disease for the onset of hepatocellular carcinoma. Am J Gastroenterol. 2012;107:253–61.

Article  CAS  PubMed  Google Scholar 

Korkida F, Stamatopoulou A, Roubelakis MG. Recent advances in mesenchymal stem/stromal cell-based therapy for alcohol-associated liver disease and non-alcoholic fatty liver disease. Stem Cells Transl Med. 2024;13:107–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sørensen HT, Mellemkjaer L, Jepsen P, Thulstrup AM, Baron J, Olsen JH, et al. Risk of cancer in patients hospitalized with fatty liver: a Danish cohort study. J Clin Gastroenterol. 2003;36:356–9.

Article  PubMed  Google Scholar 

Thomas PD, Ebert D, Muruganujan A, Mushayahama T, Albou LP, Mi H. PANTHER: making genome-scale phylogenetics accessible to all. Protein Sci. 2022;31:8–22.

Article  CAS  PubMed  Google Scholar 

Rong X, Liu J, Yao X, Jiang T, Wang Y, Xie F. Human bone marrow mesenchymal stem cells-derived exosomes alleviate liver fibrosis through the Wnt/β-catenin pathway. Stem Cell Res Ther. 2019;10:98.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thomas PD, Hill DP, Mi H, Osumi-Sutherland D, Van Auken K, Carbon S, et al. Gene ontology causal activity modeling (GO-CAM) moves beyond GO annotations to structured descriptions of biological functions and systems. Nat Genet. 2019;51:1429–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carbon S, Ireland A, Mungall CJ, Shu S, Marshall B, Lewis S, et al. AmiGO: online access to ontology and annotation data. Bioinformatics. 2009;25:288–9.

Article  CAS  PubMed  Google Scholar 

Trujano-Camacho S, de Cantú- León D, Delgado-Waldo I, Coronel-Hernández J, Millan-Catalan O, Hernández-Sotelo D, et al. Inhibition of Wnt-β-catenin signaling by ICRT14 drug depends of post-transcriptional regulation by HOTAIR in human cervical cancer HeLa cells. Front Oncol. 2021;11:729228.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gutiérrez-Cuevas J, Santos A, Armendariz-Borunda J. Pathophysiological molecular mechanisms of obesity: a link between MAFLD and NASH with cardiovascular diseases. Int J Mol Sci. 2021;22:11629.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiang W, Yin G, Liu H, Wei J, Yu X, Xie Y, et al. Arctium lappa L. polysaccharides enhanced the therapeutic effects of nasal ectomesenchymal stem cells against liver fibrosis by inhibiting the Wnt/β-catenin pathway. Int J Biol Macromol. 2024;129670.

Article  CAS  PubMed  Google Scholar 

Erdem Koc G, Gokcimen A, Sahin F. The effect of boric acid and sodium pentaborate pentahydrate-treated foreskin derived mesenchymal stem cells on liver fibrosis. Biol Trace Elem Res. 2023;201:4834–49.

Article  CAS  PubMed  Google Scholar 

Norero B, Dufour JF. Should we undertake surveillance for HCC in patients with MAFLD? Ther Adv Endocrinol Metab. 2023;14:20420188231160388.

Article  PubMed  PubMed Central  Google Scholar 

More S, Yang X, Zhu Z, Bamunuarachchi G, Guo Y, Huang C, et al. Regulation of influenza virus replication by Wnt/β-catenin signaling. PLoS One. 2018;13:e0191010.

Article  CAS  PubMed 

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