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Granulovacuolar degeneration bodies protect neurons from tau pathology
Granulovacuolar degeneration bodies protect neurons from tau pathology
Granulovacuolar degeneration bodies (GVBs) are lysosomal structures that appear in some neurons in response to pathologica...
Extracellular matrix remodelling in neurological diseases
Extracellular matrix remodelling in neurological diseases
The neural extracellular matrix (ECM) in the CNS is a dynamic network of proteins and glycans that exists in multiple form...
Nociceptive action of calcitonin gene-related peptide in the trigeminovascular system
Migraine treatments that target calcitonin gene-related peptide (CGRP) are widely used, but questions remain regarding the...
Author Correction: UK Biobank at 20 — a growing, global resource for dementia research
UK Dementia Research Institute Centre, Imperial College London, London, UKPaul M. Matthews, Eugene P. Duff, Paul Elliott, ...
Satralizumab could reduce relapse risk in people with MOGAD
Treatment with the IL-6 receptor-blocking monoclonal antibody satralizumab is associated with a reduced risk of relapse in...
CAR T cell therapy shows promise for treatment of stiff person syndrome
A new phase II trial indicates that a CAR T cell therapy is beneficial in individuals with stiff person syndrome, an autoi...
Plasma biomarkers for Alzheimer disease: the road from laboratory results to clinical practice
Plasma biomarkers for Alzheimer disease: the road from laboratory results to clinical practice
Blood-based biomarkers for Alzheimer disease have advanced rapidly, demonstrating strong diagnostic performance and associ...
Newborn screening for spinal muscular atrophy: time is motor neuron
Newborn screening for spinal muscular atrophy (SMA) has changed the diagnostic paradigm for children with the condition, y...
Health disparities in neurology
Health disparities in neurology
Health disparities are preventable differences in health between different populations, and they are endemic thro...
Non-invasive brain stimulation: current and future applications in neurology
Non-invasive brain stimulation: current and future applications in neurology
Device-based non-invasive brain stimulation (NIBS) techniques show promise for the treatment of neurological and psychiatr...
A paradigm shift away from dissemination in time in multiple sclerosis
In the 2024 revisions of the McDonald criteria for diagnosis of multiple sclerosis (MS), dissemination in time is no longe...
The 2024 revisions of the McDonald criteria pose risk of multiple sclerosis overdiagnosis
The 2024 revisions of the McDonald criteria for multiple sclerosis for the first time permit diagnosis in asymptomatic peo...
Implementation of the 2024 revision of the McDonald criteria for multiple sclerosis
Implementation of the 2024 revision of the McDonald criteria for multiple sclerosis
The 2024 revision of the McDonald criteria for diagnosis of multiple sclerosis marks a substantial departure from previous...
The multiple sclerosis prodrome: insights into how and when disease starts
The multiple sclerosis (MS) prodrome and radiologically isolated syndrome (RIS) form overlapping parts of the MS disease c...
Progress and challenges in sporadic late-onset cerebellar ataxias
Progress and challenges in sporadic late-onset cerebellar ataxias
Sporadic late-onset cerebellar ataxia (SLOCA) is a syndrome defined by subacute or chronic and progressive ataxia occurrin...
Myotonic dystrophy type 1: clinical diversity, molecular insights and therapeutic perspectives
Myotonic dystrophy type 1: clinical diversity, molecular insights and therapeutic perspectives
Myotonic dystrophy type 1 (DM1) is the most prevalent muscular dystrophy in adulthood and is one of the most clinically di...
Markers help to predict dementia with Lewy bodies
Biomarkers of Alzheimer disease (AD) pathology can predict the development of dementia with Lewy bodies (DLB) in people wi...
MS drug beneficial in an underrepresented group
Real-world data indicate that ocrelizumab is safe and effective in Latino people with multiple sclerosis (MS), according t...
Exploring the long-term neurological consequences of COVID-19
Exploring the long-term neurological consequences of COVID-19
Two recently published studies have provided new insights into the long-term effects of COVID-19 on the nervous system.
Neuron–tumour networks targeted
Characterization of the networks formed between neurons and glioblastoma cells enables targeting of these networks with th...
Imperatives and co-benefits of research into climate change and neurological disease
Imperatives and co-benefits of research into climate change and neurological disease
Evidence suggests that anthropogenic climate change is accelerating and is affecting human health globally. Despite urgent...
The impact of rare genetic variants on Alzheimer disease
The impact of rare genetic variants on Alzheimer disease
Alzheimer disease (AD) is a progressive neurodegenerative disease with a strong genetic component. Although autosomal domi...
Nothing about us, without us — establishing a patient and public involvement and engagement group
Nothing about us, without us — establishing a patient and public involvement and engagement group
Implementation of patient and public involvement and engagement (PPIE) to enable patients and carers to feel included and ...
Moving towards meaningful patient and public engagement
Patient and public involvement and engagement is increasingly mandated in funding applications, yet often remain tokenisti...
Improved quality of life with MS treatment
Cladribine tablets can improve quality of life in people with highly active relapsing multiple sclerosis (MS), according t...
IGFBP2 levels associated with Alzheimer disease
A study published in Brain has found correlations between serum and cerebrospinal fluid levels of insulin-like growth fact...
A multiple hits hypothesis for memory dysfunction in Parkinson disease
A multiple hits hypothesis for memory dysfunction in Parkinson disease
Cognitive disorders are increasingly recognized in Parkinson disease (PD), even in early disease stages, and memory is one...
Restoring synaptic plasticity after stroke
Gamma oscillations induced by optogenetic stimulation restore functional synaptic plasticity in a mouse model of stroke, a...
CD11c+ macrophages mediate brain-to-gut α-synuclein trafficking
CD11c+ macrophages mediate brain-to-gut α-synuclein trafficking
New research indicates that in a mouse model of Parkinson disease, α-synuclein is trafficked from the brain to the gu...
ALS pathogenesis linked to actin barrier collapse
Repulsive guidance molecule A (RGMa) regulates actin dynamics via neogenin 1 signalling. A new study found that the cerebr...
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