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Unraveling the core: hub genes bridging familial and sporadic Parkinson’s disease
Unraveling the core: hub genes bridging familial and sporadic Parkinson’s disease
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the selective loss of dopamine...
Alexander Robertson (1834–1908)
Alexander Robertson (1834–1908)
Jackson JH (1876) On epilepsies and on the after effects of epileptic discharges (Todd and Robertson’s hypothesis). West R...
Longitudinal myelin MR imaging in patients with multiple sclerosis: a narrative review
Longitudinal myelin MR imaging in patients with multiple sclerosis: a narrative review
Progression of multiple sclerosis (MS) remains incompletely understood. MS is characterized by demyelination, resulting in...
Disrupted and reorganized connectivity of brain networks in multiple sclerosis: a systematic review and meta-analysis of resting-state functional MRI
Disrupted and reorganized connectivity of brain networks in multiple sclerosis: a systematic review and meta-analysis of resting-state functional MRI
Abnormalities in large-scale brain functional networks are implicated in multiple sclerosis (MS) and linked to clinical im...
Association between leukocyte telomere length and neurodegenerative diseases: a prospective cohort in the UK Biobank
Association between leukocyte telomere length and neurodegenerative diseases: a prospective cohort in the UK Biobank
This study aims to investigate the association between leukocyte telomere length (LTL) and the risk of incident NDDs using...
Clinical risk factors for post-traumatic seizures: a systematic review and meta-analysis
Clinical risk factors for post-traumatic seizures: a systematic review and meta-analysis
Post-traumatic seizure (PTS) is a significant complication of traumatic brain injury (TBI), associated with unfavourable o...
Tinnitus: well known in antiquity, highly relevant today
Tinnitus: well known in antiquity, highly relevant today
Tinnitus, i.e., the subjective perception of sound without an external source, is a common symptom of various medical cond...
Oculomotor abnormalities in patients with cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) reflect midline cerebellar impairment
Oculomotor abnormalities in patients with cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) reflect midline cerebellar impairment
Biallelic intronic repeat expansions in the RFC1 gene are associated with the cerebellar ataxia, neuropathy, and vestibula...
A roadmap for a patient-centred approach to Pompe disease management
A roadmap for a patient-centred approach to Pompe disease management
Pompe disease is a rare, progressive genetic disorder caused by pathogenic variants in the GAA gene. Emerging gene therapi...
First multicenter real-world analysis of switching to next-generation enzyme replacement therapies in late-onset Pompe disease
First multicenter real-world analysis of switching to next-generation enzyme replacement therapies in late-onset Pompe disease
Next-generation enzyme replacement therapies (ERTs) for late-onset Pompe disease (LOPD), including avalglucosidase alfa an...
Rapid efficacy of efgartigimod for generalized myasthenia gravis patients in acute exacerbations/worsening: multicenter real-world retrospective study
Rapid efficacy of efgartigimod for generalized myasthenia gravis patients in acute exacerbations/worsening: multicenter real-world retrospective study
Acute exacerbations/worsening of generalized myasthenia gravis (gMG) require urgent intervention to prevent progression to...
Sex differences in baseline characteristics, stroke care, and outcomes across socioeconomic settings: a multicentre study from Switzerland, Poland, and Ukraine
Sex differences in baseline characteristics, stroke care, and outcomes across socioeconomic settings: a multicentre study from Switzerland, Poland, and Ukraine
While stroke risk and burden vary across Europe, the combined impact of sex and socioeconomic context on stroke care and r...
Early serum S100β but not neuron-specific enolase reflects baseline CNS vulnerability in ICANS after CD19 CAR T-cell therapy
Early serum S100β but not neuron-specific enolase reflects baseline CNS vulnerability in ICANS after CD19 CAR T-cell therapy
Immune effector cell-associated neurotoxicity syndrome (ICANS) is a frequent complication of CD19 CAR T-cell therapy. Alth...
Protocol of ASPro-PD: a phase 3 trial of ambroxol to slow progression in genetically stratified Parkinson’s disease
Protocol of ASPro-PD: a phase 3 trial of ambroxol to slow progression in genetically stratified Parkinson’s disease
Genetic studies have identified the GBA1 gene as a significant genetic risk factor for Parkinson’s disease (PD), wit...
Salivary total tau: a clinically practical measure of tau neuropathology in Alzheimer’s disease
Salivary total tau: a clinically practical measure of tau neuropathology in Alzheimer’s disease
Neurofibrillary tangles, consisting of intracellular accumulations of the protein tau, are a hallmark feature of Alzheimer...
Early-phase fluid diagnostic biomarkers in acute ischemic stroke: a hybrid umbrella review
Early-phase fluid diagnostic biomarkers in acute ischemic stroke: a hybrid umbrella review
Acute ischemic stroke (AIS) is a time-critical emergency in which rapid diagnosis within established therapeutic windows i...
Comprehensive effects of Parkinson’s disease multimodal complex treatment (PD-MCT): a two-center prospective trial
Comprehensive effects of Parkinson’s disease multimodal complex treatment (PD-MCT): a two-center prospective trial
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms t...
A phenomenological approach to spastic movement disorders: an international expert panel consensus
A phenomenological approach to spastic movement disorders: an international expert panel consensus
Hyperkinetic movement disorders, characterized by complex and overlapping motor patterns, present significant challenges i...
Lack of dermatological signs in the portrait of Edward Grimston (fifteenth century)
Lack of dermatological signs in the portrait of Edward Grimston (fifteenth century)
Ashrafian H, Harling L (2025) Earliest depiction of port wine stains, eye signs and ear deformity in the portrait of Edwar...
Recurrent nocturnal tongue biting mimicking epilepsy: a case report of severe obstructive sleep apnea
Recurrent nocturnal tongue biting mimicking epilepsy: a case report of severe obstructive sleep apnea
Conflicts of interest The authors declare that the research...
A multi-domain lifestyle intervention in multiple sclerosis: a longitudinal observational study
A multi-domain lifestyle intervention in multiple sclerosis: a longitudinal observational study
To examine the effects of a multi-domain lifestyle intervention that advocated a Mediterranean style diet, and concurrentl...
Regional free-water diffusion is more strongly related to neuroinflammation than neurodegeneration
Regional free-water diffusion is more strongly related to neuroinflammation than neurodegeneration
Recent research has suggested that neuroinflammation may be important in the pathogenesis of neurodegenerative diseases. F...
Joseph Arderne Ormerod (1848–1925)
Joseph Arderne Ormerod (1848–1925)
Anon (1925) Obituary. Joseph Arderne Ormerod. BMJ 1:535–536Article  Google Scholar  ...
William Halse Rivers Rivers (1864–1922)
William Halse Rivers Rivers (1864–1922)
Slobodin R (1997) WHR Rivers: Pioneer anthropologist, Psychiatrist of The Ghost Road (revised edition). Sutton Publishing ...
Mitochondrial pathology in inflammatory myopathies: a marker of worse clinical outcome
Mitochondrial pathology in inflammatory myopathies: a marker of worse clinical outcome
Mitochondrial dysfunction is well documented in inclusion body myositis (IBM), but its role in non-IBM myositis remains un...
Long-term effectiveness and safety of ocrelizumab: a single-centre real-world study
Long-term effectiveness and safety of ocrelizumab: a single-centre real-world study
This retrospective single-centre study evaluated the effectiveness and safety of ocrelizumab (OCR) in relapse-onset multip...
Added value of spinal cord MRI in detecting active disease in non-relapsing progressive multiple sclerosis patients
Added value of spinal cord MRI in detecting active disease in non-relapsing progressive multiple sclerosis patients
Spinal cord MRI is not routinely recommended in the monitoring of MS. In patients with progressive MS (pMS), presence of d...
Equity in neuromuscular research: a 20-year analysis of race, ethnicity, sex, and age representation
Equity in neuromuscular research: a 20-year analysis of race, ethnicity, sex, and age representation
We conducted a systematic analysis of studies on neuromuscular diseases registered on ClinicalTrials.gov over the last 20&...
Comparative efficacy and safety of irreversible (rasagiline) and reversible (safinamide) monoamine oxidase inhibitors as add-on therapy for Parkinson’s disease
Comparative efficacy and safety of irreversible (rasagiline) and reversible (safinamide) monoamine oxidase inhibitors as add-on therapy for Parkinson’s disease
Parkinson’s disease (PD) is a progressive, neurodegenerative condition caused by progressive loss of dopaminergic ne...
Genetic variation of low-to-medium-affinity Fc-gamma receptors in Guillain-Barré syndrome
Genetic variation of low-to-medium-affinity Fc-gamma receptors in Guillain-Barré syndrome
Fc-gamma receptors (FcγRs) are important for the effector functions of immunoglobulin G (IgG) and are therefore expec...
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