M.M. has received honoraria from Abbvie, Biogen, BMS Celgene, Ipsen, Janssen, Merck, Novartis, Roche and Sanofi-Genzyme. O.C. is a member of an independent data and safety monitoring board for Novartis; has given a teaching talk in a local symposium for Merck; and has contributed to an advisory board for Biogen. A.T. declares no competing interests.