Montalban, X. et al. Diagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria. Lancet Neurol. https://doi.org/10.1016/S1474-4422(25)00270-4 (2025).

Article  PubMed  Google Scholar 

Lebrun-Frénay, C. et al. The radiologically isolated syndrome: revised diagnostic criteria. Brain 146, 3431–3443 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Brodersen, J. et al. Overdiagnosis: what it is and what it isn’t. BMJ Evid. Based Med. 23, 1–3 (2018).

Article  PubMed  Google Scholar 

Glasziou, P. P., Jones, M. A., Pathirana, T., Barratt, A. L. & Bell, K. J. Estimating the magnitude of cancer overdiagnosis in Australia. Med. J. Aust. 212, 163–168 (2020).

Article  PubMed  Google Scholar 

Johansson, M., Hansson, A. & Brodersen, J. Estimating overdiagnosis in screening for abdominal aortic aneurysm: could a change in smoking habits and lowered aortic diameter tip the balance of screening towards harm? BMJ 350, h825 (2015).

Article  PubMed  Google Scholar 

Krist, A. H. et al. Screening for asymptomatic carotid artery stenosis: US Preventive Services Task Force recommendation statement. J. Am. Med. Assoc. 325, 476–481 (2021).

Article  Google Scholar 

Järvinen, T. L. et al. Overdiagnosis of bone fragility in the quest to prevent hip fracture. BMJ 350, h2088 (2015).

Article  PubMed  Google Scholar 

Siva, A. Asymptomatic MS. Clin. Neurol. Neurosurg. 115 (Suppl. 1), S1–S5 (2013).

Article  PubMed  Google Scholar 

Lebrun-Frenay, C. et al. Radiologically isolated syndrome. Lancet Neurol. 22, 1075–1086 (2023).

Article  PubMed  Google Scholar 

Xia, Z. et al. Assessment of early evidence of multiple sclerosis in a prospective study of asymptomatic high-risk family members. JAMA Neurol. 74, 293–300 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Maunula, A., Martola, J., Atula, S., Laakso, S. M. & Tienari, P. J. Incidental demyelination in magnetic resonance imaging and 10-year risk of multiple sclerosis: a data lake cohort study. Eur. J. Neurol. 30, 2376–2384 (2023).

Article  PubMed  Google Scholar 

Fissolo, N. et al. Prognostic factors for multiple sclerosis symptoms in radiologically isolated syndrome. JAMA Neurol. 82, 722–733 (2025).

Article  PubMed  Google Scholar 

Vilaseca, A. et al. Radiologically isolated syndrome: how could we accurately diagnose a subclinical period of multiple sclerosis? Mult. Scler. 31, 771–781 (2025).

Article  PubMed  CAS  Google Scholar 

Nielsen, S. B., Spalletta, O., Toft Kristensen, M. A. & Brodersen, J. Psychosocial consequences of potential overdiagnosis in prostate cancer a qualitative interview study. Scand. J. Prim. Health Care 38, 439–446 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Timmermans, S. & Buchbinder, M. Patients-in-waiting: living between sickness and health in the genomics era. J. Health Soc. Behav. 51, 408–423 (2010).

Article  PubMed  Google Scholar