Boon, P. et al. A strategic neurological research agenda for Europe: towards clinically relevant and patient-centred neurological research priorities. Eur. J. Neurol. 31, e16171 (2024).
Seeley, W. W., Crawford, R. K., Zhou, J., Miller, B. L. & Greicius, M. D. Neurodegenerative diseases target large-scale human brain networks. Neuron 62, 42–52 (2009).
Article PubMed PubMed Central CAS Google Scholar
Stam, C. J. Hub overload and failure as a final common pathway in neurological brain network disorders. Netw. Neurosci. 8, 1–23 (2024).
Article PubMed PubMed Central Google Scholar
Murphy, K. R. et al. A practical guide to transcranial ultrasonic stimulation from the IFCN-endorsed ITRUSST consortium. Clin. Neurophysiol. 171, 192–226 (2025).
Violante, I. R. et al. Non-invasive temporal interference electrical stimulation of the human hippocampus. Nat. Neurosci. 26, 1994–2004 (2023).
Article PubMed PubMed Central CAS Google Scholar
Wessel, M. J. et al. Noninvasive theta-burst stimulation of the human striatum enhances striatal activity and motor skill learning. Nat. Neurosci. 26, 2005–2016 (2023).
Article PubMed PubMed Central CAS Google Scholar
Vassiliadis, P. et al. Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills. Nat. Hum. Behav. 8, 1581–1598 (2024).
Article PubMed PubMed Central Google Scholar
Beanato, E. et al. Noninvasive modulation of the hippocampal-entorhinal complex during spatial navigation in humans. Sci. Adv. 10, eado4103 (2024).
Article PubMed PubMed Central CAS Google Scholar
Yang, C. et al. Transcranial temporal interference stimulation of the right globus pallidus in Parkinson’s disease. Mov. Disord. 40, 1061–1069 (2025).
Piao, Y. et al. Safety evaluation of employing temporal interference transcranial alternating current stimulation in human studies. Brain Sci. 12, 1194 (2022).
Article PubMed PubMed Central Google Scholar
Vassiliadis, P. et al. Safety, tolerability and blinding efficiency of non-invasive deep transcranial temporal interference stimulation: first experience from more than 250 sessions. J. Neural Eng. 21, 024001 (2024).
Bergmann, T. O., Karabanov, A., Hartwigsen, G., Thielscher, A. & Siebner, H. R. Combining non-invasive transcranial brain stimulation with neuroimaging and electrophysiology: current approaches and future perspectives. Neuroimage 140, 4–19 (2016).
Bradley, C., Nydam, A. S., Dux, P. E. & Mattingley, J. B. State-dependent effects of neural stimulation on brain function and cognition. Nat. Rev. Neurosci. 23, 459–475 (2022).
Article PubMed CAS Google Scholar
Hartz, S. M. et al. Assessing the clinical meaningfulness of slowing CDR-SB progression with disease-modifying therapies for Alzheimer’s disease. Alzheimers Dement. Transl. Res. Clin. Interv. 11, e70033 (2025).
Wei, N. et al. Repetitive transcranial magnetic stimulation may be superior to drug therapy in the treatment of Alzheimer’s disease: a systematic review and Bayesian network meta-analysis. CNS Neurosci. Ther. 29, 2912–2924 (2023).
Article PubMed PubMed Central CAS Google Scholar
Koch, G. et al. The emerging field of non-invasive brain stimulation in Alzheimer’s disease. Brain 147, 4003–4016 (2024).
Article PubMed PubMed Central Google Scholar
Terao, I. & Kodama, W. Comparative efficacy, tolerability and acceptability of donanemab, lecanemab, aducanumab and lithium on cognitive function in mild cognitive impairment and Alzheimer’s disease: a systematic review and network meta-analysis. Ageing Res. Rev. 94, 102203 (2024).
Article PubMed CAS Google Scholar
Šimko, P., Kent, J. A. & Rektorova, I. Is non-invasive brain stimulation effective for cognitive enhancement in Alzheimer’s disease? An updated meta-analysis. Clin. Neurophysiol. 144, 23–40 (2022).
Yang, T. et al. The cognitive effect of non-invasive brain stimulation combined with cognitive training in Alzheimer’s disease and mild cognitive impairment: a systematic review and meta-analysis. Alzheimers Res. Ther. 16, 140 (2024).
Article PubMed PubMed Central CAS Google Scholar
Rektorová, I. Non-invasive stimulation for treating cognitive impairment in Alzheimer disease. Nat. Rev. Neurol. 20, 445–446 (2024).
Moussavi, Z. et al. Repetitive transcranial magnetic stimulation as a treatment for Alzheimer’s disease: a randomized placebo-controlled double-blind clinical trial. Neurotherapeutics 21, e00331 (2024).
Article PubMed PubMed Central CAS Google Scholar
Lin, H. et al. Effects of accelerated intermittent theta-burst stimulation in modulating brain of Alzheimer’s disease. Cereb. Cortex 34, bhae106 (2024).
Wu, X. et al. Accelerated intermittent theta-burst stimulation broadly ameliorates symptoms and cognition in Alzheimer’s disease: a randomized controlled trial. Brain Stimul. 15, 35–45 (2022).
Tang, N., Shu, W. & Wang, H.-N. Accelerated transcranial magnetic stimulation for major depressive disorder: a quick path to relief? Wiley Interdiscip. Rev. Cogn. Sci. 15, e1666 (2024).
Wu, X. et al. Effects of a periodic intermittent theta burst stimulation in Alzheimer’s disease. Gen. Psychiatr. 37, e101106 (2024).
Article PubMed PubMed Central Google Scholar
Jones, D. T. et al. Cascading network failure across the Alzheimer’s disease spectrum. Brain 139, 547–562 (2016).
Giorgio, J., Adams, J. N., Maass, A., Jagust, W. J. & Breakspear, M. Amyloid induced hyperexcitability in default mode network drives medial temporal hyperactivity and early tau accumulation. Neuron 112, 676–686.e4 (2024).
Article PubMed CAS Google Scholar
Krajcovicova, L., Marecek, R., Mikl, M. & Rektorova, I. Disruption of resting functional connectivity in Alzheimer’s patients and at-risk Subjects. Curr. Neurol. Neurosci. Rep. 14, 491 (2014).
Koch, G. et al. Transcranial magnetic stimulation of the precuneus enhances memory and neural activity in prodromal Alzheimer’s disease. Neuroimage 169, 302–311 (2018).
Koch, G. et al. Precuneus magnetic stimulation for Alzheimer’s disease: a randomized, sham-controlled trial. Brain 145, 3776–3786 (2022).
Article PubMed PubMed Central Google Scholar
Yao, Q. et al. Effect of cerebellum stimulation on cognitive recovery in patients with Alzheimer disease: a randomized clinical trial. Brain Stimul. 15, 910–920 (2022).
Chen, Y. et al. Integrated cerebellar radiomic-network model for predicting mild cognitive impairment in Alzheimer’s disease. Alzheimers Dement. 21, e14361 (2025).
Article PubMed CAS Google Scholar
Majdi, A., van Boekholdt, L., Sadigh-Eteghad, S. & Mc Laughlin, M. A systematic review and meta-analysis of transcranial direct-current stimulation effects on cognitive function in patients with Alzheimer’s disease. Mol. Psychiatry 27, 2000–2009 (2022).
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