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In memoriam Prof. Pawel P. Liberski, MD PhD (November 25, 1954–August 19, 2025)
In memoriam Prof. Pawel P. Liberski, MD PhD (November 25, 1954–August 19, 2025)
Professor Pawel P. Liberski (Fig. 1), a nationally and internationally renowned neuro...
Prospective characterization of germline variants in patients with gliomas and glioneuronal tumors
Prospective characterization of germline variants in patients with gliomas and glioneuronal tumors
Several tumor predisposition syndromes have been linked to the development of gliomas and glioneuronal tumors (glioma/GNT)...
Differences and overlaps in TDP-43 pathology of ‘pure’ LATE-NC compared to LATE-NC coexisting with Alzheimer’s disease
Differences and overlaps in TDP-43 pathology of ‘pure’ LATE-NC compared to LATE-NC coexisting with Alzheimer’s disease
Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a common substrate of dementia in the elderly. LATE and Alz...
Limbic Alzheimer’s co-pathology in multiple system atrophy is associated with cognitive impairment and diagnostic inaccuracy
Limbic Alzheimer’s co-pathology in multiple system atrophy is associated with cognitive impairment and diagnostic inaccuracy
The clinical heterogeneity of multiple system atrophy (MSA) may, along with the primary aggregation of alpha-synuclein (&#...
Genetic and clinical characteristics of cranial nerve schwannoma harboring fusion gene
Genetic and clinical characteristics of cranial nerve schwannoma harboring fusion gene
The SH3PXD2A-HTRA1 fusion gene has recently been identified in a subset of schwannomas, but its frequency and clinical sig...
Alpha synuclein-mediated cytoskeletal dysfunction impairs myelination in human oligodendrocytes
Alpha synuclein-mediated cytoskeletal dysfunction impairs myelination in human oligodendrocytes
Oligodendroglial alpha-synuclein (aSyn) deposits are a key feature in the atypical parkinsonian disorder, multiple system ...
Complement profiling of sural nerves in chronic-inflammatory demyelinating polyneuropathy
Complement profiling of sural nerves in chronic-inflammatory demyelinating polyneuropathy
Chronic-inflammatory demyelinating polyneuropathy (CIDP) is a rare immune-mediated polyneuropathy causing substantial disa...
In silico purification improves DNA methylation-based classification rates of pediatric low-grade gliomas
In silico purification improves DNA methylation-based classification rates of pediatric low-grade gliomas
DNA methylation-based classification using the Heidelberg Classifier is a state-of-the-art data-driven method for molecula...
Neuropathological changes in the nucleus basalis of Meynert in people with type 1 or type 2 diabetes mellitus
Neuropathological changes in the nucleus basalis of Meynert in people with type 1 or type 2 diabetes mellitus
People with type 1 or type 2 diabetes mellitus (T1DM or T2DM) often experience cognitive impairment. We profiled cells in ...
Reversible tau hyperphosphorylation in hibernation: a blood biomarker and brain tissue study
Reversible tau hyperphosphorylation in hibernation: a blood biomarker and brain tissue study
Tau hyperphosphorylation, a key neuropathological feature of tauopathies such as Alzheimer’s disease (AD), also occu...
Expansion of the spectrum of tumors diagnosed as myxopapillary ependymomas
Expansion of the spectrum of tumors diagnosed as myxopapillary ependymomas
Both spinal ependymomas (SPE) and myxopapillary ependymomas (MPE) exhibit a character...
Impact of APOE on cerebrovascular lipid profile in Alzheimer’s disease
Impact of APOE on cerebrovascular lipid profile in Alzheimer’s disease
Disturbances within the cerebrovascular system substantially contribute to the pathogenesis of age-related cognitive impai...
Evolution of pilocytic astrocytoma to diffuse leptomeningeal glioneuronal tumor (DLGNT): bridging two distinct tumor types
Evolution of pilocytic astrocytoma to diffuse leptomeningeal glioneuronal tumor (DLGNT): bridging two distinct tumor types
DCM and JC receive support from the St. Jude Comprehensive Cancer Center (NCI grant P30CA021765) and American Lebanese Syr...
Primary age-related tauopathy
Primary age-related tauopathy
Primary age-related tauopathy (PART) was proposed in 2014 as a neuropathological term to describe patients with Alzheimer&...
Tumor-associated macrophages in meningiomas: a novel biomarker for poor survival outperforming the benefits of T cells
Tumor-associated macrophages in meningiomas: a novel biomarker for poor survival outperforming the benefits of T cells
Tumor-associated macrophages (TAMs) represent the main immune cell population in various brain malignancies, but there is ...
Molecular characterization and clinical features of diffuse midline glioma in the pediatric precision oncology registry INFORM
Molecular characterization and clinical features of diffuse midline glioma in the pediatric precision oncology registry INFORM
Diffuse midline glioma (DMG; a subtype of pediatric high-grade glioma) is a fatal disease in children, due to the localiza...
Genetic and proteomic analysis identifies BAG3 as an amyloid-responsive regulator of neuronal proteostasis
Genetic and proteomic analysis identifies BAG3 as an amyloid-responsive regulator of neuronal proteostasis
The autophagy–lysosome pathway (ALP) and the ubiquitin–proteasome system (UPS) are the primary protein degrada...
LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopathies and synucleinopathies
LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopathies and synucleinopathies
Parkinson’s disease (PD) pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with endolysoso...
Detection of H3F3A K27M or BRAF V600E in liquid biopsies of brain tumor patients as diagnostic and monitoring biomarker: impact of tumor localization and sampling method
Detection of H3F3A K27M or BRAF V600E in liquid biopsies of brain tumor patients as diagnostic and monitoring biomarker: impact of tumor localization and sampling method
Gliomas are the most common brain tumor type in children and adolescents. To date, diagnosis and therapy monitoring for th...
Essential tremor with tau pathology features seeds indistinguishable in conformation from Alzheimer’s disease and primary age-related tauopathy
Essential tremor with tau pathology features seeds indistinguishable in conformation from Alzheimer’s disease and primary age-related tauopathy
Neurodegenerative tauopathies are characterized by the deposition of distinct fibrillar tau assemblies, whose rigid core s...
White matter pathology in FTLD caused by mutations
White matter pathology in FTLD caused by mutations
This work was funded by grants from the Alzheimer’s Association US (016580) and the National Institutes of Health (UAG0639...
Concurrent RB1 and P53 pathway disruption predisposes to the development of a primitive neuronal component in high-grade gliomas depending on MYC-driven EBF3 transcription
Concurrent RB1 and P53 pathway disruption predisposes to the development of a primitive neuronal component in high-grade gliomas depending on MYC-driven EBF3 transcription
The foremost feature of glioblastoma (GBM), the most frequent malignant brain tumours in adults, is a remarkable degree of...
Comparison of the amyloid plaque proteome in Down syndrome, early-onset Alzheimer’s disease, and late-onset Alzheimer’s disease
Comparison of the amyloid plaque proteome in Down syndrome, early-onset Alzheimer’s disease, and late-onset Alzheimer’s disease
Down syndrome (DS) is strongly associated with Alzheimer’s disease (AD) due to APP overexpression, exhibiting Amyloi...
MSH2, MSH6, MLH1, and PMS2 immunohistochemistry as highly sensitive screening method for DNA mismatch repair deficiency syndromes in pediatric high-grade glioma
MSH2, MSH6, MLH1, and PMS2 immunohistochemistry as highly sensitive screening method for DNA mismatch repair deficiency syndromes in pediatric high-grade glioma
Pediatric high-grade glioma (pedHGG) can occur as first manifestation of cancer predisposition syndromes resulting from pa...
IDH-mutant astrocytomas with primitive neuronal component have a distinct methylation profile and a higher risk of leptomeningeal spread
IDH-mutant astrocytomas with primitive neuronal component have a distinct methylation profile and a higher risk of leptomeningeal spread
IDH-mutant astrocytomas are diffuse gliomas that are defined by characteristic mutations in IDH1 or IDH2 and do not have c...
Somatic variants in leading to defects in N-glycosylation in mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE)
Somatic variants in leading to defects in N-glycosylation in mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE)
Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) is a new histopathological...
fusion driver in primary central nervous system malignancy: case report
fusion driver in primary central nervous system malignancy: case report
Andreiuolo F, Varlet P, Tauziède-Espariat A, Jünger ST, Dörner E et al (2019) Childhood supratentorial ependymomas with YA...
Perivascular glial reactivity is a feature of phosphorylated tau lesions in chronic traumatic encephalopathy
Perivascular glial reactivity is a feature of phosphorylated tau lesions in chronic traumatic encephalopathy
Chronic traumatic encephalopathy (CTE), a neurodegenerative disease associated with repetitive head injuries, is character...
A novel fusion that potentially expands the concept of supratentorial ependymoma, fusion-positive
A novel fusion that potentially expands the concept of supratentorial ependymoma, fusion-positive
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
Brain tissue metal concentrations and Alzheimer’s disease neuropathology in total joint arthroplasty patients versus controls
Brain tissue metal concentrations and Alzheimer’s disease neuropathology in total joint arthroplasty patients versus controls
We examined whether total joint arthroplasty (TJA) is associated with increased metal accumulation in the brain and histop...
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