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Loss of meningothelial identity and mesenchymal fate switching in NF2-mutant meningiomas
Loss of meningothelial identity and mesenchymal fate switching in NF2-mutant meningiomas
Intracranial sarcomas can arise secondarily from primary brain tumors, including gliomas and meningiomas, either spontaneo...
A novel BEND2 monoclonal antibody enables highly specific immunohistochemical diagnosis of -fusion astroblastomas
A novel BEND2 monoclonal antibody enables highly specific immunohistochemical diagnosis of -fusion astroblastomas
Chen W, Soon YY, Pratiseyo PD, Sutanto R, Hendriansyah L, Kuick CH et al (2020) Central nervous system neuroepithelial tum...
A severe neurodevelopmental syndrome linked to a South Asian founder variant in the UFMylation adaptor
A severe neurodevelopmental syndrome linked to a South Asian founder variant in the UFMylation adaptor
We investigated the pathogenicity of a homozygous intronic variant in CDK5RAP3, a key UFMylation adapter, in three individ...
The hypoxia-inflammation cycle as a key mechanism of smoldering inflammation and progression in multiple sclerosis
The hypoxia-inflammation cycle as a key mechanism of smoldering inflammation and progression in multiple sclerosis
Disease progression in multiple sclerosis (MS) remains a major unmet clinical challenge, as it is driven by pathogenic mec...
Pathogenic IgG from long COVID patients with neurological sequelae triggers sensitive but not cognitive impairments upon transfer into mice
Pathogenic IgG from long COVID patients with neurological sequelae triggers sensitive but not cognitive impairments upon transfer into mice
Approximately 30% of long COVID patients still experience neurological symptoms (brain fog, pain, chronic fatigue) more th...
Idiotypic-susceptible Alzheimer’s disease: a clinically relevant, neurofibrillary tangle subtype
Idiotypic-susceptible Alzheimer’s disease: a clinically relevant, neurofibrillary tangle subtype
Neurofibrillary tangles in Alzheimer’s disease (AD) stereotypically spread from the medial temporal lobe to associat...
Lipofuscin accumulation in aging and CLN1 is associated with deficient de-S-acylation, lyso-mitochondrial dysfunction, and lipid dyshomeostasis
Lipofuscin accumulation in aging and CLN1 is associated with deficient de-S-acylation, lyso-mitochondrial dysfunction, and lipid dyshomeostasis
Lipofuscin is an autofluorescent material that accrues in brain tissues with age and in Neuronal Ceroid Lipofuscinosis (NC...
CnQuant: high-resolution chromosomal copy number profiling for precision oncology in the clinics
CnQuant: high-resolution chromosomal copy number profiling for precision oncology in the clinics
Assenov Y, Müller F, Lutsik P, Walter J, Lengauer T, Bock C (2014) Comprehensive analysis of DNA methylation data with RnB...
Molecular profiling of alpha-synuclein pathology and seeding activity in Parkinson’s disease
Molecular profiling of alpha-synuclein pathology and seeding activity in Parkinson’s disease
Parkinson’s disease (PD) is neuropathologically characterized by the abnormal accumulation of fibrillar alpha-synucl...
Frequency of mixed neuropathologies in individuals with down syndrome with and without Alzheimer's dementia
Frequency of mixed neuropathologies in individuals with down syndrome with and without Alzheimer's dementia
Individuals with Down syndrome (DS) develop Alzheimer's disease neuropathological change (ADNC) by the age of 40&n...
ε4 influences the widespread TDP-43 pathological subtype in sporadic amyotrophic lateral sclerosis
ε4 influences the widespread TDP-43 pathological subtype in sporadic amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder, most sporadic cases exhibiting TAR DNA-binding ...
Molecular signatures and biomarker development for limbic-predominant age-related TDP-43 encephalopathy (LATE)
Molecular signatures and biomarker development for limbic-predominant age-related TDP-43 encephalopathy (LATE)
Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a neurodegenerative disease marked by TDP-43 proteinopathy,...
Future directions in the treatment of brain metastases: evaluating the role of cellular players in the tumour microenvironment
Future directions in the treatment of brain metastases: evaluating the role of cellular players in the tumour microenvironment
Recent clinical trials have demonstrated the efficacy of different modalities of systemic therapy in treating brain metast...
A plasma protein signature for cerebral amyloid angiopathy
A plasma protein signature for cerebral amyloid angiopathy
Cerebral amyloid angiopathy (CAA) is a cerebrovascular disorder characterized by the deposition of amyloid-β (Aβ...
The phosphoproteomic landscape of the neurological manifestations in tuberous sclerosis complex
The phosphoproteomic landscape of the neurological manifestations in tuberous sclerosis complex
Tuberous sclerosis complex (TSC) is a rare disease caused by mutations in TSC1 and TSC2, resulting in activation of mechan...
Neocortical tau burden determines the degree of cognitive impairment in individuals with Braak stage V neurofibrillary degeneration
Neocortical tau burden determines the degree of cognitive impairment in individuals with Braak stage V neurofibrillary degeneration
Alzheimer disease neuropathologic change (ADNC) is considered to be the most common cause of cognitive decline and dementi...
and fusions in non-vestibular intracranial schwannomas
and fusions in non-vestibular intracranial schwannomas
Agnihotri S, Jalali S, Wilson MR, Danesh A, Li M, Klironomos G et al (2016) The genomic landscape of schwannoma. Nat Genet...
Reevaluating the role of beta2-microglobulin: new insights on selective vulnerability in ALS pathology
Reevaluating the role of beta2-microglobulin: new insights on selective vulnerability in ALS pathology
Amyotrophic lateral sclerosis (ALS) is characterized by the selective loss of motor neurons (MNs). Why these neurons are p...
GRP78 associates with alpha-synuclein in vulnerable neurons of the Parkinson’s disease brain
GRP78 associates with alpha-synuclein in vulnerable neurons of the Parkinson’s disease brain
Conflict of interest The authors declare no competing inter...
AETA peptide contributes to Alzheimer’s disease signature of synapse dysfunction
AETA peptide contributes to Alzheimer’s disease signature of synapse dysfunction
Alzheimer’s disease (AD), the leading cause of dementia, is characterized by early synaptic dysfunction that precede...
In memoriam Prof. Pawel P. Liberski, MD PhD (November 25, 1954–August 19, 2025)
In memoriam Prof. Pawel P. Liberski, MD PhD (November 25, 1954–August 19, 2025)
Professor Pawel P. Liberski (Fig. 1), a nationally and internationally renowned neuro...
Prospective characterization of germline variants in patients with gliomas and glioneuronal tumors
Prospective characterization of germline variants in patients with gliomas and glioneuronal tumors
Several tumor predisposition syndromes have been linked to the development of gliomas and glioneuronal tumors (glioma/GNT)...
Differences and overlaps in TDP-43 pathology of ‘pure’ LATE-NC compared to LATE-NC coexisting with Alzheimer’s disease
Differences and overlaps in TDP-43 pathology of ‘pure’ LATE-NC compared to LATE-NC coexisting with Alzheimer’s disease
Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a common substrate of dementia in the elderly. LATE and Alz...
Limbic Alzheimer’s co-pathology in multiple system atrophy is associated with cognitive impairment and diagnostic inaccuracy
Limbic Alzheimer’s co-pathology in multiple system atrophy is associated with cognitive impairment and diagnostic inaccuracy
The clinical heterogeneity of multiple system atrophy (MSA) may, along with the primary aggregation of alpha-synuclein (&#...
Genetic and clinical characteristics of cranial nerve schwannoma harboring fusion gene
Genetic and clinical characteristics of cranial nerve schwannoma harboring fusion gene
The SH3PXD2A-HTRA1 fusion gene has recently been identified in a subset of schwannomas, but its frequency and clinical sig...
Alpha synuclein-mediated cytoskeletal dysfunction impairs myelination in human oligodendrocytes
Alpha synuclein-mediated cytoskeletal dysfunction impairs myelination in human oligodendrocytes
Oligodendroglial alpha-synuclein (aSyn) deposits are a key feature in the atypical parkinsonian disorder, multiple system ...
Complement profiling of sural nerves in chronic-inflammatory demyelinating polyneuropathy
Complement profiling of sural nerves in chronic-inflammatory demyelinating polyneuropathy
Chronic-inflammatory demyelinating polyneuropathy (CIDP) is a rare immune-mediated polyneuropathy causing substantial disa...
In silico purification improves DNA methylation-based classification rates of pediatric low-grade gliomas
In silico purification improves DNA methylation-based classification rates of pediatric low-grade gliomas
DNA methylation-based classification using the Heidelberg Classifier is a state-of-the-art data-driven method for molecula...
Neuropathological changes in the nucleus basalis of Meynert in people with type 1 or type 2 diabetes mellitus
Neuropathological changes in the nucleus basalis of Meynert in people with type 1 or type 2 diabetes mellitus
People with type 1 or type 2 diabetes mellitus (T1DM or T2DM) often experience cognitive impairment. We profiled cells in ...
Reversible tau hyperphosphorylation in hibernation: a blood biomarker and brain tissue study
Reversible tau hyperphosphorylation in hibernation: a blood biomarker and brain tissue study
Tau hyperphosphorylation, a key neuropathological feature of tauopathies such as Alzheimer’s disease (AD), also occu...
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