The hypoxia-inflammation cycle as a key mechanism of smoldering inflammation and progression in multiple sclerosis

Absinta M, Dal-Bianco A (2021) Slowly expanding lesions are a marker of progressive MS—yes. Mult Scler 27:1679–1681. https://doi.org/10.1177/13524585211013748

Article  PubMed  Google Scholar 

Absinta M, Lassmann H, Trapp BD (2020) Mechanisms underlying progression in multiple sclerosis. Curr Opin Neurol 33:277–285. https://doi.org/10.1097/WCO.0000000000000818

Article  CAS  PubMed  PubMed Central  Google Scholar 

Absinta M, Maric D, Gharagozloo M, Garton T, Smith MD, Jin J et al (2021) A lymphocyte–microglia–astrocyte axis in chronic active multiple sclerosis. Nature 597:709–714. https://doi.org/10.1038/s41586-021-03892-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Absinta M, Sati P, Fechner A, Schindler MK, Nair G, Reich DS (2018) Identification of chronic active multiple sclerosis lesions on 3T MRI. AJNR Am J Neuroradiol 39:1233–1238. https://doi.org/10.3174/ajnr.A5660

Article  CAS  PubMed  PubMed Central  Google Scholar 

Absinta M, Sati P, Masuzzo F, Nair G, Sethi V, Kolb H et al (2019) Association of chronic active multiple sclerosis lesions with disability in vivo. JAMA Neurol 76:1474. https://doi.org/10.1001/jamaneurol.2019.2399

Article  PubMed  PubMed Central  Google Scholar 

Absinta M, Sati P, Schindler M, Leibovitch EC, Ohayon J, Wu T et al (2016) Persistent 7-tesla phase rim predicts poor outcome in new multiple sclerosis patient lesions. J Clin Invest 126:2597–2609. https://doi.org/10.1172/JCI86198

Article  PubMed  PubMed Central  Google Scholar 

Albanese M, Zagaglia S, Landi D, Boffa L, Nicoletti CG, Marciani MG et al (2016) Cerebrospinal fluid lactate is associated with multiple sclerosis disease progression. J Neuroinflammation 13:36. https://doi.org/10.1186/s12974-016-0502-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Allan KC, Hu LR, Scavuzzo MA, Morton AR, Gevorgyan AS, Cohn EF et al (2021) Non-canonical targets of HIF1a impair oligodendrocyte progenitor cell function. Cell Stem Cell 28:257-272.e11. https://doi.org/10.1016/j.stem.2020.09.019

Article  CAS  PubMed  Google Scholar 

Altokhis AI, Hibbert AM, Allen CM, Mougin O, Alotaibi A, Lim S-Y et al (2022) Longitudinal clinical study of patients with iron rim lesions in multiple sclerosis. Mult Scler 28:2202–2211. https://doi.org/10.1177/13524585221114750

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anders JJ, Elwood BW, Kardon RH, Gramlich OW (2023) Acriflavine, a HIF-1 inhibitor, preserves vision in an experimental autoimmune encephalomyelitis model of optic neuritis. Front Immunol 14:1271118. https://doi.org/10.3389/fimmu.2023.1271118

Article  CAS  PubMed  PubMed Central  Google Scholar 

Asgari R, Yarani R, Mohammadi P, Emami Aleagha MS (2021) HIF-1α in the crosstalk between reactive oxygen species and autophagy process: a review in multiple sclerosis. Cell Mol Neurobiol 42:2121–2129. https://doi.org/10.1007/s10571-021-01111-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bagnato F, Hametner S, Yao B, van Gelderen P, Merkle H, Cantor FK et al (2011) Tracking iron in multiple sclerosis: a combined imaging and histopathological study at 7 tesla. Brain 134:3602–3615. https://doi.org/10.1093/brain/awr278

Article  PubMed  PubMed Central  Google Scholar 

Bagnato F, Sati P, Hemond CC, Elliott C, Gauthier SA, Harrison DM et al (2024) Imaging chronic active lesions in multiple sclerosis: a consensus statement. Brain. https://doi.org/10.1093/brain/awae013

Article  PubMed  PubMed Central  Google Scholar 

Bartels K, Grenz A, Eltzschig HK (2013) Hypoxia and inflammation are two sides of the same coin. Proc Natl Acad Sci USA 110:18351–18352. https://doi.org/10.1073/pnas.1318345110

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ben-Shoshan J, Maysel-Auslender S, Mor A, Keren G, George J (2008) Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1alpha. Eur J Immunol 38:2412–2418. https://doi.org/10.1002/eji.200838318

Article  CAS  PubMed  Google Scholar 

Beynon V, George IC, Elliott C, Arnold DL, Ke J, Chen H et al (2022) Chronic lesion activity and disability progression in secondary progressive multiple sclerosis. BMJ Neurol Open 4:e000240. https://doi.org/10.1136/bmjno-2021-000240

Article  PubMed  PubMed Central  Google Scholar 

Bittner S, Pape K, Klotz L, Zipp F (2023) Implications of immunometabolism for smouldering MS pathology and therapy. Nat Rev Neurol 19:477–488. https://doi.org/10.1038/s41582-023-00839-6

Article  PubMed  Google Scholar 

Boyd A, Zhang H, Williams A (2013) Insufficient OPC migration into demyelinated lesions is a cause of poor remyelination in MS and mouse models. Acta Neuropathol 125:841–859. https://doi.org/10.1007/s00401-013-1112-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burtscher J, Mallet RT, Burtscher M, Millet GP (2021) Hypoxia and brain aging: neurodegeneration or neuroprotection? Ageing Res Rev 68:101343. https://doi.org/10.1016/j.arr.2021.101343

Article  CAS  PubMed  Google Scholar 

Campbell G, Mahad DJ (2018) Mitochondrial dysfunction and axon degeneration in progressive multiple sclerosis. FEBS Lett 592:1113–1121. https://doi.org/10.1002/1873-3468.13013

Article  CAS  PubMed  Google Scholar 

Campbell GR, Ziabreva I, Reeve AK, Krishnan KJ, Reynolds R, Howell O et al (2011) Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis. Ann Neurol 69:481–492. https://doi.org/10.1002/ana.22109

Article  CAS  PubMed  Google Scholar 

Cao Y, Yue X, Jia M, Wang J (2023) Neuroinflammation and anti-inflammatory therapy for ischemic stroke. Heliyon. https://doi.org/10.1016/j.heliyon.2023.e17986

Article  PubMed  PubMed Central  Google Scholar 

Carlström KE, Ewing E, Granqvist M, Gyllenberg A, Aeinehband S, Enoksson SL et al (2019) Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes. Nat Commun 10:3081. https://doi.org/10.1038/s41467-019-11139-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Charles P, Reynolds R, Seilhean D, Rougon G, Aigrot MS, Niezgoda A et al (2002) Re-expression of PSA-NCAM by demyelinated axons: an inhibitor of remyelination in multiple sclerosis? Brain 125:1972–1979. https://doi.org/10.1093/brain/awf216

Article  PubMed  Google Scholar 

Cho SH, Raybuck AL, Stengel K, Wei M, Beck TC, Volanakis E et al (2016) Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system. Nature 537:234–238. https://doi.org/10.1038/nature19334

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi YK (2024) Detrimental roles of hypoxia-inducible factor-1α in severe hypoxic brain diseases. Int J Mol Sci 25:4465. https://doi.org/10.3390/ijms25084465

Article  CAS  PubMed  PubMed Central 

Comments (0)

No login
gif