Idiotypic-susceptible Alzheimer’s disease: a clinically relevant, neurofibrillary tangle subtype

Arezoumandan S, Xie SX, Cousins KAQ, Mechanic-Hamilton DJ, Peterson CS, Huang CY et al (2022) Regional distribution and maturation of tau pathology among phenotypic variants of Alzheimer’s disease. Acta Neuropathol (Berl) 144:1103–1116. https://doi.org/10.1007/s00401-022-02472-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Armstrong MJ, Litvan I, Lang AE, Bak TH, Bhatia KP, Borroni B et al (2013) Criteria for the diagnosis of corticobasal degeneration. Neurology 80:496–503. https://doi.org/10.1212/WNL.0b013e31827f0fd1

Article  PubMed  PubMed Central  Google Scholar 

Bezgin G, Pascoal TA, Therriault J, Lussier FZ, Servaes S, Kang MS et al (2025) Tau profiling across Alzheimer’s disease staging reveals vulnerability to disease pathophysiology. Eur J Nucl Med Mol Imaging. https://doi.org/10.1007/s00259-025-07257-4

Article  PubMed  PubMed Central  Google Scholar 

Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berl) 82:239–259

Article  CAS  PubMed  Google Scholar 

Coughlan GT, Klinger HM, Boyle R, Betthauser TJ, Binette AP, Christenson L et al (2025) Sex differences in longitudinal Tau-PET in preclinical Alzheimer disease: a meta-analysis. JAMA Neurol 82:364–375. https://doi.org/10.1001/jamaneurol.2025.0013

Article  PubMed  PubMed Central  Google Scholar 

Crutch SJ, Schott JM, Rabinovici GD, Murray M, Snowden JS, van der Flier WM et al (2017) Consensus classification of posterior cortical atrophy. Alzheimers Dement 13:870–884. https://doi.org/10.1016/j.jalz.2017.01.014

Article  PubMed  PubMed Central  Google Scholar 

Ferreira D, Pereira JB, Volpe G, Westman E (2019) Subtypes of Alzheimer’s Disease display distinct network abnormalities extending beyond their pattern of brain atrophy. Front Neurol 10:524. https://doi.org/10.3389/fneur.2019.00524

Article  PubMed  PubMed Central  Google Scholar 

Gefen T, Gasho K, Rademaker A, Lalehzari M, Weintraub S, Rogalski E et al (2012) Clinically concordant variations of Alzheimer pathology in aphasic versus amnestic dementia. Brain 135:1554–1565. https://doi.org/10.1093/brain/aws076

Article  PubMed  PubMed Central  Google Scholar 

Giannakopoulos P, Hof PR, Mottier S, Michel JP, Bouras C (1994) Neuropathological changes in the cerebral cortex of 1258 cases from a geriatric hospital: retrospective clinicopathological evaluation of a 10-year autopsy population. Acta Neuropathol (Berl) 87:456–468. https://doi.org/10.1007/BF00294172

Article  CAS  PubMed  Google Scholar 

Gorno-Tempini ML, Hillis AE, Weintraub S, Kertesz A, Mendez M, Cappa SF et al (2011) Classification of primary progressive aphasia and its variants. Neurology 76:1006–1014. https://doi.org/10.1212/WNL.0b013e31821103e6

Article  PubMed  PubMed Central  Google Scholar 

Hojjati SH, Chiang GC, Butler TA, Chen K, Khalafi M, Yazdi BG et al (2025) Heterogeneous tau deposition patterns in the preclinical stage link to domain-specific cognitive deficits. Alzheimers Dement 21:e70153. https://doi.org/10.1002/alz.70153

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jack CR, Knopman DS, Jagust WJ, Petersen RC, Weiner MW, Aisen PS et al (2013) Update on hypothetical model of Alzheimer’s disease biomarkers. Lancet Neurol 12:207–216. https://doi.org/10.1016/S1474-4422(12)70291-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Josephs KA, Dickson DW, Murray ME, Senjem ML, Parisi JE, Petersen RC et al (2013) Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer’s disease presenting as logopenic progressive aphasia. Brain Lang. https://doi.org/10.1016/j.bandl.2013.02.003

Article  PubMed  PubMed Central  Google Scholar 

Kim B, Suh E, Nguyen AT, Prokop S, Mikytuck B, Olatunji OA et al (2022) TREM2 risk variants are associated with atypical Alzheimer’s disease. Acta Neuropathol (Berl) 144:1085–1102. https://doi.org/10.1007/s00401-022-02495-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kouri N, Frankenhauser I, Peng Z, Labuzan SA, Boon BDC, Moloney CM et al (2024) Clinicopathologic heterogeneity and glial activation patterns in Alzheimer disease. JAMA Neurol 81:619–629. https://doi.org/10.1001/jamaneurol.2024.0784

Article  PubMed  PubMed Central  Google Scholar 

Lee SE, Rabinovici GD, Mayo MC, Wilson SM, Seeley WW, DeArmond SJ et al (2011) Clinicopathological correlations in corticobasal degeneration. Ann Neurol 70:327–340. https://doi.org/10.1002/ana.22424

Article  PubMed  PubMed Central  Google Scholar 

McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR, Kawas CH et al (2011) The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7:263–269. https://doi.org/10.1016/j.jalz.2011.03.005

Article  PubMed  PubMed Central  Google Scholar 

Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW et al (2012) National Institute on Aging-Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach. Acta Neuropathol (Berl) 123:1–11. https://doi.org/10.1007/s00401-011-0910-3

Article  CAS  PubMed  Google Scholar 

Murray ME, Graff-Radford NR, Ross OA, Petersen RC, Duara R, Dickson DW (2011) Neuropathologically defined subtypes of Alzheimer’s disease with distinct clinical characteristics: a retrospective study. Lancet Neurol 10:785–796. https://doi.org/10.1016/S1474-4422(11)70156-9

Article  PubMed  PubMed Central  Google Scholar 

Ohm DT, Fought AJ, Rademaker A, Kim G, Sridhar J, Coventry C et al (2019) Neuropathologic basis of in vivo cortical atrophy in the aphasic variant of Alzheimer’s disease. Brain Pathol 30:332–344. https://doi.org/10.1111/bpa.12783

Article  CAS  PubMed  Google Scholar 

Ossenkoppele R, Schonhaut DR, Schöll M, Lockhart SN, Ayakta N, Baker SL et al (2016) Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease. Brain 139:1551–1567. https://doi.org/10.1093/brain/aww027

Article  PubMed  PubMed Central  Google Scholar 

Ottoy J, Kang MS, Tan JXM, Boone L, Vos de Wael R, Park B et al (2024) Tau follows principal axes of functional and structural brain organization in Alzheimer’s disease. Nat Commun 15:5031. https://doi.org/10.1038/s41467-024-49300-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Petersen C, Nolan AL, de Paula França Resende E, Miller Z, Ehrenberg AJ, Gorno-Tempini ML et al (2019) Alzheimer’s disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulation. Acta Neuropathol 138:597–612. https://doi.org/10.1007/s00401-019-02036-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Phillips JS, Da Re F, Dratch L, Xie SX, Irwin DJ, McMillan CT et al (2018) Neocortical origin and progression of gray matter atrophy in nonamnestic Alzheimer’s disease. Neurobiol Aging 63:75–87. https://doi.org/10.1016/j.neurobiolaging.2017.11.008

Article  PubMed  Google Scholar 

Phillips JS, Nitchie FJ, Da Re F, Olm CA, Cook PA, McMillan CT et al (2022) Rates of longitudinal change in 18 F-flortaucipir PET vary by brain region, cognitive impairment, and age in atypical Alzheimer’s disease. Alzheimers Dement J Alzheimers Assoc 18:1235–1247. https://doi.org/10.1002/alz.12456

Article  CAS  Google Scholar 

Putcha D, Katsumi Y, Touroutoglou A, Eloyan A, Taurone A, Thangarajah M et al (2025) Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer’s disease: a neuropsychological data-driven approach. Alzheimers Res Ther 17:38. https://doi.org/10.1186/s13195-025-01689-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif