Aaron KA, Manojlovic Z, Tu N, Xu Y, Jin Y, Chang S et al (2020) What genes can tell: a closer look at Vestibular Schwannoma. Otol Neurotol 41:522–529. https://doi.org/10.1097/MAO.0000000000002580
Agnihotri S, Jalali S, Wilson MR, Danesh A, Li M, Klironomos G et al (2016) The genomic landscape of schwannoma. Nat Genet 48:1339–1348. https://doi.org/10.1038/ng.3688
Article CAS PubMed Google Scholar
Bal J, Bruneau M, Berhouma M, Cornelius JF, Cavallo LM, Daniel RT et al (2022) Management of non-vestibular schwannomas in adult patients: a systematic review and consensus statement on behalf of the EANS skull base section part III: lower cranial nerve schwannomas, jugular foramen (CN IX, X, XI) and hypoglossal schwannoma (XII). Acta Neurochir (Wien) 164:321–329. https://doi.org/10.1007/s00701-021-05072-y
Bal J, Bruneau M, Berhouma M, Cornelius JF, Cavallo LM, Daniel RT et al (2022) Management of non-vestibular schwannomas in adult patients: a systematic review and consensus statement on behalf of the EANS skull base section. Part I: oculomotor and other rare non-vestibular schwannomas (I, II, III, IV, VI). Acta Neurochir (Wien) 164:285–297. https://doi.org/10.1007/s00701-021-05048-y
Bal J, Bruneau M, Berhouma M, Cornelius JF, Cavallo LM, Daniel RT et al (2022) Management of non-vestibular schwannomas in adult patients: a systematic review and consensus statement on behalf of the EANS skull base section Part II: trigeminal and facial nerve schwannomas (CN V, VII). Acta Neurochir (Wien) 164:299–319. https://doi.org/10.1007/s00701-021-05092-8
Carlson ML, Smadbeck JB, Link MJ, Klee EW, Vasmatzis G, Schimmenti LA (2018) Next generation sequencing of sporadic vestibular schwannoma: Necessity of biallelic NF2 inactivation and implications of accessory non-NF2 variants: Necessity of biallelic NF2 inactivation and implications of accessory non-NF2 variants. Otol Neurotol 39:e860–e871. https://doi.org/10.1097/MAO.0000000000001932
Chen H, Xue L, Wang H, Wang Z, Wu H (2017) Differential NF2 gene status in sporadic vestibular schwannomas and its prognostic impact on tumour growth patterns. Sci Rep 7:5470. https://doi.org/10.1038/s41598-017-05769-0
Article CAS PubMed PubMed Central Google Scholar
Chen Z, Prasad SC, Di Lella F, Medina M, Piccirillo E, Taibah A et al (2014) The behavior of residual tumors and facial nerve outcomes after incomplete excision of vestibular schwannomas: clinical article. J Neurosurg 120:1278–1287. https://doi.org/10.3171/2014.2.jns131497
Chien J, Campioni M, Shridhar V, Baldi A (2009) HtrA serine proteases as potential therapeutic targets in cancer. Curr Cancer Drug Targets 9:451–468. https://doi.org/10.2174/156800909788486704
Article CAS PubMed PubMed Central Google Scholar
Clark VE, Erson-Omay EZ, Serin A, Yin J, Cotney J, Ozduman K et al (2013) Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO. Science 339:1077–1080. https://doi.org/10.1126/science.1233009
Article CAS PubMed PubMed Central Google Scholar
Collins K, Hwang M, Antic T, Paintal A, Argani P, Matoso A et al (2022) Merlin immunohistochemistry is useful in diagnosis of tumours within the spectrum of biphasic hyalinizing psammomatous renal cell carcinoma. Histopathology 81:577–586. https://doi.org/10.1111/his.14731
Fukaya R, Yoshida K, Ohira T, Kawase T (2010) Trigeminal schwannomas: experience with 57 cases and a review of the literature. Neurosurg Rev 34:159–171. https://doi.org/10.1007/s10143-010-0289-y
Glembocki A, Siddaway R, Arnoldo A, Jakeman M, Lafreniere A (2024) Clinical and pathological features of a schwannoma harboring a SH3PXD2A::HTRA1 gene fusion in a pre-pubescent patient. Pediatr Dev Pathol. https://doi.org/10.1177/10935266241308946
Article PubMed PubMed Central Google Scholar
Goldbrunner R, Weller M, Regis J, Lund-Johansen M, Stavrinou P, Reuss D et al (2020) EANO guideline on the diagnosis and treatment of vestibular schwannoma. Neuro Oncol 22:31–45. https://doi.org/10.1093/neuonc/noz153
Hardin EC, Schmid S, Sommerkamp A, Bodden C, Heipertz A-E, Sievers P et al (2023) LOGGIC Core BioClinical Data Bank: added clinical value of RNA-Seq in an international molecular diagnostic registry for pediatric low-grade glioma patients. Neuro Oncol 25:2087–2097. https://doi.org/10.1093/neuonc/noad078
Article CAS PubMed PubMed Central Google Scholar
Jacob JT, Carlson ML, Driscoll CL, Link MJ (2016) Volumetric analysis of tumor control following subtotal and near-total resection of vestibular schwannoma: recurrence following partial VS resection. Laryngoscope 126:1877–1882. https://doi.org/10.1002/lary.25779
Article CAS PubMed Google Scholar
Karajannis MA, Li BK, Souweidane MM, Liechty B, Yao J, Benhamida JK et al (2022) YAP1-MAML2 fusion in a pediatric NF2-wildtype intraparenchymal brainstem schwannoma. Acta Neuropathol Commun 10:117. https://doi.org/10.1186/s40478-022-01423-7
Article CAS PubMed PubMed Central Google Scholar
Klose R, Adam MG, Weis E-M, Moll I, Wüstehube-Lausch J, Tetzlaff F et al (2018) Inactivation of the serine protease HTRA1 inhibits tumor growth by deregulating angiogenesis. Oncogene 37:4260–4272. https://doi.org/10.1038/s41388-018-0258-4
Article CAS PubMed Google Scholar
Lee J-C, Lee P-H, Li S-C, Liao K-C, Chang Y-M, Chen H-C et al (2024) Systematic characterization of the clinical and pathological features of schwannomas harboring SH3PXD2A::HTRA1 fusion. Mod Pathol 37:100427. https://doi.org/10.1016/j.modpat.2024.100427
Article CAS PubMed Google Scholar
Li Y, Wei Y, Ultsch M, Li W, Tang W, Tombling B et al (2024) Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region. Nat Commun 15:4359. https://doi.org/10.1038/s41467-024-48655-w
Article CAS PubMed PubMed Central Google Scholar
Liu SJ, Casey-Clyde T, Cho NW, Swinderman J, Pekmezci M, Dougherty MC et al (2024) Epigenetic reprogramming shapes the cellular landscape of schwannoma. Nat Commun 15:476. https://doi.org/10.1038/s41467-023-40408-5
Article CAS PubMed PubMed Central Google Scholar
Mansouri S, Suppiah S, Mamatjan Y, Paganini I, Liu JC, Karimi S et al (2021) Epigenomic, genomic, and transcriptomic landscape of schwannomatosis. Acta Neuropathol 141:101–116. https://doi.org/10.1007/s00401-020-02230-x
Article CAS PubMed Google Scholar
Martin SD, Cheung S, Churg A (2023) Immunohistochemical demonstration of Merlin/NF2 loss in mesothelioma. Mod Pathol 36:100036
Article CAS PubMed Google Scholar
Ogasawara N, Yamashita S, Yamasaki K, Kawano T, Kawano T, Muta J et al (2023) Spontaneous malignant transformation of trigeminal schwannoma: consideration of responsible gene alterations for tumorigenesis—a case report. Brain Tumor Pathol 40:222–229. https://doi.org/10.1007/s10014-023-00466-5
Article CAS PubMed Google Scholar
Ohara K, Miyawaki S, Teranishi Y, Komura D, Mitsui J, Ikemura M et al (2025) Genetic analysis of intracranial schwannomas: differential NF2 alteration frequencies in nonvestibular schwannomas versus vestibular schwannomas. Neurosurgery. https://doi.org/10.1227/neu.0000000000003508
Comments (0)