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Treatment Persistence and Switch Among Medicare-Insured People with HIV and Gaps in Care
Treatment Persistence and Switch Among Medicare-Insured People with HIV and Gaps in Care
Adherence to antiretroviral therapy (ART) is crucial for people with HIV (PWH) to maintain health. The Medicare program in...
High-Dose Minocycline Improves Outcomes in Group Pneumonia: A Propensity-Weighted Cohort Study with MIC-Based Insights for Breakpoint Revision
High-Dose Minocycline Improves Outcomes in Group Pneumonia: A Propensity-Weighted Cohort Study with MIC-Based Insights for Breakpoint Revision
Optimal minocycline dosing for Acinetobacter baumannii group pneumonia remains unclear. We assessed the clinical impact of...
Post-cranial Neurosurgery Infections: Clinical Correlates, Presentation, and Outcomes—A Matched Case–Case–Control Study
Post-cranial Neurosurgery Infections: Clinical Correlates, Presentation, and Outcomes—A Matched Case–Case–Control Study
Although Cutibacterium acnes is considered a typical pathogen of postoperative central nervous system (CNS) infections, da...
Microbiological, Clinical, and Pharmacokinetic/Pharmacodynamic Data to Support EUCAST Aztreonam–Avibactam Minimum Inhibitory Concentration Susceptibility Breakpoints Against Enterobacterales
Microbiological, Clinical, and Pharmacokinetic/Pharmacodynamic Data to Support EUCAST Aztreonam–Avibactam Minimum Inhibitory Concentration Susceptibility Breakpoints Against Enterobacterales
Aztreonam–avibactam was approved for adults with limited treatment options for multiple infections due to aerobic Gr...
Bone Mineral Density Changes in People with HIV Who had Immediate Switch Versus Deferred Switch from Tenofovir Disoproxil Fumarate-Based Regimens to Bictegravir/Emtricitabine/Tenofovir Alafenamide: A Multicenter, Open-Label, Randomized Clinical Trial
Bone Mineral Density Changes in People with HIV Who had Immediate Switch Versus Deferred Switch from Tenofovir Disoproxil Fumarate-Based Regimens to Bictegravir/Emtricitabine/Tenofovir Alafenamide: A Multicenter, Open-Label, Randomized Clinical Trial
Tenofovir disoproxil fumarate (TDF)-based antiretroviral therapy regimens remain one of the first-line treatments in many ...
Epidemiology of Invasive Disease in Adults Using Routine Healthcare Records from the United States, 2002–2022
Epidemiology of Invasive Disease in Adults Using Routine Healthcare Records from the United States, 2002–2022
Extraintestinal pathogenic Escherichia coli can infect normally sterile body sites, causing invasive E. coli disease (IED)...
Quality of Life and Treatment Satisfaction in People with HIV Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide: Pooled Analysis from Observational Cohort Studies
Quality of Life and Treatment Satisfaction in People with HIV Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide: Pooled Analysis from Observational Cohort Studies
Patient-reported outcomes (PROs) provide important insights into individuals’ health and well-being. We report PROs ...
Growth in Anaerobic Bottles is an Independent Predictor of Mortality in Bloodstream Infections
Growth in Anaerobic Bottles is an Independent Predictor of Mortality in Bloodstream Infections
Pseudomonas aeruginosa is a leading cause of bloodstream infections (BSI) in hospitalized patients. Although it is regarde...
Cost-Effectiveness Analysis of Aztreonam–Avibactam Compared with Colistin Plus Meropenem in Treating Metallo-Beta-Lactamase-Producing Enterobacterales Infections in Spain
Cost-Effectiveness Analysis of Aztreonam–Avibactam Compared with Colistin Plus Meropenem in Treating Metallo-Beta-Lactamase-Producing Enterobacterales Infections in Spain
Aztreonam–avibactam (ATM-AVI) is the first β-lactam/β-lactamase inhibitor antibiotic for treating serious ...
Dual Transmission Dynamics of Carbapenem Resistance in Pediatric Oncology: Plasmid-Mediated and Clonal Spread of NDM-5 Enterobacterales
Dual Transmission Dynamics of Carbapenem Resistance in Pediatric Oncology: Plasmid-Mediated and Clonal Spread of NDM-5 Enterobacterales
Carbapenem-resistant Enterobacterales (CRE) pose a major threat to immunocompromised pediatric oncology patients. However,...
How to Better Screen for Blood-Borne Viruses, Specifically HIV, in Hospital Emergency Departments: French and European Perspectives
How to Better Screen for Blood-Borne Viruses, Specifically HIV, in Hospital Emergency Departments: French and European Perspectives
Hospital emergency departments (EDs) represent an acceptable and economically viable source of data on screening for blood...
Acute and Long-Term Healthcare Utilization and Expenditures for Serious Bacterial Infections among Newborns in US Hospitals
Acute and Long-Term Healthcare Utilization and Expenditures for Serious Bacterial Infections among Newborns in US Hospitals
Serious bacterial infections among newborns are associated with significant morbidity, mortality, and economic costs. Whil...
Understanding the Epidemiology and Contributing Factors of Post-COVID-19 Pertussis Outbreaks: A Narrative Review
Understanding the Epidemiology and Contributing Factors of Post-COVID-19 Pertussis Outbreaks: A Narrative Review
Pertussis or whooping cough, caused by the bacteria Bordetella pertussis, is a highly contagious respiratory dise...
The Structure, Properties, and Clinical Utility of Contezolid for Antituberculosis: A Narrative Review
The Structure, Properties, and Clinical Utility of Contezolid for Antituberculosis: A Narrative Review
Tuberculosis (TB) continues to represent a significant global public health concern, with China being a country that bears...
Impact of Risk Stacking on COVID-19–Related Healthcare Utilization: A Real-World Retrospective Cohort Study
Impact of Risk Stacking on COVID-19–Related Healthcare Utilization: A Real-World Retrospective Cohort Study
This study evaluated the impact of “risk stacking” on COVID-19–related hospitalizations, emergency depar...
Chest Computed Tomography Patterns Associated with Severity in Adults with Respiratory Syncytial Virus Infection: A Retrospective Cohort Study
Chest Computed Tomography Patterns Associated with Severity in Adults with Respiratory Syncytial Virus Infection: A Retrospective Cohort Study
There are limited data available on the relationship between chest computed tomography (CT) patterns and clinical severity...
A Review of Doxycycline Post-Exposure Prophylaxis and Its Implications for Antimicrobial Resistance and the Human Microbiome
A Review of Doxycycline Post-Exposure Prophylaxis and Its Implications for Antimicrobial Resistance and the Human Microbiome
Sexually transmitted infections (STIs) remain a major global health burden, with rising incidence of Neisseria gonorrhoeae...
From Clinical Trials to Real-World Experiences: Evidence About Cefiderocol Use and Potential Role in Empirical Therapy
From Clinical Trials to Real-World Experiences: Evidence About Cefiderocol Use and Potential Role in Empirical Therapy
Cefiderocol is a novel siderophore cephalosporin that has gained attention for its potent activity against multidrug-resis...
Characteristics and Outcomes of Patients Treated with Carbapenem Versus Non-carbapenem Therapy for AmpC-Producing Enterobacterales Bacteremia: A Retrospective Study
Characteristics and Outcomes of Patients Treated with Carbapenem Versus Non-carbapenem Therapy for AmpC-Producing Enterobacterales Bacteremia: A Retrospective Study
Inducible AmpC β-lactamases in Gram-negative Enterobacterales pose therapeutic challenges. Although carbapenems are t...
Burden and Outcomes of Severe Lower Respiratory Tract Infections with Unknown Etiology: A Retrospective Observational Study on Epidemiological Trends Over an 8-Year Period (2016–2024)
Burden and Outcomes of Severe Lower Respiratory Tract Infections with Unknown Etiology: A Retrospective Observational Study on Epidemiological Trends Over an 8-Year Period (2016–2024)
Severe lower respiratory tract infections often require hospitalization, but a significant proportion lack microbiological...
Long-Term Hepatic and Extrahepatic Outcomes of Chronic Hepatitis C Patients After Sofosbuvir-Based Treatment (LONGHEAD Study)
Long-Term Hepatic and Extrahepatic Outcomes of Chronic Hepatitis C Patients After Sofosbuvir-Based Treatment (LONGHEAD Study)
Direct-acting antivirals (DAAs) are highly effective in treating hepatitis C virus (HCV) infection. The long-term hepatic ...
Healthcare-Associated Infections: The Role of Microbial and Environmental Factors in Infection Control—A Narrative Review
Healthcare-Associated Infections: The Role of Microbial and Environmental Factors in Infection Control—A Narrative Review
Healthcare-associated infections (HAIs), previously known as nosocomial infections, represent a significant threat to heal...
Indirect Comparison of PCV20 Immunogenicity with PCV10 in Pediatric 3 + 1 and 2 + 1 Schedules
Indirect Comparison of PCV20 Immunogenicity with PCV10 in Pediatric 3 + 1 and 2 + 1 Schedules
The 20-valent pneumococcal conjugate vaccine (PCV20) was licensed for prevention of pneumococcal disease in infants and ch...
Clinical Impact and Cost-Effectiveness of Updated 2023/24 COVID-19 mRNA Vaccination in High-Risk Populations in the United States
Clinical Impact and Cost-Effectiveness of Updated 2023/24 COVID-19 mRNA Vaccination in High-Risk Populations in the United States
In the post-pandemic era, people with underlying medical conditions continue to be at increased risk for severe COVID-19 d...
Efficacy of Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) After A Viremic Event: A Pooled Analysis of Studies in People with HIV
Efficacy of Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) After A Viremic Event: A Pooled Analysis of Studies in People with HIV
Transient viremia can occur in people with human immunodeficiency virus (HIV), often referred to as people with HIV (PWH),...
Real-Life Experiences of Herpes Simplex Virus Type 2 Genital Herpes in the United States: A Structured Literature Review and Qualitative Concept Elicitation Study
Real-Life Experiences of Herpes Simplex Virus Type 2 Genital Herpes in the United States: A Structured Literature Review and Qualitative Concept Elicitation Study
Research on real-life experiences of herpes simplex virus type 2 (HSV-2) genital herpes (GH) is scarce. This study primari...
Ensitrelvir in Hospitalized Patients with SARS-CoV-2 During the Omicron Epidemic: A Single-Center Observational Study
Ensitrelvir in Hospitalized Patients with SARS-CoV-2 During the Omicron Epidemic: A Single-Center Observational Study
Ensitrelvir, a novel oral 3C-like protease inhibitor targeting severe acute respiratory syndrome coronavirus 2, has been a...
Predicting ICU Admission Risk in Children with Respiratory Syncytial Virus
Predicting ICU Admission Risk in Children with Respiratory Syncytial Virus
Respiratory syncytial virus (RSV) is a common infection in young children and a frequent cause of hospitalization. In some...
An Economic Model to Assess the Cost Impact of Using Xpert Carba-R to Screen Carbapenemase-Producing Enterobacterales in Comparison with Standard of Care, in a National Health Service Setting
An Economic Model to Assess the Cost Impact of Using Xpert Carba-R to Screen Carbapenemase-Producing Enterobacterales in Comparison with Standard of Care, in a National Health Service Setting
Carbapenemase-producing Enterobacterales (CPE) are bacteria that produce carbapenemases, enzymes that destroy carbapenem a...
A Systematic Literature Review of the Epidemiology of Complicated Urinary Tract Infection
A Systematic Literature Review of the Epidemiology of Complicated Urinary Tract Infection
Urinary tract infections (UTIs) are common bacterial infections and present with heterogeneous clinical phenotypes. Wherea...
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