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From Clinical Trials to Real-World Experiences: Evidence About Cefiderocol Use and Potential Role in Empirical Therapy
From Clinical Trials to Real-World Experiences: Evidence About Cefiderocol Use and Potential Role in Empirical Therapy
Cefiderocol is a novel siderophore cephalosporin that has gained attention for its potent activity against multidrug-resis...
Characteristics and Outcomes of Patients Treated with Carbapenem Versus Non-carbapenem Therapy for AmpC-Producing Enterobacterales Bacteremia: A Retrospective Study
Characteristics and Outcomes of Patients Treated with Carbapenem Versus Non-carbapenem Therapy for AmpC-Producing Enterobacterales Bacteremia: A Retrospective Study
Inducible AmpC β-lactamases in Gram-negative Enterobacterales pose therapeutic challenges. Although carbapenems are t...
Burden and Outcomes of Severe Lower Respiratory Tract Infections with Unknown Etiology: A Retrospective Observational Study on Epidemiological Trends Over an 8-Year Period (2016–2024)
Burden and Outcomes of Severe Lower Respiratory Tract Infections with Unknown Etiology: A Retrospective Observational Study on Epidemiological Trends Over an 8-Year Period (2016–2024)
Severe lower respiratory tract infections often require hospitalization, but a significant proportion lack microbiological...
Long-Term Hepatic and Extrahepatic Outcomes of Chronic Hepatitis C Patients After Sofosbuvir-Based Treatment (LONGHEAD Study)
Long-Term Hepatic and Extrahepatic Outcomes of Chronic Hepatitis C Patients After Sofosbuvir-Based Treatment (LONGHEAD Study)
Direct-acting antivirals (DAAs) are highly effective in treating hepatitis C virus (HCV) infection. The long-term hepatic ...
Healthcare-Associated Infections: The Role of Microbial and Environmental Factors in Infection Control—A Narrative Review
Healthcare-Associated Infections: The Role of Microbial and Environmental Factors in Infection Control—A Narrative Review
Healthcare-associated infections (HAIs), previously known as nosocomial infections, represent a significant threat to heal...
Indirect Comparison of PCV20 Immunogenicity with PCV10 in Pediatric 3 + 1 and 2 + 1 Schedules
Indirect Comparison of PCV20 Immunogenicity with PCV10 in Pediatric 3 + 1 and 2 + 1 Schedules
The 20-valent pneumococcal conjugate vaccine (PCV20) was licensed for prevention of pneumococcal disease in infants and ch...
Clinical Impact and Cost-Effectiveness of Updated 2023/24 COVID-19 mRNA Vaccination in High-Risk Populations in the United States
Clinical Impact and Cost-Effectiveness of Updated 2023/24 COVID-19 mRNA Vaccination in High-Risk Populations in the United States
In the post-pandemic era, people with underlying medical conditions continue to be at increased risk for severe COVID-19 d...
Efficacy of Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) After A Viremic Event: A Pooled Analysis of Studies in People with HIV
Efficacy of Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) After A Viremic Event: A Pooled Analysis of Studies in People with HIV
Transient viremia can occur in people with human immunodeficiency virus (HIV), often referred to as people with HIV (PWH),...
Real-Life Experiences of Herpes Simplex Virus Type 2 Genital Herpes in the United States: A Structured Literature Review and Qualitative Concept Elicitation Study
Real-Life Experiences of Herpes Simplex Virus Type 2 Genital Herpes in the United States: A Structured Literature Review and Qualitative Concept Elicitation Study
Research on real-life experiences of herpes simplex virus type 2 (HSV-2) genital herpes (GH) is scarce. This study primari...
Ensitrelvir in Hospitalized Patients with SARS-CoV-2 During the Omicron Epidemic: A Single-Center Observational Study
Ensitrelvir in Hospitalized Patients with SARS-CoV-2 During the Omicron Epidemic: A Single-Center Observational Study
Ensitrelvir, a novel oral 3C-like protease inhibitor targeting severe acute respiratory syndrome coronavirus 2, has been a...
Predicting ICU Admission Risk in Children with Respiratory Syncytial Virus
Predicting ICU Admission Risk in Children with Respiratory Syncytial Virus
Respiratory syncytial virus (RSV) is a common infection in young children and a frequent cause of hospitalization. In some...
An Economic Model to Assess the Cost Impact of Using Xpert Carba-R to Screen Carbapenemase-Producing Enterobacterales in Comparison with Standard of Care, in a National Health Service Setting
An Economic Model to Assess the Cost Impact of Using Xpert Carba-R to Screen Carbapenemase-Producing Enterobacterales in Comparison with Standard of Care, in a National Health Service Setting
Carbapenemase-producing Enterobacterales (CPE) are bacteria that produce carbapenemases, enzymes that destroy carbapenem a...
A Systematic Literature Review of the Epidemiology of Complicated Urinary Tract Infection
A Systematic Literature Review of the Epidemiology of Complicated Urinary Tract Infection
Urinary tract infections (UTIs) are common bacterial infections and present with heterogeneous clinical phenotypes. Wherea...
Respiratory Syncytial Virus (RSV) as a Secondary Diagnosis among Hospitalized Patients in Germany: Outcomes and Economic Burden
Respiratory Syncytial Virus (RSV) as a Secondary Diagnosis among Hospitalized Patients in Germany: Outcomes and Economic Burden
Respiratory syncytial virus (RSV) is a pathogen that may cause severe respiratory infections. Recent research indicates th...
Clinical Pharmacokinetics and Safety of a New HIV-1 Capsid Inhibitor, VH4004280, After Oral Administration in Adults Without HIV
Clinical Pharmacokinetics and Safety of a New HIV-1 Capsid Inhibitor, VH4004280, After Oral Administration in Adults Without HIV
The pharmacokinetics, drug–drug interaction potential, and safety of a new HIV-1 capsid inhibitor, VH4004280 (VH-280...
Tackling CMV in Transplant Recipients: Past, Present, and Future
Tackling CMV in Transplant Recipients: Past, Present, and Future
Cytomegalovirus (CMV), a beta-herpesvirus capable of maintaining lifelong latency, presents a substantial risk to transpla...
Correction: Epidemiological Changes and Improvement in Outcomes of Infective Endocarditis in Europe in the Twenty-First Century: An International Collaboration on Endocarditis (ICE) Prospective Cohort Study (2000–2012)
Correction: Epidemiological Changes and Improvement in Outcomes of Infective Endocarditis in Europe in the Twenty-First Century: An International Collaboration on Endocarditis (ICE) Prospective Cohort Study (2000–2012)
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 Internationa...
Assessing the Underestimation of Adult Pertussis Disease in Five Latin American Countries
Assessing the Underestimation of Adult Pertussis Disease in Five Latin American Countries
Pertussis, a contagious respiratory disease, is underreported in adults. The study objective was to quantify underestimati...
Burden of Herpes Zoster in Individuals with Immunocompromised Conditions and Autoimmune Diseases in the Republic of Korea: A Nationwide Population-Based Database Study
Burden of Herpes Zoster in Individuals with Immunocompromised Conditions and Autoimmune Diseases in the Republic of Korea: A Nationwide Population-Based Database Study
To estimate herpes zoster (HZ) incidence rate (IR) and economic burden in individuals with immunocompromised conditions an...
Safety and Immunogenicity of a Recombinant Two-Component SARS-CoV-2 Protein Vaccine: Randomized, Double-Blind, Placebo-Controlled Phase I and Phase II Studies
Safety and Immunogenicity of a Recombinant Two-Component SARS-CoV-2 Protein Vaccine: Randomized, Double-Blind, Placebo-Controlled Phase I and Phase II Studies
ReCOV is a recombinant protein vaccine that aims to induce cross-neutralization against SARS-CoV-2 variants. The phase&...
A Randomized, Open-Label, Non-inferiority Clinical Trial Assessing 7 Versus 14 Days of Antimicrobial Therapy for Severe Multidrug-Resistant Gram-Negative Bacterial Infections: The OPTIMISE Trial Protocol
A Randomized, Open-Label, Non-inferiority Clinical Trial Assessing 7 Versus 14 Days of Antimicrobial Therapy for Severe Multidrug-Resistant Gram-Negative Bacterial Infections: The OPTIMISE Trial Protocol
Shorter courses of antimicrobials have been shown to be non-inferior to longer, “traditional” duration of ther...
Developing a Tool for Differentiation Between Bacterial and Viral Respiratory Infections Using Myxovirus Resistance Protein A and C-Reactive Protein
Developing a Tool for Differentiation Between Bacterial and Viral Respiratory Infections Using Myxovirus Resistance Protein A and C-Reactive Protein
The aim was to assess the performance of a blood assay combining measurements of MxA (myxovirus resistance protein A) and ...
Global Prevalence of Varicella-Associated Complications: A Systematic Review and Meta-Analysis
Global Prevalence of Varicella-Associated Complications: A Systematic Review and Meta-Analysis
Varicella (chickenpox) is an infectious disease caused by the varicella zoster virus affecting children, adolescents, and ...
Meningococcal Disease in the Post–COVID-19 Era: A Time to Prepare
Meningococcal Disease in the Post–COVID-19 Era: A Time to Prepare
The global invasive meningococcal disease (IMD) landscape changed considerably during the COVID-19 pandemic, as evidenced ...
Factors Associated with Geographical Variability of Antimicrobial Use in Japan
Factors Associated with Geographical Variability of Antimicrobial Use in Japan
Evidence regarding the factors affecting the geographical variation of antimicrobial use (AMU) is relatively scarce. This ...
Safety and Immunogenicity of Homologous Recombinant Adenovirus Type 5-Vectored COVID-19 Vaccine Booster Dose in Healthy Adults Aged 18–60 Years: a Single-Center, Open-Label Trial
Safety and Immunogenicity of Homologous Recombinant Adenovirus Type 5-Vectored COVID-19 Vaccine Booster Dose in Healthy Adults Aged 18–60 Years: a Single-Center, Open-Label Trial
The waning antibody levels several months after prime vaccination and the persistent epidemics of severe acute respiratory...
Podcast: Influenza-Associated Complications and the Impact of Vaccination on Public Health
Podcast: Influenza-Associated Complications and the Impact of Vaccination on Public Health
Influenza is primarily considered an acute respiratory infection but can lead to a myriad of medium and long-term sequelae...
Virologic Outcomes with Molnupiravir in Non-hospitalized Adult Patients with COVID-19 from the Randomized, Placebo-Controlled MOVe-OUT Trial
Virologic Outcomes with Molnupiravir in Non-hospitalized Adult Patients with COVID-19 from the Randomized, Placebo-Controlled MOVe-OUT Trial
The randomized, placebo-controlled, double-blind MOVe-OUT trial demonstrated molnupiravir (800 mg every 12&nb...
New Insights into Biomarkers for Evaluating Therapy Efficacy in Pulmonary Tuberculosis: A Narrative Review
New Insights into Biomarkers for Evaluating Therapy Efficacy in Pulmonary Tuberculosis: A Narrative Review
Evaluating therapy efficacy is crucial for patients with tuberculosis (TB), especially those with drug-resistant tuberculo...
Cabotegravir + Rilpivirine Long-Acting Injections for HIV Treatment in the US: Real World Data from the OPERA Cohort
Cabotegravir + Rilpivirine Long-Acting Injections for HIV Treatment in the US: Real World Data from the OPERA Cohort
The first complete long-acting antiretroviral therapy (ART) regimen, cabotegravir + rilpivirine long-act...
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