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Identifying patients at high risk for antibiotic treatment following hospital admission: a predictive score to improve antimicrobial stewardship measures
Identifying patients at high risk for antibiotic treatment following hospital admission: a predictive score to improve antimicrobial stewardship measures
Identifying patients for clinical studies evaluating strategies to reduce unnecessary antibiotic usage in hospitals is cha...
Efficacy of tocilizumab for hospitalized patients with COVID-19 pneumonia and high IL-6 levels: A randomized controlled trial
Efficacy of tocilizumab for hospitalized patients with COVID-19 pneumonia and high IL-6 levels: A randomized controlled trial
The objective of this clinical trial is to evaluate the efficacy and safety of IL-6 driven personalized treatment strategy...
Piperacillin/tazobactam versus carbapenems for 30-day mortality in patients with ESBL-producing Enterobacterales bloodstream infections: a retrospective, multicenter, non-inferiority, cohort study
Piperacillin/tazobactam versus carbapenems for 30-day mortality in patients with ESBL-producing Enterobacterales bloodstream infections: a retrospective, multicenter, non-inferiority, cohort study
Antimicrobial resistance increases with the use of broad-spectrum antibiotics. Studies evaluating antibiotic stewardship a...
Towards shortening the duration of antibiotic therapy for Lyme borreliosis: a systematic review and meta-analysis
Towards shortening the duration of antibiotic therapy for Lyme borreliosis: a systematic review and meta-analysis
Systematic review and meta-analysis on shortening antibiotic therapy for Lyme borreliosis (LB) patients. Data sources: Med...
Molecular and ecological determinants of mammalian adaptability in avian influenza virus
Molecular and ecological determinants of mammalian adaptability in avian influenza virus
The avian influenza virus (AIV) primarily affects birds and poses an increasing concern due to its growing adaptability to...
When oral health affects overall health: biofilms, dental infections, and emerging antimicrobial strategies
When oral health affects overall health: biofilms, dental infections, and emerging antimicrobial strategies
Dental health is a crucial component of overall health, yet it is frequently overlooked in discussions about well-being. T...
A simple clinical tool for effective screening of haemophagocytic lymphohistiocytosis in dengue
A simple clinical tool for effective screening of haemophagocytic lymphohistiocytosis in dengue
Haemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disorder. Dengue fever is a common trigger for HLH i...
Clinical impact of bronchoalveolar lavage fluid metagenomic next-generation sequencing in immunocompromised patients with severe community-acquired pneumonia in ICU: a multicenter retrospective study
Clinical impact of bronchoalveolar lavage fluid metagenomic next-generation sequencing in immunocompromised patients with severe community-acquired pneumonia in ICU: a multicenter retrospective study
An increasing number of critically ill patients are immunocompromised. These patients are at high risk of intensive care u...
Healthcare professionals challenged by 14 distinct carbapenemase-producing micro-organisms in a war-injured Ukrainian patient
Healthcare professionals challenged by 14 distinct carbapenemase-producing micro-organisms in a war-injured Ukrainian patient
The Russia-Ukraine war lead to evacuation of patients across Europe. We present an unprecedented case of a severely injure...
Acral necrosis in a 62-year-old female after travelling to Equatorial Guinea
Acral necrosis in a 62-year-old female after travelling to Equatorial Guinea
A previously healthy 62-year-old woman presented to our clinic after a two-day stay in Equatorial Guinea. Her symptoms inc...
Model-informed identification of optimised dosing strategies for meropenem in critically ill patients receiving SLEDD: an observational study
Model-informed identification of optimised dosing strategies for meropenem in critically ill patients receiving SLEDD: an observational study
An increasing number of critically ill patients receive slow extended daily dialysis (SLEDD) due to their pathophysiology ...
Raising awareness of : a neglected cause of skin disease
Raising awareness of : a neglected cause of skin disease
Demodex mites are among the most prevalent human parasites. While commonly found on healthy individuals, an overpopulation...
Delayed but successful development of immune memory against SARS-COV-2 after B cell-depleting monotherapy
Delayed but successful development of immune memory against SARS-COV-2 after B cell-depleting monotherapy
Patients receiving CD20-directed therapies are known to insufficiently develop neutralizing antibody titers against SARS-C...
Early and late mortality in vertebral osteomyelitis: who dies within the first year after diagnosis
Early and late mortality in vertebral osteomyelitis: who dies within the first year after diagnosis
Vertebral osteomyelitis (VO) is a severe clinical entity associated with high mortality rates, especially within the first...
Prevalence and outcomes of Urinary tract infections caused by Enterobacterales resistant to third-generation cephalosporins in the Emergency Department: results from UTILY cohort, a prospective multicentre study
Prevalence and outcomes of Urinary tract infections caused by Enterobacterales resistant to third-generation cephalosporins in the Emergency Department: results from UTILY cohort, a prospective multicentre study
In accordance with the spread of drug-resistant bacteria worldwide, an increase in the prevalence of Antimicrobial Resista...
Clinical and patient-reported outcomes of self-administered outpatient parenteral antimicrobial treatment (S-OPAT): a scoping review
Clinical and patient-reported outcomes of self-administered outpatient parenteral antimicrobial treatment (S-OPAT): a scoping review
This study aimed to provide a comprehensive overview of the existing literature on Self-administered Outpatient Parenteral...
Effective surveillance of acute COVID-19 using a cost- and labor-efficient approach: a paradigm for the longitudinal monitoring of respiratory infections in larger cohorts
Effective surveillance of acute COVID-19 using a cost- and labor-efficient approach: a paradigm for the longitudinal monitoring of respiratory infections in larger cohorts
To reduce the risk of viral transmission in a large cohort of individuals by longitudinal surveillance of COVID-19. A cost...
Genomic perspectives on NDM Typhi, and a case report from India
Genomic perspectives on NDM Typhi, and a case report from India
Carbapenem resistance in Enterobacterales is a growing public health concern, primarily driven by carbapenemase enzymes su...
Natural course of AIDS following HIV-2 infection
Natural course of AIDS following HIV-2 infection
In a 21-year-old female, AIDS following infection with HIV-2 was diagnosed alongside an HIV-associated high-grade B cell l...
Clinical phenotype and outcome of persistent SARS-CoV-2 replication in immunocompromised hosts: a retrospective observational study in the Omicron era
Clinical phenotype and outcome of persistent SARS-CoV-2 replication in immunocompromised hosts: a retrospective observational study in the Omicron era
This study aims to describe clinical, virological and radiological characteristics as well as treatment strategies and out...
Social and clinical predictors of perianal colonisation by multidrug-resistant bacteria for geriatric patients in the internal medicine service
Social and clinical predictors of perianal colonisation by multidrug-resistant bacteria for geriatric patients in the internal medicine service
Colonisation by multidrug-resistant (MDR) bacteria is a global health issue. The identification of patients with a higher ...
Postpartum cryptococcosis in an HIV-negative patient
Postpartum cryptococcosis in an HIV-negative patient
We present an unusual case of an HIV-negative patient with postpartum pulmonary cryptococcosis and cryptococcemia. The dia...
Is antiviral treatment at the acute phase of COVID-19 effective for decreasing the risk of long-COVID? A systematic review
Is antiviral treatment at the acute phase of COVID-19 effective for decreasing the risk of long-COVID? A systematic review
Preliminary evidence suggests a potential effect of antiviral medication used during the acute COVID-19 phase for preventi...
A variant of KSHV-associated inflammatory cytokine syndrome in elderly men of Mediterranean descent
A variant of KSHV-associated inflammatory cytokine syndrome in elderly men of Mediterranean descent
The spectrum of HHV-8-associated disorders includes Kaposi’s sarcoma, primary effusion lymphoma, multicentric Castle...
Clinical correlates of circulating small dense low-density lipoproteins in acute infective endocarditis
Clinical correlates of circulating small dense low-density lipoproteins in acute infective endocarditis
Infective endocarditis (IE) is a complex thrombo-inflammatory disorder, the pathogenesis of which involves a multifaceted ...
Evaluation and clinical practice of pathogens and antimicrobial resistance genes of BioFire FilmArray Pneumonia panel in lower respiratory tract infections
Evaluation and clinical practice of pathogens and antimicrobial resistance genes of BioFire FilmArray Pneumonia panel in lower respiratory tract infections
Existing panels for lower respiratory tract infections (LRTIs) are slow and lack quantification of important pathogens and...
Clinical evaluation of a multiplex droplet digital PCR for pathogen detection in critically ill COVID-19 patients with bloodstream infections
Clinical evaluation of a multiplex droplet digital PCR for pathogen detection in critically ill COVID-19 patients with bloodstream infections
Nosocomial bloodstream infections (nBSI) have emerged as a clinical concern for physicians treating COVID-19 patients. In ...
Fatal pulmonary hemorrhage, pneumothorax and skin necrosis caused by IRIS to an Aspergillus flavus infection in a young patient with metamizole associated agranulocytosis
Fatal pulmonary hemorrhage, pneumothorax and skin necrosis caused by IRIS to an Aspergillus flavus infection in a young patient with metamizole associated agranulocytosis
We report the case of a young female with steroid-dependent ulcerative colitis (UC) who developed a complex systemic infec...
SARS-CoV-2 nucleocapsid protein, rather than spike protein, triggers a cytokine storm originating from lung epithelial cells in patients with COVID-19
SARS-CoV-2 nucleocapsid protein, rather than spike protein, triggers a cytokine storm originating from lung epithelial cells in patients with COVID-19
The aim of this study was to elucidate the factors associated with severe acute respiratory syndrome coronavirus 2 (SARS-C...
High prevalence of pneumocystis pneumonia in interstitial lung disease: a retrospective study
High prevalence of pneumocystis pneumonia in interstitial lung disease: a retrospective study
Interstitial lung disease (ILD) is a new risk category for pneumocystis pneumonia (PCP) with a high mortality rate. The de...
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