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Are Health Gains to Children and Adolescents More Important Than Health Gains to Adults? A Person Trade-Off Study
Are Health Gains to Children and Adolescents More Important Than Health Gains to Adults? A Person Trade-Off Study
Healthcare decision-making often assumes equal value for quality-adjusted life years (QALYs) across patient groups, yet so...
Development of a Patient-Level Multi-objective Optimisation Model for Screening Strategies for Childhood Type 1 Diabetes
Development of a Patient-Level Multi-objective Optimisation Model for Screening Strategies for Childhood Type 1 Diabetes
To develop a patient-level simulation model of type 1 diabetes (T1D) covering both childhood and adulthood. The goal is to...
From Paper to Platform: Updating the Dutch Costing Manual and Launching a Web Application
From Paper to Platform: Updating the Dutch Costing Manual and Launching a Web Application
The Dutch costing manual, part of the national guideline for economic evaluations, provides reference prices and standardi...
The Cost Effectiveness of Upgrading Cochlear Implant Sound Processors in Australia: A Novel Application of Individual-Level Microsimulation Models
The Cost Effectiveness of Upgrading Cochlear Implant Sound Processors in Australia: A Novel Application of Individual-Level Microsimulation Models
Cochlear implants (CIs) can be used to address severe to profound sensorineural hearing loss, which is more prevalent in o...
Schrodinger’s Pricing: Conceptual and Practical Challenges of Conditional PAS in the NICE Technology Appraisal of Lorlatinib for Untreated ALK-Positive Advanced Non-small-cell Lung Cancer (Review of TA1103): An External Assessment Group Perspective
Schrodinger’s Pricing: Conceptual and Practical Challenges of Conditional PAS in the NICE Technology Appraisal of Lorlatinib for Untreated ALK-Positive Advanced Non-small-cell Lung Cancer (Review of TA1103): An External Assessment Group Perspective
NICE invited Pfizer to submit evidence on the clinical and cost effectiveness of lorlatinib for previously untreated ALK-p...
Ten Recommendations for Modelling Cost Effectiveness of Screening: Perspectives of an International Stakeholder Group
Ten Recommendations for Modelling Cost Effectiveness of Screening: Perspectives of an International Stakeholder Group
Modelling the cost effectiveness of screening interventions presents unique challenges. These relate to a lack of knowledg...
Economic Burden of Idiopathic Pulmonary Fibrosis: Updated Evidence on Costs and Resource Use
Economic Burden of Idiopathic Pulmonary Fibrosis: Updated Evidence on Costs and Resource Use
Idiopathic pulmonary fibrosis is a rare progressive respiratory disease associated with high morbidity, poor survival and ...
Public Health Impact and Cost-Effectiveness of Revising the Adolescent Meningococcal Vaccine Schedule in the United States
Public Health Impact and Cost-Effectiveness of Revising the Adolescent Meningococcal Vaccine Schedule in the United States
In 2025, invasive meningococcal disease (IMD) vaccination in United States (US) adolescents consisted of two standard of c...
Component Clinical and Cost Outcomes Complementing Value of Information: Case Study of a Tuberculosis Diagnostics Clinical Trial
Component Clinical and Cost Outcomes Complementing Value of Information: Case Study of a Tuberculosis Diagnostics Clinical Trial
Conventional value-of-information (VOI) analysis bases decisions on a composite cost-effectiveness measure that aggregates...
Cost-Effectiveness of Immunising Interventions to Reduce Respiratory Syncytial Virus Disease Burden in Infants in Australia
Cost-Effectiveness of Immunising Interventions to Reduce Respiratory Syncytial Virus Disease Burden in Infants in Australia
Two immunising products are emerging to prevent the burden of respiratory syncytial virus (RSV) in infants: long-lasting m...
Evaluating the Cost Effectiveness of Rapid Diagnostic Testing for the Identification of Pathogens and Resistance Genes in Bloodstream Infections
Evaluating the Cost Effectiveness of Rapid Diagnostic Testing for the Identification of Pathogens and Resistance Genes in Bloodstream Infections
Bloodstream infections (BSI) are a leading cause of mortality worldwide. Rapid detection of the causative pathogen can hel...
Economic Evaluation of the Addition of Vancomycin to Cefazolin Prophylaxis in Patients Undergoing Arthroplasty
Economic Evaluation of the Addition of Vancomycin to Cefazolin Prophylaxis in Patients Undergoing Arthroplasty
The addition of a glycopeptide antimicrobial to cephalosporin therapy has been reportedly adopted in practice to prevent s...
Are Economic Evaluations of Task Shifting Too Narrow in Focus? A Rapid Review
Are Economic Evaluations of Task Shifting Too Narrow in Focus? A Rapid Review
Task shifting between different cadres of health worker has been proposed as an approach to address workforce shortages. W...
Health Care Resource Utilization and Costs Associated with US Medicaid Sobriety Restrictions on Direct-Acting Antivirals for Hepatitis C Virus: A Retrospective Claims Database Analysis
Health Care Resource Utilization and Costs Associated with US Medicaid Sobriety Restrictions on Direct-Acting Antivirals for Hepatitis C Virus: A Retrospective Claims Database Analysis
Many state Medicaid programs implemented sobriety restrictions that delay timely initiation of direct-acting antivirals (D...
An Updated Systematic Literature Review of the Economic Costs of Loneliness and Social Isolation and the Cost Effectiveness of Interventions
An Updated Systematic Literature Review of the Economic Costs of Loneliness and Social Isolation and the Cost Effectiveness of Interventions
There has been growing interest in understanding the economic impacts of loneliness and social isolation. This study updat...
Inequalities in Quality-Adjusted Life Expectancy in Australia by Educational Attainment
Inequalities in Quality-Adjusted Life Expectancy in Australia by Educational Attainment
Summary measures such as quality-adjusted life expectancy (QALE) are increasingly used to monitor health inequalities. Soc...
Key Considerations for Assessing Real-World Comparative Effectiveness in the Context of the Drug Price Negotiation Program: A Case Study of Pembrolizumab
Key Considerations for Assessing Real-World Comparative Effectiveness in the Context of the Drug Price Negotiation Program: A Case Study of Pembrolizumab
The Centers for Medicare and Medicaid Services increasingly rely on real-world evidence to inform drug price negotiations ...
The Psychometric Performance of Generic Preference-Based Measures in Informal Carers: A Systematic Review of Validation Studies
The Psychometric Performance of Generic Preference-Based Measures in Informal Carers: A Systematic Review of Validation Studies
A growing number of health technology assessment agencies recommend inclusion of informal carer outcomes in health economi...
The Burden of Informal Caregiving for Adults with Musculoskeletal Conditions: A Systematic Review
The Burden of Informal Caregiving for Adults with Musculoskeletal Conditions: A Systematic Review
Informal caregivers play a critical role in supporting individuals with musculoskeletal conditions. This systematic review...
Integrating Environmental Impact in Health Technology Assessment: An Exploratory Study
Integrating Environmental Impact in Health Technology Assessment: An Exploratory Study
To what extent a care pathway, due to its associated pollution, may be more detrimental to future health than beneficial t...
Microsimulation Modeling for Health Decision Sciences Using C++: A Tutorial
Microsimulation Modeling for Health Decision Sciences Using C++: A Tutorial
Microsimulation models have become increasingly common in the field of decision modeling for health. Because microsimulati...
Challenges and Criteria for Single-Arm Trials Leading to an Added Benefit in German Health Technology Assessments
Challenges and Criteria for Single-Arm Trials Leading to an Added Benefit in German Health Technology Assessments
Randomized controlled trials are the standard for health technology assessment, but when they are infeasible or unethical,...
Can We Make Health Economic Decision Models as Simple as Possible, But Not Simpler? Introducing SMART tool
Can We Make Health Economic Decision Models as Simple as Possible, But Not Simpler? Introducing SMART tool
Developing health economic decision-analytic models requires making modelling choices to simplify reality while addressing...
The Cost-Effective Price of Lecanemab for Patients with Early Alzheimer’s Disease in Sweden
The Cost-Effective Price of Lecanemab for Patients with Early Alzheimer’s Disease in Sweden
We sought to estimate the cost-effective price for lecanemab for treating early Alzheimer’s disease in Sweden from t...
Evaluating the Role and Policy Implications of Using External Evidence in Survival Extrapolations: A Case Study of Axicabtagene Ciloleucel Therapy for Second-Line DLBCL
Evaluating the Role and Policy Implications of Using External Evidence in Survival Extrapolations: A Case Study of Axicabtagene Ciloleucel Therapy for Second-Line DLBCL
Health technology assessment (HTA) of haemato-oncology therapies typically requires extrapolation of long-term survival be...
Cost Effectiveness of Tremelimumab Plus Durvalumab for Unresectable Hepatocellular Carcinoma in the USA
Cost Effectiveness of Tremelimumab Plus Durvalumab for Unresectable Hepatocellular Carcinoma in the USA
Treating unresectable hepatocellular carcinoma (uHCC) is challenging. Clinical trials have shown that Single Tremelimumab ...
Unravelling the Association Between Uncertainties in Model-based Economic Analysis and Funding Recommendations of Medicines in Australia
Unravelling the Association Between Uncertainties in Model-based Economic Analysis and Funding Recommendations of Medicines in Australia
Health technology assessment is used extensively by the Pharmaceutical Benefits Advisory Committee (PBAC) to inform medici...
Economic Evaluations of Non-Pharmacological Interventions for Treating Disorders of Gut-Brain Interaction: A Scoping Review
Economic Evaluations of Non-Pharmacological Interventions for Treating Disorders of Gut-Brain Interaction: A Scoping Review
Disorders of gut-brain interaction are highly prevalent and burdensome conditions for both patients and healthcare systems...
A Multistate Model Incorporating Relative Survival Extrapolation and Mixed Time Scales for Health Technology Assessment
A Multistate Model Incorporating Relative Survival Extrapolation and Mixed Time Scales for Health Technology Assessment
Multistate models have been widely applied in health technology assessment. However, extrapolating survival in a multistat...
Public Health Impact of Introducing a Pentavalent Vaccine Against Invasive Meningococcal Disease in the United States
Public Health Impact of Introducing a Pentavalent Vaccine Against Invasive Meningococcal Disease in the United States
Invasive meningococcal disease (IMD) is primarily associated with five Neisseria meningitidis serogroups: A, B, C, W, or Y...
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