SCI Abstract

search
+
Vitamin D receptor suppresses pulmonary fibroblast activation by downregulating the TGF-β1/Smad signaling pathway
Vitamin D receptor suppresses pulmonary fibroblast activation by downregulating the TGF-β1/Smad signaling pathway
The vitamin D receptor (VDR) has been implicated in anti-inflammatory and antifibrotic effects, but its role in r...
Relationships between clusters of interchromatin granules and chromatin fibers
Relationships between clusters of interchromatin granules and chromatin fibers
Among nuclear compartments, interchromatin granule clusters (IGCs) are widely regarded as biomolecular condensates implica...
Follicle-dependent differential localization of adipokines in the letrozole-induced hyperandrogenized mouse ovary
Follicle-dependent differential localization of adipokines in the letrozole-induced hyperandrogenized mouse ovary
This study investigated whether ovarian adipokines exhibit uniform or stage-specific expression patterns across different ...
Electric field–induced inflammatory and angiogenic responses in rat female reproductive tissues: evidence for early extracellular matrix remodeling
Electric field–induced inflammatory and angiogenic responses in rat female reproductive tissues: evidence for early extracellular matrix remodeling
High-intensity electric fields (EFs) are increasingly encountered in occupational and environmental settings, raising conc...
February in focus in HCB: spatial transcriptomics
February in focus in HCB: spatial transcriptomics
Welcome to the February 2026 In focus in HCB editorial. In this editorial we will highlight one recent manuscript utilizin...
Time-dependent integrated tissue and circulating biomarker dynamics of spexin and progranulin in an experimental myocardial infarction model
Time-dependent integrated tissue and circulating biomarker dynamics of spexin and progranulin in an experimental myocardial infarction model
Inflammation, oxidative stress and apoptosis, in particular, play critical roles in the pathophysiology of myocardial infa...
Histochemical characterization of muscularis macrophage loss and disruption of a miR-93-5p–AHNAK neuro-immune axis in Hirschsprung’s disease
Histochemical characterization of muscularis macrophage loss and disruption of a miR-93-5p–AHNAK neuro-immune axis in Hirschsprung’s disease
Hirschsprung’s disease (HSCR) is a congenital disorder of the distal intestine characterized by aganglionosis of the...
Targeting SAT1 alleviates high glucose-induced tubular ferroptosis and fibrosis: implications for diabetic kidney disease
Targeting SAT1 alleviates high glucose-induced tubular ferroptosis and fibrosis: implications for diabetic kidney disease
Renal tubular damage and interstitial fibrosis are highly linked to diabetic kidney disease (DKD) progression. Ferroptosis...
Fibre morphology, intramyocellular lipid content and 3D capillary architecture in human postural, respiratory and locomotor muscles in type 2 diabetes mellitus
Fibre morphology, intramyocellular lipid content and 3D capillary architecture in human postural, respiratory and locomotor muscles in type 2 diabetes mellitus
In type 2 diabetes mellitus (T2DM), skeletal muscle is a major site of metabolic and microvascular dysfunction, yet most h...
Periostin in joint physiology and pathology: multiple roles from mechanisms to clinical perspectives
Periostin in joint physiology and pathology: multiple roles from mechanisms to clinical perspectives
Joint-related diseases, including osteoarthritis (OA), rheumatoid arthritis (RA), intervertebral disc degeneration (IDD), ...
ER stress affects proliferation and induces polyploidization of cultured human HaCaT and A431 cells
ER stress affects proliferation and induces polyploidization of cultured human HaCaT and A431 cells
Endoplasmic reticulum (ER) stress is the accumulation of misfolded or defective proteins in the ER. ER stress is capable o...
Fiber type-specific expression of LACTB leverages a function in oxidative metabolism
Fiber type-specific expression of LACTB leverages a function in oxidative metabolism
Skeletal muscle is composed of type I and type II fibers, each characterized by specific metabolic machinery. LACTB is a c...
Functional suppression accompanies internal mitochondrial reorganization during cellular reprogramming
Functional suppression accompanies internal mitochondrial reorganization during cellular reprogramming
During the conversion of fibroblasts into induced pluripotent stem cells (iPSCs), cellular metabolism shifts from oxidativ...
Oncogenic overexpression of kallikrein-related peptidase 7 is associated with the progression of thyroid cancer
Oncogenic overexpression of kallikrein-related peptidase 7 is associated with the progression of thyroid cancer
Mounting evidence suggests that the kallikrein-related peptidase family is dysregulated in thyroid cancer. However, previo...
Localization of dendritic cells and T cells within the tumor microenvironment in different types of skin cancer
Localization of dendritic cells and T cells within the tumor microenvironment in different types of skin cancer
Immunophenotyping of tumor-infiltrating immune cells is increasingly important for understanding the tumor microenvironmen...
SASP-driven vascular aging: unraveling the transcriptional nexus in endothelial senescence and cardiovascular disease
SASP-driven vascular aging: unraveling the transcriptional nexus in endothelial senescence and cardiovascular disease
Endothelial cell senescence represents a critical mechanistic driver in the initiation and progression of cardiovascular d...
Effects of obesity on DNA methylation and DNA methyltransferases in the reproductive system
Effects of obesity on DNA methylation and DNA methyltransferases in the reproductive system
Obesity is increasingly recognized as a condition with profound systemic and epigenetic consequences. However, the molecul...
Approaches to visualize, quantify, and manipulate phosphoinositides in cells
Approaches to visualize, quantify, and manipulate phosphoinositides in cells
Phosphoinositides are low-abundance regulatory lipids that control a broad range of cellular processes, from membrane traf...
Methodological framework for chromogenic mRNA detection using in situ hybridization chain reaction
Methodological framework for chromogenic mRNA detection using in situ hybridization chain reaction
In situ hybridization chain reaction (HCR) is a highly sensitive method for visualizing single-molecule messenger RNA (mRN...
Differentiation to insulin-positive cells from human amnion epithelial cells using a pancreatic development mimicry protocol
Differentiation to insulin-positive cells from human amnion epithelial cells using a pancreatic development mimicry protocol
Diabetes mellitus (DM) is characterized by the loss or dysfunction pancreatic β-cells. Human amniotic epithelial cell...
Excessive intake of fructose and alcohol aggravates high-fat diet-induced steatohepatitis and changes hepatic iron homeostasis
Excessive intake of fructose and alcohol aggravates high-fat diet-induced steatohepatitis and changes hepatic iron homeostasis
Hepatocytes play a vital role in maintaining iron homeostasis, which can be compromised by poor diet and lifestyle. This s...
The ILK–PINCH–parvin complex: a conserved primary adhesome regulating biological processes
The ILK–PINCH–parvin complex: a conserved primary adhesome regulating biological processes
Intracellularly expressed integrin associated proteins (IAPs) play pivotal role in facilitating cellular adhesion and surv...
Exploring the expression of MMP-2, MT1-MMP, and MMP-9 in the pectoral muscle of Ross chickens during E11, E15, and E19 of fetal development
Exploring the expression of MMP-2, MT1-MMP, and MMP-9 in the pectoral muscle of Ross chickens during E11, E15, and E19 of fetal development
There are pertinent studies on the relationship between matrix metalloproteinases (MMPs) and muscle cell differentiation i...
Secreted Frizzled-related proteins in animal development
Secreted Frizzled-related proteins in animal development
Secreted Frizzled-related proteins (SFRPs) are a small, ancient family of extracellular signaling pathway agonists and ant...
Development of optimized differentiation media for murine bone marrow multipotent mesenchymal stromal cells
Development of optimized differentiation media for murine bone marrow multipotent mesenchymal stromal cells
Here, we aimed to define adipogenic, osteogenic, and chondrogenic media for the differentiation of murine mesenchymal stro...
Comparative assessment of human chondroprogenitor viability and molecular phenotype in various parenteral transport media
Comparative assessment of human chondroprogenitor viability and molecular phenotype in various parenteral transport media
Chondroprogenitors derived from articular cartilage offer a promising approach for treating cartilage pathologies owing to...
Proneural gene Mash1 (Ascl1) is expressed in multiple lineages and regulates their differentiation and specification
Proneural gene Mash1 (Ascl1) is expressed in multiple lineages and regulates their differentiation and specification
Ascl1 (Mash1), a bHLH transcription factor, is widely expressed by neuronal progenitors. The gene plays a key role in the ...
The first link between ADAMTS-13 and apoptosis in type 1 diabetic liver injury
The first link between ADAMTS-13 and apoptosis in type 1 diabetic liver injury
Type 1 diabetes mellitus (T1DM) is associated with oxidative stress and inflammation in the liver, which contribute to hep...
Telocytes: history, origin, identification, structure, distribution, and functions
Telocytes: history, origin, identification, structure, distribution, and functions
Telocytes are specialized interstitial cells characterized by their unique structure, which features a relatively small ce...
Combined treatment of melatonin and alpha-lipoic acid facilitates wound healing in rat palate: A macroscopic, histological, and immunohistochemical study
Combined treatment of melatonin and alpha-lipoic acid facilitates wound healing in rat palate: A macroscopic, histological, and immunohistochemical study
Oxidative stress is known to have a detrimental effect on wound healing following oral mucosal injuries. Exogenous antioxi...
Load More
format_indent_increase