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Differentiation to insulin-positive cells from human amnion epithelial cells using a pancreatic development mimicry protocol
Differentiation to insulin-positive cells from human amnion epithelial cells using a pancreatic development mimicry protocol
Diabetes mellitus (DM) is characterized by the loss or dysfunction pancreatic β-cells. Human amniotic epithelial cell...
Excessive intake of fructose and alcohol aggravates high-fat diet-induced steatohepatitis and changes hepatic iron homeostasis
Excessive intake of fructose and alcohol aggravates high-fat diet-induced steatohepatitis and changes hepatic iron homeostasis
Hepatocytes play a vital role in maintaining iron homeostasis, which can be compromised by poor diet and lifestyle. This s...
The ILK–PINCH–parvin complex: a conserved primary adhesome regulating biological processes
The ILK–PINCH–parvin complex: a conserved primary adhesome regulating biological processes
Intracellularly expressed integrin associated proteins (IAPs) play pivotal role in facilitating cellular adhesion and surv...
Exploring the expression of MMP-2, MT1-MMP, and MMP-9 in the pectoral muscle of Ross chickens during E11, E15, and E19 of fetal development
Exploring the expression of MMP-2, MT1-MMP, and MMP-9 in the pectoral muscle of Ross chickens during E11, E15, and E19 of fetal development
There are pertinent studies on the relationship between matrix metalloproteinases (MMPs) and muscle cell differentiation i...
Secreted Frizzled-related proteins in animal development
Secreted Frizzled-related proteins in animal development
Secreted Frizzled-related proteins (SFRPs) are a small, ancient family of extracellular signaling pathway agonists and ant...
Development of optimized differentiation media for murine bone marrow multipotent mesenchymal stromal cells
Development of optimized differentiation media for murine bone marrow multipotent mesenchymal stromal cells
Here, we aimed to define adipogenic, osteogenic, and chondrogenic media for the differentiation of murine mesenchymal stro...
Comparative assessment of human chondroprogenitor viability and molecular phenotype in various parenteral transport media
Comparative assessment of human chondroprogenitor viability and molecular phenotype in various parenteral transport media
Chondroprogenitors derived from articular cartilage offer a promising approach for treating cartilage pathologies owing to...
Proneural gene Mash1 (Ascl1) is expressed in multiple lineages and regulates their differentiation and specification
Proneural gene Mash1 (Ascl1) is expressed in multiple lineages and regulates their differentiation and specification
Ascl1 (Mash1), a bHLH transcription factor, is widely expressed by neuronal progenitors. The gene plays a key role in the ...
The first link between ADAMTS-13 and apoptosis in type 1 diabetic liver injury
The first link between ADAMTS-13 and apoptosis in type 1 diabetic liver injury
Type 1 diabetes mellitus (T1DM) is associated with oxidative stress and inflammation in the liver, which contribute to hep...
Telocytes: history, origin, identification, structure, distribution, and functions
Telocytes: history, origin, identification, structure, distribution, and functions
Telocytes are specialized interstitial cells characterized by their unique structure, which features a relatively small ce...
Combined treatment of melatonin and alpha-lipoic acid facilitates wound healing in rat palate: A macroscopic, histological, and immunohistochemical study
Combined treatment of melatonin and alpha-lipoic acid facilitates wound healing in rat palate: A macroscopic, histological, and immunohistochemical study
Oxidative stress is known to have a detrimental effect on wound healing following oral mucosal injuries. Exogenous antioxi...
MyoAnalyst: an ImageJ plugin for accurate and automatic myofiber segmentation and analysis in skeletal muscle cross sections
MyoAnalyst: an ImageJ plugin for accurate and automatic myofiber segmentation and analysis in skeletal muscle cross sections
Quantifying myofiber size is essential for assessing the health and function of skeletal muscle. Although several ImageJ p...
July in focus in HCB
July in focus in HCB
The inhibitor of growth protein family (ING) consists of at least five family members (ING1–5), with a range of proposed a...
Increased Fos immunoreactivity in astrocytes in the raphe pallidus under hypoxia, not hypercapnia
Increased Fos immunoreactivity in astrocytes in the raphe pallidus under hypoxia, not hypercapnia
The raphe pallidus (RPa), a part of the caudal medullary raphe nucleus, has been suggested to participate in respiratory r...
Unveiling the intricacies of exosome biology: from biogenesis to therapeutic applications
Unveiling the intricacies of exosome biology: from biogenesis to therapeutic applications
Exosomes are small membrane-bound nanovesicles that are secreted by cells when multivesicular bodies merge with the plasma...
Gamma smooth muscle actin as a new potential marker of cancer-associated fibroblasts
Gamma smooth muscle actin as a new potential marker of cancer-associated fibroblasts
Cancer-associated fibroblasts (CAFs) represent an important component of the cancer ecosystem, influencing the broad scale...
Co-culture of postnatal mouse spinal cord and skeletal muscle explants as an experimental model of neuromuscular interactions
Co-culture of postnatal mouse spinal cord and skeletal muscle explants as an experimental model of neuromuscular interactions
The intercommunication between nerves and muscles plays an important role in the functioning of our body, and its failure ...
A novel tape-free sample preparation method for human osteochondral cryosections for high throughput hyperspectral imaging
A novel tape-free sample preparation method for human osteochondral cryosections for high throughput hyperspectral imaging
Understanding the osteochondral junction, where non-mineralised cartilage and mineralised bone converge, is crucial for jo...
Effect of middle-age plasma therapy on ileum morphology, immune defense (IgA) and cell proliferation (Ki-67) of female aged rats
Effect of middle-age plasma therapy on ileum morphology, immune defense (IgA) and cell proliferation (Ki-67) of female aged rats
Blood plasma therapy, a new treatment method to eliminate the damage and deterioration caused by aging in many organ syste...
Protective effects of adipose-derived stem cells against testicular injury induced after ischemia–reperfusion by regulating autophagy
Protective effects of adipose-derived stem cells against testicular injury induced after ischemia–reperfusion by regulating autophagy
The damaged organ may experience severe pathological alterations as a result of tissue ischemia–reperfusion (I/R). T...
Ku70 silencing aggravates oxygen–glucose deprivation/reperfusion-induced injury by activation of the p53 apoptotic pathway in rat cortical astrocytes
Ku70 silencing aggravates oxygen–glucose deprivation/reperfusion-induced injury by activation of the p53 apoptotic pathway in rat cortical astrocytes
Oxidative stress-induced DNA damage is an important mechanism that leads to the death of neuronal cells after ischemic str...
Effect of bone marrow niche on hematopoietic stem cells
Effect of bone marrow niche on hematopoietic stem cells
Hematopoietic stem cells (HSCs) reside in a milieu that supports their functions, differentiation, and survival. This nich...
Multimodal tumor suppression by METTL3 gene knockdown in melanoma and colon cancer cells
Multimodal tumor suppression by METTL3 gene knockdown in melanoma and colon cancer cells
METTL3, an m6A methyltransferase, is integral to the regulation of messenger RNA (mRNA) biogenesis, degradation, and trans...
Differential expression of the ubiquitin-editing enzyme A20 in gastric biopsies indicates the severity of disease
Differential expression of the ubiquitin-editing enzyme A20 in gastric biopsies indicates the severity of disease
A20, an ubiquitin-editing enzyme, plays a pivotal role in regulating cell signaling and immune responses. Dysregulated A20...
Differential cell architecture and microenvironmental responses of pretumoral and tumoral cellular models exposed to coverslip-induced hypoxia
Differential cell architecture and microenvironmental responses of pretumoral and tumoral cellular models exposed to coverslip-induced hypoxia
The tumor microenvironment is an altered milieu that imposes multiple selective pressures leading to the survival and diss...
Seventy years of peroxisome research: current advances and future perspectives
Seventy years of peroxisome research: current advances and future perspectives
The 9th Open European Peroxisome Meeting (OEPM) took place in Sant Feliu de Guíxols, Costa Brava, Spain at the Eden Roc Ho...
mTORC1 regulates the proliferation of SOX9+ porcine skin-derived stem cells (pSDSCs) by promoting S6K phosphorylation
mTORC1 regulates the proliferation of SOX9+ porcine skin-derived stem cells (pSDSCs) by promoting S6K phosphorylation
Skin-derived stem cells (SDSCs) are a subtype of adult stem cells (ASCs) that are widely harvested and exempt from ethical...
The dynamic interaction of pediatric ALL cells and MSCs: influencing leukemic cell survival and modulating MSC β-catenin expression
The dynamic interaction of pediatric ALL cells and MSCs: influencing leukemic cell survival and modulating MSC β-catenin expression
Bone marrow mesenchymal stromal cells (BM-MSCs) are integral components of the bone marrow microenvironment, playing a cru...
Differentiation of stem cells into chondrocytes and their potential clinical application in cartilage regeneration
Differentiation of stem cells into chondrocytes and their potential clinical application in cartilage regeneration
Cartilage diseases and injuries are considered difficult to treat owing to the low regenerative capacity of this tissue. U...
Modulation of placental angiogenesis by metformin in a rat model of gestational diabetes
Modulation of placental angiogenesis by metformin in a rat model of gestational diabetes
Gestational diabetes mellitus (GDM) significantly disrupts placental structure and function, leading to complications such...
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