Follicle-dependent differential localization of adipokines in the letrozole-induced hyperandrogenized mouse ovary

Anima B, Gurusubramanian G, Roy VK (2024) Apelin receptor modulation mitigates letrozole-induced polycystic ovarian pathogenesis in mice. Cytokine 179:156639. https://doi.org/10.1016/j.cyto.2024.156639

Article  CAS  PubMed  Google Scholar 

Annie L, Gurusubramanian G, Roy VK (2021) Inhibition of visfatin by FK866 mitigates pathogenesis of cystic ovary in letrozole-induced hyperandrogenised mice. J Life Sci 276:119409. https://doi.org/10.1016/j.lfs.2021.119409

Article  CAS  Google Scholar 

Benrick A, Chanclón B, Micallef P, Wu Y, Hadi L, Shelton JM, Stener-Victorin E, WernstedtAsterholm I (2017) Adiponectin protects against development of metabolic disturbances in a PCOS mouse model. Proc Natl Acad Sci U S A 114(34):E7187–E7196. https://doi.org/10.1073/pnas.1708854114

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bohler H Jr, Mokshagundam S, Winters SJ (2010) Adipose tissue and reproduction in women. Fertil Steril 94(3):795–825. https://doi.org/10.1016/j.fertnstert.2009.03.079

Article  CAS  PubMed  Google Scholar 

Bongrani A, Mellouk N, Rame C, Cornuau M, Guérif F, Froment P, Dupont J (2019) Ovarian expression of adipokines in polycystic ovary syndrome: a role for chemerin, omentin, and apelin in follicular growth arrest and ovulatory dysfunction? Int J Mol Sci 20(15):3778. https://doi.org/10.3390/ijms20153778

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bongrani A, Plotton I, Mellouk N, Ramé C, Guérif F, Froment P, Dupont J (2022) High androgen concentrations in follicular fluid of polycystic ovary syndrome women. Reprod Biol Endocrinol 20(1):88

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen P, Jia R, Liu Y, Cao M, Zhou L, Zhao Z (2022) Progress of adipokines in the female reproductive system: a focus on polycystic ovary syndrome. Front Endocrinol 13:881684

Article  Google Scholar 

Cibas ES (2014) Ovary. In: Cibas ES, Ducatman BS (eds) Cytology: diagnostic principles and clinical correlates. Saunders: Philadelphia; p 453–70

Comim FV, Hardy K, Franks S (2013) Adiponectin and its receptors in the ovary: further evidence for a link between obesity and hyperandrogenism in polycystic ovary syndrome. PLoS ONE 8(11):e80416

Article  PubMed  PubMed Central  Google Scholar 

Du J, Ruan X, Jin F, Li Y, Cheng J, Gu M, Mueck AO (2021) Abnormalities of early folliculogenesis and serum anti-Müllerian hormone in Chinese patients with polycystic ovary syndrome. J Ovarian Res 14(1):36

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dumesic DA, Richards JS (2013) Ontogeny of the ovary in polycystic ovary syndrome. Fertil Steril 100(1):23–38

Article  PubMed  PubMed Central  Google Scholar 

Dupont J, Pollet-Villard X, Reverchon M, Mellouk N, Levy R (2015) Adipokines in human reproduction. Horm Mol Biol Clin Investig 24(1):11–24

Article  CAS  PubMed  Google Scholar 

Dutta A, Gurusubramanian G, Roy VK (2025) Effects of zingerone supplementation on ovarian steroidogenesis and folliculogenesis in mouse. J Nutr Biochem 145:110043. https://doi.org/10.1016/j.jnutbio.2025.110043

Article  CAS  PubMed  Google Scholar 

Dutta A, Anima B, Riba P, Gurusubramanian G, Roy VK (2024) Expression and localization of apelin and apelin receptor protein in the oviduct of letrozole-induced hyperandrogenized mice. Cell Biol. Int. 48(7):1007–1021. https://doi.org/10.1002/cbin.12164

Article  CAS  Google Scholar 

Estienne A, Brossaud A, Reverchon M, Ramé C, Froment P, & Dupont J (2020). Adipokines Expression and Effects in Oocyte Maturation, Fertilization and Early Embryo Development: Lessons from Mammals and Birds.International journal of molecular sciences, 21(10), 3581.https://doi.org/10.3390/ijms21103581

Franks S, Stark J, Hardy K (2008) Follicle dynamics and anovulation in polycystic ovary syndrome. Hum Reprod Update 14(4):367–378

Article  CAS  PubMed  Google Scholar 

Goumenou AG, Matalliotakis IM, Koumantakis GE, Panidis DK (2003) The role of leptin in fertility. Eur J Obstet Gynecol Reprod Biol 106(2):118–124

Article  CAS  PubMed  Google Scholar 

Gregoraszczuk EL, Rak-Mardyła A (2013) Supra physiological leptin levels shift the profile of steroidogenesis in porcine ovarian follicles toward progesterone and testosterone secretion through increased expressions of CYP11A1 and 17b-HSD: A tissue culture approach. Reproduction 145:311–317. https://doi.org/10.1530/rep-12-0269

Article  CAS  PubMed  Google Scholar 

Jerang M, Gurusubramanian G, Singh VP, Roy VK (2025) Zingerone modulates the circulating steroid hormone levels and testicular steroidogenic markers expression in mice: an in vivo and in silico study. J Steroid Biochem Mol Biol 251:106748

Article  CAS  PubMed  Google Scholar 

Kim JY, Xue K, Cao M, Wang Q, Liu JY, Leader A, Tsang BK (2013) Chemerin suppresses ovarian follicular development and its potential involvement in follicular arrest in rats treated chronically with dihydrotestosterone. Endocrinology 154(8):2912–2923

Article  CAS  PubMed  Google Scholar 

Liao B, Qi X, Yun C, Qiao J, Pang Y (2022) Effects of androgen excess-related metabolic disturbances on granulosa cell function and follicular development. Front Endocrinol 13:815968

Article  Google Scholar 

Löffler S, Aust G, Köhler U, Spanel-Borowski K (2001) Evidence of leptin expression in normal and polycystic human ovaries. Mol Hum Reprod 7(12):1143–1149

Article  PubMed  Google Scholar 

Luo X, Gong Y, Cai L, Zhang L, Dong X (2021) Chemerin regulates autophagy to participate in polycystic ovary syndrome. J Int Med Res 49(11):3000605211058376. https://doi.org/10.1177/03000605211058376

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luo M, Yang X, Zhou M, Zhang J, Yu B, Lian H, Ye J (2024) Integrated single-cell and spatial transcriptomics reveal microenvironment disruptions by androgen in mouse ovary. iScience 27(10):111028

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maciel GA, Baracat EC, Benda JA, Markham SM, Hensinger K, Chang RJ, Erickson GF (2004) Stockpiling of transitional and classic primary follicles in ovaries of women with polycystic ovary syndrome. J Clin Endocrinol Metab 89(11):5321–5327

Article  CAS  PubMed  Google Scholar 

Mantzoros CS, Dunaif A, Flier JS (1997) Leptin concentrations in the polycystic ovary syndrome. J Clin Endocrinol Metab 82(6):1687–1691

CAS  PubMed  Google Scholar 

Merza WM, Yaseen AK, Mahmood MA (2025) FSH, LH, lipid and adipokines in polycystic ovary syndrome: clinical biochemistry insights for diagnosis and management. J Steroid Biochem Mol Biol 251:106773

Article  CAS  PubMed  Google Scholar 

Mlyczyńska E, Kieżun M, Kurowska P, Dawid M, Pich K, Respekta N, Rak A (2022) New aspects of corpus luteum regulation in physiological and pathological conditions: involvement of adipokines and neuropeptides. Cells. 11(6):957

Article  PubMed  PubMed Central  Google Scholar 

Moore AM, Prescott M, Campbell RE (2013) Estradiol negative and positive feedback in a prenatal androgen-induced mouse model of polycystic ovarian syndrome. Endocrinology 154:796–806

Article  CAS  PubMed  Google Scholar 

Orszulak D, Niziński K, Matonóg A, Zięba-Domalik M, Stojko R, Drosdzol-Cop A (2025) Adipokines as biochemical marker of polycystic ovary syndrome in adolescents – review. Front Endocrinol 16:1475465

Article  Google Scholar 

Pich K, Pietroń K, Szlaga A, Billert M, Skrzypski M, Pawlicki P, Kotula-Balak M, Dupont J, Błasiak A, Rak A (2025) Adipokines level in plasma, hypothalamus, ovaries and adipose tissue of rats with polycystic ovary syndrome. Reprod Biomed Online 50(5):104693. https://doi.org/10.1016/j.rbmo.2024.104693

Article  CAS  PubMed  Google Scholar 

Schüler-Toprak S, Ortmann O, Buechler C, Treeck O (2022) The complex roles of adipokines in polycystic ovary syndrome and endometriosis. Biomedicines 10(10):2503

Article 

Comments (0)

No login
gif