Ahmad T, Khan T, Tabassum T, Alqahtani YS, Mahnashi MH, Alyami BA et al (2022) Juglone from walnut produces cardioprotective effects against isoproterenol-induced myocardial injury in SD rats. Curr Issues Mol Biol 44:3180–3193

Article  CAS  PubMed  PubMed Central  Google Scholar 

Al Masri A, Al HA (2015) The adipokine, progranulin (PGRN), is cardio-protective in myocardial ischemia reperfusion injury in the rat. Atherosclerosis 241:e207–e208

Article  Google Scholar 

Althunibat OY, Abduh MS, Abukhalil MH, Aladaileh SH, Hanieh H, Mahmoud AM (2022) Umbelliferone prevents isoproterenol-induced myocardial injury by upregulating Nrf2/HO-1 signaling, and attenuating oxidative stress, inflammation, and cell death in rats. Biomed Pharmacother 149:112900

Article  CAS  PubMed  Google Scholar 

Alyahya AM, Al-Masri A, Hersi A, El Eter E, Husain S, Lateef R et al (2019) The effects of progranulin in a rat model of acute myocardial ischemia/reperfusion are mediated by activation of the PI3K/Akt signaling pathway. Med Sci Monit Basic Res 25:229–237

Article  PubMed  PubMed Central  Google Scholar 

Anajirih N, Abdeen A, Taher ES, Abdelkader A, Abd-Ellatieff HA, Gewaily MS et al (2024) Alchemilla vulgaris modulates isoproterenol-induced cardiotoxicity: Interplay of oxidative stress, inflammation, autophagy, and apoptosis. Front Pharmacol 15:1394557

Article  CAS  PubMed  PubMed Central  Google Scholar 

Asiwe JN, Ben-Azu B, Yovwin GD, Ehebha SE, Igben VJO, Ahama EE et al (2023) Enhancements of Bcl-2/mTOR/ERK1/2 activities by antioxidant mechanisms confer cardioprotection on Ginkgo biloba supplement against isoprenaline-induced myocardial infarction in rats. Pharmacol Res Mod Chin Med 8:100293

Article  Google Scholar 

Bateman A, Bennett HP (1998) Granulins: the structure and function of an emerging family of growth factors. J Endocrinol 158:145–151

Article  CAS  PubMed  Google Scholar 

Coggins M, Rosenzweig A (2012) The fire within: cardiac inflammatory signaling in health and disease. Circ Res 110:116–125

Article  CAS  PubMed  Google Scholar 

Cui Y, Wu J, Wang Y, Li D, Zhang F, Jin X et al (2024) Protective effects of ginsenoside F2 on isoproterenol-induced myocardial infarction by activating the Nrf2/HO-1 and PI3K/Akt signaling pathways. Phytomedicine 129:155637

Article  CAS  PubMed  Google Scholar 

de Castro AL, Fernandes RO, Ortiz VD, Campos C, Bonetto JH, Fernandes TRG et al (2018) Thyroid hormones decrease the proinflammatory TLR4/NF-κB pathway and improve functional parameters of the left ventricle of infarcted rats. Mol Cell Endocrinol 461:132–142

Article  PubMed  Google Scholar 

Egashira Y, Suzuki Y, Azuma Y et al (2013) The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment. J Neuroinflammation 10:2–13

Article  Google Scholar 

Gambaro SE, Zubiría MG, Giordano AP, Portales AE, Alzamendi A, Rumbo M, Giovambattista A (2020) Spexin improves adipose tissue inflammation and macrophage recruitment in obese mice. Biochim Biophys Acta Mol Cell Biol Lipids 1865:158700

Article  CAS  PubMed  Google Scholar 

Habotta OA, Abdeen A, El-Hanafy AA, Yassin N, Elgameel D, Ibrahim SF et al (2023) Sesquiterpene nootkatone counteracted the melamine-induced neurotoxicity via repressing oxidative stress, inflammatory, and apoptotic trajectories. Biomed Pharmacother 165:115133

Article  CAS  PubMed  Google Scholar 

Jain PG, Mahajan UB, Shinde SD, Surana SJ (2018) Cardioprotective role of ferulic acid against isoproterenol-induced cardiac toxicity. Mol Biol Rep 45:1357–1365

Article  CAS  PubMed  Google Scholar 

Kanazawa M et al (2015) Multiple therapeutic effects of progranulin on experimental acute ischaemic stroke. Brain 138:1932–1948

Article  PubMed  Google Scholar 

Kaya S, Yalçin T (2023) In an experimental myocardial infarction model, L-arginine pre-intervention may exert cardioprotective effects by regulating OTULIN levels and mitochondrial dynamics. Cell Stress Chaperones 28:811–820

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaya S, Yalçin T, Boydak M, Dönmez HH (2023a) Protective effect of N-acetylcysteine against aluminum-induced kidney tissue damage in rats. Biol Trace Elem Res 201(4):1806–1815

Article  CAS  PubMed  Google Scholar 

Kaya S, Yalçin T, Kuloğlu T (2023b) Resveratrol may reduce oxidative stress and apoptosis in doxorubicin-induced cardiotoxicity by regulating meteorin-like and TRPM2 levels. Comp Clin Pathol 32:393–404

Article  CAS  Google Scholar 

Khadir A, Kavalakatt S, Madhu D, Devarajan S, Abubaker J, Al-Mulla F et al (2020) Spexin as an indicator of beneficial effects of exercise in human obesity and diabetes. Sci Rep 10:10635

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khan V, Sharma S, Bhandari U, Ali SM, Haque SE (2018) Raspberry ketone protects against isoproterenol-induced myocardial infarction in rats. Life Sci 194:205–212

Article  CAS  PubMed  Google Scholar 

Kojima Y, Ono K, Inoue K, Takagi Y, Kikuta K, Nishimura M et al (2009) Progranulin expression in advanced human atherosclerotic plaque. Atherosclerosis 206:102–108

Article  CAS  PubMed  Google Scholar 

Kulsoom B, Shamsi TS, Afsar NA, Memon Z, Ahmed N, Hasnain SN (2018) Bax, Bcl-2, and Bax/Bcl-2 as prognostic markers in acute myeloid leukemia: Are we ready for Bcl-2-directed therapy? Cancer Manag Res 10:403–416

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumar S, Hossain MJ, Javed A, Kullo IJ, Balagopal PB (2018) Relationship of circulating spexin with markers of cardiovascular disease: a pilot study in adolescents with obesity. Pediatr Obes 13:374–380

Article  CAS  PubMed  Google Scholar 

Li D, Liu Y, Li C, Zhou Z, Gao K, Bao H et al (2024) Spexin diminishes atrial fibrillation vulnerability by acting on galanin receptor 2. Circulation 150:111–127

Article  CAS  PubMed  Google Scholar 

Liu ZY, Hu SP, Ji QR, Yang HB, Zhou DH, Wu FF (2017) Sevoflurane pretreatment inhibits the myocardial apoptosis caused by hypoxia reoxygenation through AMPK pathway: an experimental study. Asian Pac J Trop Med 10:148–151

Article  CAS  PubMed  Google Scholar 

Liu J, Chen L, Lu H (2018) Cardioprotective effect of salvianolic acid B against isoproterenol-induced inflammation and histological changes in a cardiotoxicity rat model. Trop J Pharm Res 17:2189–2197

Article  CAS  Google Scholar 

Liu Y, Sun L, Zheng L, Su M, Liu H, Wei Y et al (2020) Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction. Naunyn-Schmiedebergs Arch Pharmacol 393:25–33

Article  CAS  PubMed  Google Scholar 

Martin TP, MacDonald EA, Elbassioni AAM, O’Toole D, Zaeri AAI, Nicklin SA et al (2022) Preclinical models of myocardial infarction: from mechanism to translation. Br J Pharmacol 179:770–791

Article  CAS  PubMed  Google Scholar 

Martínez-Noguera FJ, Alcaraz PE, Ortolano-Ríos R, Dufour SP, Marín-Pagán C (2021) Differences between professional and amateur cyclists in endogenous antioxidant system profile. Antioxidants (Basel) 10:282

Article  PubMed  PubMed Central  Google Scholar 

Mirabeau O, Perlas E, Severini C, Audero E, Gascuel O, Possenti R et al (2007) Identification of novel peptide hormones in the human proteome by hidden Markov model screening. Genome Res 17:320–327

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nahrendorf M, Swirski FK (2013) Monocyte and macrophage heterogeneity in the heart. Circ Res 112:1624–1633

Article  CAS  PubMed