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Pharmacological evaluation of physcion as a TRPV1 inhibitor with multimodal analgesic efficacy in experimental pain models
Pharmacological evaluation of physcion as a TRPV1 inhibitor with multimodal analgesic efficacy in experimental pain models
Pain serves as a vital protective mechanism triggered by tissue damage. While NSAIDs and opioids offer relief, their prolo...
Chinese herbal formula Huayu-Qiangshen-Tongbi decoction ameliorates rheumatoid arthritis through enhancing the release of exosomal miR-125b-5p derived from adipose-derived stem cells by CD63
Chinese herbal formula Huayu-Qiangshen-Tongbi decoction ameliorates rheumatoid arthritis through enhancing the release of exosomal miR-125b-5p derived from adipose-derived stem cells by CD63
Rheumatoid arthritis (RA) is a chronic and multifactorial inflammatory disease inducing damages in joints and extra-articu...
Exposure to polystyrene nanoparticles leads to dysfunction in DNA repair mechanisms in Caco-2 cells
Exposure to polystyrene nanoparticles leads to dysfunction in DNA repair mechanisms in Caco-2 cells
Recent studies have highlighted the critical health implications of environmental exposure to nanoplastics, particularly c...
Molecular basis for the biosynthesis of the siderophore coprogen in the cheese-ripening fungus Penicillium roqueforti
Molecular basis for the biosynthesis of the siderophore coprogen in the cheese-ripening fungus Penicillium roqueforti
Iron is an essential nutrient for microorganisms, including fungi, which have evolved strategies to acquire it. The most c...
Study on the therapeutic potential of induced neural stem cells for Alzheimer's disease in mice
Study on the therapeutic potential of induced neural stem cells for Alzheimer's disease in mice
Induced neural stem cells (iNSCs), which have similar properties to neural stem cells and are able to self-proliferate and...
Female prediabetic rats are protected from vascular dysfunction: the role of nitroso and sulfide signaling
Female prediabetic rats are protected from vascular dysfunction: the role of nitroso and sulfide signaling
The activity of perivascular adipose tissue (PVAT), a specific deposit of adipose tissue surrounding blood vessels, could ...
Stress drives premature hive exiting behavior that leads to death in young honey bee (Apis mellifera) workers
Stress drives premature hive exiting behavior that leads to death in young honey bee (Apis mellifera) workers
The Western honey bee, Apis mellifera, is an economically important pollinator, as well as a tractable species for studyin...
Heterogeneity in the formation of primary and secondary visual fields during human prenatal development
Heterogeneity in the formation of primary and secondary visual fields during human prenatal development
The human neocortex has a huge surface area with unique cytoarchitectonics, most of which is concealed in sulci. Some cyto...
A single-base deletion in exon 2 of Hd1 delineates monogenic recessive photoperiod insensitivity in aromatic Joha rice: a novel allele for seasonal adaptability
A single-base deletion in exon 2 of Hd1 delineates monogenic recessive photoperiod insensitivity in aromatic Joha rice: a novel allele for seasonal adaptability
Assam's aromatic Joha rice is a unique rice class famous for its aroma, taste, and nutritional benef...
Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome
Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome
Growing evidence has suggested that Type I Interferon (I-IFN) plays a potential role in the pathogenesis of Down Syndrome ...
The novel roles of YULINK in the migration, proliferation and glycolysis of pulmonary arterial smooth muscle cells: implications for pulmonary arterial hypertension
The novel roles of YULINK in the migration, proliferation and glycolysis of pulmonary arterial smooth muscle cells: implications for pulmonary arterial hypertension
Abnormal remodeling of the pulmonary vasculature, characterized by the proliferation and migration of pulmonary arterial s...
Electroacupuncture promotes neurogenesis in the dentate gyrus and improves pattern separation in an early Alzheimer's disease mouse model
Electroacupuncture promotes neurogenesis in the dentate gyrus and improves pattern separation in an early Alzheimer's disease mouse model
Impaired pattern separation occurs in the early stage of Alzheimer’s disease (AD), and hippocampal dentate gyrus (DG...
Advances towards the use of gastrointestinal tumor patient-derived organoids as a therapeutic decision-making tool
Advances towards the use of gastrointestinal tumor patient-derived organoids as a therapeutic decision-making tool
In December 2022 the US Food and Drug Administration (FDA) removed the requirement that drugs in development must undergo ...
Role of SYVN1 in the control of airway remodeling in asthma protection by promoting SIRT2 ubiquitination and degradation
Role of SYVN1 in the control of airway remodeling in asthma protection by promoting SIRT2 ubiquitination and degradation
Asthma is a heterogenous disease that characterized by airway remodeling. SYVN1 (Synoviolin 1) acts as an E3 ligase to med...
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression
Atherosclerosis (AS), a significant contributor to cardiovascular disease (CVD), is steadily rising with the aging of the ...
Prenatal ethanol exposure and changes in fetal neuroendocrine metabolic programming
Prenatal ethanol exposure and changes in fetal neuroendocrine metabolic programming
Prenatal ethanol exposure (PEE) (mainly through maternal alcohol consumption) has become widespread. However, studies sugg...
Autologous non-invasively derived stem cells mitochondria transfer shows therapeutic advantages in human embryo quality rescue
Autologous non-invasively derived stem cells mitochondria transfer shows therapeutic advantages in human embryo quality rescue
The decline in the quantity and quality of mitochondria are closely associated with infertility, particularly in advanced ...
Chemogenetic inhibition of NTS astrocytes normalizes cardiac autonomic control and ameliorate hypertension during chronic intermittent hypoxia
Chemogenetic inhibition of NTS astrocytes normalizes cardiac autonomic control and ameliorate hypertension during chronic intermittent hypoxia
Obstructive sleep apnea (OSA) is characterized by recurrent episodes of chronic intermittent hypoxia (CIH), which has been...
Heat-responsive microRNAs participate in regulating the pollen fertility stability of CMS-D2 restorer line under high-temperature stress
Heat-responsive microRNAs participate in regulating the pollen fertility stability of CMS-D2 restorer line under high-temperature stress
Anther development and pollen fertility of cytoplasmic male sterility (CMS) conditioned by Gossypium harknessii cytoplasm ...
Development of synthetic modulator enabling long-term propagation and neurogenesis of human embryonic stem cell-derived neural progenitor cells
Development of synthetic modulator enabling long-term propagation and neurogenesis of human embryonic stem cell-derived neural progenitor cells
Neural progenitor cells (NPCs) are essential for in vitro drug screening and cell-based therapies for brain-related disord...
Two murine models of sepsis: immunopathological differences between the sexes—possible role of TGFβ1 in female resistance to endotoxemia
Two murine models of sepsis: immunopathological differences between the sexes—possible role of TGFβ1 in female resistance to endotoxemia
Endotoxic shock (ExSh) and cecal ligature and puncture (CLP) are models that induce sepsis. In this work, we investigated ...
An intracellular, non-oxidative factor activates in vitro chromatin fragmentation in pig sperm
An intracellular, non-oxidative factor activates in vitro chromatin fragmentation in pig sperm
In vitro incubation of epididymal and vas deferens sperm with Mn2+ induces Sperm Chromatin Fragmentation (SCF), a mechanis...
SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics
SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19). An as...
The effect of zofenopril on the cardiovascular system of spontaneously hypertensive rats treated with the ACE2 inhibitor MLN-4760
The effect of zofenopril on the cardiovascular system of spontaneously hypertensive rats treated with the ACE2 inhibitor MLN-4760
Angiotensin converting enzyme 2 (ACE2) plays a crucial role in the infection cycle of SARS-CoV-2 responsible for formation...
Focal ischemic stroke modifies microglia-derived exosomal miRNAs: potential role of mir-212-5p in neuronal protection and functional recovery
Focal ischemic stroke modifies microglia-derived exosomal miRNAs: potential role of mir-212-5p in neuronal protection and functional recovery
Ischemic stroke is a severe type of stroke with high disability and mortality rates. In recent years, microglial exosome-d...
S-Nitrosylation in endothelial cells contributes to tumor cell adhesion and extravasation during breast cancer metastasis
S-Nitrosylation in endothelial cells contributes to tumor cell adhesion and extravasation during breast cancer metastasis
Nitric oxide is produced by different nitric oxide synthases isoforms. NO activates two signaling pathways, one dependent ...
Identifying pyroptosis- and inflammation-related genes in intracranial aneurysms based on bioinformatics analysis
Identifying pyroptosis- and inflammation-related genes in intracranial aneurysms based on bioinformatics analysis
Intracranial aneurysm (IA) is the most common cerebrovascular disease, and subarachnoid hemorrhage caused by its rupture c...
Drosophila Atlastin regulates synaptic vesicle mobilization independent of bone morphogenetic protein signaling
Drosophila Atlastin regulates synaptic vesicle mobilization independent of bone morphogenetic protein signaling
The endoplasmic reticulum (ER) contacts endosomes in all parts of a motor neuron, including the axon and presynaptic termi...
Mucin1 induced trophoblast dysfunction in gestational diabetes mellitus via Wnt/β-catenin pathway
Mucin1 induced trophoblast dysfunction in gestational diabetes mellitus via Wnt/β-catenin pathway
To elucidate the role of Mucin1 (MUC1) in the trophoblast function (glucose uptake and apoptosis) of gestational diabetes ...
Human umbilical cord mesenchymal stem cells (hUC-MSCs) alleviate paclitaxel-induced spermatogenesis defects and maintain male fertility
Human umbilical cord mesenchymal stem cells (hUC-MSCs) alleviate paclitaxel-induced spermatogenesis defects and maintain male fertility
Chemotherapeutic drugs can cause reproductive damage by affecting sperm quality and other aspects of male fertility. Stem ...
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