Liu Y, Xiao X, Yang Y, Yao R, Yang Q, Zhu Y, et al. The risk of Alzheimer’s disease and cognitive impairment characteristics in eight mental disorders: a UK Biobank observational study and Mendelian randomization analysis. Alzheimers Dement. 2024;20:4841–53.
Article CAS PubMed PubMed Central Google Scholar
Hamilton CA, Donaghy PC, Durcan R, Ciafone J, Olsen K, Roberts G, et al. Outcomes of patients with mild cognitive impairment with Lewy bodies or Alzheimer disease at 3 and 5 years after diagnosis. Neurology. 2024;103(2): e209499.
Article CAS PubMed PubMed Central Google Scholar
Goel P, Chakrabarti S, Goel K, Bhutani K, Chopra T, Bali S. Neuronal cell death mechanisms in Alzheimer’s disease: an insight. Front Mol Neurosci. 2022;15: 937133.
Article CAS PubMed PubMed Central Google Scholar
Duncan T, Valenzuela M. Alzheimer’s disease, dementia, and stem cell therapy. Stem Cell Res Ther. 2017;8(1):111.
Article PubMed PubMed Central Google Scholar
Zhao X, Moore DL. Neural stem cells: developmental mechanisms and disease modeling. Cell Tissue Res. 2018;371(1):1–6.
Article PubMed PubMed Central Google Scholar
Marsh SE, Blurton-Jones M. Neural stem cell therapy for neurodegenerative disorders: the role of neurotrophic support. Neurochem Int. 2017;106:94–100.
Article CAS PubMed PubMed Central Google Scholar
Zhu Q, Zhang N, Hu N, Jiang R, Lu H, Xuan A, et al. Neural stem cell transplantation improves learning and memory by protecting cholinergic neurons and restoring synaptic impairment in an amyloid precursor protein/presenilin 1 transgenic mouse model of Alzheimer’s disease. Mol Med Rep. 2020;21(3):1172–80.
CAS PubMed PubMed Central Google Scholar
McGinley LM, Kashlan ON, Bruno ES, Chen KS, Hayes JM, Kashlan SR, et al. Human neural stem cell transplantation improves cognition in a murine model of Alzheimer’s disease. Sci Rep. 2018;8(1):14776.
Article PubMed PubMed Central Google Scholar
Mazzini L, Gelati M, Profico DC, Sgaravizzi G, Projetti Pensi M, Muzi G, et al. Human neural stem cell transplantation in ALS: initial results from a phase I trial. J Transl Med. 2015;13:17.
Article PubMed PubMed Central Google Scholar
Paul S, Pflieger L, Dansithong W, Figueroa KP, Gao F, Coppola G, et al. Co-expression networks in generation of induced pluripotent stem cells. Biol Open. 2016;5(3):300–10.
Article CAS PubMed PubMed Central Google Scholar
Tiemann U, Sgodda M, Warlich E, Ballmaier M, Scholer HR, Schambach A, et al. Optimal reprogramming factor stoichiometry increases colony numbers and affects molecular characteristics of murine induced pluripotent stem cells. Cytometry A. 2011;79(6):426–35.
Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131(5):861–72.
Article CAS PubMed Google Scholar
Pang ZP, Yang N, Vierbuchen T, Ostermeier A, Fuentes DR, Yang TQ, et al. Induction of human neuronal cells by defined transcription factors. Nature. 2011;476(7359):220–3.
Article CAS PubMed PubMed Central Google Scholar
Yoo AS, Sun AX, Li L, Shcheglovitov A, Portmann T, Li Y, et al. MicroRNA-mediated conversion of human fibroblasts to neurons. Nature. 2011;476(7359):228–31.
Article CAS PubMed PubMed Central Google Scholar
Fontcuberta-PiSunyer M, Garcia-Alaman A, Prades E, Tellez N, Alves-Figueiredo H, Ramos-Rodriguez M, et al. Direct reprogramming of human fibroblasts into insulin-producing cells using transcription factors. Commun Biol. 2023;6(1):256.
Article CAS PubMed PubMed Central Google Scholar
Zhu Q, Xu X, Chen B, Liao Y, Guan X, He Y, et al. Ultrasound-targeted microbubbles destruction assists dual delivery of beta-amyloid antibody and neural stem cells to restore neural function in transgenic mice of Alzheimer’s disease. Med Phys. 2022;49(3):1357–67.
Article CAS PubMed Google Scholar
Hayashi Y, Lin HT, Lee CC, Tsai KJ. Effects of neural stem cell transplantation in Alzheimer’s disease models. J Biomed Sci. 2020;27(1):29.
Article PubMed PubMed Central Google Scholar
Cheng Q, Ma X, Liu J, Feng X, Liu Y, Wang Y, et al. Pharmacological inhibition of the asparaginyl endopeptidase (AEP) in an Alzheimer’s disease model improves the survival and efficacy of transplanted neural stem cells. Int J Mol Sci. 2023;24(9):7739.
Article CAS PubMed PubMed Central Google Scholar
Boese AC, Hamblin MH, Lee JP. Neural stem cell therapy for neurovascular injury in Alzheimer’s disease. Exp Neurol. 2020;324: 113112.
Article CAS PubMed Google Scholar
Moechars D, Dewachter I, Lorent K, Reversé D, Baekelandt V, Naidu A, et al. Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J Biol Chem. 1999;274(10):6483–92.
Article CAS PubMed Google Scholar
Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods. 1984;11(1):47–60.
Article CAS PubMed Google Scholar
Shahbazi E, Mirakhori F, Ezzatizadeh V, Baharvand H. Reprogramming of somatic cells to induced neural stem cells. Methods. 2018;133:21–8.
Article CAS PubMed Google Scholar
Kim SM, Kim JW, Kwak TH, Park SW, Kim KP, Park H, et al. Generation of integration-free induced neural stem cells from mouse fibroblasts. J Biol Chem. 2016;291(27):14199–212.
Article CAS PubMed PubMed Central Google Scholar
Liu GH, Yi F, Suzuki K, Qu J, Izpisua Belmonte JC. Induced neural stem cells: a new tool for studying neural development and neurological disorders. Cell Res. 2012;22(7):1087–91.
Article PubMed PubMed Central Google Scholar
Chen X, Jiang S, Wang R, Bao X, Li Y. Neural stem cells in the treatment of Alzheimer’s disease: current status, challenges, and future prospects. J Alzheimers Dis. 2023;94(s1):S173–86.
Article CAS PubMed PubMed Central Google Scholar
Piao J, Zabierowski S, Dubose BN, Hill EJ, Navare M, Claros N, et al. Preclinical efficacy and safety of a human embryonic stem cell-derived midbrain dopamine progenitor product, MSK-DA01. Cell Stem Cell. 2021;28(2):217–29.
Article CAS PubMed PubMed Central Google Scholar
Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126(4):663–76.
Article CAS PubMed Google Scholar
Chen J, Huang L, Yang Y, Xu W, Qin Q, Qin R, et al. Somatic cell reprogramming for nervous system diseases: techniques, mechanisms, potential applications, and challenges. Brain Sci. 2023;13(3):524.
Article CAS PubMed PubMed Central Google Scholar
Nie L, Yao D, Chen S, Wang J, Pan C, Wu D, et al. Directional induction of neural stem cells, a new therapy for neurodegenerative diseases and ischemic stroke. Cell Death Discov. 2023;9(1):215.
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