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Superacid-Catalysed α-Deuteration of Ketones with D2O
In this study, we present a superacid catalyzed protocol of α-deuteration of ketones with D2O using [Ph₃C]⁺[B(C₆F₅)₄]⁻ as ...
Catalytic dynamic kinetic reductive addition of simple aldehydes and aldimines with heterobiaryl triflates: harnessing both central and axial chirality
A nickel-catalyzed intramolecular dynamic kinetic resolution (DKR) strategy has been developed for the enantioselective sy...
Nickel-Catalyzed Reductive Coupling of 2-Pyridyl Esters with Unreactivated Alkyl Chlorides: A Universal Synthesis of Aryl-Alkyl and Dialkyl Ketones via Dynamic Halide Exchange
Direct synthesis of ketones by the nickel-catalyzed reductive coupling between aryl, 1o, 2o, 3o-alkyl 2-pyridyl esters, an...
Dual Photoredox/Copper-Catalyzed Selective Difluoromethylthiolation of Remote Unactivated C(sp3) −H Bonds
A photocatalysis/copper dual catalyzed difluoromethylthiolation of remote unactivated C(sp³)−H bonds using N-fluorosu...
Highly Sensitive Detection and Labelling of Proteins with a Molecular Rotor-based Fluorogenic probe
Reported herein is a highly sensitive fluorogenic reagent based on an environment-sensitive molecular rotor for the detect...
A Comprehensive Review of Triterpenoids, Structures and Cytotoxicity: An update from 2015 to 2024
Triterpenoids are important natural products, usually found in medicinal plants, marine organisms, and fungi, and they exh...
Pd(II)-catalyzed synthesis of aryl ketones in water
A mild and efficient Pd-catalyzed protocol for the direct synthesis of aryl ketones has been developed through a reaction ...
Visible-Light-Mediated Decarboxylative Allylation of Vinylcyclopropanes with α-Keto Acids toward β,γ-Alkenyl Ketones
β,γ-Alkenyl ketones are privileged structural motifs in organic synthesis with broad pharmaceutical relevance. In this con...
Development of Bifunctional Fluorescent Probes and their Application to alpha-Helix Labelling
The site selective modification of proteins and peptides is an important venture when it comes to the study of biological ...
Ribosomal Incorporation of N-Acetyl-3,5-Bis(Chloromethyl)benzylthio-L-Alanine for Developing an mRNA-Displayed Bicyclic Peptide Library Cyclized via 1,3,5-Tris(methyl)benzene
We report a novel method for constructing an mRNA-displayed bicyclic peptide library cyclized through 1,3,5-tris(methyl)be...
Synthesis of the Tricyclic Skeleton of Aberrarone
A synthesis of the 6-5-5 tricyclic skeleton of the diterpenoid aberrarone is reported. The synthesis strategically feature...
Molybdenum-Catalyzed Deoxygenative Heterocyclization of 2-Nitroazobenzenes: A Novel Strategy for Catalytic Synthesis of 2-Aryl-2H-benzo[d][1,2,3]triazoles
A novel strategy for catalytic synthesis of 2-aryl-2H-benzo[d][1,2,3]triazoles by non-noble molybdenum-catalyzed deoxygena...
Non-enzymatic Synthesis of C-Methylated Fluostatins: Discovery and Reaction Mechanism
Two methylation FSTs, FST B3/FST B4 (1/2), were obtained from oxidative ring-opening reaction. The structure of 1/2 were e...
Oxidative cascade cyclization of N-arylacrylamides with TMSN3
An azido-radical-triggered cyclization of N-(o-cyanobiaryl)acrylamides with TMSN3 via a C(sp3)–N/C(sp2)–C(sp3)/C(sp2)–N bo...
Highly effective and selective FeBr3-promoted deuterium bromination/cyclization of 1,n-enynes
A highly effective and selective FeBr3 promoted deuterium bromination/cyclization of 1,n-enynes is reported. On one hand, ...
Practical and scalable enantioselective synthesis of (+)-majoranolide from Cyrene
A two-step enantioselective gram scale synthesis of the Persea derived γ-lactones (+)-majoranolide and (+)-majoranolide B ...
A transition-metal-free azide-alkyne cycloaddition / hydroamination cascade reaction for the construction of triazole-fused piperazin-2-ones
A time-dependent, divergent synthesis of highly functionalized [1,2,3]triazolo[1,5-a]pyrazin-4(5H)-one (reaction time: 12 ...
Visible-light-induced decarboxylative cascade cyclization of acryloylbenzamides with N-hydroxyphthalimide esters via EDA complexes
Visible-light-induced decarboxylative cascade reactions of acryloylbenzamides with alkyl N-hydroxyphthalimide (NHP) esters...
Isocyanide-based multicomponent reactions for the synthesis of benzopyran derivatives with biological scaffolds
Benzopyrans (BZPs) are one of the most privileged and influential small O-heterocycles that form the core of many natural ...
Iridium (III)-Catalyzed β-Trifluoromethyl Enone Carbonyl Directed Regio-Selective C(sp2)-H Olefination
Due to the lower LUMO energy level at β-position of α,β-unsaturated-β-trifluoromethyl enone than its non-fluorinated count...
Selective α-oxidation of amides via visible-light-driven Iron-catalysis
The hydroxyl radical (•OH) as one of the highly reactive species can react unselectively with a wide range of chemicals. T...
Direct Synthesis of Phenanthrenyl Triflates from 1-Biphenylyl-2-diazo-2-aryl Ketones and Triflic Anhydride
A strategy for direct synthesis of phenanthrenyl triflates from 1-biphenylyl-2-diazo-2-aryl ketones and triflic anhydride ...
Synthesis of 4-Sulfonyl-1,7-diesters via K2CO3-Mediated Alkylative Debenzoylation of α-Sulfonyl o-Hydroxyacetophenones with Acrylates
The synthesis of 4-sulfonyl-1,7-diesters was well-developed, under the open-vessel condition, by K2CO3-mediated double alk...
Brønsted Acid and Ni(II)-catalyzed C-H Oxidation/Rearrangement of Cyclotriveratrylenes (CTVs) to Cyclic and Acyclic Quinones as Potential Anti-cancer Agents
This paper describes a simple and practical protocol for the direct synthesis of acyclic and cyclic quinone derivatives vi...
Asymmetric synthesis of (R)-baclofen and (3S,4S)-tetflupyrolimet via “on water” organocatalytic addition reactions: a tip on catalysts screening
This work demonstrated asymmetric synthesis of GABA derivative (R)-baclofen and a new herbicidal mode-of-action inhibitor ...
Metal‑ and Base-Free, Aerobic Photoredox Catalysis with Riboflavin to Synthesize 2-Substituted Benzothiazoles
Sustainable approaches for the synthesis of 2-substituted benzothiazoles are sought after for their use in organic chemist...
5-exo-Selective Asymmetric Bromolactonization of Stilbenecarboxylic Acids Catalyzed by Phenol-bearing Chiral Thiourea
We developed a novel thiourea Lewis-base catalyst with phenol moieties for the enantioselective 5-exo-bromolactonization o...
Electrochemical oxidative dehydrogenative annulation of 1-(2-aminophenyl)pyrroles with cleavage of ethers to synthesize pyrrolo[1,2-a]quinoxaline derivatives
An array of pyrrolo[1,2-a]quinoxaline derivatives were achieved with moderate to good yields via the electrochemical redox...
Efficient Amidation of Weak Amine: Synthesis, Chiral Separation by SFC, and Antimicrobial Activity of N-(9, 10-dioxo-9, 10-dihydro anthracene-1-yl) carboxamide
An effective and straight forward method for the synthesis of 1-aminoanthracene-9,10-dione carboxamides, by coupling weakl...
Synthesis of Sulfinamides via Photocatalytic Alkylation or Arylation of Sulfinylamine with Potassium Trifluoro(organo)borates
Sulfinamides are a versatile class of compounds that find applications in both organic synthesis and pharmaceuticals. Here...
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