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4-chloro-2H-chromene-3-carbaldehyde: A Valid Scaffold in Organic Synthesis and Future Molecules for Healthcare and Energy
In the past decade, 4-chloro-2H-chromene-3-carbaldehyde scaffolds (CCCS) have gained significant interest in organic synth...
Electrochemical Cross-Electrophile Coupling of Unactivated Tertiary Alkyl Bromides with Benzyl Chloride to Access Quaternary Stereocenters
Constructing quaternary carbon centers represents a significant yet challenging work in synthetic and medicinal chemistry....
High-throughput DoE synthesis of chalcones and pyrazolines for fluorescent sensing
Pyrazolines are attractive scaffolds for fluorescent sensors due to their unique photophysical properties and the ease of ...
Recent Advances in Pd-Catalysed Decarboxylative Asymmetric Allylic Alkylation
This comprehensive review on the Pd-catalysed decarboxylative asymmetric allylic alkylation details the development of thi...
Recent advances in tert-butyl nitrite-mediated nitration cyclization/spirocyclization reactions
Nitro-functionalized compounds and their derivatives have attracted considerable attention because of their synthetic valu...
Determinants of undesired α2-6-sialoside formation by PmST1 M144D
Sialyltransferases catalyze the regioselective glycosidic bond formation between sialic acid and a glycan acceptor. Pasteu...
Base-dependent divergent α-cyanation and pyridylation of tertiary amines with cyanoaromatics †
Divergent synthesis has emerged as a powerful and economical approach in synthetic chemistry. Herein, we show a basedepend...
Metal-free quinoline synthesis via Brønsted acid-promoted cyclization of ene-ynamides
We report a metal-free strategy for the efficient synthesis of polysubstituted quinolines via Brønsted acid-promoted ...
Superacid-Catalysed α-Deuteration of Ketones with D2O
In this study, we present a superacid catalyzed protocol of α-deuteration of ketones with D2O using [Ph₃C]⁺[B(C₆F₅)₄]⁻ as ...
Catalytic dynamic kinetic reductive addition of simple aldehydes and aldimines with heterobiaryl triflates: harnessing both central and axial chirality
A nickel-catalyzed intramolecular dynamic kinetic resolution (DKR) strategy has been developed for the enantioselective sy...
Nickel-Catalyzed Reductive Coupling of 2-Pyridyl Esters with Unreactivated Alkyl Chlorides: A Universal Synthesis of Aryl-Alkyl and Dialkyl Ketones via Dynamic Halide Exchange
Direct synthesis of ketones by the nickel-catalyzed reductive coupling between aryl, 1o, 2o, 3o-alkyl 2-pyridyl esters, an...
Dual Photoredox/Copper-Catalyzed Selective Difluoromethylthiolation of Remote Unactivated C(sp3) −H Bonds
A photocatalysis/copper dual catalyzed difluoromethylthiolation of remote unactivated C(sp³)−H bonds using N-fluorosu...
Highly Sensitive Detection and Labelling of Proteins with a Molecular Rotor-based Fluorogenic probe
Reported herein is a highly sensitive fluorogenic reagent based on an environment-sensitive molecular rotor for the detect...
A Comprehensive Review of Triterpenoids, Structures and Cytotoxicity: An update from 2015 to 2024
Triterpenoids are important natural products, usually found in medicinal plants, marine organisms, and fungi, and they exh...
Pd(II)-catalyzed synthesis of aryl ketones in water
A mild and efficient Pd-catalyzed protocol for the direct synthesis of aryl ketones has been developed through a reaction ...
Visible-Light-Mediated Decarboxylative Allylation of Vinylcyclopropanes with α-Keto Acids toward β,γ-Alkenyl Ketones
β,γ-Alkenyl ketones are privileged structural motifs in organic synthesis with broad pharmaceutical relevance. In this con...
Development of Bifunctional Fluorescent Probes and their Application to alpha-Helix Labelling
The site selective modification of proteins and peptides is an important venture when it comes to the study of biological ...
Ribosomal Incorporation of N-Acetyl-3,5-Bis(Chloromethyl)benzylthio-L-Alanine for Developing an mRNA-Displayed Bicyclic Peptide Library Cyclized via 1,3,5-Tris(methyl)benzene
We report a novel method for constructing an mRNA-displayed bicyclic peptide library cyclized through 1,3,5-tris(methyl)be...
Synthesis of the Tricyclic Skeleton of Aberrarone
A synthesis of the 6-5-5 tricyclic skeleton of the diterpenoid aberrarone is reported. The synthesis strategically feature...
Molybdenum-Catalyzed Deoxygenative Heterocyclization of 2-Nitroazobenzenes: A Novel Strategy for Catalytic Synthesis of 2-Aryl-2H-benzo[d][1,2,3]triazoles
A novel strategy for catalytic synthesis of 2-aryl-2H-benzo[d][1,2,3]triazoles by non-noble molybdenum-catalyzed deoxygena...
Non-enzymatic Synthesis of C-Methylated Fluostatins: Discovery and Reaction Mechanism
Two methylation FSTs, FST B3/FST B4 (1/2), were obtained from oxidative ring-opening reaction. The structure of 1/2 were e...
Oxidative cascade cyclization of N-arylacrylamides with TMSN3
An azido-radical-triggered cyclization of N-(o-cyanobiaryl)acrylamides with TMSN3 via a C(sp3)–N/C(sp2)–C(sp3)/C(sp2)–N bo...
Highly effective and selective FeBr3-promoted deuterium bromination/cyclization of 1,n-enynes
A highly effective and selective FeBr3 promoted deuterium bromination/cyclization of 1,n-enynes is reported. On one hand, ...
Practical and scalable enantioselective synthesis of (+)-majoranolide from Cyrene
A two-step enantioselective gram scale synthesis of the Persea derived γ-lactones (+)-majoranolide and (+)-majoranolide B ...
A transition-metal-free azide-alkyne cycloaddition / hydroamination cascade reaction for the construction of triazole-fused piperazin-2-ones
A time-dependent, divergent synthesis of highly functionalized [1,2,3]triazolo[1,5-a]pyrazin-4(5H)-one (reaction time: 12 ...
Visible-light-induced decarboxylative cascade cyclization of acryloylbenzamides with N-hydroxyphthalimide esters via EDA complexes
Visible-light-induced decarboxylative cascade reactions of acryloylbenzamides with alkyl N-hydroxyphthalimide (NHP) esters...
Isocyanide-based multicomponent reactions for the synthesis of benzopyran derivatives with biological scaffolds
Benzopyrans (BZPs) are one of the most privileged and influential small O-heterocycles that form the core of many natural ...
Iridium (III)-Catalyzed β-Trifluoromethyl Enone Carbonyl Directed Regio-Selective C(sp2)-H Olefination
Due to the lower LUMO energy level at β-position of α,β-unsaturated-β-trifluoromethyl enone than its non-fluorinated count...
Selective α-oxidation of amides via visible-light-driven Iron-catalysis
The hydroxyl radical (•OH) as one of the highly reactive species can react unselectively with a wide range of chemicals. T...
Direct Synthesis of Phenanthrenyl Triflates from 1-Biphenylyl-2-diazo-2-aryl Ketones and Triflic Anhydride
A strategy for direct synthesis of phenanthrenyl triflates from 1-biphenylyl-2-diazo-2-aryl ketones and triflic anhydride ...
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