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Bionic bearing-inspired lubricating microspheres with Immunomodulatory effects for osteoarthritis therapy
Bionic bearing-inspired lubricating microspheres with Immunomodulatory effects for osteoarthritis therapy
Inflammatory infiltration and inappropriate friction remain the two main challenges in treating osteoarthritis (OA). An ef...
An imaging-guided self-amplifying photo-immunotherapeutic nanoparticle for STING pathway activation and enhanced cancer therapy
An imaging-guided self-amplifying photo-immunotherapeutic nanoparticle for STING pathway activation and enhanced cancer therapy
The stimulator of interferon genes (STING) pathway is a promising target in cancer immunotherapy. However, current nanomed...
Advancing liver cancer treatment with dual-targeting CAR-T therapy
Advancing liver cancer treatment with dual-targeting CAR-T therapy
Chimeric antigen receptor (CAR)-T cell therapy targeting glypican-3 (GPC3) has shown promise in the treatment of hepatocel...
Delivery of LOXL1-AS1-siRNAs using targeting peptide-engineered extracellular vesicles with focused ultrasound to suppress medulloblastoma metastasis
Delivery of LOXL1-AS1-siRNAs using targeting peptide-engineered extracellular vesicles with focused ultrasound to suppress medulloblastoma metastasis
Metastasis of medulloblastomas (MBs) is difficult to treat and remains the primary cause of death in children with this br...
NIR-IIb fluorescence antiangiogenesis copper nano-reaper for enhanced synergistic cancer therapy
NIR-IIb fluorescence antiangiogenesis copper nano-reaper for enhanced synergistic cancer therapy
The formation of blood vessel system under a relatively higher Cu2+ ion level is an indispensable precondition for tumor p...
A comprehensive review on Moringa oleifera nanoparticles: importance of polyphenols in nanoparticle synthesis, nanoparticle efficacy and their applications
A comprehensive review on Moringa oleifera nanoparticles: importance of polyphenols in nanoparticle synthesis, nanoparticle efficacy and their applications
Moringa oleifera is one of the popular functional foods that has been tremendously exploited for synthesis of a vast major...
M2 macrophage-derived exosomal miR-26b-5p regulates macrophage polarization and chondrocyte hypertrophy by targeting TLR3 and COL10A1 to alleviate osteoarthritis
M2 macrophage-derived exosomal miR-26b-5p regulates macrophage polarization and chondrocyte hypertrophy by targeting TLR3 and COL10A1 to alleviate osteoarthritis
Osteoarthritis (OA) is one of the most prevalent chronic musculoskeletal diseases among the elderly population. In this st...
Link between organic nanovescicles from vegetable kingdom and human cell physiology: intracellular calcium signalling
Link between organic nanovescicles from vegetable kingdom and human cell physiology: intracellular calcium signalling
Plant-derived nanovesicles (PDNVs) are a novelty in medical and agrifood environments, with several studies exploring thei...
Dual peptides-modified cationic liposomes for enhanced Lung cancer gene therapy by a gap junction regulating strategy
Dual peptides-modified cationic liposomes for enhanced Lung cancer gene therapy by a gap junction regulating strategy
Gene therapy for lung cancer has emerged as a novel tumor-combating strategy for its superior tumor specificity, low syste...
Nanogels with covalently bound and releasable trehalose for autophagy stimulation in atherosclerosis
Nanogels with covalently bound and releasable trehalose for autophagy stimulation in atherosclerosis
Atherosclerosis, cholesterol-driven plaque formation in arteries, is a complex multicellular disease which is a leading ca...
Investigation of nanotopography on SOCE mediated cell migration via live-cell
Investigation of nanotopography on SOCE mediated cell migration via live-cell
The exploration of cell response to nanotopography has attracted considerable attentions for years. This article focuses o...
Stem cell-derived small extracellular vesicles embedded into methacrylated hyaluronic acid wound dressings accelerate wound repair in a pressure model of diabetic ulcer
Stem cell-derived small extracellular vesicles embedded into methacrylated hyaluronic acid wound dressings accelerate wound repair in a pressure model of diabetic ulcer
Over the past years, the development of innovative smart wound dressings is revolutionizing wound care management and rese...
Identifying tumor cell-released extracellular vesicles as biomarkers for breast cancer diagnosis by a three-dimensional hydrogel-based electrochemical immunosensor
Identifying tumor cell-released extracellular vesicles as biomarkers for breast cancer diagnosis by a three-dimensional hydrogel-based electrochemical immunosensor
Tumor cell-released LC3+ extracellular vesicles (LC3+ EVs) participate in immunosuppression during autophagy and contribut...
Visualization of photothermal therapy by semiconducting polymer dots mediated photoacoustic detection in NIR II
Visualization of photothermal therapy by semiconducting polymer dots mediated photoacoustic detection in NIR II
Visualization of photothermal therapy mediated by photothermal transduction agents (PTAs) is important to promote individu...
Mesenchymal stem cells-derived extracellular vesicles protect against oxidative stress-induced xenogeneic biological root injury via adaptive regulation of the PI3K/Akt/NRF2 pathway
Mesenchymal stem cells-derived extracellular vesicles protect against oxidative stress-induced xenogeneic biological root injury via adaptive regulation of the PI3K/Akt/NRF2 pathway
Xenogeneic extracellular matrices (xECM) for cell support have emerged as a potential strategy for addressing the scarcity...
Correction: Injectable hydrogel loaded with lysed OK-432 and doxorubicin for residual liver cancer after incomplete radiofrequency ablation
Correction: Injectable hydrogel loaded with lysed OK-432 and doxorubicin for residual liver cancer after incomplete radiofrequency ablation
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Nano-modulators with the function of disrupting mitochondrial Ca2+ homeostasis and photothermal conversion for synergistic breast cancer therapy
Nano-modulators with the function of disrupting mitochondrial Ca2+ homeostasis and photothermal conversion for synergistic breast cancer therapy
Breast cancer treatment has been a global puzzle, and apoptosis strategies based on mitochondrial Ca2+ overload have attra...
Functionalized MoS2-nanosheets with NIR-Triggered nitric oxide delivery and photothermal activities for synergistic antibacterial and regeneration-promoting therapy
Functionalized MoS2-nanosheets with NIR-Triggered nitric oxide delivery and photothermal activities for synergistic antibacterial and regeneration-promoting therapy
Bacterial infection in skin and soft tissue has emerged as a critical concern. Overreliance on antibiotic therapy has led ...
Ropivacaine-loaded hydrogels for prolonged relief of chemotherapy-induced peripheral neuropathic pain and potentiated chemotherapy
Ropivacaine-loaded hydrogels for prolonged relief of chemotherapy-induced peripheral neuropathic pain and potentiated chemotherapy
Chemotherapy can cause severe pain for patients, but there are currently no satisfactory methods of pain relief. Enhancing...
Visualization of microRNA therapy in cancers delivered by small extracellular vesicles
Visualization of microRNA therapy in cancers delivered by small extracellular vesicles
MicroRNA (miRNA) delivery by extracellular vesicles (EVs) has recently inspired tremendous developments in cancer treatmen...
Extracellular vesicle-derived silk fibroin nanoparticles loaded with MFGE8 accelerate skin ulcer healing by targeting the vascular endothelial cells
Extracellular vesicle-derived silk fibroin nanoparticles loaded with MFGE8 accelerate skin ulcer healing by targeting the vascular endothelial cells
Reduced supplies of oxygen and nutrients caused by vascular injury lead to difficult-to-heal pressure ulcers (PU) in clini...
Extracellular vesicles in venous thromboembolism and pulmonary hypertension
Extracellular vesicles in venous thromboembolism and pulmonary hypertension
Venous thromboembolism (VTE) is a multifactorial disease, and pulmonary hypertension (PH) is a serious condition character...
Biomimetic composite hydrogel promotes new bone formation in rat bone defects through regulation of miR-19b-3p/WWP1 axis by loaded extracellular vesicles
Biomimetic composite hydrogel promotes new bone formation in rat bone defects through regulation of miR-19b-3p/WWP1 axis by loaded extracellular vesicles
This study aims to investigate the mechanism by which biomimetic composite hydrogels loaded with bone marrow mesenchymal s...
Colchicine delivered by a novel nanoparticle platform alleviates atherosclerosis by targeted inhibition of NF-κB/NLRP3 pathways in inflammatory endothelial cells
Colchicine delivered by a novel nanoparticle platform alleviates atherosclerosis by targeted inhibition of NF-κB/NLRP3 pathways in inflammatory endothelial cells
Atherosclerosis, a chronic inflammatory disease characterized by arterial plaque formation, is one of the most prominent c...
Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategies
Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategies
As a naturally occurring cytolytic peptide, melittin (MLT) not only exhibits a potent direct tumor cell-killing effect but...
Transplantation of active nucleus pulposus cells with a keep-charging hydrogel microsphere system to rescue intervertebral disc degeneration
Transplantation of active nucleus pulposus cells with a keep-charging hydrogel microsphere system to rescue intervertebral disc degeneration
Cell transplantation has been demonstrated as a promising approach in tissue regeneration. However, the reactive oxygen sp...
Fluorescence-enhanced dual signal lateral flow immunoassay for flexible and ultrasensitive detection of monkeypox virus
Fluorescence-enhanced dual signal lateral flow immunoassay for flexible and ultrasensitive detection of monkeypox virus
The outbreak of the monkeypox virus (MPXV) worldwide in 2022 highlights the need for a rapid and low-cost MPXV detection t...
Hypoxic preconditioned MSCs-derived small extracellular vesicles for photoreceptor protection in retinal degeneration
Hypoxic preconditioned MSCs-derived small extracellular vesicles for photoreceptor protection in retinal degeneration
Photoreceptor apoptosis is an important pathogenesis of retinal degeneration and a primary cause of vision loss with limit...
Zn-Shik-PEG nanoparticles alleviate inflammation and multi-organ damage in sepsis
Zn-Shik-PEG nanoparticles alleviate inflammation and multi-organ damage in sepsis
Sepsis is defined as a life-threatening organ dysfunction caused by excessive formation of reactive oxygen species (ROS) a...
Pericyte-derived exosomal miR-210 improves mitochondrial function and inhibits lipid peroxidation in vascular endothelial cells after traumatic spinal cord injury by activating JAK1/STAT3 signaling pathway
Pericyte-derived exosomal miR-210 improves mitochondrial function and inhibits lipid peroxidation in vascular endothelial cells after traumatic spinal cord injury by activating JAK1/STAT3 signaling pathway
Spinal cord injury (SCI) remains a significant health concern, with limited available treatment options. This condition po...
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