Excessive intake of fructose and alcohol aggravates high-fat diet-induced steatohepatitis and changes hepatic iron homeostasis

Ahmad S, Moriconi F, Naz N, Sultan S, Sheikh N, Ramadori G, Malik IA (2013) Ferritin L and Ferritin H are differentially located within hepatic and extra hepatic organs under physiological and acute phase conditions. Int J Clin Exp Pathol 6(4):622–629

CAS  PubMed  PubMed Central  Google Scholar 

Ahmad S, Sultan S, Naz N, Ahmad G, Alwahsh SM, Cameron S, Moriconi F, Ramadori G, Malik IA (2014) Regulation of iron uptake in primary culture rat hepatocytes: the role of acute-phase cytokines. Shock 41(4):337–345. https://doi.org/10.1097/SHK.0000000000000107

Article  CAS  PubMed  Google Scholar 

Alexeev EE, Lonnerdal B, Griffin IJ (2015) Effects of postnatal growth restriction and subsequent catch-up growth on neurodevelopment and glucose homeostasis in rats. BMC Physiol 15:3. https://doi.org/10.1186/s12899-015-0017-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ali N, Ferrao K, Mehta KJ (2023) Liver iron loading in alcohol-associated liver disease. Am J Pathol 193(10):1427–1439. https://doi.org/10.1016/j.ajpath.2022.08.010

Article  CAS  PubMed  Google Scholar 

Alkhateeb AA, Connor JR (2010) Nuclear ferritin: a new role for ferritin in cell biology. Biochim Biophys Acta 1800 8:793–797. https://doi.org/10.1016/j.bbagen.2010.03.017

Article  CAS  Google Scholar 

Allameh A, Niayesh-Mehr R, Aliarab A, Sebastiani G, Pantopoulos K (2023) Oxidative stress in liver pathophysiology and disease. Antioxidants (Basel). https://doi.org/10.3390/antiox12091653

Article  PubMed  Google Scholar 

Alwahsh SM, Gebhardt R (2017) Dietary fructose as a risk factor for non-alcoholic fatty liver disease (NAFLD). Arch Toxicol 91(4):1545–1563. https://doi.org/10.1007/s00204-016-1892-7

Article  CAS  PubMed  Google Scholar 

Alwahsh SM, Xu M, Schultze FC, Wilting J, Mihm S, Raddatz D, Ramadori G (2014a) Combination of alcohol and fructose exacerbates metabolic imbalance in terms of hepatic damage, dyslipidemia, and insulin resistance in rats. PLoS ONE 9(8):e104220. https://doi.org/10.1371/journal.pone.0104220

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alwahsh SM, Xu M, Seyhan HA, Ahmad S, Mihm S, Ramadori G, Schultze FC (2014b) Diet high in fructose leads to an overexpression of lipocalin-2 in rat fatty liver. World J Gastroenterol 20(7):1807–1821. https://doi.org/10.3748/wjg.v20.i7.1807

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alwahsh SM, Dwyer BJ, Forbes S, Thiel DH, Lewis PJ, Ramadori G (2017) Insulin production and resistance in different models of diet-induced obesity and metabolic syndrome. Int J Mol Sci. https://doi.org/10.3390/ijms18020285

Article  PubMed  PubMed Central  Google Scholar 

Amanzada A, Malik IA, Nischwitz M, Sultan S, Naz N, Ramadori G (2011) Myeloperoxidase and elastase are only expressed by neutrophils in normal and in inflamed liver. Histochem Cell Biol 135(3):305–315. https://doi.org/10.1007/s00418-011-0787-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anderson ER, Taylor M, Xue X, Martin A, Moons DS, Omary MB, Shah YM (2012) The hypoxia-inducible factor-C/EBPalpha axis controls ethanol-mediated hepcidin repression. Mol Cell Biol 32(19):4068–4077. https://doi.org/10.1128/MCB.00723-12

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bahr TM, Christensen RD, Ward DM, Meng F, Jackson LK, Doyle K, Christensen DR, Harvey AG, Yaish HM (2019) Ferritin in serum and urine: a pilot study. Blood Cells Mol Dis 76:59–62. https://doi.org/10.1016/j.bcmd.2019.02.001

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bridle K, Cheung TK, Murphy T, Walters M, Anderson G, Crawford DG, Fletcher LM (2006) Hepcidin is down-regulated in alcoholic liver injury: implications for the pathogenesis of alcoholic liver disease. Alcohol Clin Exp Res 30(1):106–112. https://doi.org/10.1111/j.1530-0277.2006.00002.x

Article  CAS  PubMed  Google Scholar 

Bulacio RP, Torres AM (2023) Novel finding of urinary erythropoietin as an early biomarker of cisplatin-induced nephrotoxicity. Int J Toxicol 42(3):269–277. https://doi.org/10.1177/10915818231152612

Article  CAS  PubMed  Google Scholar 

Choi J-H, Kim M-S, Yu H-J, Kim K-H, Lee H-S, Cho H-Y, Lee S-H (2014) Hepatoprotective effects of lactic acid-fermented garlic extracts on fatty liver-induced mouse by alcohol. J Korean Soc Food Sci Nutr 43(11):1642

Article  CAS  Google Scholar 

Christiansen H, Sheikh N, Saile B, Reuter F, Rave-Frank M, Hermann RM, Dudas J, Hille A, Hess CF, Ramadori G (2007) x-Irradiation in rat liver: consequent upregulation of hepcidin and downregulation of hemojuvelin and ferroportin-1 gene expression. Radiology 242(1):189–197. https://doi.org/10.1148/radiol.2421060083

Article  PubMed  Google Scholar 

Dinarello A, Betto RM, Diamante L, Tesoriere A, Ghirardo R, Cioccarelli C, Meneghetti G, Peron M, Laquatra C, Tiso N, Martello G, Argenton F (2023) STAT3 and HIF1alpha cooperatively mediate the transcriptional and physiological responses to hypoxia. Cell Death Discov 9(1):226. https://doi.org/10.1038/s41420-023-01507-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dongiovanni P, Lanti C, Gatti S, Rametta R, Recalcati S, Maggioni M, Fracanzani AL, Riso P, Cairo G, Fargion S, Valenti L (2015) High fat diet subverts hepatocellular iron uptake determining dysmetabolic iron overload. PLoS ONE 10(2):e0116855. https://doi.org/10.1371/journal.pone.0116855

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dostalikova-Cimburova M, Balusikova K, Kratka K, Chmelikova J, Hejda V, Hnanicek J, Neubauerova J, Vranova J, Kovar J, Horak J (2014) Role of duodenal iron transporters and hepcidin in patients with alcoholic liver disease. J Cell Mol Med 18(9):1840–1850. https://doi.org/10.1111/jcmm.12310

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fefelova N, Wongjaikam S, Pamarthi SH, Siri-Angkul N, Comollo T, Kumari A, Garg V, Ivessa A, Chattipakorn SC, Chattipakorn N, Gwathmey JK, Xie LH (2023) Deficiency of mitochondrial calcium uniporter abrogates iron overload-induced cardiac dysfunction by reducing ferroptosis. Basic Res Cardiol 118(1):21. https://doi.org/10.1007/s00395-023-00990-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fujita N, Takei Y (2011) Iron overload in nonalcoholic steatohepatitis. Adv Clin Chem 55:105–132. https://doi.org/10.1016/b978-0-12-387042-1.00006-x

Article  CAS  PubMed  Google Scholar 

Handa P, Vemulakonda AL, Maliken BD, Morgan-Stevenson V, Nelson JE, Dhillon BK, Hennessey KA, Gupta R, Yeh MM, Kowdley KV (2017) Differences in hepatic expression of iron, inflammation and stress-related genes in patients with nonalcoholic steatohepatitis. Ann Hepatol 16(1):77–85. https://doi.org/10.5604/16652681.1226818

Article  CAS  PubMed  Google Scholar 

Harrison-Findik DD, Lu S, Zmijewski EM, Jones J, Zimmerman MC (2013) Effect of alcohol exposure on hepatic superoxide generation and hepcidin expression. World J Biol Chem 4(4):119–130. https://doi.org/10.4331/wjbc.v4.i4.119

Article  PubMed  PubMed Central  Google Scholar 

Heikkinen S, Argmann CA, Champy MF, Auwerx J (2007) Evaluation of glucose homeostasis. Curr Protoc Mol Biol. https://doi.org/10.1002/0471142727.mb29b03s77

Article  PubMed  Google Scholar 

Jenkitkasemwong S, Wang CY, Coffey R, Zhang W, Chan A, Biel T, Kim JS, Hojyo S, Fukada T, Knutson MD (2015) SLC39A14 is required for the development of hepatocellular iron overload in murine models of hereditary hemochromatosis. Cell Metab 22(1):138–150. https://doi.org/10.1016/j.cmet.2015.05.002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kanbay M, Altintas A, Yavuz F, Copur S, Sanchez-Lozada LG, Lanaspa MA, Johnson RJ (2023) Responses to hypoxia: how fructose metabolism and hypoxia-inducible factor-1a pathways conve

Comments (0)

No login
gif