Combined treatment of melatonin and alpha-lipoic acid facilitates wound healing in rat palate: A macroscopic, histological, and immunohistochemical study

Adikwu E, Adikwu E, Braimbaifa N, Wolfe Obianime A (2015) Melatonin and alpha-lipoic acid: possible mitigants for lopinavir/ritonavir-induced renal toxicity in male albino rats. Physiol Pharmacol 19:232–240

Google Scholar 

Adikwu E, Ebinyo NC, Bokolo B (2020) Melatonin and alpha lipoic acid attenuate methotrexate/cisplatin-induced kidney toxicity in albino rats. J Nephropharmacol 9(2):e17

Article  CAS  Google Scholar 

Andersson L (2013) Epidemiology of traumatic dental injuries. J Endod 39(3):S2-5. https://doi.org/10.1016/J.JOEN.2012.11.021

Article  PubMed  Google Scholar 

Arita S, Hatta M, Uchida K, Kita T, Okamura K, Ryu T, Murakami H, Sakagami R, Yamazaki J (2018) Peptidylarginine deiminase is involved in maintaining the cornified oral mucosa of rats. J Periodontol Res 53(5):750–761. https://doi.org/10.1111/JRE.12561

Article  CAS  Google Scholar 

Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M (2008) Growth factors and cytokines in wound healing. Wound Repair Regen 16(5):585–601. https://doi.org/10.1111/J.1524-475X.2008.00410.X

Article  PubMed  Google Scholar 

Chitimus DM, Popescu MR, Voiculescu SE, Panaitescu AM, Pavel B, Zagrean L, Zagrean AM (2020) Melatonin’s impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease. Biomolecules 10(9):1–28. https://doi.org/10.3390/BIOM10091211

Article  Google Scholar 

Claustrat B, Brun J, Chazot G (2005) The basic physiology and pathophysiology of melatonin. Sleep Med Rev 9(1):11–24. https://doi.org/10.1016/J.SMRV.2004.08.001

Article  PubMed  Google Scholar 

Comino-Sanz IM, López-Franco MD, Castro B, Pancorbo-Hidalgo PL (2021) The role of antioxidants on wound healing: a review of the current evidence. J Clin Med 10(16):3558. https://doi.org/10.3390/JCM10163558

Article  PubMed  PubMed Central  CAS  Google Scholar 

Correa VLR, Martins JA, de Souza TR, Rincon GDCN, Miguel MP, de Menezes LB, Amaral AC (2020) Melatonin loaded lecithin-chitosan nanoparticles improved the wound healing in diabetic rats. Int J Biol Macromol 162:1465–1475. https://doi.org/10.1016/J.IJBIOMAC.2020.08.027

Article  Google Scholar 

Cui HS, Cho YS, Joo SY, Mun CH, Seo CH, Kim JB (2019) Wound healing potential of low temperature plasma in human primary epidermal keratinocytes. Tissue Eng Regen Med 16(6):585–593. https://doi.org/10.1007/S13770-019-00215-W

Article  PubMed  PubMed Central  CAS  Google Scholar 

da Silva JGM, de Melo IMF, Alves ÉR, de Oliveira GM, da Silva AA, Cavalcanti IMF, Araujo DN, Pinto FCM, de Andrade Aguiar JL, Teixeira VW, Teixeira ÁAC (2024) Melatonin and bacterial cellulose regulate the expression of inflammatory cytokines, VEGF, PCNA, and collagen in cutaneous wound healing in diabetic rats. Polymers 16(18):2611. https://doi.org/10.3390/polym16182611

Article  PubMed  PubMed Central  CAS  Google Scholar 

de Souza TR, Rocha VL, de Rincon GC, de Oliveira Junior ER, Celes MRN, Lima EM, Amaral AC, Miguel MP, de Menezes LB (2022) Topical application of melatonin accelerates the maturation of skin wounds and increases collagen deposition in a rat model of diabetes. J Tissue Viability 31(4):606–613

Article  PubMed  Google Scholar 

Kim Y, Lim KM (2021) Skin barrier dysfunction and filaggrin. Arch Pharm Res 44(1):36–48. https://doi.org/10.1007/S12272-021-01305-X

Article  PubMed  CAS  Google Scholar 

Kim TK, Kleszczyński K, Janjetovic Z, Sweatman T, Lin Z, Li W, Reiter RJ, Fischer TW, Slominski AT (2013) Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells. FASEB J 27(7):2742–2755. https://doi.org/10.1096/fj.12-224691

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kim K, Kim J, Kim H, Sung GY (2021) Effect of α-lipoic acid on the development of human skin equivalents using a pumpless skin-on-a-chip model. Int J Mol Sci 22(4):2160. https://doi.org/10.3390/IJMS22042160

Article  PubMed  PubMed Central  CAS  Google Scholar 

Konturek PC, Konturek SJ, Burnat G, Brzozowski T, Brzozowska I, Reiter RJ (2008) Dynamic physiological and molecular changes in gastric ulcer healing achieved by melatonin and its precursor L-tryptophan in rats. J Pineal Res 45(2):180–190. https://doi.org/10.1111/J.1600-079X.2008.00574.X

Article  PubMed  CAS  Google Scholar 

Kozlovsky A, Artzi Z, Hirshberg A, Israeli-Tobias C, Reich L (2007) Effect of local antimicrobial agents on excisional palatal wound healing: a clinical and histomorphometric study in rats. J Clin Periodontol 34(2):164–171. https://doi.org/10.1111/J.1600-051X.2006.01033.X

Article  PubMed  Google Scholar 

Kurokawa I, Mizutani H, Kusumoto K, Nishijima S, Tsujita-Kyutoku M, Shikata N, Tsubura A (2006) Cytokeratin, filaggrin, and p63 expression in reepithelialization during human cutaneous wound healing. Wound Repair Regen 14(1):38–45. https://doi.org/10.1111/J.1524-475X.2005.00086.X

Article  PubMed  Google Scholar 

Lateef H, Aslam MN, Stevens MJ, Varani J (2005) Pretreatment of diabetic rats with lipoic acid improves healing of subsequently-induced abrasion wounds. Arch Dermatol Res 297(2):75–83. https://doi.org/10.1007/S00403-005-0576-6

Article  PubMed  CAS  Google Scholar 

LaVan FB, Hunt TK (1990) Oxygen and wound healing. Clin Plast Surg 17(3):463–472. https://doi.org/10.1016/S0094-1298(20)30621-0

Article  PubMed  CAS  Google Scholar 

Li D, Tian Z, Tang W, Zhang J, Lu L, Sun Z, Zhou Z, Fan F (2016) The protective effects of 5-methoxytryptamine-α-lipoic acid on ionizing radiation-induced hematopoietic injury. Int J Mol Sci 17(6):935. https://doi.org/10.3390/IJMS17060935

Article  PubMed  PubMed Central  Google Scholar 

Li Q, Liu K, Jiang T, Ren S, Kang Y, Li W, Yao H, Yang X, Dai H, Chen Z (2021) Injectable and self-healing chitosan-based hydrogel with MOF-loaded α-lipoic acid promotes diabetic wound healing. Mater Sci Eng C Mater Biol Appl 131:112519. https://doi.org/10.1016/J.MSEC.2021.112519

Article  PubMed  CAS  Google Scholar 

López-Burillo S, Tan DX, Mayo JC, Sainz RM, Manchester LC, Reiter RJ (2003) Melatonin, xanthurenic acid, resveratrol, EGCG, vitamin C and α-lipoic acid differentially reduce oxidative DNA damage induced by fenton reagents: a study of their individual and synergistic actions. J Pineal Res 34:269–277. https://doi.org/10.1034/J.1600-079X.2003.00041.X

Article  PubMed  Google Scholar 

McGrath JA, Uitto J (2008) The filaggrin story: novel insights into skin-barrier function and disease. Trends Mol Med 14:20–27. https://doi.org/10.1016/J.MOLMED.2007.10.006

Article  PubMed  CAS  Google Scholar 

Mukherjee R, Banerjee S, Joshi N, Singh PK, Baxi D, Ramachandran AV (2011) A combination of melatonin and alpha-lipoic acid has greater cardioprotective effect than either of them singly against cadmium-induced oxidative damage. Cardiovasc Toxicol 11:78–88. https://doi.org/10.1007/s12012-010-9092-9

Article  PubMed  CAS  Google Scholar 

Narda M, Brown A, Muscatelli-Groux B, Grimaud JA, Granger C (2020) Epidermal and dermal hallmarks of photoaging are prevented by treatment with night serum containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: in vitro and ex vivo studies. Dermatol Ther 10:191–202. https://doi.org/10.1007/s13555-019-00349-8

Article  Google Scholar 

Nauta A, Gurtner GC, Longaker MT (2011) Wound healing and regenerative strategies. Oral Dis 17:541–549. https://doi.org/10.1111/j.1601-0825.2011.01787.x

Article  PubMed  CAS  Google Scholar 

Ozler M, Simsek K, Ozkan C, Akgul EO, Topal T, Oter S, Korkmaz A (2010) Comparison of the effect of topical and systemic melatonin administration on delayed wound healing in rats that underwent pinealectomy. Scand J Clin Lab Invest 70:447–452. https://doi.org/10.3109/00365513.2010.506926

Article  PubMed  CAS  Google Scholar 

Pugazhenthi K, Kapoor M, Clarkson AN, Hall I, Appleton I (2008) Melatonin accelerates the process of wound repair in full-thickness incisional wounds. J Pineal Res 44:387–396. https://doi.org/10.1111/J.1600-079X.2007.00541.X

Article  PubMed  CAS 

Comments (0)

No login
gif