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Fatty Acids Dysregulation Correlates with Lung Function in Idiopathic Pulmonary Fibrosis
Fatty Acids Dysregulation Correlates with Lung Function in Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a poor survival rate and undefined molecular mechan...
Fibrinogen Gamma Chain Mediates Airway Inflammation and Remodeling Through the Focal Adhesion and TGF-β/Smad2 Pathways in Chronic Obstructive Pulmonary Disease
Fibrinogen Gamma Chain Mediates Airway Inflammation and Remodeling Through the Focal Adhesion and TGF-β/Smad2 Pathways in Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by chronic airway inflammation and rem...
Synergistic Interactions Between the Quinolone-Derived Compound HT61 and Tobramycin Against a Range of Clinical Isolates of In Vitro
Synergistic Interactions Between the Quinolone-Derived Compound HT61 and Tobramycin Against a Range of Clinical Isolates of In Vitro
Antimicrobial-resistant pathogens such as Pseudomonas aeruginosa (P. aeruginosa) represent a significant challeng...
COPD Patients on Inhaled Corticosteroids Managed in Primary Care: Proportion of Patients Potentially Eligible for Biologic Therapy
COPD Patients on Inhaled Corticosteroids Managed in Primary Care: Proportion of Patients Potentially Eligible for Biologic Therapy
Christenson SA, Smith BM, Bafadhel M, Putcha N (2022) Chronic obstructive pulmonary disease. Lancet 399(10342):2227–2242. ...
Prevalence of Laryngeal Abnormal Sensation in a Hospital Worker Population and its Association with Cough Hypersensitivity
Prevalence of Laryngeal Abnormal Sensation in a Hospital Worker Population and its Association with Cough Hypersensitivity
Cough hypersensitivity is characterized by exaggerated cough responses to mild stimuli, which is frequently associated wit...
State of the Art Review: Glucagon-Like Peptide-1 in Obesity-Related Asthma
State of the Art Review: Glucagon-Like Peptide-1 in Obesity-Related Asthma
Asthma is a heterogeneous condition characterized by chronic airway inflammation, airway hyperresponsiveness, and mucin hy...
Acute Right Ventricular Failure in the Medical ICU
Acute Right Ventricular Failure in the Medical ICU
Right ventricular failure (RVF) is a complex clinical syndrome resulting from anatomical and physiological dysfunction of ...
A Prospective Study of Safety and the Incremental Diagnostic Value of Transbronchial Cryobiopsy Incorporated into Robotic-Assisted Bronchoscopy in a Cancer Population
A Prospective Study of Safety and the Incremental Diagnostic Value of Transbronchial Cryobiopsy Incorporated into Robotic-Assisted Bronchoscopy in a Cancer Population
Shape-sensing robotic-assisted bronchoscopy (ssRAB) combined with intraoperative imaging optimizes tool-lesion relationshi...
Sputum Eosinophils Predict Annual Remission of the Frequent Exacerbator Phenotype in COPD: A Prospective Cohort Study
Sputum Eosinophils Predict Annual Remission of the Frequent Exacerbator Phenotype in COPD: A Prospective Cohort Study
The frequent-exacerbator (FE) phenotype guides COPD management, yet its year-to-year stability and the role of airway eosi...
Four Methods to Determine Expiratory Time Constants from Spirometry and Their Sensitivity to Detect Airway Obstruction
Four Methods to Determine Expiratory Time Constants from Spirometry and Their Sensitivity to Detect Airway Obstruction
The expiratory time constant (TC), reflecting the rate of lung emptying, has emerged as a marker of early small airway dis...
Stratified Comparison of Risk Factors for Mild Versus Moderate-to-Severe Bronchopulmonary Dysplasia in Very Preterm Infants (< 32 Weeks Gestational Age)
Stratified Comparison of Risk Factors for Mild Versus Moderate-to-Severe Bronchopulmonary Dysplasia in Very Preterm Infants (< 32 Weeks Gestational Age)
Bronchopulmonary dysplasia (BPD) remains a significant complication in very preterm infants (&lt; 32 weeks gesta...
Oxygen Saturation Sample Entropy, a Novel Diagnostic Tool in Sleep Disordered Breathing
Oxygen Saturation Sample Entropy, a Novel Diagnostic Tool in Sleep Disordered Breathing
To assess whether a Network Physiology approach using Sample Entropy and Transfer Entropy can be applied to simple physiol...
Sputum from Individuals with Primary Ciliary Dyskinesia Drives M2-like Macrophage Polarization
Sputum from Individuals with Primary Ciliary Dyskinesia Drives M2-like Macrophage Polarization
Primary ciliary dyskinesia (PCD) is a rare, congenital condition in which impaired ciliary function leads to bronchiectasi...
HU308, A Selective Cannabinoid Type-2 Receptor Agonist, Mitigates SARS-CoV-2 Spike Protein–Induced Acute Lung Injury in Mice
HU308, A Selective Cannabinoid Type-2 Receptor Agonist, Mitigates SARS-CoV-2 Spike Protein–Induced Acute Lung Injury in Mice
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ...
Repetitive Exposure to Nicotine-Free Vaping Impairs Airway Defences and Delays Recovery
Repetitive Exposure to Nicotine-Free Vaping Impairs Airway Defences and Delays Recovery
E-cigarette use, or vaping, is increasing in prevalence, especially among adolescents. There is a paucity of information o...
Clinical History, Spirometry, and CT Features Can Predict Dyspnea in Smokers with and without Spirometry-Defined COPD
Clinical History, Spirometry, and CT Features Can Predict Dyspnea in Smokers with and without Spirometry-Defined COPD
Dyspnea is common in smokers with or without chronic obstructive pulmonary disease. Its multifactorial nature makes it cha...
Kappa and Mu Opioid Receptors in Chronic Cough: Current Evidence and Future Treatment
Kappa and Mu Opioid Receptors in Chronic Cough: Current Evidence and Future Treatment
Chronic cough is a significant burden on patient quality of life and is associated with poor health outcomes. Chronic coug...
Efficacy and Safety of Superior Laryngeal Nerve Block in the Management of Neuropathic Cough: A Systematic Review
Efficacy and Safety of Superior Laryngeal Nerve Block in the Management of Neuropathic Cough: A Systematic Review
To systematically review the efficacy and safety, both short and long-term, of superior laryngeal nerve block (SLNB) for m...
Role of Slc7a11 in Bleomycin-Induced Lung Injury
Role of Slc7a11 in Bleomycin-Induced Lung Injury
Oxidative stress has been implicated in lung injury and repair. We seek to understand how alterations in the plasma redox ...
Pericytes in the Pulmonary Microenvironment: Guardians or Adversaries?
Pericytes in the Pulmonary Microenvironment: Guardians or Adversaries?
Pericytes, specialized mural cells residing within the basement membrane of pulmonary microvessels, participate in various...
Impact of Asthma and Obstructive Sleep Apnea on Central Airways Resistance During Pregnancy
Impact of Asthma and Obstructive Sleep Apnea on Central Airways Resistance During Pregnancy
Pregnancy is a risk factor for the development of obstructive sleep apnea (OSA) and for worsening of asthma; the interacti...
Roles of Pyruvate Kinase M2 in Pulmonary Diseases: What Do We Know So Far?
Roles of Pyruvate Kinase M2 in Pulmonary Diseases: What Do We Know So Far?
Pyruvate kinase M2 (PKM2) is a critical enzyme regulating cell metabolism and growth under different physiological conditi...
Overexpression of BPIFB4 Alleviates COPD Inflammatory Damage by Inhibiting M1 Macrophage Activation via the PI3K/AKT Pathway
Overexpression of BPIFB4 Alleviates COPD Inflammatory Damage by Inhibiting M1 Macrophage Activation via the PI3K/AKT Pathway
Macrophage polarization is essential for inflammatory regulation in COPD. The precise role of BPI Fold-Containing Family B...
Genetic Factors Explain Half of the Individual Susceptibility to Chronic Bronchitis, Airflow Obstruction and COPD Regardless of the Spirometric Definition: A Nationwide Twin Study
Genetic Factors Explain Half of the Individual Susceptibility to Chronic Bronchitis, Airflow Obstruction and COPD Regardless of the Spirometric Definition: A Nationwide Twin Study
Smoking is a major risk factor for lung function decline and chronic obstructive pulmonary disease (COPD), but the individ...
Right Ventricular-Pulmonary Arterial Uncoupling Thresholds in Acute Pulmonary Embolism
Right Ventricular-Pulmonary Arterial Uncoupling Thresholds in Acute Pulmonary Embolism
Right ventricle (RV) dysfunction in the setting of acute pulmonary embolism (PE) is associated with worse outcomes. The ra...
The Advantages of FEV Percent Predicted Change During Bronchial Challenge Testing
The Advantages of FEV Percent Predicted Change During Bronchial Challenge Testing
The methacholine challenge requires a 20% fall in forced expiratory volume in one second (FEV1). The fall is measured as l...
Cmpk2 Protects Against Acute Lung Injury in Mice
Cmpk2 Protects Against Acute Lung Injury in Mice
Acute respiratory distress syndrome (ARDS)/Acute lung injury (ALI), characterized by severe hypoxemia and pulmonary edema,...
Prophylactic Inhaled Antibiotics for Ventilator-Associated Pneumonia: A Systematic Review and Meta-Analysis of Incidence and Mortality Outcomes
Prophylactic Inhaled Antibiotics for Ventilator-Associated Pneumonia: A Systematic Review and Meta-Analysis of Incidence and Mortality Outcomes
Ventilator-associated pneumonia (VAP) is a common ICU complication linked to high morbidity and mortality. Inhaled antibio...
Electronic-Nose Technology for Lung Cancer Detection: A Non-Invasive Diagnostic Revolution
Electronic-Nose Technology for Lung Cancer Detection: A Non-Invasive Diagnostic Revolution
Lung cancer (LC) remains a leading cause of cancer-related mortality worldwide, primarily due to late-stage diagnosis and ...
Effectiveness of Nintedanib in Progressive Pulmonary Fibrosis Assessed by Progression Criteria: An Italian, Observational, Multicenter Study
Effectiveness of Nintedanib in Progressive Pulmonary Fibrosis Assessed by Progression Criteria: An Italian, Observational, Multicenter Study
Pulmonary fibrosis is defined as progressive based on the combination of radiological, clinical, and functional criteria. ...
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