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Kappa and Mu Opioid Receptors in Chronic Cough: Current Evidence and Future Treatment
Kappa and Mu Opioid Receptors in Chronic Cough: Current Evidence and Future Treatment
Chronic cough is a significant burden on patient quality of life and is associated with poor health outcomes. Chronic coug...
Efficacy and Safety of Superior Laryngeal Nerve Block in the Management of Neuropathic Cough: A Systematic Review
Efficacy and Safety of Superior Laryngeal Nerve Block in the Management of Neuropathic Cough: A Systematic Review
To systematically review the efficacy and safety, both short and long-term, of superior laryngeal nerve block (SLNB) for m...
Role of Slc7a11 in Bleomycin-Induced Lung Injury
Role of Slc7a11 in Bleomycin-Induced Lung Injury
Oxidative stress has been implicated in lung injury and repair. We seek to understand how alterations in the plasma redox ...
Pericytes in the Pulmonary Microenvironment: Guardians or Adversaries?
Pericytes in the Pulmonary Microenvironment: Guardians or Adversaries?
Pericytes, specialized mural cells residing within the basement membrane of pulmonary microvessels, participate in various...
Impact of Asthma and Obstructive Sleep Apnea on Central Airways Resistance During Pregnancy
Impact of Asthma and Obstructive Sleep Apnea on Central Airways Resistance During Pregnancy
Pregnancy is a risk factor for the development of obstructive sleep apnea (OSA) and for worsening of asthma; the interacti...
Roles of Pyruvate Kinase M2 in Pulmonary Diseases: What Do We Know So Far?
Roles of Pyruvate Kinase M2 in Pulmonary Diseases: What Do We Know So Far?
Pyruvate kinase M2 (PKM2) is a critical enzyme regulating cell metabolism and growth under different physiological conditi...
Overexpression of BPIFB4 Alleviates COPD Inflammatory Damage by Inhibiting M1 Macrophage Activation via the PI3K/AKT Pathway
Overexpression of BPIFB4 Alleviates COPD Inflammatory Damage by Inhibiting M1 Macrophage Activation via the PI3K/AKT Pathway
Macrophage polarization is essential for inflammatory regulation in COPD. The precise role of BPI Fold-Containing Family B...
Genetic Factors Explain Half of the Individual Susceptibility to Chronic Bronchitis, Airflow Obstruction and COPD Regardless of the Spirometric Definition: A Nationwide Twin Study
Genetic Factors Explain Half of the Individual Susceptibility to Chronic Bronchitis, Airflow Obstruction and COPD Regardless of the Spirometric Definition: A Nationwide Twin Study
Smoking is a major risk factor for lung function decline and chronic obstructive pulmonary disease (COPD), but the individ...
Right Ventricular-Pulmonary Arterial Uncoupling Thresholds in Acute Pulmonary Embolism
Right Ventricular-Pulmonary Arterial Uncoupling Thresholds in Acute Pulmonary Embolism
Right ventricle (RV) dysfunction in the setting of acute pulmonary embolism (PE) is associated with worse outcomes. The ra...
The Advantages of FEV Percent Predicted Change During Bronchial Challenge Testing
The Advantages of FEV Percent Predicted Change During Bronchial Challenge Testing
The methacholine challenge requires a 20% fall in forced expiratory volume in one second (FEV1). The fall is measured as l...
Cmpk2 Protects Against Acute Lung Injury in Mice
Cmpk2 Protects Against Acute Lung Injury in Mice
Acute respiratory distress syndrome (ARDS)/Acute lung injury (ALI), characterized by severe hypoxemia and pulmonary edema,...
Prophylactic Inhaled Antibiotics for Ventilator-Associated Pneumonia: A Systematic Review and Meta-Analysis of Incidence and Mortality Outcomes
Prophylactic Inhaled Antibiotics for Ventilator-Associated Pneumonia: A Systematic Review and Meta-Analysis of Incidence and Mortality Outcomes
Ventilator-associated pneumonia (VAP) is a common ICU complication linked to high morbidity and mortality. Inhaled antibio...
Electronic-Nose Technology for Lung Cancer Detection: A Non-Invasive Diagnostic Revolution
Electronic-Nose Technology for Lung Cancer Detection: A Non-Invasive Diagnostic Revolution
Lung cancer (LC) remains a leading cause of cancer-related mortality worldwide, primarily due to late-stage diagnosis and ...
Effectiveness of Nintedanib in Progressive Pulmonary Fibrosis Assessed by Progression Criteria: An Italian, Observational, Multicenter Study
Effectiveness of Nintedanib in Progressive Pulmonary Fibrosis Assessed by Progression Criteria: An Italian, Observational, Multicenter Study
Pulmonary fibrosis is defined as progressive based on the combination of radiological, clinical, and functional criteria. ...
Use of Telomere Length as a Biomarker in Idiopathic Pulmonary Fibrosis
Use of Telomere Length as a Biomarker in Idiopathic Pulmonary Fibrosis
Telomere shortening, a hallmark of cellular aging, is associated with poor outcomes in idiopathic pulmonary fibrosis (IPF)...
Soluble Transferrin Receptor-1 in Pulmonary Hypertension Associated with COPD
Soluble Transferrin Receptor-1 in Pulmonary Hypertension Associated with COPD
The pulmonary vascular involvement of COPD ranges from severe airway obstruction without pulmonary hypertension (PH) to mi...
From Glucotoxicity to Lung Injury: Emerging Perspectives on Diabetes-Associated Respiratory Complications
From Glucotoxicity to Lung Injury: Emerging Perspectives on Diabetes-Associated Respiratory Complications
Emerging evidence highlights glucose toxicity as a pivotal driver of diabetic respiratory complications, characterized by ...
Mucus Transpiration as the Basis for Chronic Cough and Cough Hypersensitivity
Mucus Transpiration as the Basis for Chronic Cough and Cough Hypersensitivity
Chronic cough is characterized by a state of cough hypersensitivity. We analyze the process of transpiration, by which wat...
Efficacy and Safety of Re-administration of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor (EGFR-TKI) After EGFR-TKI-Induced Interstitial Lung Disease (CS-Lung-005)
Efficacy and Safety of Re-administration of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor (EGFR-TKI) After EGFR-TKI-Induced Interstitial Lung Disease (CS-Lung-005)
This study investigated the safety and efficacy of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI)...
Predictors of Early and Late Lung Function Improvement in Severe Eosinophilic Asthma on Type2-Biologics in the PRISM Study
Predictors of Early and Late Lung Function Improvement in Severe Eosinophilic Asthma on Type2-Biologics in the PRISM Study
The determinants linked to the short- and long-term improvement in lung function in patients with severe eosinophilic asth...
The Therapeutic Landscape in Chronic Cough
The Therapeutic Landscape in Chronic Cough
In recent years, there has been a substantial increase in the development of antitussive therapies and the first new&n...
Elevated Eosinophil Counts in Acute Exacerbations of Bronchiectasis: Unveiling a Distinct Clinical Phenotype
Elevated Eosinophil Counts in Acute Exacerbations of Bronchiectasis: Unveiling a Distinct Clinical Phenotype
Non-cystic fibrosis bronchiectasis is a chronic respiratory disease characterized by bronchial dilation. However, the sign...
Cardiovascular Events with the Use of Long-Acting Muscarinic Receptor Antagonists: An Analysis of the FAERS Database 2020–2023
Cardiovascular Events with the Use of Long-Acting Muscarinic Receptor Antagonists: An Analysis of the FAERS Database 2020–2023
This study aimed to examine reports of cardiovascular adverse events (CV AEs) observed in the real-world during treatment ...
Missing Nuts and Bolts: Translating Pulmonary Fibrosis from Preclinical Murine Models to Human Clinical Trials
Missing Nuts and Bolts: Translating Pulmonary Fibrosis from Preclinical Murine Models to Human Clinical Trials
IKS is supported in part by the National Institutes of Health NIH R01HL142543, the National Institute of General Medical S...
Identification of Idiopathic Pulmonary Fibrosis and Prediction of Disease Severity via Machine Learning Analysis of Comprehensive Metabolic Panel and Complete Blood Count Data
Identification of Idiopathic Pulmonary Fibrosis and Prediction of Disease Severity via Machine Learning Analysis of Comprehensive Metabolic Panel and Complete Blood Count Data
Diagnosis of idiopathic pulmonary fibrosis (IPF) typically relies on high-resolution computed tomography imaging (HRCT) or...
Characterization of Codeine Treatment Responders Among Patients with Refractory or Unexplained Chronic Cough: A Prospective Real-World Cohort Study
Characterization of Codeine Treatment Responders Among Patients with Refractory or Unexplained Chronic Cough: A Prospective Real-World Cohort Study
Codeine is a narcotic antitussive often considered for managing patients with refractory or unexplained chronic cough. Thi...
Genetic Testing Goes Beyond Imaging and Histological Evaluation in Pleuroparenchymal Fibroelastosis
Genetic Testing Goes Beyond Imaging and Histological Evaluation in Pleuroparenchymal Fibroelastosis
Lung biopsy remains the gold standard in the diagnosis of fibrotic interstitial lung disease (F-ILD), but there is a growi...
Pressure Support Ventilation Versus T-piece as Spontaneous Breathing Trials for Extubation of Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Pressure Support Ventilation Versus T-piece as Spontaneous Breathing Trials for Extubation of Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Weaning patients with COPD from mechanical ventilation (MV) presents a challenge, as literature on this topic is limited. ...
Circulating Osteopontin Predicts Clinical and Radiological Response in First-Line Treatment of Advanced Non-Small Cell Lung Cancer
Circulating Osteopontin Predicts Clinical and Radiological Response in First-Line Treatment of Advanced Non-Small Cell Lung Cancer
Pembrolizumab-based regimens are conditioned by the expression of PD-L1, but durable response rate is limited by innate an...
Human Bronchial Epithelial Cell Transcriptome Changes in Response to Serum from Patients with Different Status of Inflammation
Human Bronchial Epithelial Cell Transcriptome Changes in Response to Serum from Patients with Different Status of Inflammation
To investigate the transcriptome of human bronchial epithelial cells (HBEC) in response to serum from patients with differ...
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