Mucus Transpiration as the Basis for Chronic Cough and Cough Hypersensitivity

Chung KF, McGarvey L, Song WJ, Chang AB, Lai K, Canning BJ et al (2022) Cough hypersensitivity and chronic cough. Nat Rev Dis Primers 8(1):45

Article  PubMed  PubMed Central  Google Scholar 

Chung KF, McGarvey L, Mazzone SB (2013) Chronic cough as a neuropathic disorder. Lancet Respir Med. 1(5):414–422

Article  PubMed  Google Scholar 

Edwards DA, Chung KF (2023) Breathing dry air promotes inflammation, activates neural pathways and disrupts clearance by osmotic stresses imparted on airway epithelia. Q Rev Biophys Discov 4:e3

Google Scholar 

Purokivi M, Koskela H, Brannan JD, Kontra K (2011) Cough response to isocapnic hyperpnoea of dry air and hypertonic saline are interrelated. Cough 7(1):8

Article  PubMed  PubMed Central  Google Scholar 

Eklund LM, Sköndal Å, Tufvesson E, Sjöström R, Söderström L, Hanstock HG, Sandström T, Stenfors N (2022) Cold air exposure at - 15 °C induces more airway symptoms and epithelial stress during heavy exercise than rest without aggravated airway constriction. Eur J Appl Physiol 122(12):2533–2544

Article  CAS  PubMed  PubMed Central  Google Scholar 

Musseau D (2016) Mouth breathing and some of its consequences. Int J Orthod Milwaukee 27(2):51–54

PubMed  Google Scholar 

Simpson AJ, Romer LM, Kippelen P (2017) Exercise-induced dehydration alters pulmonary function but does not modify airway responsiveness to dry air in athletes with mild asthma. J Appl Physiol 122(5):1329–1335

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wei W, Sun Z, He S, Zhang W, Chen S, Cao YN, Wang N (2022) Mechanical ventilation induces lung and brain injury through ATP production, P2Y1 receptor activation and dopamine release. Bioeng 13(2):2346–2359

CAS  Google Scholar 

Zhang M, Sykes DL, Sadofsky LR, Morice AH (2022) ATP, an attractive target for the treatment of refractory chronic cough. Purinergic Signal 18(3):289–305

Article  CAS  PubMed  PubMed Central  Google Scholar 

Romaszko-Wojtowicz A, Cymes I, Dragańska E, Doboszyńska A, Romaszko J, Glińska-Lewczuk K (2020) Relationship between biometeorological factors and the number of hospitalizations due to asthma. Sci Rep 10(1):9593

Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

D’Amato M, Molino A, Calabrese G, Cecchi L, Annesi-Maesano I, D’Amato G (2018) The impact of cold on the respiratory tract and its consequences to respiratory health. Clin Transl Allergy. https://doi.org/10.1186/213601-018-0208-9

Article  PubMed  PubMed Central  Google Scholar 

Kudo E, Song E, Yockey LJ, Rakib T, Wong PW, Homer RJ, Iwasaki A (2019) Influenza worsens dry air Low ambient humidity impairs barrier function and innate resistance against influenza infection. Proc of the Natl Acad of Sci 116(22):10905–10910

Article  CAS  ADS  Google Scholar 

Mecenas P, Bastos R, Vallinoto A, Normando D (2020) Effects of temperature and humidity on the spread of COVID-19: A systematic review. PLoS ONE 15(9):e0238339

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kelly SJ, Martinsen P, Tatkov S (2021) Rapid changes in mucociliary transport in the tracheal epithelium caused by unconditioned room air or nebulized hypertonic saline and mannitol are not determined by frequency of beating cilia. Intensive Care Med Exp 9(1):8

Article  PubMed  PubMed Central  Google Scholar 

Xing YF, Xu YH, Shi MH, Lian YX (2016) The impact of PM2.5 on the human respiratory system. J Thorac Dis 1:E69–E74

Google Scholar 

Bolger C, Tufvesson E, Anderson SD, Devereux G, Ayres JG, Bjermer L, Sue-Chu M, Kippelen P (2011) Effect of inspired air conditions on exercise-induced bronchoconstriction and urinary CC16 levels in athletes. J Appl Physiol 111(4):1059–1065

Article  CAS  PubMed  Google Scholar 

Lappharat S, Taneepanichskul N, Reutrakul S, Chirakalwasan N (2018) Effects of bedroom environmental conditions on the severity of obstructive sleep apnea. J Clin Sleep Med 14(4):565–573

Article  PubMed  PubMed Central  Google Scholar 

Tatsuya U, Yoshikawa T, Ueda YK, Orita K, Fujimoto S (2011) Effects of acute prolonged strenuous exercise on the salivary stress markers and inflammatory cytokines. Jpn J Phys Fitness Sports Med 60(3):295–304

Article  Google Scholar 

Boulet LP, Turmel J (2019) Cough in exercise and athletes. Pulm Pharmacol Ther 55:67–74

Article  CAS  PubMed  Google Scholar 

Vanderlei FM, Moreno IL, Vanderlei LC, Pastre CM, de Abreu LC, Ferreira C (2013) Effects of different protocols of hydration on cardiorespiratory parameters during exercise and recovery. Int Arch Med 6(1):33

Article  PubMed  PubMed Central  Google Scholar 

McFadden ER Jr, Pichurko BM, Bowman HF, Ingenito E, Burns S, Dowling N, Solway J (1985) Thermal mapping of the airways in humans. J Appl Physiol 58(2):564–570

Article  PubMed  Google Scholar 

Strauss RH, McFadden ER Jr, Ingram RH Jr, Deal EC Jr, Jaeger JJ (1978) Influence of heat and humidity on the airway obstruction induced by exercise in asthma. J Clin Invest 61(2):433–440

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haut B, Karamaoun C, Mauroy B, Sobac B (2023) Water and heat exchanges in mammalian lungs. Sci Rep 13(1):6636

Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

Haut B, Nonclercq A, Buess A, Rabineau J, Rigaut C, Sobac B (2021) Comprehensive analysis of heat and water exchanges in the human lungs. Front Physiol 8(12):649497

Article  Google Scholar 

Lin CL, Tawhai MH, McLennan G, Hoffman EA (2007) Characteristics of the turbulent laryngeal jet and its effect on airflow in the human intra-thoracic airways. Respir Physiol Neurobiol 157(2–3):295–309

Article  PubMed  PubMed Central  Google Scholar 

Wheeler T, Stroock A (2008) The transpiration of water at negative pressures in a synthetic tree. Nature 455:208–212

Article  CAS  PubMed  ADS  Google Scholar 

Burkhardt J, Hunsche M (2013) “Breath figures” on leaf surfaces-formation and effects of microscopic leaf wetness. Front Plant Sci 24(4):422

Google Scholar 

Van Hove LWA, Adema EH (1996) The effective thickness of water films on leaves. Atmos Environ 30(16):2933–2936

Article  ADS  Google Scholar 

Reeves ER, Molloy K, McElvaney NG et al (2012) Hypertonic saline in treatment of pulmonary disease in cystic fibrosis. The Scientific World J 2012(465230):11

Google Scholar 

Vermeulen R, van der Linde J, Abdoola S, van Lierde K, Graham MA (2021) The effect of superficial hydration, with or without systemic hydration, on voice quality in future female professional singers. J Voice 35(5):728–738

Article  PubMed  Google Scholar 

Elkins MR, Bye PT (2011) Mechanisms and applications of hypertonic saline. J R Soc Med. 104(Suppl 1):S2–S5

Article  PubMed  PubMed Central  Google Scholar 

George CE, Scheuch G, Seifart U, Inbaraj LR, Chandrasingh S, Nair IK, Hickey AJ, Barer MR, Fletcher E, Field RD, Salzman J, Moelis N, Ausiello D, Edwards DA (2022) COVID-19 symptoms are reduced by targeted hydration of the nose, larynx and trachea. Sci Rep 12(1):4599

Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

Darwin F (1914) On a method of studying transpiration. Proc Roy Soc Lond 87(595):269–280

CAS  ADS  Google Scholar 

Peppin SSL, Elliot JAW, Worster MG (2005) Pressure and relative motion in colloidal suspensions. Phys Fluids 17:053301

Article  ADS  Google Scholar 

von Caemmerer S, Baker N (2007) The biology of transpiration. From guard cells to globe. Plant Physiol. 143(1):3

Article  Google Scholar 

Geng H, Xu Q, Wu M et al (2019) Plant leaves inspired sunlight-driven purifier for high-efficiency clean water production. Nat Commun 10:1512

Article  PubMed  PubMed Central  ADS  Google Scholar 

Choi YH, Lee SS, Chung KH (2010) Microfluidic actuation and sampling by dehydration of hydrogel. BioChip J 4(1):63–69

Article  CAS  Google Scholar 

Lee SJ, Kim H, Ahn S (2015) Water transport in porous hydrogel structures analogous to leaf mesophyll cells. Microfluid Nanofluid 18(5):775–784

Article  CAS  Google Scholar 

Martin DK (1995) Water transport in dehydrating hydrogel contact lenses: implications for corneal desiccation. J Biomed Mater Res 29(7):857–865

Article  CAS  PubMed  Google Scholar 

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