Pericytes in the Pulmonary Microenvironment: Guardians or Adversaries?

Rayner Samuel G, Hung Chi F, Conrad Liles W et al (2023) Lung pericytes as mediators of inflammation. Am J Physiol Lung Cell Mol Physiol 325(1):L1–L8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feng Jifan, Mantesso Andrea, Sharpe Paul T (2010) Perivascular cells as mesenchymal stem cells. Exp Opin Biol Ther 10:1441–151

Article  Google Scholar 

Rowley Jessica E, Johnson Jill R (2014) Pericytes in chronic lung disease. Int Arch Allergy Immunol 3:178–188

Article  Google Scholar 

Birbrair Alexander, Zhang Tan, Wang Zhong-Min et al (2013) Role of pericytes in skeletal muscle regeneration and fat accumulation. Stem Cells Dev 22(16):2298–2314

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barron Luke, Gharib Sina A, Duffield Jeremy S (2016) Lung pericytes and resident fibroblasts: busy multitaskers. Am J Pathol 186(10):2519–2531

Article  PubMed  PubMed Central  Google Scholar 

Lin Shuei-Liong, Kisseleva Tatiana, Brenner David A et al (2008) Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol 173(6):1617–1627

Article  CAS  PubMed  PubMed Central  Google Scholar 

Caruso RA, Fedele F, Finocchiaro G et al (2009) Ultrastructural descriptions of pericyte/endothelium peg-socket interdigitations in the microvasculature of human gastric carcinomas. Anticancer Res 29(1):449

CAS  PubMed  Google Scholar 

Ke Yuan Yu, Liu Yue Zhang et al (2020) Mural cell SDF1 signaling is associated with the pathogenesis of pulmonary arterial hypertension. Am J Respir Cell Mol Biol. 62(6):747–759

Article  PubMed  PubMed Central  Google Scholar 

Geevarghese Anita, Herman Ira M (2014) Pericyte-endothelial crosstalk: implications and opportunities for advanced cellular therapies. Transl Res 163(4):296–306

Article  PubMed  PubMed Central  Google Scholar 

Randall Harrell C, Markovic Bojana Simovic, Fellabaum Crissy et al (2018) Molecular mechanisms underlying therapeutic potential of pericytes. J Biomed Sci 25(1):21

Article  PubMed  Google Scholar 

Prazeres Pedro Henrique Dias Moura, Sena Isadora Fernandes Gilson, da Terra Isabella, Borges, et al (2017) Pericytes are heterogeneous in their origin within the same tissue. Dev Biol 427(1):6–11

Article  CAS  PubMed Central  Google Scholar 

Annegret Holm, Tina Heumann, Hellmut-G Augustin (2018) Microvascular mural cell organotypic heterogeneity and functional plasticity. Trends Cell Biol 28(4):302–316

Article  Google Scholar 

Cho H, Kozasa T, Bondjers C et al (2003) Pericyte-specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturation. FASEB J 17(3):1–17

Article  Google Scholar 

Wilson Carole L, Stephenson Sarah E, Higuero Jean Paul et al (2018) Characterization of human PDGFR-β-positive pericytes from IPF and non-IPF lungs. Am J Physiol Lung Cell Mol Physiol 315(6):L991–L1002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garrison Annelise T, Bignold Rebecca E, Xinhui Wu et al (2023) Pericytes: the lung-forgotten cell type. Front Physiol 14:1150028

Article  PubMed  PubMed Central  Google Scholar 

Lindahl Per, Johansson Bengt R, Levéen Per et al (1997) Pericyte loss and microaneurysm formation in pdgf-b-deficient mice. Am Assoc Adv Sci 277(5323):242–245

CAS  Google Scholar 

Soderblom Cynthia, Luo Xueting, Blumenthal Ezra et al (2013) Perivascular fibroblasts form the fibrotic scar after contusive spinal cord injury. J Neurosci 33(34):13882–13887

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ozerdem Ugur, Grako Kathryn A, Dahlin-Huppe Kimberlee et al (2001) NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis. Dev Dyn 222(2):218–227

Article  CAS  PubMed  Google Scholar 

Armulik Annika, Genové Guillem, Betsholtz Christer (2011) Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Dev cell. 21(2):193–215

Article  CAS  PubMed  Google Scholar 

Noskovičová N, Petřek M, Eickelberg O et al (2015) Platelet-derived growth factor signaling in the lung. From lung development and disease to clinical studies. Am J Respir Cell Mol Biol 52(3):263–284

Article  PubMed  Google Scholar 

Ozerdem U, Grako KA, Dahlin-Huppe K et al (2001) NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis. Dev Dyn 222(2):218–227

Article  CAS  PubMed  Google Scholar 

Crisan Mihaela, Yap Solomon, Casteilla Louis et al (2008) A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 3(3):301–313

Article  CAS  PubMed  Google Scholar 

Smyth Leon C D, Rustenhoven Justin, Scotter Emma L et al (2018) Markers for human brain pericytes and smooth muscle cells. J Chem Neuroanat 92:48–60

Article  CAS  PubMed  Google Scholar 

Ethan A Winkler,Robert D Bell,Berislav V Zlokovic (2010) Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling. Mol Neurodegener. 32.

Wilson Carole L, Stephenson Sarah E, Higuero Jean Paul et al (2018) Characterization of human PDGFR-β-positive pericytes from IPF and non-IPF lungs. Am J Physiol Lung Cell Mol Physiol. 315(6):L991–L1002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jung Bongnam, Arnold Thomas D, Raschperger Elisabeth et al (2017) Visualization of vascular mural cells in developing brain using genetically labeled transgenic reporter mice. J Cereb Blood Flow Metab 38(3):456–468

Article  PubMed  PubMed Central  Google Scholar 

Song Steven, Ewald Andrew J, Stallcup William et al (2005) PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nat Cell Biol 7(9):870–879

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cho Hyeseon, Kozasa Tohru, Bondjers Cecilia et al (2003) Pericyte-specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturation. Faseb J 3:440–442

Google Scholar 

Alarcon-Martinez Luis, Yilmaz-Ozcan Sinem, Yemisci Muge et al (2018) Capillary pericytes express α-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection. Elife 7:e34861

Article  PubMed  PubMed Central  Google Scholar 

MacFadyen John, Savage Kay, Wienke Dirk et al (2006) Endosialin is expressed on stromal fibroblasts and CNS pericytes in mouse embryos and is downregulated during development. Gene Expr Patterns 7(3):363–369

Article  PubMed  Google Scholar 

Lax Siân, Hou Tie Zheng, Jenkinson Eric et al (2007) CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair. Febs Lett 581(18):3550–3556

Article  CAS  PubMed  Google Scholar 

Virgintino Daniela, Girolamo Francesco, Errede Mariella et al (2007) An intimate interplay between precocious, migrating pericytes and endothelial cells governs human fetal brain angiogenesis. Angiogenesis. 10(1):35–45

Article  PubMed  Google Scholar 

Rafael Kramann,Rebekka K Schneider,Derek P DiRocco, et al. (2014) Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis. Cell Stem Cell. (1): 51–66.

Guimarães-Camboa Nuno, Cattaneo Paola, Sun Yunfu et al (2017) Pericytes of multiple organs do not behave as mesenchymal stem cells in vivo. Cell Stem Cell 20(3):345–359

Article  PubMed  PubMed Central  Google Scholar 

Morrisey Edward E, Hogan Brigid L M (2010) Preparing for the first breath: genetic and cellular mechanisms in lung development. Dev Cell 18(1):8–23

Comments (0)

No login
gif