Fibrinogen Gamma Chain Mediates Airway Inflammation and Remodeling Through the Focal Adhesion and TGF-β/Smad2 Pathways in Chronic Obstructive Pulmonary Disease

Christenson SA, Smith BM, Bafadhel M, Putcha N (2022) Chronic obstructive pulmonary disease. Lancet 399:2227–2242

Article  PubMed  Google Scholar 

Easter M, Bollenbecker S, Barnes JW, Krick S (2020) Targeting aging pathways in chronic obstructive pulmonary disease. Int J Mol Sci 21:6924

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, Cao X, Guo M, Xie M, Liu X (2020) Trends and risk factors of mortality and disability adjusted life years for chronic respiratory diseases from 1990 to 2017: systematic analysis for the Global Burden of Disease Study 2017. BMJ m3150. https://doi.org/10.1136/bmj.m3150

Article  Google Scholar 

Hopkinson NS (2022) COPD, smoking, and social justice. Lancet Respir Med 10:428–430

Article  PubMed  Google Scholar 

Brusselle GG, Joos GF, Bracke KR (2011) New insights into the immunology of chronic obstructive pulmonary disease. Lancet 378:1015–1026

Article  CAS  PubMed  Google Scholar 

Li C-L, Liu S-F (2024) Exploring molecular mechanisms and biomarkers in COPD: an overview of current advancements and perspectives. Int J Mol Sci 25:7347

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barnes PJ (2016) Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol 138:16–27

Article  CAS  PubMed  Google Scholar 

David B, Bafadhel M, Koenderman L, De Soyza A (2021) Eosinophilic inflammation in COPD: from an inflammatory marker to a treatable trait. Thorax 76:188–195

Article  PubMed  Google Scholar 

Sohal SS, Mahmood MQ, Walters EH (2014) Clinical significance of epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD): potential target for prevention of airway fibrosis and lung cancer. Clin Transl Med 3:e33

Article  Google Scholar 

Rao W et al (2020) Regenerative metaplastic clones in COPD lung drive inflammation and fibrosis. Cell 181:848-864.e18

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sohal SS, Ward C, Walters EH (2014) Importance of epithelial mesenchymal transition (EMT) in COPD and asthma. Thorax 69:768–768

Article  PubMed  Google Scholar 

Eapen MS et al (2021) Increased myofibroblasts in the small airways, and relationship to remodelling and functional changes in smokers and COPD patients: potential role of epithelial–mesenchymal transition. ERJ Open Res 7:00876–02020

Article  PubMed  PubMed Central  Google Scholar 

Wang Y, Xu J, Meng Y, Adcock IM, Yao X (2018) Role of inflammatory cells in airway remodeling in COPD. Int J Chron Obstruct Pulmon Dis 13:3341–3348

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Q et al (2022) Icaritin inhibited cigarette smoke extract-induced CD8+ T cell chemotaxis enhancement by targeting the CXCL10/CXCR3 axis and TGF-β/Smad2 signaling. Phytomedicine 96:153907

Article  CAS  PubMed  Google Scholar 

Peng H et al (2023) Semaphorin 7a aggravates TGF-β1-induced airway EMT through the FAK/ERK1/2 signaling pathway in asthma. Front Immunol 14:1167605

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guan J, Wang M, Zhao M, Ni W, Zhang M (2023) Discovery of fibrinogen γ-chain as a potential urinary biomarker for renal interstitial fibrosis in IgA nephropathy. BMC Nephrol 24:60

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang W et al (2020) Clinical significance of urinary plasminogen and fibrinogen gamma chain as novel potential diagnostic markers for non-small-cell lung cancer. Clin Chim Acta 502:55–65

Article  CAS  PubMed  Google Scholar 

Honda KI, Asada R, Kageyama K, Fukuda T, Terada H, Yasui T, Sumi T, Koyama M, Ishiko O, Sugawa T (2017) Protein Complex of Fibrinogen Gamma Chain and Complement Factor H in Ovarian Cancer Patient Plasma. Anticancer Res 37(6):2861–2866

CAS  PubMed  Google Scholar 

Yokoyama K, Erickson HP, Ikeda Y, Takada Y (2000) Identification of amino acid sequences in fibrinogen γ-chain and tenascin C C-terminal domains critical for binding to integrin αvβ3. J Biol Chem 275:16891–16898

Article  CAS  PubMed  Google Scholar 

Luyendyk JP, Schoenecker JG, Flick MJ (2019) The multifaceted role of fibrinogen in tissue injury and inflammation. Blood 133:511–520

Article  CAS  PubMed  Google Scholar 

Zhang X et al (2019) FGG promotes migration and invasion in hepatocellular carcinoma cells through activating epithelial to mesenchymal transition. Cancer Manag Res 11:1653–1665

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang H et al (2021) Integrated analysis reveals lung fibrinogen gamma chain as a biomarker for chronic obstructive pulmonary disease. Ann Transl Med 9:1765–1765

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu Y, Esnault S, Ge Y, Jarjour NN, Brasier AR (2022) Airway fibrin formation cascade in allergic asthma exacerbation: implications for inflammation and remodeling. Clin Proteomics 19:15

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davalos D, Akassoglou K (2012) Fibrinogen as a key regulator of inflammation in disease. Semin Immunopathol 34:43–62

Article  CAS  PubMed  Google Scholar 

Simurda T et al (2020) Genetic variants in the FGB and FGG genes mapping in the beta and gamma nodules of the fibrinogen molecule in congenital quantitative fibrinogen disorders associated with a thrombotic phenotype. Int J Mol Sci 21:4616

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dean T et al (2024) Fibrin promotes oxidative stress and neuronal loss in traumatic brain injury via innate immune activation. J Neuroinflammation 21:94

Article  CAS  PubMed  PubMed Central  Google Scholar 

Polverino F, Sin DD (2024) Type 2 airway inflammation in COPD. Eur Respir J 63:2400150

Article  CAS  PubMed  Google Scholar 

Xu J, Zeng Q, Li S, Su Q, Fan H (2024) Inflammation mechanism and research progress of COPD. Front Immunol 15:1404615

Article  CAS  PubMed  PubMed Central  Google Scholar 

McDonough JE et al (2011) Small-airway obstruction and emphysema in chronic obstructive pulmonary disease. N Engl J Med 365:1567–1575

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brightling C, Greening N (2019) Airway inflammation in COPD: progress to precision medicine. Eur Respir J 54:1900651

Article  CAS  PubMed  Google Scholar 

Tang K, Zhao J, Xie J, Wang J (2019) Decreased miR-29b expression is associated with airway inflammation in chronic obstructive pulmonary disease. Am J Physiol-Lung Cell Mol Physiol 316:L621–L629

Article  CAS  PubMed 

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