Roman J (2023) Fibroblasts—Warriors at the intersection of wound healing and disrepair. Biomolecules 13(6):945
Article CAS PubMed PubMed Central Google Scholar
Jones DP, Yongliang L (2009) Measuring the poise of thiol/disulfide couples in vivo. Free Radic Biol Med 47:1329–1338
Article CAS PubMed PubMed Central Google Scholar
Jones DP (2024) Redox organization of living systems. Free Rad Biol Med 217:179–189
Article CAS PubMed Google Scholar
Go YM, Jones DP (2011) Cysteine/cystine redox signaling in cardiovascular disease. Free Radic Biol Med 50:495–509
Article CAS PubMed Google Scholar
Iyer SS, Jones DP, Brigham KL, Rojas M (2009) Oxidation of plasma cysteine/cystine redox state in endotoxin-induced lung injury. Am J Respir Cell Mol Biol 40:90–98
Article CAS PubMed Google Scholar
Iyer SS, Ramirez AM, Ritzenthaler JD, Torres-Gonzalez E, Roser-Page S, Mora AL, Brigham KL, Jones DP, Roman J, Rojas M (2009) Oxidation of extracellular cysteine/cystine redox state in bleomycin-induced lung injury fibrosis. Am J Physiol Lung Cell Mol Physiol 296:L37–L45
Article CAS PubMed Google Scholar
Jones DP (2006) Extracellular redox state: refining the definition of oxidative stress in aging. Rejuvenation Res 9:169–181
Article CAS PubMed Google Scholar
Ramirez A, Ramadan B, Ritzenthaler JD, Rivera HN, Jones DP, Roman J (2007) Extracellular cysteine/cystine redox potential controls lung fibroblast proliferation and matrix expression through upregulation of transforming growth factor-beta. Am J Physiol—Lung Cell Mol Physiol 293:L972–L981
Article CAS PubMed Google Scholar
Watson WH, Burke TJ, Zelko IN, Torres-Gonzalez E, Ritzenthaler JD, Roman J (2016) Differential regulation of the extracellular cysteine/cystine Redox State (Eh CySS) by lung fibroblasts from young and old mice. Oxidative Med Cell Longevity 2016:1561305
Sueblingvon V, Neujahr DC, Mills ST, Roser-Page S, Ritzenthaler JD, Guidot DM, Rojas M, Roman J (2012) Predisposition for disrepair in the aged lung. Am J Med Sci 344:41–51
Zheng Y, Ritzenthaler JD, Burke TJ, Otero J, Roman J, Watson WH (2018) Age-dependent oxidation of Eh Cys/CySS in lung fibroblasts is mediated by decline in Slc7a11. Free Radic Biol Med 118:13–22
Article CAS PubMed PubMed Central Google Scholar
Ritzenthaler JD, Torres-Gonzalez E, Zheng Y, Zelko IN, van Berkel V, Nunley DR, Kindane B, Halayko AJ, Summer R, Watson WH, Roman J (2022) The profibrotic and senescence phenotype of old lung fibroblasts is reversed or ameliorated by genetic and pharmacological manipulation of Slc7a11 expression. Am J Physiol Lung Cell Mol Physiol 322:L449–L461
Article CAS PubMed PubMed Central Google Scholar
Sato H, Shiiya A, Kimata M, Maebara K, Tamba M, Sakakura Y, Makino N, Sugiyama F, Yagami K-i, Moriguchi T, Takahashi S, Bannai S (2005) Redox imbalance in cystine/glutamate transporter-deficient mice. J Biol Chem 280:37423–37429
Article CAS PubMed Google Scholar
Yan B, Ma Z, Shi S, Hu Y, Ma T, Rong G, Yang J (2017) Sulforaphane prevents bleomycin-induced pulmonary fibrosis in mice by inhibiting oxidative stress via nuclear factor erythroid 2-related factor-2 activation. Mol Med Resp 15:4005–4014
Artaud-Macari E, Goven D, Brayer S, Hamimi A, Besnard V, Marchal-Somme J, El Ali Z, Cretani B, Kerdine-Rober S, Boutten A, Bonay M (2013) Nuclear Factor Erythroid 2-Related Factor 2 nuclear translocation induces myofibroblastic dedifferentiation in idiopathic pulmonary fibrosis. Anxioxidants Redox Signal 18:66–78
Kyung SY, Kim DY, Yoo JY, Son ES, Kim YJ, Park JW, Jeong SH (2018) Sulforaphane attenuates pulmonary fibrosis by inhibiting the epithelia-mesenchymal transition. BMC Pharmacol Toxicol 19:13
Article PubMed PubMed Central Google Scholar
Pekovic-Vaughan V, Gibbs J, Yoshitane H, Yang N, Pathiranage D, Guo B, Sagami A, Taguchi K, Bechtold D, Loudon A, Yamamoto M, Chan J, van der Horst GTJ, Fukada Y, Meng Q-J (2014) The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis. Genes Dev 28(6):548–560
Article CAS PubMed PubMed Central Google Scholar
Cheng Y, Jiao Y, Wei W, Kou M, Cai Y, Li Y, Li H, Liu T (2025) FBR2 modulates ferroptosis via the SIRT3/p52 pathway to ameliorate pulmonary fibrosis. Front Pharmacol 16:1509665
Article CAS PubMed PubMed Central Google Scholar
Zhang J, Zheng Y, Wang Y, Wang J, Sang A, Song X, Li X (2022) YAP1 alleviates sepsis-induced acute lung injury via inhibiting ferriinophagy-mediated ferroptosis. Front Immunol 13:884362
Article CAS PubMed PubMed Central Google Scholar
Verbruggen L, Ates G, Lara O, De Munck J, Villers A, De Pauw L, Ottestad-Hansen S, Kobayashi S, Beckers P, Janssen P, Sato H, Zhou Y, Hermans E, Njemini R, Archens L, Danbolt NC, De Bundel D, Aerts JL, Barbe K, Guillaume B, Ris L, Bentea E, Massie A (2022) Lifespan extension with preservation of hippocampal function in aged system Xc-—deficient mice. Mol Psychiatry 27:2355–2368
Comments (0)