Genetic Factors Explain Half of the Individual Susceptibility to Chronic Bronchitis, Airflow Obstruction and COPD Regardless of the Spirometric Definition: A Nationwide Twin Study

World Health Organization (2008) World health statistics 2008. World Health Organization, Geneva, pp 1–112

Google Scholar 

Hogg JC, Timens W (2009) The pathology of chronic obstructive pulmonary disease. Annu Rev Pathol 4(1):435–459

Article  CAS  PubMed  Google Scholar 

Vogelmeier CF, Criner GJ, Martinez FJ, Anzueto A, Barnes PJ, Bourbeau J et al (2017) Global strategy for the diagnosis, management and prevention of chronic obstructive lung disease 2017 report: GOLD executive summary. Respirology 22(3):575–601

Article  PubMed  Google Scholar 

Pellegrino R, Viegi G, Brusasco V, Crapo RO, Burgos F, Casaburi R et al (2005) Interpretative strategies for lung function tests. Eur Respir J 26(5):948–968

Article  CAS  PubMed  Google Scholar 

Kim V, Criner GJ (2013) Chronic bronchitis and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 187(3):228–237

Article  CAS  PubMed  PubMed Central  Google Scholar 

Viegi G, Pistelli F, Sherrill DL, Maio S, Baldacci S, Carrozzi L (2007) Definition, epidemiology and natural history of COPD. Eur Respir J 30(5):993–1013

Article  CAS  PubMed  Google Scholar 

Meteran H, Thomsen SF, Harmsen L, Kyvik KO, Skytthe A, Backer V (2012) Risk of chronic bronchitis in twin pairs discordant for smoking. Lung 190(5):557–561

Article  PubMed  Google Scholar 

Davis RM, Novotny TE (1989) The epidemiology of cigarette smoking and its impact on chronic obstructive pulmonary disease. Am Rev Respir Dis 140(3_pt_2):S82–S84

Article  CAS  PubMed  Google Scholar 

Løkke A, Lange P, Scharling H, Fabricius P, Vestbo J (2006) Developing COPD: a 25 year follow up study of the general population. Thorax 61(11):935–939

Article  PubMed  PubMed Central  Google Scholar 

Omland O, Würtz ET, Aasen TB, Blanc P, Brisman JB, Miller MR et al (2014) Occupational chronic obstructive pulmonary disease: a systematic literature review. Scand J Work Environ Health 40(1):19–35

Article  PubMed  Google Scholar 

Sommer I, Griebler U, Mahlknecht P, Thaler K, Bouskill K, Gartlehner G et al (2015) Socioeconomic inequalities in non-communicable diseases and their risk factors: an overview of systematic reviews. BMC Public Health 15(1):914

Article  PubMed  PubMed Central  Google Scholar 

Meteran H, Thomsen SF, Miller MR, Hjelmborg J, Sigsgaard T, Backer V (2018) Self-reported intake of fruit and vegetables and risk of chronic obstructive pulmonary disease: a nation-wide twin study. Respir Med 144:16–21

Article  PubMed  Google Scholar 

Szmidt MK, Kaluza J, Harris HR, Linden A, Wolk A (2019) Long-term dietary fiber intake and risk of chronic obstructive pulmonary disease: a prospective cohort study of women. Eur J Nutr 195(suppl):557–611

Google Scholar 

Trupin L, Earnest G, San Pedro M, Balmes JR, Eisner MD, Yelin E et al (2003) The occupational burden of chronic obstructive pulmonary disease. Eur Respir J 22(3):462–469

Article  CAS  PubMed  Google Scholar 

Stoller JK, Aboussouan LS (2005) α1-antitrypsin deficiency. The Lancet 365(9478):2225–2236

Article  CAS  Google Scholar 

Patel BD, Coxson HO, Pillai SG, Agustí AGN, Calverley PMA, Donner CF et al (2008) Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 178(5):500–505

Article  PubMed  Google Scholar 

McCloskey SC, Patel BD, Hinchliffe SJ, Reid ED, Wareham NJ, Lomas DA (2001) Siblings of patients with severe chronic obstructive pulmonary disease have a significant risk of airflow obstruction. Am J Respir Crit Care Med 164(8 Pt 1):1419–1424

Article  CAS  PubMed  Google Scholar 

Chen Y (1999) Genetics and pulmonary medicine.10 Genetic epidemiology of pulmonary function. Thorax 54(9):818–824

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ingebrigtsen TS, Thomsen SF, van der Sluis S, Miller M, Christensen K, Sigsgaard T et al (2011) Genetic influences on pulmonary function: a large sample twin study. Lung 4:323–330

Article  Google Scholar 

Meteran H, Backer V, Kyvik KO, Skytthe A, Thomsen SF (2014) Heredity of chronic bronchitis: a registry-based twin study. Respir Med 108(9):1321–1326

Article  PubMed  Google Scholar 

Hallberg J, Dominicus A, Eriksson UK, Gerhardsson de Verdier M, Pedersen NL, Dahlbäck M et al (2008) Interaction between smoking and genetic factors in the development of chronic bronchitis. Am J Respir Crit Care Med 177(5):486–490

Article  PubMed  Google Scholar 

Ingebrigtsen T, Thomsen SF, Vestbo J, van der Sluis S, Kyvik KO, Silverman EK et al (2010) Genetic influences on chronic obstructive pulmonary disease - a twin study. Respir Med 104(12):1890–1895

Article  PubMed  Google Scholar 

Christiansen L, Frederiksen H, Schousboe K, Skytthe A, von Wurmb-Schwark N, Christensen K et al (2003) Age- and sex-differences in the validity of questionnaire-based zygosity in twins. Twin Res 6(4):275–278

Article  PubMed  Google Scholar 

Neale MC, Cardon LR (1992) Methodology for genetic studies of twins and families. Kluwer Academic, Dordrecht

Book  Google Scholar 

Keller MC, Coventry WL (2005) Quantifying and addressing parameter indeterminacy in the classical twin design. Twin Res Hum Genet 8(3):201–213

Article  PubMed  Google Scholar 

Sham P (1998) Statistics in human genetics. Wiley, Hoboken, Vol. 19(10), pp 1384–1385

Google Scholar 

R:. A language and environment for statistical computing. [Internet]. R Foundation for Statistical Computing; 2014. https://www.r-project.org/

Holst KK, Scheike TH, Hjelmborg JB (2016) The liability threshold model for censored twin data. Comput Stat Data Anal 93:324–335

Article  Google Scholar 

Redline S, Tishler PV, Lewitter FI, Tager IB, Munoz A, Speizer FE (1987) Assessment of genetic and nongenetic influences on pulmonary function. A twin study. Am Rev Respir Dis 135:217–222

CAS  PubMed  Google Scholar 

McClearn GE, Svartengren M, Pedersen NL, Heller DA, Plomin R (1994) Genetic and environmental influences on pulmonary function in aging Swedish twins. J Gerontol 49(6):264–268

Article  CAS  PubMed  Google Scholar 

Ghio AJ, Crapo RO, Elliott CG, Adams TD, Hunt SC, Jensen RL et al (1989) Heritability estimates of pulmonary function. Chest 96(4):743–746

Article  CAS  PubMed  Google Scholar 

Montnémery P, Lanke J, Lindholm LH, LUNDBÄCK B, Nyberg P, Adelroth E, et al (2000) Familial related risk-factors in the development of chronic bronchitis/emphysema as compared to asthma assessed in a postal survey. Eur J Epidemiol 16(11):1003–1007

Article  PubMed  Google Scholar 

Dharmage SC, Perret JL, Burgess JA, Lodge CJ, Johns DP, Thomas PS et al (2016) Current asthma contributes as much as smoking to chronic bronchitis in middle age: a prospective population-based study. Int J Chron Obstruct Pulmon Dis 11:1911–1920

Article  PubMed  PubMed Central  Google Scholar 

Chapman KR, Burdon JGW, Piitulainen E, Sandhaus RA, Seersholm N, Stocks JM et al (2015) Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): a randomised, double-blind, placebo-controlled trial. Lancet 386(9991):360–368

Article  CAS  PubMed  Google Scholar 

Pillai SG, Ge D, Zhu G, Kong X, Shianna KV, Need AC et al (2009) A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet 5(3):1000421

Article  Google Scholar 

Hersh CP, Hansel NN, Barnes KC, Lomas DA, Pillai SG, Coxson HO et al (2009) Transforming growth factor-beta receptor-3 is associated with pulmonary emphysema. Am J Respir Cell Mol Biol 41(3):324–331

Article  CAS  PubMed 

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