Use of Telomere Length as a Biomarker in Idiopathic Pulmonary Fibrosis

Richeldi L, Collard HR, Jones MG (2017) Idiopathic pulmonary fibrosis. Lancet 389:1941–1952

Article  PubMed  Google Scholar 

Borie R, Kannengiesser C, Antoniou K, Bonella F, Crestani B, Fabre A et al (2023) European respiratory society statement on familial pulmonary fibrosis. Eur Respir J 61(3):2201383

Article  CAS  PubMed  Google Scholar 

Zhang K, Xu L, Cong YS (2021) Telomere dysfunction in idiopathic pulmonary fibrosis. Front Med (Lausanne) 8:739810

Article  PubMed  Google Scholar 

Armanios MY, Chen JJ, Cogan JD, Alder JK, Ingersoll RG, Markin C et al (2007) Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med 356(13):1317–1326

Article  CAS  PubMed  Google Scholar 

Courtwright AM, El-Chemaly S (2019) Telomeres in interstitial lung disease: the short and the long of it. Ann Am Thorac Soc 16(2):175–181

Article  PubMed  PubMed Central  Google Scholar 

Armanios M (2013) Telomeres and age-related disease: how telomere biology informs clinical paradigms. J Clin Invest 123(3):996–1002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alder JK, Armanios M (2022) Telomere-mediated lung disease. Physiol Rev 102(4):1703–1720

Article  CAS  PubMed  PubMed Central  Google Scholar 

Astuti Y, Wardhana A, Watkins J, Wulaningsih W, Network PR (2017) Cigarette smoking and telomere length: a systematic review of 84 studies and meta-analysis. Environ Res 158:480–489

Article  CAS  PubMed  PubMed Central  Google Scholar 

Newton CA, Zhang D, Oldham JM, Kozlitina J, Ma SF, Martinez FJ et al (2019) Telomere length and use of immunosuppressive medications in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 200(3):336–347

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adegunsoye A, Vij R, Noth I (2019) Integrating genomics into management of fibrotic interstitial lung disease. Chest 155(5):1026–1040

Article  PubMed  PubMed Central  Google Scholar 

Alder JK, Hanumanthu VS, Strong MA, DeZern AE, Stanley SE, Takemoto CM et al (2018) Diagnostic utility of telomere length testing in a hospital-based setting. Proc Natl Acad Sci U S A 115(10):E2358–E2365

Article  PubMed  PubMed Central  Google Scholar 

Cronkhite JT, Xing C, Raghu G, Chin KM, Torres F, Rosenblatt RL et al (2008) Telomere shortening in familial and sporadic pulmonary fibrosis. Am J Respir Crit Care Med 178(7):729–737

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dai J, Cai H, Zhuang Y, Wu Y, Min H, Li J et al (2014) Telomerase gene mutations and telomere length shortening in patients with idiopathic pulmonary fibrosis in a Chinese population. Respirology 20(1):122–128

Article  PubMed  Google Scholar 

Molina-Molina M, Borie R (2018) Clinical implications of telomere dysfunction in lung fibrosis. Curr Opin Pulm Med 24(5):440–444

Article  CAS  PubMed  Google Scholar 

Raghu G, Remy-Jardin M, Myers JL, Richeldi L, Ryerson CJ, Lederer DJ et al (2018) Diagnosis of idiopathic pulmonary fibrosis. An official ATS/ERS/JRS/ALAT clinical practice guideline. Am J Respir Crit Care Med 198(5):e44–e68

Article  PubMed  Google Scholar 

Ley B, Ryerson CJ, Vittinghoff E, Ryu JH, Tomassetti S, Lee JS et al (2012) A multidimensional index and staging system for idiopathic pulmonary fibrosis. Ann Intern Med 156(10):684–691

Article  PubMed  Google Scholar 

Froidure A, Mahieu M, Hoton D, Laterre PF, Yombi JC, Koenig S et al (2020) Short telomeres increase the risk of severe COVID-19. Aging (Albany NY) 12(20):19911–19922

Article  CAS  PubMed  Google Scholar 

Richards S, Aziz N, Bale S, Bick D, Das S, Gastier-Foster J et al (2015) Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med 17(5):405–424

Article  PubMed  PubMed Central  Google Scholar 

Petrovski S, Todd JL, Durheim MT, Wang Q, Chien JW, Kelly FL et al (2017) An exome sequencing study to assess the role of rare genetic variation in pulmonary fibrosis. Am J Respir Crit Care Med 196(1):82–93

Article  CAS  PubMed  PubMed Central  Google Scholar 

Borie R, Kannengiesser C, de Fontbrune FS, Gouya L, Nathan N, Crestani B (2017) Management of suspected monogenic lung fibrosis in a specialised centre. Eur Respir Rev 26(144):160122

Article  PubMed  PubMed Central  Google Scholar 

van der Vis JJ, van der Smagt JJ, van Batenburg AA, Goldschmeding R, van Es HW, Grutters JC et al (2021) Pulmonary fibrosis in non-mutation carriers of families with short telomere syndrome gene mutations. Respirology 26(12):1160–1170

Article  PubMed  Google Scholar 

Newton CA, Batra K, Torrealba J, Kozlitina J, Glazer CS, Aravena C et al (2016) Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive. Eur Respir J 48(6):1710–1720

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang D, Eckhardt CM, McGroder C, Benesh S, Porcelli J, Depender C et al (2024) Clinical impact of telomere length testing for interstitial lung disease. Chest 166(5):1071–1081

Article  CAS  PubMed  Google Scholar 

Adegunsoye A, Newton CA, Oldham JM, Ley B, Lee CT, Linderholm AL et al (2023) Telomere length associates with chronological age and mortality across racially diverse pulmonary fibrosis cohorts. Nat Commun 14(1):1489

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ptasinski VA, Stegmayr J, Belvisi MG, Wagner DE, Murray LA (2021) Targeting alveolar repair in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 65(4):347–365

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alder JK, Barkauskas CE, Limjunyawong N, Stanley SE, Kembou F, Tuder RM et al (2015) Telomere dysfunction causes alveolar stem cell failure. Proc Natl Acad Sci U S A 112(16):5099–5104

Article  CAS  PubMed  PubMed Central  Google Scholar 

van Batenburg AA, Kazemier KM, van Oosterhout MFM, van der Vis JJ, van Es HW, Grutters JC et al (2020) From organ to cell: Multi-level telomere length assessment in patients with idiopathic pulmonary fibrosis. PLoS ONE 15(1):e0226785

Article  PubMed  PubMed Central  Google Scholar 

Stuart BD, Lee JS, Kozlitina J, Noth I, Devine MS, Glazer CS et al (2014) Effect of telomere length on survival in patients with idiopathic pulmonary fibrosis: an observational cohort study with independent validation. Lancet Respir Med 2(7):557–565

Article  CAS  PubMed  PubMed Central  Google Scholar 

Armanios M, Blackburn EH (2012) The telomere syndromes. Nat Rev Genet 13(10):693–704

Article  CAS  PubMed  PubMed Central  Google Scholar 

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