Reck M, Rodriguez-Abreu D, Robinson AG, Hui R, Csoszi T, Fulop A et al (2016) Pembrolizumab versus chemotherapy for PD-L1-Positive Non-small-cell lung cancer. N Engl J Med 375:1823–1833
Article CAS PubMed Google Scholar
Boyero L, Sanchez-Gastaldo A, Alonso M, Noguera-Ucles JF, Molina-Pinelo S, Bernabe-Caro R (2020) Primary and acquired resistance to immunotherapy in lung cancer: unveiling the mechanisms underlying of immune checkpoint blockade therapy. Cancers (Basel). https://doi.org/10.3390/cancers12123729
Zaretsky JM, Garcia-Diaz A, Shin DS, Escuin-Ordinas H, Hugo W, Hu-Lieskovan S et al (2016) Mutations associated with acquired resistance to PD-1 blockade in melanoma. N Engl J Med 375:819–829
Article CAS PubMed PubMed Central Google Scholar
Hellmann MD, Nathanson T, Rizvi H, Creelan BC, Sanchez-Vega F, Ahuja A et al (2018) Genomic features of response to combination immunotherapy in patients with advanced non-small-cell lung cancer. Cancer Cell 33(843–52):e4
Chen X, Pan X, Zhang W, Guo H, Cheng S, He Q et al (2020) Epigenetic strategies synergize with PD-L1/PD-1 targeted cancer immunotherapies to enhance antitumor responses. Acta Pharm Sin B 10:723–733
Article CAS PubMed Google Scholar
Shergold AL, Millar R, Nibbs RJB (2019) Understanding and overcoming the resistance of cancer to PD-1/PD-L1 blockade. Pharmacol Res 145:104258
Article CAS PubMed Google Scholar
Zhang Z, Liu S, Zhang B, Qiao L, Zhang Y, Zhang Y (2020) T cell dysfunction and exhaustion in cancer. Front Cell Dev Biol 8:17
Article CAS PubMed PubMed Central ADS Google Scholar
Iams WT, Porter J, Horn L (2020) Immunotherapeutic approaches for small-cell lung cancer. Nat Rev Clin Oncol 17:300–312
Article PubMed PubMed Central Google Scholar
Zhao H, Chen Q, Alam A, Cui J, Suen KC, Soo AP et al (2018) The role of osteopontin in the progression of solid organ tumour. Cell Death Dis 9:356
Article PubMed PubMed Central Google Scholar
Hao C, Lane J, Jiang WG (2023) Osteopontin and cancer: insights into its role in drug resistance. Biomedicines 11(1):197
Article CAS PubMed PubMed Central Google Scholar
Wang Y, Yang J, Liu H, Bi JR, Liu Y, Chen YY et al (2015) The association between osteopontin and survival in non-small-cell lung cancer patients: a meta-analysis of 13 cohorts. Onco Targets Ther 8:3513–3521
CAS PubMed PubMed Central Google Scholar
Gandhi L, Rodriguez-Abreu D, Gadgeel S, Esteban E, Felip E, De Angelis F et al (2018) Pembrolizumab plus chemotherapy in metastatic non-small-cell lung cancer. N Engl J Med 378:2078–2092
Article CAS PubMed Google Scholar
Hanna NH, Schneider BJ, Temin S, Baker S Jr, Brahmer J, Ellis PM et al (2020) Therapy for stage iv non-small-cell lung cancer without driver alterations: ASCO and OH (CCO) joint guideline update. J Clin Oncol 38:1608–1632
Seymour L, Bogaerts J, Perrone A, Ford R, Schwartz LH, Mandrekar S et al (2017) iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics. Lancet Oncol 18:e143–e152
Article PubMed PubMed Central Google Scholar
Ezzelle J, Rodriguez-Chavez IR, Darden JM, Stirewalt M, Kunwar N, Hitchcock R et al (2008) Guidelines on good clinical laboratory practice: bridging operations between research and clinical research laboratories. J Pharm Biomed Anal 46:18–29
Article CAS PubMed Google Scholar
Carbone F, Grossi F, Bonaventura A, Vecchie A, Minetti S, Bardi N et al (2019) Baseline serum levels of osteopontin predict clinical response to treatment with nivolumab in patients with non-small cell lung cancer. Clin Exp Metastasis 36:449–456
Article CAS PubMed Google Scholar
Ministrini S, Andreozzi F, Montecucco F, Minetti S, Bertolotto M, Liberale L et al (2021) Neutrophil degranulation biomarkers characterize restrictive echocardiographic pattern with diastolic dysfunction in patients with diabetes. Eur J Clin Invest 51:e13640
Article CAS PubMed PubMed Central Google Scholar
Fidler MJ, Fhied CL, Roder J, Basu S, Sayidine S, Fughhi I et al (2018) The serum-based VeriStrat(R) test is associated with proinflammatory reactants and clinical outcome in non-small cell lung cancer patients. BMC Cancer 18:310
Article PubMed PubMed Central Google Scholar
Du Y, Mao L, Wang Z, Yan K, Zhang L, Zou J (2022) Osteopontin - The stirring multifunctional regulatory factor in multisystem aging. Front Endocrinol (Lausanne) 13:1014853
Schafer MJ, Zhang X, Kumar A, Atkinson EJ, Zhu Y, Jachim S et al (2020) The senescence-associated secretome as an indicator of age and medical risk. JCI Insight. https://doi.org/10.1172/jci.insight.133668
Article PubMed PubMed Central Google Scholar
Komici K, Bencivenga L, Navani N, D’Agnano V, Guerra G, Bianco A et al (2022) Frailty in patients with lung cancer: a systematic review and meta-analysis. Chest 162:485–497
Scott JM, Stene G, Edvardsen E, Jones LW (2020) Performance status in cancer: not broken, but time for an upgrade? J Clin Oncol 38:2824–2829
Article PubMed PubMed Central Google Scholar
Moth EB, Kiely BE, Stefanic N, Naganathan V, Martin A, Grimison P et al (2019) Oncologists’ perceptions on the usefulness of geriatric assessment measures and the CARG toxicity score when prescribing chemotherapy for older patients with cancer. J Geriatr Oncol 10:210–215
Jensen CE, Vohra SN, Nyrop KA, Deal AM, Muss HB, Lichtman EI et al (2022) Geriatric-assessment-identified functional deficits among adults with multiple myeloma with normal performance status. J Geriatr Oncol 13:182–189
Article CAS PubMed Google Scholar
Suto H, Inui Y, Okamura A (2022) Validity of the cancer and aging research group predictive tool in older Japanese patients. Cancers (Basel). https://doi.org/10.3390/cancers14092075
Frelaut M, Paillaud E, Beinse G, Scain AL, Culine S, Tournigand C et al (2023) External validity of two scores for predicting the risk of chemotherapy toxicity among older patients with solid tumors: results from the ELCAPA prospective cohort. Oncologist. https://doi.org/10.1093/oncolo/oyad050
Article PubMed PubMed Central Google Scholar
Zhai WY, Duan FF, Chen S, Wang JY, Zhao ZR, Wang YZ et al (2022) An Aging-Related Gene Signature-Based Model for Risk Stratification and Prognosis Prediction in Lung Squamous Carcinoma. Front Cell Dev Biol 10:770550
Article PubMed PubMed Central Google Scholar
Domen A, Deben C, De Pauw I, Hermans C, Lambrechts H, Verswyvel J et al (2022) Prognostic implications of cellular senescence in resected non-small cell lung cancer. Transl Lung Cancer Res 11:1526–1539
Article CAS PubMed PubMed Central Google Scholar
Chen B, Liang Y, Chen L, Wei Y, Li Y, Zhao W et al (2018) Overexpression of klotho inhibits HELF fibroblasts SASP-related protumoral effects on non-small cell lung cancer cells. J Cancer 9:1248–1258
Article PubMed PubMed Central Google Scholar
Xu W, Li Y, Yuan WW, Yin Y, Song WW, Wang Y et al (2018) Membrane-bound CD40L promotes senescence and initiates senescence-associated secretory phenotype via NF-kappaB activation in lung adenocarcinoma. Cell Physiol Biochem 48:1793–1803
Article CAS PubMed Google Scholar
Gong L, Cui D, Liu D, Shen X, Pan H, Xiong X et al (2022) FBXW7 inactivation induces cellular senescence via accumulation of p53. Cell Death Dis 13:788
Article CAS PubMed PubMed Central Google Scholar
Tesei A, Arienti C, Bossi G, Santi S, De Santis I, Bevilacqua A et al (2021) TP53 drives abscopal effect by secretion of senescence-associated molecular signals in non-small cell lung cancer. J Exp Clin Cancer Res 40:89
Article CAS PubMed PubMed Central Google Scholar
Sharma A, Almasan A (2021) Autophagy and PTEN in DNA damage-induced senescence. Adv Cancer Res 150:249–284
Article CAS PubMed Google Scholar
Patil S, Reedy JL, Scroggins BT, White AO, Kwon S, Shankavaram U et al (2022) Senescence-associated tumor growth is promoted by 12-lipoxygenase. Aging (Albany NY) 14:1068–1086
Article CAS PubMed Google Scholar
Kong P, Yang X, Zhang Y, Dong H, Liu X, Xu X et al (2022) Palbociclib enhances migration and invasion of cancer cells via senescence-associated secretory phenotype-related CCL5 in non-small-cell lung cancer. J Oncol 2022:2260625
Article PubMed PubMed Central Google Scholar
Zhang B, Fu D, Xu Q, Cong X, Wu C, Zhong X et al (2018) The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involvin
Comments (0)