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Development and validation of nomogram model predicting overall survival and cancer specific survival in glioblastoma patients
Development and validation of nomogram model predicting overall survival and cancer specific survival in glioblastoma patients
Identifying the incidence and risk factors of Glioblastoma (GBM) and establishing effective predictive m...
Purinosomes as a therapeutic target in hepatocellular carcinoma: insights and opportunities
Purinosomes as a therapeutic target in hepatocellular carcinoma: insights and opportunities
The formation of purinosomes, dynamic complexes involved in de novo purine biosynthesis, has been recognized as a critical...
CXCR7 promoted proliferation, migration and invasion in HCC Cells by inactivating Hippo-YAP signaling
CXCR7 promoted proliferation, migration and invasion in HCC Cells by inactivating Hippo-YAP signaling
CXCR7 (ACKR3) has been well-supported as a promoter of growth and metastasis in hepatocellular carcinoma (HCC). Both CXCR7...
ZNF280A promotes malignant melanoma development through regulating cell proliferation, apoptosis, and cell cycle
ZNF280A promotes malignant melanoma development through regulating cell proliferation, apoptosis, and cell cycle
Malignant melanoma (MM) is the most lethal skin cancer globally, with a high incidence of over 300,000 per year. Though co...
is an independent predictor for the prognosis of gastric cancer
is an independent predictor for the prognosis of gastric cancer
To explore novel biomarkers capable of predicting the prognosis of gastric cancer (GC) and investigate the mechanisms unde...
Thrombospondin-1 induces immunogenic cell death in human mucoepidermoid carcinoma MC-3 cells via the PERK/eIF2α signaling pathway: potential implications for tumor immunotherapy
Thrombospondin-1 induces immunogenic cell death in human mucoepidermoid carcinoma MC-3 cells via the PERK/eIF2α signaling pathway: potential implications for tumor immunotherapy
To investigate whether Thrombospondin-1 (TSP-1) induces immunogenic cell death (ICD) in human mucoepidermoid carcinoma (MC...
Single-cell RNA sequencing reveals key signaling pathways and biological functions in giant cell tumors of bone
Single-cell RNA sequencing reveals key signaling pathways and biological functions in giant cell tumors of bone
Giant cell tumor of bone (GCTB) represents a group of tumors that characterized by their heterogeneity and the presence of...
LPCAT3 regulates the immune infiltration and prognosis of ccRCC patients by mediating ferroptosis and endoplasmic reticulum stress
LPCAT3 regulates the immune infiltration and prognosis of ccRCC patients by mediating ferroptosis and endoplasmic reticulum stress
Clear cell renal cell carcinoma (ccRCC) accounts for 70% of renal cell carcinoma (RCC) cases. Although surgery remains the...
P4HA1 is highly expressed in gastric cancer and promotes proliferation and metastasis of gastric cancer cells
P4HA1 is highly expressed in gastric cancer and promotes proliferation and metastasis of gastric cancer cells
Gastric cancer (GC), a prevalent aggressive form of tumor, imposes a significant burden in terms of morbidity and mortalit...
Plasma protein levels and hepatocellular carcinoma: a Mendelian randomization study with drug screening implications
Plasma protein levels and hepatocellular carcinoma: a Mendelian randomization study with drug screening implications
Hepatocellular carcinoma (HCC) remains a significant cause of cancer-related mortality, highlighting the need for novel th...
Advances in the roles and molecular mechanisms of exosomal circular RNAs in regulating the pre-metastatic niche of tumors
Advances in the roles and molecular mechanisms of exosomal circular RNAs in regulating the pre-metastatic niche of tumors
Metastasis remains a major cause of morbidity and mortality in patients with malignant tumors. The pre-metastatic niche is...
Prognostic value of combined nutritional and inflammatory markers in NSCLC patients receiving ICIs
Prognostic value of combined nutritional and inflammatory markers in NSCLC patients receiving ICIs
In the treatment of non-small cell lung cancer (NSCLC), immune checkpoint inhibitors (ICIs) have markedly improved patient...
Research progress on ADAM28 in malignant tumors
Research progress on ADAM28 in malignant tumors
A disintegrin and metalloproteinase (ADAM) 28 belongs to the zinc-dependent metalloproteinase superfamily and has a signal...
Glycosphingolipids as emerging attack points in bladder cancer
Glycosphingolipids as emerging attack points in bladder cancer
Bladder cancer is a prevalent malignancy associated with significant morbidity and mortality worldwide. Emerging research ...
Histopathological biomarkers in squamous cell carcinoma of the vulva: the prognostic relevance of tumor-infiltrating lymphocytes (TILs)—a retrospective study of 157 cases
Histopathological biomarkers in squamous cell carcinoma of the vulva: the prognostic relevance of tumor-infiltrating lymphocytes (TILs)—a retrospective study of 157 cases
The prognostic relevance of tumor-infiltrating lymphocytes (TILs) has so far been recognized in several solid tumors like ...
Next-generation sequencing in cancer diagnosis and treatment: clinical applications and future directions
Next-generation sequencing in cancer diagnosis and treatment: clinical applications and future directions
Next-generation sequencing (NGS) has emerged as a pivotal technology in the field of oncology, transforming the approach t...
Interactions between long non-coding RNAs and m6 A modification in cancer
Interactions between long non-coding RNAs and m6 A modification in cancer
Long non-coding RNAs (lncRNAs) are a class of transcripts exceeding 200 nucleotides (nt) in length, which are broadly impl...
MTHFD2 marks pemetrexed resistance in pulmonary adenocarcinoma with EGFR wild type
MTHFD2 marks pemetrexed resistance in pulmonary adenocarcinoma with EGFR wild type
Lung cancer is the leading cause of cancer-related deaths worldwide. Patients with an amplification of the MTHFD2 gene hav...
Machine learning-based prognostic modelling of NK cells in PAAD for immunotherapy guidance
Machine learning-based prognostic modelling of NK cells in PAAD for immunotherapy guidance
Pancreatic cancer’s high incidence and mortality rates are underscored by ineffective treatments, particularly immun...
Thyroid hormone receptor interacting protein 13 is associated with prognosis and immunotherapy efficacy in human cancers: a pan-cancer analysis
Thyroid hormone receptor interacting protein 13 is associated with prognosis and immunotherapy efficacy in human cancers: a pan-cancer analysis
Thyroid hormone receptor-interacting protein 13 (TRIP13) is involved in the regulation of mitosis and is overexpressed in ...
LncRNA HOTAIR down-expression inhibits the invasion and tumorigenicity of epithelial ovarian cancer cells by suppressing TGF-β1 and ZEB1
LncRNA HOTAIR down-expression inhibits the invasion and tumorigenicity of epithelial ovarian cancer cells by suppressing TGF-β1 and ZEB1
Epithelial ovarian cancer (EOC) is a pathological type with a higher mortality rate among gynecological cancers today. Lon...
Infection with COVID-19 promotes the progression of pancreatic cancer through the PI3K-AKT signaling pathway
Infection with COVID-19 promotes the progression of pancreatic cancer through the PI3K-AKT signaling pathway
To investigate the effect of COVID-19 infection on pancreatic cancer. Based on the mRNA-Seq data of COVID-19 patients and ...
Increased PAFAH1B3 was associated with poor prognosis and T-cell exhaustion microenvironment in hepatocellular carcinoma
Increased PAFAH1B3 was associated with poor prognosis and T-cell exhaustion microenvironment in hepatocellular carcinoma
The link between T-cell exhaustion (TEX) and PAFAH1B3 in hepatocellular carcinoma (HCC) remains unknown, even though both ...
Treatment outcomes of radiotherapy with concurrent weekly cisplatin in older patients with locally advanced head and neck squamous cell carcinoma
Treatment outcomes of radiotherapy with concurrent weekly cisplatin in older patients with locally advanced head and neck squamous cell carcinoma
Tri-weekly cisplatin and radiotherapy (CDDP + RT) is a standard of care for locally advanced head and neck squ...
Using machine learning-based radiomics to differentiate between glioma and solitary brain metastasis from lung cancer and its subtypes
Using machine learning-based radiomics to differentiate between glioma and solitary brain metastasis from lung cancer and its subtypes
To establish a machine learning-based radiomics model to differentiate between glioma and solitary brain metastasis from l...
Deep-learning-based survival prediction of patients with lower limb melanoma
Deep-learning-based survival prediction of patients with lower limb melanoma
For the purpose to examine lower limb melanoma (LLM) and its long-term survival rate, we used data from the Surveillance, ...
Dynamic estimates of survival in oncocytic cell carcinoma of the thyroid
Dynamic estimates of survival in oncocytic cell carcinoma of the thyroid
Little is known about death hazard and conditional survival of oncocytic cell carcinoma of the thyroid (OCC). Patients dia...
Mitophagy genes in ovarian cancer: a comprehensive analysis for improved immunotherapy
Mitophagy genes in ovarian cancer: a comprehensive analysis for improved immunotherapy
Mitophagy is a process of selectively degrading damaged mitochondria, which has been found to be related to immunity, tumo...
Breast cancer stem cells generate immune-suppressive T regulatory cells by secreting TGFβ to evade immune-elimination
Breast cancer stem cells generate immune-suppressive T regulatory cells by secreting TGFβ to evade immune-elimination
Cancer stem cells (CSCs), being the primary contributors in tumor initiation, metastasis, and relapse, ought to have semin...
Clinical application of 192Ir High-Dose-Rate brachytherapy in metastatic lymph nodes of the neck
Clinical application of 192Ir High-Dose-Rate brachytherapy in metastatic lymph nodes of the neck
The objective of this study was to investigate the safety and effectiveness of high-dose-rate brachytherapy as a treatment...
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