Brown ZJ, Tsilimigras DI, Ruff SM, Mohseni A, Kamel IR, Cloyd JM, et al. Management of hepatocellular carcinoma: a review. JAMA Surg. 2023;158(4):410–20.

Article  PubMed  Google Scholar 

Toh MR, Wong EYT, Wong SH, Ng AWT, Loo LH, Chow PK, et al. Global epidemiology and genetics of hepatocellular carcinoma. Gastroenterology. 2023;164(5):766–82.

Article  PubMed  Google Scholar 

Chan LL, Chan SL. Drug development for hepatocellular carcinoma. Lancet Oncol. 2023;24(12):1292–4.

Article  CAS  PubMed  Google Scholar 

Wang Y, Deng B. Hepatocellular carcinoma: molecular mechanism, targeted therapy, and biomarkers. Cancer Metastasis Rev. 2023;42(3):629–52.

Article  PubMed  Google Scholar 

Chung SW, Moon HS, Shin H, Han H, Park S, Cho H, et al. Inhibition of sodium-glucose cotransporter-2 and liver-related complications in individuals with diabetes: a Mendelian randomization and population-based cohort study. Hepatology. 2024;80(3):633–48.

Article  PubMed  Google Scholar 

Daghlas I, Gill D. Mendelian randomization as a tool to inform drug development using human genetics. Camb Prism Precis Med. 2023;1: e16.

Article  PubMed  PubMed Central  Google Scholar 

Gill D, Dib MJ, Cronje HT, Karhunen V, Woolf B, Gagnon E, et al. Common pitfalls in drug target Mendelian randomization and how to avoid them. BMC Med. 2024;22(1):473.

Article  PubMed  PubMed Central  Google Scholar 

Fowler KJ, Chernyak V, Ronot M, Vilgrain V, Kitao A, Lee JM, et al. Hepatocellular carcinoma: it is time to focus on prognosis. Radiology. 2023;307(3): e220884.

Article  PubMed  Google Scholar 

Reig M, Forner A, Rimola J, Ferrer-Fabrega J, Burrel M, Garcia-Criado A, et al. BCLC strategy for prognosis prediction and treatment recommendation: the 2022 update. J Hepatol. 2022;76(3):681–93.

Article  PubMed  Google Scholar 

Xie DY, Zhu K, Ren ZG, Zhou J, Fan J, Gao Q. A review of 2022 Chinese clinical guidelines on the management of hepatocellular carcinoma: updates and insights. Hepatobiliary Surg Nutr. 2023;12(2):216–28.

Article  PubMed  PubMed Central  Google Scholar 

Cho Y, Kim BH, Park JW. Overview of Asian clinical practice guidelines for the management of hepatocellular carcinoma: an Asian perspective comparison. Clin Mol Hepatol. 2023;29(2):252–62.

Article  PubMed  PubMed Central  Google Scholar 

Singal AG, Haaland B, Parikh ND, Ozbay AB, Kirshner C, Chakankar S, et al. Comparison of a multitarget blood test to ultrasound and alpha-fetoprotein for hepatocellular carcinoma surveillance: results of a network meta-analysis. Hepatol Commun. 2022;6(10):2925–36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tzartzeva K, Obi J, Rich NE, Parikh ND, Marrero JA, Yopp A, et al. Surveillance imaging and alpha fetoprotein for early detection of hepatocellular carcinoma in patients with cirrhosis: a meta-analysis. Gastroenterology. 2018;154(6):1706-1718 e1701.

Article  CAS  PubMed  Google Scholar 

Chan YT, Zhang C, Wu J, Lu P, Xu L, Yuan H, et al. Biomarkers for diagnosis and therapeutic options in hepatocellular carcinoma. Mol Cancer. 2024;23(1):189.

Article  PubMed  PubMed Central  Google Scholar 

Parikh ND, Tayob N, Singal AG. Blood-based biomarkers for hepatocellular carcinoma screening: approaching the end of the ultrasound era? J Hepatol. 2023;78(1):207–16.

Article  CAS  PubMed  Google Scholar 

Yu B, Ma W. Biomarker discovery in hepatocellular carcinoma (HCC) for personalized treatment and enhanced prognosis. Cytokine Growth Factor Rev. 2024;79:29–38.

Article  CAS  PubMed  Google Scholar 

Kalnina Z, Meistere I, Kikuste I, Tolmanis I, Zayakin P, Line A. Emerging blood-based biomarkers for detection of gastric cancer. World J Gastroenterol. 2015;21(41):11636–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shimada H, Noie T, Ohashi M, Oba K, Takahashi Y. Clinical significance of serum tumor markers for gastric cancer: a systematic review of literature by the Task Force of the Japanese Gastric Cancer Association. Gastric Cancer. 2014;17(1):26–33.

Article  CAS  PubMed  Google Scholar 

Ke H, Yuan R, Liu H, Luo M, Hu H, Zhang E, et al. Serum protein biomarkers for HCC risk prediction in HIV/HBV co-infected people: a clinical proteomic study using mass spectrometry. Front Immunol. 2023;14:1282469.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferkingstad E, Sulem P, Atlason BA, Sveinbjornsson G, Magnusson MI, Styrmisdottir EL, et al. Large-scale integration of the plasma proteome with genetics and disease. Nat Genet. 2021;53(12):1712–21.

Article  CAS  PubMed  Google Scholar 

Birney E. Mendelian Randomization. Cold Spring Harb Perspect Med. 2022;12(4):a041302.

PubMed  PubMed Central  Google Scholar 

Richmond RC, Davey Smith G. Mendelian randomization: concepts and scope. Cold Spring Harb Perspect Med. 2022;12(1):a040501.

Article  PubMed  PubMed Central  Google Scholar 

Pegg AE. Mammalian polyamine metabolism and function. IUBMB Life. 2009;61(9):880–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pegg AE. Functions of polyamines in mammals. J Biol Chem. 2016;291(29):14904–12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bachmann AS, Geerts D. Polyamine synthesis as a target of MYC oncogenes. J Biol Chem. 2018;293(48):18757–69.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hogarty MD, Norris MD, Davis K, Liu X, Evageliou NF, Hayes CS, et al. ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma. Cancer Res. 2008;68(23):9735–45.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martinez ME, O’Brien TG, Fultz KE, Babbar N, Yerushalmi H, Qu N, et al. Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene. Proc Natl Acad Sci USA. 2003;100(13):7859–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cho LY, Yang JJ, Ko KP, Ma SH, Shin A, Choi BY, et al. Gene polymorphisms in the ornithine decarboxylase-polyamine pathway modify gastric cancer risk by interaction with isoflavone concentrations. Gastric Cancer. 2015;18(3):495–503.

Article  CAS  PubMed  Google Scholar 

Brown I, Halliday S, Greig H, Heys SD, Wallace HM, Schofield AC. Genetic polymorphism in ornithine decarboxylase and risk of breast cancer. Fam Cancer. 2009;8(4):307–11.

Article  CAS  PubMed  Google Scholar 

Visvanathan K, Helzlsouer KJ, Boorman DW, Strickland PT, Hoffman SC, Comstock GW, et al. Association among an ornithine decarboxylase polymorphism, androgen receptor gene (CAG) repeat length and prostate cancer risk. J Urol. 2004;171(2 Pt 1):652–5.

Article  PubMed  Google Scholar 

Sollis E, Mosaku A, Abid A, Buniello A, Cerezo M, Gil L, et al. The NHGRI-EBI GWAS Catalog: knowledgebase and deposition resource. Nucleic Acids Res. 2023;51(D1):D977–85.

Article  CAS