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Schisandrin B Improves Mitochondrial Function and Inhibits HT22 Cell Apoptosis by Regulating Sirt3 Protein
Schisandrin B Improves Mitochondrial Function and Inhibits HT22 Cell Apoptosis by Regulating Sirt3 Protein
Neurological diseases refer to pathological changes that occur in the brain, spinal cord, and peripheral nerves. Their eti...
Single-Molecule Insights into GPCR Conformational Landscapes
Single-Molecule Insights into GPCR Conformational Landscapes
Agyemang E, Gonneville AN, Tiruvadi-Krishnan S, Lamichhane R (2024) Exploring GPCR conformational dynamics using single-mo...
Metabolic Energy is Stored in a Homeostatic Trans-Membrane Water Barochemical Gradient
Metabolic Energy is Stored in a Homeostatic Trans-Membrane Water Barochemical Gradient
Trans-membrane water transport and co-transport is ubiquitous in cell biology. Integrated over all the c...
Correction: Single‑Molecule Insights into GPCR Conformational Landscapes
Correction: Single‑Molecule Insights into GPCR Conformational Landscapes
Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a sh...
Action of the Terminal Complement Pathway on Cell Membranes
Action of the Terminal Complement Pathway on Cell Membranes
The complement pathway is one of the most ancient elements of the host's innate response and includes a set of protein...
Cholesterol Concentration in Cell Membranes and its Impact on Receptor–Ligand Interaction: A Computational Study of ATP-Sensitive Potassium Channels and ATP Binding
Cholesterol Concentration in Cell Membranes and its Impact on Receptor–Ligand Interaction: A Computational Study of ATP-Sensitive Potassium Channels and ATP Binding
This work describes a computer study that looks at how different amounts of cholesterol (0%, 25%, and 50%) in cell membran...
Pore Formation by Pore Forming Proteins in Lipid Membranes: Structural Insights Through Cryo-EM
Pore Formation by Pore Forming Proteins in Lipid Membranes: Structural Insights Through Cryo-EM
Many pathogenic bacteria utilize their complicated appalling arsenal, bacterial virulence factors, to attack host cells by...
The Effect of Xenon on the Voltage‒Current Characteristics of Tethered Lipid Bilayers
The Effect of Xenon on the Voltage‒Current Characteristics of Tethered Lipid Bilayers
In this study, we describe the effect of the noble gas, xenon on the electrical properties of tethered lipid bilayer membr...
Role of Ion Channels in Alzheimer’s Disease Pathophysiology
Role of Ion Channels in Alzheimer’s Disease Pathophysiology
Ion channels play an integral role in the normal functioning of the brain. They regulate neuronal electrical properties li...
Cholesterol Affects the Pore Formation and the Membrane–Membrane Interaction Induced by an Antimicrobial Peptide, NK-2, in Phospholipid Vesicles
Cholesterol Affects the Pore Formation and the Membrane–Membrane Interaction Induced by an Antimicrobial Peptide, NK-2, in Phospholipid Vesicles
Antimicrobial peptides are part of the innate immune response and show their antimicrobial activity by forming pores, foll...
Functional and Physiological Implications of Oligopeptide Transporters: Potential Targets for Pharmacological Interventions
Functional and Physiological Implications of Oligopeptide Transporters: Potential Targets for Pharmacological Interventions
Peptide transporters are important plasma membrane proteins that facilitate the cellular uptake of di- and tripeptides in ...
Oxysterols Outcompete Cholesterol Binding to the Membrane-Inserted Cytolysin A Pore Complex
Oxysterols Outcompete Cholesterol Binding to the Membrane-Inserted Cytolysin A Pore Complex
Pore-forming toxins (PFTs) belong to a class of proteins expressed by bacteria to initiate infections by unregulated pore ...
Resurrection of the Helical Hairpin Hypothesis for Understanding Coronavirus Fusion
Resurrection of the Helical Hairpin Hypothesis for Understanding Coronavirus Fusion
Coronaviruses use the spike protein (spike) to bind to target cells, and fuse the viral envelope with a host lipi...
Biomimetic Bacterial Membrane Models for Comprehending Membrane Dynamics
Biomimetic Bacterial Membrane Models for Comprehending Membrane Dynamics
Boucher HW et al (2009) Bad bugs, no drugs: no ESKAPE! An update from the infectious diseases society of America. Clin Inf...
TtfA is a Highly Stable Membrane-Anchored DNA-Binding Protein
TtfA is a Highly Stable Membrane-Anchored DNA-Binding Protein
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a deadly intracellular pathogen, with a per...
Passage of the Channel-Forming Agent Nystatin Through Ergosterol-Containing Lipid Membranes
Passage of the Channel-Forming Agent Nystatin Through Ergosterol-Containing Lipid Membranes
The passage of nystatin through the ergosterol-containing phospholipid bilayer was studied on monovesicular and multivesic...
Stomatin and Stomatin-Like Proteins Can Regulate Transporter Proteins Activity and Has a Role in Cancer Metastasis
Stomatin and Stomatin-Like Proteins Can Regulate Transporter Proteins Activity and Has a Role in Cancer Metastasis
Stomatin, encoded by STOM gene, is an integral membrane protein found in a wide variety of species. Although years have pa...
Molecular Insights into Interactions between Ofloxacin and Ionic Micelles
Molecular Insights into Interactions between Ofloxacin and Ionic Micelles
The growing antimicrobial resistance presents a challenge in developing new potent drugs, but this effort is hindered by a...
Abundance of the Membrane Proteome in Yeast Cells Lacking Spc1, a Non-catalytic Subunit of the Signal Peptidase Complex
Abundance of the Membrane Proteome in Yeast Cells Lacking Spc1, a Non-catalytic Subunit of the Signal Peptidase Complex
The signal peptidase complex (SPC) mediates processing of signal peptides of secretory precursors. But, recent studies sho...
A Critical Review of Short Antimicrobial Peptides from Scorpion Venoms, Their Physicochemical Attributes, and Potential for the Development of New Drugs
A Critical Review of Short Antimicrobial Peptides from Scorpion Venoms, Their Physicochemical Attributes, and Potential for the Development of New Drugs
Scorpion venoms have proven to be excellent sources of antimicrobial agents. However, although many of them have been func...
Sperm-Specific CatSper is Not Conserved in All Vertebrates and May Not be the Only Progesterone-Responsive Ion Channel Present in Sperm
Sperm-Specific CatSper is Not Conserved in All Vertebrates and May Not be the Only Progesterone-Responsive Ion Channel Present in Sperm
Progesterone (P4) acts as a key conserved signalling molecule in vertebrate reproduction. P4 is especially important for m...
Beyond Hormones: Investigating the Impact of Progesterone Receptor Membrane Component 1 in Lung Adenocarcinoma
Beyond Hormones: Investigating the Impact of Progesterone Receptor Membrane Component 1 in Lung Adenocarcinoma
Progesterone Receptor Membrane Component 1 (PGRMC1) is a candidate oncogene with a prominent involvement in the pathogenes...
Aggregation Behavior of Amyloid Beta Peptide Depends Upon the Membrane Lipid Composition
Aggregation Behavior of Amyloid Beta Peptide Depends Upon the Membrane Lipid Composition
Protein aggregation plays a crucial role in the development of several neurodegenerative diseases. It is important to unde...
N-Glycosylation Deficiency in Transgene α7 nAChR and RIC3 Expressing CHO Cells Without NACHO
N-Glycosylation Deficiency in Transgene α7 nAChR and RIC3 Expressing CHO Cells Without NACHO
The human neuronal nicotinic acetylcholine receptor α7 (nAChR) is an important target implicated in diseases like Alz...
Sphingomyelin Inhibits Hydrolytic Activity of Heterodimeric PLA2 in Model Myelin Membranes: Pharmacological Relevance
Sphingomyelin Inhibits Hydrolytic Activity of Heterodimeric PLA2 in Model Myelin Membranes: Pharmacological Relevance
In this work, the heterodimeric phospholipase A2, HDP-2, from viper venom was investigated for its hydrolytic activity in ...
The Role of the Swollen State in Cell Proliferation
The Role of the Swollen State in Cell Proliferation
Cell swelling is known to be involved in various stages of the growth of plant cells and microorganisms but in mammalian c...
Postsynaptic Density Proteins and Their Role in the Trafficking of Group I Metabotropic Glutamate Receptors
Postsynaptic Density Proteins and Their Role in the Trafficking of Group I Metabotropic Glutamate Receptors
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system that regulates multiple differe...
Early Events in β2AR Dimer Dynamics Mediated by Activation-Related Microswitches
Early Events in β2AR Dimer Dynamics Mediated by Activation-Related Microswitches
G-Protein-Coupled Receptors (GPCRs) make up around 3–4% of the human genome and are the targets of one-third of FDA-...
Enhancing Anti-Cancer Immune Response by Acidosis-Sensitive Nanobody Display
Enhancing Anti-Cancer Immune Response by Acidosis-Sensitive Nanobody Display
One of the main challenges with many cancer immunotherapies is that biomarkers are needed for targeting. These biomarkers ...
Voltage Gated Ion Channels and Sleep
Voltage Gated Ion Channels and Sleep
Ion channels are integral components of the nervous system, playing a pivotal role in shaping membrane potential, neuronal...
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