Agarwal S, Boddu SHS, Jain R et al (2008) Peptide prodrugs: improved oral absorption of lopinavir, a HIV protease inhibitor. Int J Pharm 359:7–14
Article CAS PubMed PubMed Central Google Scholar
Agu R, Cowley E, Shao D et al (2011) Proton-coupled oligopeptide transporter (POT) family expression in human nasal epithelium and their drug transport potential. Mol Pharm 8:664–672
Article CAS PubMed Google Scholar
Akarawut W, Lin C-J, Smith DE (1998) Noncompetitive inhibition of glycylsarcosine transport by quinapril in rabbit renal brush border membrane vesicles: effect on high-affinity peptide transporter. J Pharmacol Exp Ther 287:684–690
Article CAS PubMed Google Scholar
Alghamdi OA, King N, Andronicos NM et al (2019) Molecular changes to the rat renal cotransporters PEPT1 and PEPT2 due to ageing. Mol Cell Biochem 452:71–82
Article CAS PubMed Google Scholar
Anand BS, Patel J, Mitra AK (2003) Interactions of the dipeptide ester prodrugs of acyclovir with the intestinal oligopeptide transporter: competitive inhibition of glycylsarcosine transport in human intestinal cell line-Caco-2. J Pharmacol Exp Ther 304:781–791
Article CAS PubMed Google Scholar
Ashida K, Katsura T, Motohashi H et al (2024) Thyroid hormone regulates the activity and expression of the peptide transporter PEPT1 in Caco-2 cells. Am J Physiol Liver Physiol 282:G617–G623
Atluri H, Anand BS, Patel J, Mitra AK (2004) Mechanism of a model dipeptide transport across blood-ocular barriers following systemic administration. Exp Eye Res 78:815–822
Article CAS PubMed Google Scholar
Azad MAK, Roberts KD, Yu HH et al (2015) Significant accumulation of polymyxin in single renal tubular cells: a medicinal chemistry and triple correlative microscopy approach. Anal Chem 87:1590–1595
Article CAS PubMed PubMed Central Google Scholar
Babizhayev MA (2008) Ocular drug metabolism of the bioactivating antioxidant N-acetylcarnosine for vision in ophthalmic prodrug and codrug design and delivery. Drug Dev Ind Pharm 34:1071–1089
Article CAS PubMed Google Scholar
Babizhayev MA (2012) Bioactivation antioxidant and transglycating properties of N-acetylcarnosine autoinduction prodrug of a dipeptide L-carnosine in mucoadhesive drug delivery eye-drop formulation: powerful eye health application technique and therapeutic platform. Drug Test Anal 4:468–485
Article CAS PubMed Google Scholar
Babizhayev A, M (2014) Biochemical, biomedical and metabolic aspects of imidazole-containing dipeptides with the inherent complexity to neurodegenerative diseases and various states of mental well-being: A challenging correction and neurotherapeutic pharmaceutical biotechnology. Curr Pharm Biotechnol 15:738–778
Article CAS PubMed Google Scholar
Bajraktari-Sylejmani G, von Linde T, Burhenne J et al (2022) Evaluation of PepT1 (SLC15A1) substrate characteristics of therapeutic cyclic peptides. Pharmaceutics 14:1610
Article CAS PubMed PubMed Central Google Scholar
Barca A, Gatti F, Spagnolo D et al (2018) Responsiveness of carnosine homeostasis genes in the pancreas and brain of streptozotocin-treated mice exposed to dietary carnosine. Int J Mol Sci 19:1713
Article PubMed PubMed Central Google Scholar
Berger UV, Hediger MA (1999) Distribution of peptide transporter PEPT2 mRNA in the rat nervous system. Anat Embryol (Berl) 199:439–449
Article CAS PubMed Google Scholar
Bermúdez M-L, Seroogy KB, Genter MB (2019) Evaluation of carnosine intervention in the Thy1-aSyn mouse model of Parkinson’s disease. Neuroscience 411:270–278
Biegel A, Knütter I, Hartrodt B et al (2006) The renal type H+/peptide symporter PEPT2: structure-affinity relationships. Amino Acids 31:137–156
Article CAS PubMed Google Scholar
Boll M, Markovich D, Weber W-M et al (1994) Expression cloning of a cDNA from rabbit small intestine related to proton-coupled transport of peptides, ßlactam antibiotics and ACE-inhibitors. Pflügers Arch 429:146–149
Article CAS PubMed Google Scholar
Boll M, Herget M, Wagener M et al (1996) Expression cloning and functional characterization of the kidney cortex high-affinity proton-coupled peptide transporter. Proc Natl Acad Sci 93:284–289
Article CAS PubMed PubMed Central Google Scholar
Brahmajothi MV, Sun NZ, Auten RL (2013) S-nitrosothiol transport via PEPT2 mediates biological effects of nitric oxide gas exposure in macrophages. Am J Respir Cell Mol Biol 48:230–239
Article CAS PubMed Google Scholar
Brandsch M, Knütter I, Bosse-doenecke E (2008) Pharmaceutical and pharmacological importance of peptide transporters. J Pharm Pharmacol 60:543–585
Article CAS PubMed Google Scholar
Bravo SA, Nielsen CU, Amstrup J et al (2004) Epidermal growth factor decreases PEPT2 transport capacity and expression in the rat kidney proximal tubule cell line SKPT0193 cl. 2. Am J Physiol Physiol 286:F385–F393
Brecht K, Schäfer AM, Meyer zu Schwabedissen HE, (2020) Uptake transporters of the SLC21, SLC22A, and SLC15A families in anticancer therapy—modulators of cellular entry or pharmacokinetics? Cancers (Basel) 12:2263
Article CAS PubMed Google Scholar
Cheng J, Yang J, Liu Y et al (2019) Profiling and targeting of cellular mitochondrial bioenergetics: inhibition of human gastric cancer cell growth by carnosine. Acta Pharmacol Sin 40:938–948
Article CAS PubMed Google Scholar
Chourasia TK, d’Cotta H, Baroiller J-F et al (2018) Effects of the acclimation to high salinity on intestinal ion and peptide transporters in two tilapia species that differ in their salinity tolerance. Comp Biochem Physiol Part A Mol Integr Physiol 218:16–23
Content R (2018) SLC15A2 and SLC15A4 mediate the transport of bacterially derived Di/Tripeptides to enhance the nucleotide-binding oligomerization domain-dependent immune response in mouse bone marrow-derived macrophages. J Immunol 201:652–662
Cunha-Vaz J (2017) The blood-retinal barrier in the management of retinal disease: EURETINA award lecture. Ophthalmologica 237:1–10
Article CAS PubMed Google Scholar
Daniel H, Kottra G (2004) The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. Pflügers Arch 447:610–618
Article CAS PubMed Google Scholar
Daniel H, Spanier B, Kottra G, Weitz D (2006) From bacteria to man: archaic proton- dependent peptide transporters at work. Physiology 21:93–102
Article CAS PubMed Google Scholar
Der-Boghossian AH, Saad SR, Perreault C et al (2010) Role of insulin on jejunal PepT1 expression and function regulation in diabetic male and female rats. Can J Physiol Pharmacol 88:753–759
Article CAS PubMed Google Scholar
Dias C, Nashed Y, Atluri H, Mitra A (2002) Ocular penetration of acyclovir and its peptide prodrugs valacyclovir and val-valacyclovir following systemic administration in rabbits: An evaluation using ocular microdialysis and LC-MS. Curr Eye Res 25:243–252. https://doi.org/10.1076/ceyr.25.4.243.13488
Do TTH, Hindlet P, Waligora-Dupriet A-J et al (2014) Disturbed intestinal nitrogen homeostasis in a mouse model of high-fat diet-induced obesity and glucose intolerance. Am J Physiol Metab 306:E668–E680
Döring F, Schmitt R, Bernhardt WM et al (2005) (2005) Hypothyroidism induces expression of the peptide transporter PEPT2. Biol Chem 386(8):785–790. https://doi.org/10.1515/BC.2005.092
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