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Genetic and pharmacological targeting of mTORC1 in mouse models of arteriovenous malformation expose non-cell autonomous signalling in HHT
Genetic and pharmacological targeting of mTORC1 in mouse models of arteriovenous malformation expose non-cell autonomous signalling in HHT
Arteriovenous malformations (AVMs) are abnormal high flow shunts between arteries and veins with major negative impact on ...
Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions
Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions
Neuropilin-1 (NRP1) regulates endothelial cell (EC) biology through modulation of vascular endothelial growth factor recep...
Effect of oral nintedanib vs placebo on epistaxis in hereditary hemorrhagic telangiectasia: the EPICURE multicenter randomized double-blind trial
Effect of oral nintedanib vs placebo on epistaxis in hereditary hemorrhagic telangiectasia: the EPICURE multicenter randomized double-blind trial
Epistaxis greatly affects patients with hereditary hemorrhagic telangiectasia (HHT). Although few systemic treatment exist...
Anti-angiogenic therapy as potential treatment for adenomyosis
Anti-angiogenic therapy as potential treatment for adenomyosis
Adenomyosis is characterized by abnormal uterine bleeding, dysmenorrhea and subfertility. Increased expression of angiogen...
The role of liver sinusoidal endothelial cells in metabolic dysfunction-associated steatotic liver diseases and liver cancer: mechanisms and potential therapies
The role of liver sinusoidal endothelial cells in metabolic dysfunction-associated steatotic liver diseases and liver cancer: mechanisms and potential therapies
Liver sinusoidal endothelial cells (LSECs), with their unique morphology and function, have garnered increasing attention ...
From bench to bedside: murine models of inherited and sporadic brain arteriovenous malformations
From bench to bedside: murine models of inherited and sporadic brain arteriovenous malformations
Brain arteriovenous malformations are abnormal vascular structures in which an artery shunts high pressure blood directly ...
Clioquinol inhibits angiogenesis by promoting VEGFR2 degradation and synergizes with AKT inhibition to suppress triple-negative breast cancer vascularization
Clioquinol inhibits angiogenesis by promoting VEGFR2 degradation and synergizes with AKT inhibition to suppress triple-negative breast cancer vascularization
Inhibition of angiogenesis, either as monotherapy or in conjunction with other treatments, holds significant promise in ca...
Correction: Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions
Correction: Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Cxcl9 modulates aging associated microvascular metabolic and angiogenic dysfunctions in subcutaneous adipose tissue
Cxcl9 modulates aging associated microvascular metabolic and angiogenic dysfunctions in subcutaneous adipose tissue
Microvascular aging, predominantly driven by endothelial cells (ECs) dysfunction, is a critical early event in cardiovascu...
Correction: CCL4 contributes to aging related angiogenic insufficiency through activating oxidative stress and endothelial inflammation
Correction: CCL4 contributes to aging related angiogenic insufficiency through activating oxidative stress and endothelial inflammation
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Isolated human adipose microvessels retain native microvessel structure and recapitulate sprouting angiogenesis
Isolated human adipose microvessels retain native microvessel structure and recapitulate sprouting angiogenesis
With interest growing in modeling more complex aspects of human disease in the laboratory, the need for effectively vascul...
Immune-privileged cord blood-derived endothelial colony-forming cells: advancing immunomodulation and vascular regeneration
Immune-privileged cord blood-derived endothelial colony-forming cells: advancing immunomodulation and vascular regeneration
Cord blood-derived endothelial colony-forming cells (CB-ECFCs) hold significant promise for regenerative medicine due to t...
Microvascular and cerebrovascular alterations in Raynaud’s phenomenon and fibromyalgia
Microvascular and cerebrovascular alterations in Raynaud’s phenomenon and fibromyalgia
Consent for publication Written informed consent was obtain...
Endothelial USP11 drives VEGFR2 signaling and angiogenesis via PRDX2/c-MYC axis
Endothelial USP11 drives VEGFR2 signaling and angiogenesis via PRDX2/c-MYC axis
Angiogenesis is a crucial component of various physiological and pathological processes, including embryonic development, ...
ApoM-bound S1P acts via endothelial S1PR1 to suppress choroidal neovascularization and vascular leakage
ApoM-bound S1P acts via endothelial S1PR1 to suppress choroidal neovascularization and vascular leakage
Neovascular age-related macular degeneration (nAMD) is a major cause of vision loss worldwide. Current standard of care is...
Role of endothelial PDGFB in arterio-venous malformations pathogenesis
Role of endothelial PDGFB in arterio-venous malformations pathogenesis
Arterial-venous malformations (AVMs) are direct connections between arteries and veins without an intervening capillary be...
Circulating Von Willebrand factor: a consistent biomarker predicting in-hospital mortality across different waves of the COVID-19 pandemic
Circulating Von Willebrand factor: a consistent biomarker predicting in-hospital mortality across different waves of the COVID-19 pandemic
Paris Cité University, Innovative Therapies in Hemostasis, INSERM, 75006, Paris, FranceDavid M. Smadja, Aurélien Philippe,...
Multimodality imaging reveals angiogenic evolution in vivo during calvarial bone defect healing
Multimodality imaging reveals angiogenic evolution in vivo during calvarial bone defect healing
The healing of calvarial bone defects is a pressing clinical problem that involves the dynamic interplay between angiogene...
Correction: The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells
Correction: The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells
The Fig. 3a of this article originally contained an incorrect picture showing “HDAC7/AKAP12 siRNA” condition at t = 0 h. I...
Notch ligands are biomarkers of anti-TNF response in RA patients
Notch ligands are biomarkers of anti-TNF response in RA patients
Notch and its ligands play a critical role in rheumatoid arthritis (RA) pathogenesis. Hence, studies were conducted to del...
Targeting the microenvironment in the treatment of arteriovenous malformations
Targeting the microenvironment in the treatment of arteriovenous malformations
Extracranial arteriovenous malformations (AVMs) are regarded as rare diseases and are prone to complications such as pain,...
Executive summary of the 14th HHT international scientific conference
Executive summary of the 14th HHT international scientific conference
Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant vascular disorder characterized by small, dilated clu...
A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells
A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells
FLT1/VEGFR1 negatively regulates VEGF-A signaling and is required for proper vessel morphogenesis during vascular developm...
2022 14th HHT International Scientific Conference Abstracts
2022 14th HHT International Scientific Conference Abstracts
Medical therapeuticsO1 Cure HHT research network: building the roadmap to cure HHTFriday C, MS1; Krock N1; Schaefer N1; Le...
Reply to “Embracing imatinib: a novel approach to safeguarding the endothelial barrier in patients with COVID-19”
Reply to “Embracing imatinib: a novel approach to safeguarding the endothelial barrier in patients with COVID-19”
Kow CS, Ramachandram DS, Hasan SS (2022) The effect of higher-intensity dosing of anticoagulation on the clinical outcomes...
The modes of angiogenesis: an updated perspective
The modes of angiogenesis: an updated perspective
Following the process of vasculogenesis during development, angiogenesis generates new vascular structures through a varie...
Correction: Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation
Correction: Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation
School of Medicine, Klinikum Rechts Der Isar, Department of Nephrology, Technical University of Munich, Ismaninger Str. 22...
Aging impairs the ability of vascular endothelial stem cells to generate endothelial cells in mice
Aging impairs the ability of vascular endothelial stem cells to generate endothelial cells in mice
Tissue-resident vascular endothelial stem cells (VESCs), marked by expression of CD157, possess long-term repopulating pot...
VEGF-A plasma levels are associated with impaired DLCO and radiological sequelae in long COVID patients
VEGF-A plasma levels are associated with impaired DLCO and radiological sequelae in long COVID patients
Long COVID, also known as post-acute sequelae of COVID-19 (PASC), is characterized by persistent clinical symptoms followi...
Embracing Imatinib: a novel approach to safeguarding the endothelial barrier in patients with COVID-19
Embracing Imatinib: a novel approach to safeguarding the endothelial barrier in patients with COVID-19
Imatinib, an ABL tyrosine-kinase inhibitor, shows promise in restoring endothelial barrier function in patients with COVID...
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