Wang J, Metheny L (2023) Umbilical cord blood derived cellular therapy: advances in clinical development. Front Oncol 13:1167266. https://doi.org/10.3389/fonc.2023.1167266

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smadja DM (2019) Vasculogenic stem and progenitor cells in human: future cell therapy product or liquid biopsy for vascular disease. Adv Exp Med Biol 1201:215–237. https://doi.org/10.1007/978-3-030-31206-0_11

Article  CAS  PubMed  Google Scholar 

Smadja DM, Melero-Martin JM, Eikenboom J et al (2019) Standardization of methods to quantify and culture endothelial colony-forming cells derived from peripheral blood: position paper from the international society on thrombosis and haemostasis SSC. J Thromb Haemost 17:1190–1194. https://doi.org/10.1111/jth.14462

Article  PubMed  PubMed Central  Google Scholar 

Blandinieres A, Randi AM, Paschalaki KE et al (2023) Results of an international survey about methods used to isolate human endothelial colony-forming cells (ECFCs): guidance from the scientific and standardization committee on vascular biology of the international society of thrombosis and hemostasis. J Thromb Haemost S 1538–7836(23):00498–00491. https://doi.org/10.1016/j.jtha.2023.06.014

Article  Google Scholar 

Yoder MC, Mead LE, Prater D et al (2007) Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood 109:1801–1809. https://doi.org/10.1182/blood-2006-08-043471

Article  CAS  PubMed  PubMed Central  Google Scholar 

Asahara T, Murohara T, Sullivan A et al (1997) Isolation of putative progenitor endothelial cells for angiogenesis. Science 275:964–967. https://doi.org/10.1126/science.275.5302.964

Article  CAS  PubMed  Google Scholar 

Hassanpour M, Salybekov AA, Kobayashi S, Asahara T (2023) CD34 positive cells as endothelial progenitor cells in biology and medicine. Front Cell Dev Biol 11:1128134. https://doi.org/10.3389/fcell.2023.1128134

Article  PubMed  PubMed Central  Google Scholar 

Lin Y, Weisdorf DJ, Solovey A, Hebbel RP (2000) Origins of Circulating endothelial cells and endothelial outgrowth from blood. J Clin Invest 105:71–77. https://doi.org/10.1172/JCI8071

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fujisawa T, Tura-Ceide O, Hunter A et al (2019) Endothelial progenitor cells do not originate from the bone marrow. Circulation 140:1524–1526. https://doi.org/10.1161/CIRCULATIONAHA.119.042351

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hur J, Yoon C-H, Kim H-S et al (2004) Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis. Arterioscler Thromb Vasc Biol 24:288–293. https://doi.org/10.1161/01.ATV.0000114236.77009.06

Article  CAS  PubMed  Google Scholar 

Delorme B, Basire A, Gentile C et al (2005) Presence of endothelial progenitor cells, distinct from mature endothelial cells, within human CD146 + blood cells. Thromb Haemost 94:1270–1279. https://doi.org/10.1160/TH05-07-0499

Article  CAS  PubMed  Google Scholar 

Smadja DM, Bièche I, Uzan G et al (2005) PAR-1 activation on human late endothelial progenitor cells enhances angiogenesis in vitro with upregulation of the SDF-1/CXCR4 system. Arterioscler Thromb Vasc Biol 25:2321–2327. https://doi.org/10.1161/01.ATV.0000184762.63888.bd

Article  CAS  PubMed  Google Scholar 

Lee JH, Lee SH, Yoo SY et al (2013) CD34 hybrid cells promote endothelial Colony-Forming cell bioactivity and therapeutic potential for ischemic diseases. ATVB 33:1622–1634. https://doi.org/10.1161/ATVBAHA.112.301052

Article  CAS  Google Scholar 

Case J, Mead LE, Bessler WK et al (2007) Human CD34 + AC133 + VEGFR-2 + cells are not endothelial progenitor cells but distinct, primitive hematopoietic progenitors. Exp Hematol 35:1109–1118. https://doi.org/10.1016/j.exphem.2007.04.002

Article  CAS  PubMed  Google Scholar 

Timmermans F, Van Hauwermeiren F, De Smedt M et al (2007) Endothelial outgrowth cells are not derived from CD133 + cells or CD45 + hematopoietic precursors. Arterioscler Thromb Vasc Biol 27:1572–1579. https://doi.org/10.1161/ATVBAHA.107.144972

Article  CAS  PubMed  Google Scholar 

Tura O, Skinner EM, Barclay GR et al (2013) Late outgrowth endothelial cells resemble mature endothelial cells and are not derived from bone marrow. Stem Cells 31:338–348. https://doi.org/10.1002/stem.1280

Article  CAS  PubMed  Google Scholar 

Lin Y, Banno K, Gil C-H et al (2023) Origin, prospective identification, and function of Circulating endothelial colony-forming cells in mice and humans. JCI Insight 8:e164781. https://doi.org/10.1172/jci.insight.164781

Article  PubMed  PubMed Central  Google Scholar 

Ratajczak MZ, Ratajczak J, Kucia M (2019) Very small Embryonic-Like stem cells (VSELs). Circ Res 124:208–210. https://doi.org/10.1161/CIRCRESAHA.118.314287

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guerin CL, Loyer X, Vilar J et al (2015) Bone-marrow-derived very small embryonic-like stem cells in patients with critical leg ischaemia: evidence of vasculogenic potential. Thromb Haemost 113:1084–1094. https://doi.org/10.1160/TH14-09-0748

Article  PubMed  Google Scholar 

Lahlil R, Scrofani M, Barbet R et al (2018) VSELs maintain their pluripotency and competence to differentiate after enhanced ex vivo expansion. Stem Cell Rev Rep 14:510–524. https://doi.org/10.1007/s12015-018-9821-1

Article  CAS  PubMed  Google Scholar 

Domingues A, Rossi E, Bujko K et al (2022) Human CD34 + very small embryonic-like stem cells can give rise to endothelial colony-forming cells with a multistep differentiation strategy using UM171 and nicotinamide acid. https://doi.org/10.1038/s41375-022-01517-0. Leukemia

Saucourt C, Vogt S, Merlin A et al (2019) Design and validation of an automated process for the expansion of peripheral Blood-Derived CD34 + Cells for clinical use after myocardial infarction. Stem Cells Transl Med 8:822–832. https://doi.org/10.1002/sctm.17-0277

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hénon P, Kowalczyk M, Aries A et al (2022) Industrialized GMP production of CD34 + Cells (ProtheraCytes®) at clinical scale for treatment of ischemic cardiac diseases is feasible and safe. Stem Cell Rev Rep 18:1614–1626. https://doi.org/10.1007/s12015-022-10373-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hénon P (2020) Key success factors for regenerative medicine in acquired heart diseases. Stem Cell Rev Rep 16:441–458. https://doi.org/10.1007/s12015-020-09961-0

Article  PubMed  PubMed Central  Google Scholar 

Wakabayashi T, Naito H, Suehiro J-I et al (2018) CD157 marks Tissue-Resident endothelial stem cells with homeostatic and regenerative properties. Cell Stem Cell 22:384–397e6. https://doi.org/10.1016/j.stem.2018.01.010

Article  CAS  PubMed  Google Scholar 

Naito H, Wakabayashi T, Ishida M et al (2020) Isolation of tissue-resident vascular endothelial stem cells from mouse liver. Nat Protoc 15:1066–1081. https://doi.org/10.1038/s41596-019-0276-x

Article  CAS  PubMed  Google Scholar 

Bhagwani AR, Farkas D, Harmon B et al (2020) Clonally selected primitive endothelial cells promote occlusive pulmonary arteriopathy and severe pulmonary hypertension in rats exposed to chronic hypoxia. Sci Rep 10:1136. https://doi.org/10.1038/s41598-020-58083-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin Y, Gil C-H, Banno K et al (2024) ABCG2-Expressing clonal repopulating endothelial cells serve to form and maintain blood vessels. Circulation 150:451–465. https://doi.org/10.1161/CIRCULATIONAHA.122.061833

Article